Junior, on 18 December 2009 - 07:30 PM, said:
Neurons (brain cells) communicate with each other via chemical messengers called neurotransmitters. The sending neuron emits this chemical messenger and the receiving neuron has receptors.. there are different receptors for different chemicals. SSRIs (Paxil, Prozac, etc) and SNRIs (Cymbalta and Effexor)work by stopping the sending neuron from clearing the synapse (gap between neurons) from taking the excess back up - reuptake. This leaves the chemical in the synapse longer and allows more time for the receiving neuron to accept it. Does that make sense?
In effect, these drugs down-regulate the receptors on the sending neuron and when the drug is stopped, it can take a while for it to return to its pre-medication state. This means that we are processing LESS of the serotonin or serotonin and norepinephrine (depending which drug we are on) than we did before going on the medication. In addition, if you alter one or two of these chemical messengers, the brain alters others (there are over 50) in order to find a new balance.
SO... it can take a while for the receptors to return to normal function.. AND.. it can take a while for the other chemical messengers to return to pre-medication levels. Any change in what the receptors are doing is going to affect all the other neurotransmitters.....
At this forum, and another I go to (Paxil Progress) many find that a VERY slow taper (in some cases taking months) is more effective than anything else. The reason being that each small drop gives the brain time to heal a bit before dropping the dose again. It makes withdrawal a lot more bearable and seems to have a better long term outcome.
Hope all of that makes sense. I know it is complicated
Junior
Hi Junior,
I have spent two days reading this site now and I am both encouraged (because it is NOT in my head! Okay, it is, but, well, you know what I mean! =) and I am outraged these kinds of medication cause such harm. The doctors oath is to Due No Harm but unfortunately, big pharma does not have to take that oath. =( I know I have made the right decision to come off this horrible medication.
I was on Wellbutrin 300mg for about a year after having a particularly tough bought of depression. I have suffered from depression my entire life and this was the worst. I actually took six weeks off work to recover. Then, I also began working with a very wonderful specialist to try and get my IBS under control. After months of working with her, she suggested I try Cymbalta because she had read it was working in some people and would also work for my depression. Now almost two years later, my life is in shambles, sort of.
The good: I moved back to my home town after divorcing my husband of 11 years ( a very good thing) and bought my own adorable little house. I have a loving furry family including three dogs, two cats and a few others both finned and furred. I have an okay job in my field but I just got to the city a year ago so I have time to check out the scene a bit. And to top it all off, I have the most amazing boyfriend ever! He is all I want in a guy and he is cute too! Oh, and single! =) Things have been great up until about nine months ago.
The bad: The cravings for alcohol started shortly after I moved back. I am a huge wine fan so I buy a lot and stash it in my basement for special occasions but right around November, I started a "kick" of a bottle a night, sometimes two. I eat constantly and this is the most I have even weighed in my life. I have a very physically demanding job so it is kind of like getting paid to work out but I am now hungry all the time. Sometimes, I am *starving* only an hour after I eat a big meal. Then the brain zaps began about 4 months ago when I forgot to take my dose in the morning. My early afternoon I would get a zap warning me to take my pills and every time I would find that I indeed had forgotten to take them. I honestly thought it was due to the alcohol but it happened even on the rare nights when I did not drink. I also began to realize how much of my life I had missed because I could not remember it. My boyfriend (Mike) would talk to me about something we did and I would not be able to recall anything about it, even if it was just two weeks ago! And random crap too, like going to the store or seeing a movie. Again, I could not attribute it to alcohol. Then one day I had a very long conversation with my best friend and we made plans to go see a show the next day. The tickets were $80. Having just bought a house I should not be spending that money but the next day she just shows up and Ta Da! Wow.
That day with my friend was not really enjoyable because I realized that my life was out of control. Something had to be done. I began by quitting all medications except the Cymbalta which was the only perscription I was taking daily. I tried that for a week, no better. Then I stopped the Cymbalta. BAD IDEA! So, then I tried the weaning but until last night, I had no idea how long that should have taken and now I am kind of stuck. It has been almost three weeks since I had a pill and I am still so unstable. So here is the list of my "problems":
Brain zaps are a daily thing, anywhere from annoying to call-in-sick-to-work debilitating. Weight gain, but that is likely due to the huge amounts of calories I am consuming daily. Alcohol use is not good in this amount, no matter what, and the cost is not all that great either. I occasionally feeling like I am standing while an earthquake is going on (I lived in LA for the last 13 years) and no one else around me feels a thing. We don't have earthquakes you can feel in Minnesota. Confusion? Heck yeah! I can't even call clients and leave simple messages because I sometimes have trouble putting together full sentences. Ears ringing, listen to people talk like I am underwater, body aches, night sweats - my god! The list goes on! Actually, I thought I might be going through peri- or early menopause but then I found this site, you people and something I have not had in a while...... hope.
This is one nasty drug and I am going to make it my mission to let the world know how nasty, just as soon as I can make complete sentences! =) But in the mean time, how did those of you who are over it manage your symptoms WITHOUT more drugs? Being out this far I don't know that I want to take anything at this point. I am also not sure if I want to go back to the Wellbutrin. My life was very happy (except for the ex-husband) during that time. I felt whole and blessed. I want that back. I could go on but after the last two nights of no sleep, I am going to take a little helper tonight and get some rest. Thank you for the neurology lesson on healing. I will use that to my advantage.
Night all,
Pamela