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#1 fishinghat

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Posted 30 June 2016 - 10:29 AM

I have been working on this info for 6 years as the info came out. I collected this information and with time developed a interesting relationship of a vit D gene, low vit D, psoriasis, high triglycerides, TB, CMV virus, hypothyroidism and low serum calcium. All of which I have. Most interesting to all of you might be the strong link of vitamin D to a certain lipid profile which is strongly linked to BUT vit D is NOT linked to anxiety. If you have any interest in the details of the research ley me know.
 
Vitamin D. psoriasis and triglycerides.

Vitamin D is actually a hormone not a vitamin and is critical to antiinflammitory/ immune system responses with the body. There is at least 8 morphs of the VDR gene (Vitamin D Receptor Gene), more morphs than any other human gene known at this time. The vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem-cell proliferation, and microbial defense. However, decreased levels of Vit D3 are not caused by vitamin D deficiency. 1,25(OH)2D3 elicits its action on target tissues through the vitamin D receptor (VDR). The receptor-hormone complex binds to hormone response elements in regulatory regions of target genes, and modulates the gene transcription.
It has been suggested that continuous separation of psoriatic scales caused the permanent loss of lipids which adversely affects lipid homeostasis. Healthy skin secretes 85 mg of cholesterol within 24 hours, whereas a psoriatic patient loses 1-2 grams of cholesterol with scales during that time. Alterations in plasma lipid and lipoprotein composition including a tendency toward an increase in total cholesterol (TC) and triglyceride (TG) and decrease in high-density lipoprotein cholesterol (HDL-C) levels suggest that psoriasis may associate with the disorders of lipid metabolism .
It is known that vitamin D insufficiency is present in about one billion people worldwide and that this high prevalence is independent of location, age and socioeconomic or cultural levels, and is mainly related to inadequate sun exposure aggravated by inadequate consumption of foods containing this vitamin. An estimated 30 to 40% of the USA population is beleive to be iodine insufficient and 75% for those over 70 years old.

Research Summary
Items that apply to me are underlined.
1) High triglycerides associated with low vitamin D and Vit D supplementation has been used to successfully treat high triglycerides.
2) Psoriasis associated with high triglycerides
3) Psoriasis is correlated to low Vit D and has been successfully treated with Vit D.
4) VDR polymorphism linked to psoriasis, high triglycerides and low Vit D
5) Low Vit D associated with developing myopathy from statins (In my case fibrates)
7) Lipid imbalance linked to anxiety as listed below:
           Anxiety associated with;
                        low total cholesterol (<75) or elevated total cholesterol (>200, >240)) (4)
                        elevated low-density lipoprotein cholesterol (4)
                        elevated triglycerides (3)
                        high ratio of total cholesterol to high-density lipoprotein cholesterol (2)
                        low HDL cholesterol (2)
                        Increased noradrenergic activity were present for elevations in lipid levels in   patients with anxiety. (2)
8) Low vitamin D minimal link to Anxiety
9) Omega 3 and Vit D most successful supplements for treating psoriasis.
10) Both successfully used to treat high trigylcerides and some benefit for anxiety..
11) Low Vitamin D linked to hypothyroidism.
12) Low Vitamin A also linked to low calcium.
13) VDR polymorphs linked to TB susceptability.

#2 FiveNotions

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Posted 30 June 2016 - 12:48 PM

Wow, FH, fascinating stuff here ... yes, I'm definitely interested in knowing more ... have a friend who seems to fit the profile of what you've outlined ... 

 

Research librarian (me) tips hat to you !! :D


#3 fishinghat

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Posted 30 June 2016 - 01:30 PM

Well lets see if I can get this posted. lol

 

Vitamin D. psoriasis and triglycerides.

Vitamin D is actually a hormone not a vitamin and is critical to antiinflammitory/ immune system responses with the body. There is at least 8 morphs of the VDR gene (Vitamin D Receptor Gene), more morphs than any other human gene known at this time. The vitamin D receptor (VDR) is a master regulator of epidermal barrier function, inflammation, stem-cell proliferation, and microbial defense. However, decreased levels of Vit D3 are not caused by vitamin D deficiency. 1,25(OH)2D3 elicits its action on target tissues through the vitamin D receptor (VDR). The receptor-hormone complex binds to hormone response elements in regulatory regions of target genes, and modulates the gene transcription.

It has been suggested that continuous separation of psoriatic scales caused the permanent loss of lipids which adversely affects lipid homeostasis. Healthy skin secretes 85 mg of cholesterol within 24 hours, whereas a psoriatic patient loses 1-2 grams of cholesterol with scales during that time. Alterations in plasma lipid and lipoprotein composition including a tendency toward an increase in total cholesterol (TC) and triglyceride (TG) and decrease in high-density lipoprotein cholesterol (HDL-C) levels suggest that psoriasis may associate with the disorders of lipid metabolism .
It is known that vitamin D insufficiency is present in about one billion people worldwide and that this high prevalence is independent of location, age and socioeconomic or cultural levels, and is mainly related to inadequate sun exposure aggravated by inadequate consumption of foods containing this vitamin. An estimated 30 to 40% of the USA population is beleive to be iodine insufficient and 75% for those over 70 years old.

Research Summary
Items that apply to me are underlined.
1) High triglycerides associated with low vitamin D and Vit D supplementation has been used to successfully treat high triglycerides.
2) Psoriasis associated with high triglycerides
3) Psoriasis is correlated to low Vit D and has been successfully treated with Vit D.
4) VDR polymorphism linked to psoriasis, high triglycerides and low Vit D
5) Low Vit D associated with developing myopathy from statins (In my case fibrates)
7) Lipid imbalance linked to anxiety as listed below:
Anxiety associated with;
low total cholesterol (<75) or elevated total cholesterol (>200, >240)) (4)
elevated low-density lipoprotein cholesterol (4)
elevated triglycerides (3)
high ratio of total cholesterol to high-density lipoprotein cholesterol (2)
low HDL cholesterol (2)
Increased noradrenergic activity were present for elevations in lipid levels in patients with anxiety. (2)
8) Low vitamin D minimal link to Anxiety
9) Omega 3 and Vit D most successful supplements for treating psoriasis.
10) Both successfully used to treat high trigylcerides and some benefit for anxiety..
11) Low Vitamin D linked to hypothyroidism.
12) Low Vitamin A also linked to low calcium.
13) VDR polymorphs linked to TB susceptability.
All these situations have also been correlated with Metabolic Syndrome. Symptoms include ...high blood pressure, decreased fasting serum HDL, cholesterol, elevated fasting serum triglyceride level (VLDL triglyceride), impaired fasting glucose, insulin resistance, or prediabetes.
Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction, and acanthosis nigricans.

No. 1
High Triglycerides linked to low Vit D

https://www.ncbi.nlm...les/PMC4276603/
We observed insufficient intake of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) for both cases and controls. Patients with psoriasis were at greater risk of associated pathologies: dyslipidaemia (OR: 3.6, 95% CI: 0.8–15.2); metabolic syndrome (OR: 3.3, 95% CI: 0.2–53.9); hypertension (OR: 1.7, 95% CI: 0.4–7.2). Insufficient vitamin D intake in both psoriasis patients and controls in the Mediterranean population, and cardiovascular comorbility is more frequent in patients with psoriasis.

https://www.ncbi.nlm...pubmed/22835076
These results indicate that oxidative stress, impairment of the antioxidant system and abnormal lipid metabolism may play a role in the pathogenesis and progression of psoriasis and its related

https://www.ncbi.nlm...les/PMC3981009/
Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients.

https://www.ncbi.nlm...les/PMC2914266/
Dyslipidemia is one of comorbidities in psoriatic patients. Lipid metabolism studies in psoriasis have been started at the beginning of the 20th century and are concentrated on skin surface lipids, stratum corneum lipids and epidermal phospholipids, serum lipids, dermal low-density lipoproteins in the psoriatic skin, lipid metabolism, oxidative stress and correlations between inflammatory parameters, lipid parameters and clinical symptoms of the disease.

https://www.ncbi.nlm...les/PMC4000177/
Cardiovascular disease, obesity, diabetes, hypertension, dyslipidemia, metabolic syndrome, nonalcoholic fatty liver disease, cancer, anxiety and depression, and inflammatory bowel disease have been found at a higher prevalence in psoriasis patients compared to the general population.

https://www.ncbi.nlm...pubmed/25453396
Our results suggest that supplementation with vitamin D (4000 IU/d) may have a beneficial effect on serum triglyceride levels without otherwise affecting levels of other lipids.

https://www.ncbi.nlm...pubmed/24844869
Vitamin D supplementation might improve serum lipid levels in statin-treated patients with hypercholesterolemia, it might be an adjuvant therapy for patients with hypercholesterolemia.

https://www.ncbi.nlm...pubmed/24845422
Improvement in lipid profile after vitamin D supplementation in indigenous argentine school children.

No. 2
Psoriasis linked to high triglycerides
https://www.ncbi.nlm...pubmed/27051926
[POSSIBLE DRUG CORRECTION OF LIPID METABOLISM DISTURBANCES ASSOCIATED WITH METABOLIC SYNDROME IN PATIENTS WITH PSORIASIS].

https://www.ncbi.nlm...pubmed/24784863
Certain parameters, including serum triglyceride, cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDL), were significantly higher in the case group compared to the controls (P < 0.001), while high density lipoprotein (HDL) was significantly lower in the former (P < 0.001). In addition, there was a significant relationship between severity of psoriasis and serum lipid profile.

https://www.ncbi.nlm...pubmed/23909936
Based on the NHANES data 2003-2006 and 2009-2010, psoriasis is not significantly associated with alterations in certain lipid levels. Larger sample sizes may be necessary to detect appreciable differences in the lipid levels between patients with and without psoriasis.

https://www.ncbi.nlm...les/PMC3520693/
There were significant declines in total cholesterol (TC) and low-density lipoprotein (LDL) levels during the 5 years before and after psoriasis incidence/index date in both the psoriasis and the non-psoriasis cohorts, with a greater decrease noted in the TC levels (p=0.022) and LDL (p=0.054) in the non-psoriasis cohort. High-density lipoprotein (HDL) levels increased significantly both before and after psoriasis incidence date in the psoriasis cohort. Triglyceride (TG) levels were significantly higher (p<0.001), and HDL levels significantly lower (p=0.013) in patients with psoriasis compared to non-psoriasis subjects.

https://www.ncbi.nlm...pubmed/23985295

No.3
Psoriasis linked to low Vit D and successfully treated with it.
https://www.ncbi.nlm...pubmed/25601579
Oral and topical vitamin D therapies provide comparable efficacies to corticosteroids when used as monotherapy and may be superior when used in combination with a potent topical steroid. Additionally topical vitamin D analogs demonstrate a favorable safety profile with "steroid-sparing" effects

https://www.ncbi.nlm...pubmed/25377657
Daily low-emission UV therapy is an effective treatment for psoriasis patients, diminishing the amount of steroid ointment needed and improving disease activity, quality of life, and vitamin D scores.

https://www.ncbi.nlm...pubmed/23986164
Patterns of vitamin D analog use for the treatment of psoriasis.

https://www.ncbi.nlm...pubmed/26126320
The results indicate that psoriasis is associated with significantly lowered 25-hydroxy vitamin D levels, along with increased systemic inflammation and oxidative stress, especially in severe disease. Thus, vitamin D supplementation might reduce systemic inflammation and oxidative stress and help in delaying the pathogenesis of co-morbidities associated with psoriasis.

https://www.ncbi.nlm...pubmed/23995795
In conclusion, NB-UVB treatment significantly increases serum 25(OH)D in patients with psoriasis who are taking oral vitamin D supplementation, and the concentrations remain far from the toxicity level. Healing psoriasis lesions show similar mRNA expression of vitamin D metabolizing enzymes, but higher antimicrobial peptide levels than NB-UVB-treated skin in healthy subjects.

https://www.ncbi.nlm...pubmed/25904071
Our findings show that the vitamin D analogue calcipotriol reduces the frequency of CD8(+) IL-17(+) T cells in psoriasis lesions concomitant with clinical improvement.

https://www.ncbi.nlm...pubmed/24377473
The elevation of serum 25(OH)D and cathelicidin LL-37 could be an additional possible mechanism of action of NB-UVB therapy in the treatment of psoriasis.

https://www.ncbi.nlm...pubmed/23760318
Our study showed that the low serum levels of vitamin D, and higher blood levels of cathelicidin could form a molecular level clue in the pathogenesis of psoriasis patients, who are more likely to develop co-morbidities.

https://www.ncbi.nlm...pubmed/22103655
Psoriatic patients as a population are at increased risk of developing adverse health complications such as cardiovascular disease, and oral vitamin D may prove to be of benefit in this population. Oral vitamin D is inexpensive and easily available. It is still a viable option and should not be forgotten as a possible treatment for psoriasis.

https://www.ncbi.nlm...pubmed/25039309
https://www.ncbi.nlm...pubmed/23346664
Vitamin D analogs are an indispensable component of the current physician's armamentarium for psoriasis treatment. This review, therefore, is oriented to give a comprehensive understanding of this group of drugs and display the available clinical data for each formulation.

https://www.ncbi.nlm...pubmed/24509438
In psoriasis patients, lower serum 25-OHD levels were associated with higher MIMT after adjusting for selected confounding factors. The MIMT risk increases with a longer history of psoriasis, regardless of the patient's age.

https://www.ncbi.nlm...pubmed/23749583
https://www.ncbi.nlm...pubmed/24780177
https://www.ncbi.nlm...les/PMC4134971/
Patients with psoriasis are increasingly turning to the use of alternative and complementary medicine to manage their psoriasis. Patients often inquire about what dietary supplements may be beneficial, including the use of oral vitamin D, vitamin B12, selenium, and omega-3 fatty acids in fish oils. In this review we examine the extent to which each of these common nutritional interventions has been studied for the treatment of psoriasis. We weighed evidence from both controlled and uncontrolled prospective trials. The evidence of benefit was highest for fish oils.

https://www.ncbi.nlm...pubmed/23995104
Association of 25-hydroxyvitamin D with metabolic syndrome in patients with psoriasis: a case-control study.

https://www.ncbi.nlm...pubmed/23435685
Interleukin-1 family members are enhanced in psoriasis and suppressed by vitamin D and retinoic acid.

https://www.ncbi.nlm...pubmed/22013980
Vitamin D deficiency may be common in patients with psoriasis, especially in winter.

And others..
https://www.ncbi.nlm...pubmed/26654984
https://www.ncbi.nlm...pubmed/22991733
https://www.ncbi.nlm...pubmed/24094453
https://www.ncbi.nlm...pubmed/25741403
https://www.ncbi.nlm...pubmed/27057487
https://www.ncbi.nlm...pubmed/25693749
https://www.ncbi.nlm...les/PMC2946663/
https://www.ncbi.nlm...les/PMC4134971/
https://www.ncbi.nlm...les/PMC2709447/
https://www.ncbi.nlm...les/PMC4822855/
https://www.ncbi.nlm...276603/........

No. 4
Genetics linked to psoriasis/Vit D/high triglycerides
https://www.ncbi.nlm...pubmed/24055231
These data suggest that VDR polymorphisms are associated with psoriasis in Northeastern Han Chinese population.

https://www.ncbi.nlm...pubmed/24320988
Furthermore, a significant association of A-1012G risk genotypes with a lower expression of VDR mRNA emerged (p=0.0028). Our data show that VDR promoter A-1012G polymorphism is associated with psoriasis risk and suggest that this polymorphism may modulate psoriasis risk by affecting VDR expression.

https://www.ncbi.nlm...pubmed/23111742
Vitamin D receptor gene polymorphisms and haplotypes (Apa I, Bsm I, Fok I, Taq I) in Turkish psoriasis patients.

https://www.ncbi.nlm...les/PMC3981009/
https://www.ncbi.nlm...pubmed/23488577
No genetic variant examined in the VDR gene showed a robust and reproducible association with risk for psoriasis. Any association that may exist is likely to be weak and potentially restricted to specific populations.

https://www.ncbi.nlm...pubmed/22540341
This meta-analysis showed that ApaI, TaqI polymorphisms in VDR gene correlate with psoriasis in Caucasians.

https://www.ncbi.nlm...pubmed/22835076
The PON1 55 M allele is a risk factor for psoriasis. Carriers of this allele have high levels of MDA, APOB and LP(a), a high APOB/APOA1 ratio and low ARE activity. These results indicate that oxidative stress, impairment of the antioxidant system and abnormal lipid metabolism may play a role in the pathogenesis and progression of psoriasis and its related complications.

https://www.ncbi.nlm...pubmed/25827670
Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency: Vitamin D3 megadose reduces inflammatory markers.

https://www.ncbi.nlm...pubmed/25227839
There is significant association between low 25(OH)D serum level and colorectal cancer risk. The VDRTaq1 polymorphism was associated with increased colorectal cancer risk among patient with VDRTaq1 TT and Tt genotypes. Understanding the functional mechanism of VDRTaq1 TT and Tt may provide a strategy for colorectal cancer prevention and treatment.

https://www.ncbi.nlm...pubmed/23855914
A significant lower concentration of 25(OH)D₃ was observed only in individuals without MetSyn in the VDR 1544410 A > G genotype. Additionally, individuals without MetSyn and heterozygosis for VDR 2228570 C > T presented higher concentration of triglycerides and lower HDL than those without this polymorphism.

https://www.ncbi.nlm...pubmed/25413050
FOKi polymorphism significantly increased postprandial blood glucose (P=0.035), triglycerides (P=0.049) and uric acid (P=0.031

https://www.ncbi.nlm...les/PMC3824827/
VDR BsmI polymorphism affected individual response being the GG genotype the ones that showed dose-dependent manner responsiveness in the reduction in total cholesterol, LDL and triglycerides in comparison with the AA/AG genotype.

https://www.ncbi.nlm...les/PMC4287888/
Vitamin D increases intestinal calcium absorption and this can trigger a decrease in serum triglycerides levels by reducing the hepatic triglyceride formation and secretion


https://www.ncbi.nlm...les/PMC3334480/

Associated with low HDL-C in individuals. (n=1060 individuals with HDL-C, 1057 with triglycerides in 70 families) As HDL and triglycerides are inversely correlated and APOA5 is known to influence primarily triglycerides, we used jPAP maximum likelihood analysis to evaluate 25OHD interactions with triglycerides in both family samples and winter subsamples.This observation should be taken in the context of growing evidence that the role of HDL-C in cardiovascular disease may not be causal, but may be due to the inverse relationship with triglycerides \l "

No. 5
Special note
https://www.ncbi.nlm...pubmed/26423691
The mean levels of 25OHD at baseline were 50 ± 4 nmol/L among patients developing myopathy and 60 ± 2 nmol/L among patients without myopathy (p < 0.01). Individuals homozygous for the C allele in the VDR polymorphism TaqI (rs731236) had a four times higher risk of developing muscular symptoms; (RR 4.37, 95% CI 1.9-10.1, p < 0.01). In conclusion, 25OHD levels <50 nmol/L might be a useful marker to predict muscular adverse events during statin treatment. In addition, the finding that the VDR polymorphism TaqI was associated with myopathy may indicate a causal relationship between vitamin D function and myopathy.

N0. 6
Genetic link to high triglycerides

https://www.ncbi.nlm...pubmed/25967388
Association of tumor necrosis factor-α promoter G-308A gene polymorphism with increased triglyceride level of subjects with metabolic syndrome.

https://www.ncbi.nlm...les/PMC4457007/
Associations of the APOC3 rs5128 polymorphism with plasma APOC3 and lipid levels: a meta-analysis

No. 7
High Triglyceride linked to anxiety

www.ncbi.nlm.nih.gov/pubmed/10367605
1999 May-Jun;61(3):273-9.
Relations of trait depression and anxiety to low lipid and lipoprotein concentrations in healthy young adult women.
RESULTS:
NEO depression was inversely associated with total cholesterol (p = .027), triglycerides (p = .012), and the ratio of total cholesterol to high-density lipoprotein cholesterol (p = .059). Similarly, STPI anxiety was inversely associated with total cholesterol (p = .002), low-density lipoprotein cholesterol (p = .016), triglycerides (p = .024), and ratio of total cholesterol to high-density lipoprotein cholesterol (p = .075). These associations were significant after adjustment for age, body mass index, physical activity, oral contraceptive use, and hostility. Neither depression nor anxiety was associated with high-density lipoprotein cholesterol. Univariate analyses indicated that women with low total cholesterol concentrations (<4.14 mmol/liter), relative to those with moderate to high cholesterol levels, were more likely to have higher scores on the NEO depression subscale (27 of 69 (39%) vs. 10 of 52 (19%)) and STPI anxiety subscale (24 of 69 (35%) vs. 11 of 52 (21%)).
CONCLUSIONS:
In healthy young adult women, low lipid and lipoprotein concentrations are inversely associated with trait measures of depression and anxiety. These findings are independent of age, body mass index, physical activity, and other factors known to influence lipid concentrations.

https://www.ncbi.nlm...pubmed/16250690
Int J Behav Med. 1999;6(1):30-9.
Clinically relevant cholesterol elevation in anxiety disorders: a comparison with normal controls.
Recently, several studies reported elevated cholesterol levels in panic disorder, agoraphobia, and general anxiety disorder, but the clinical relevance is still unsettled. All studies so far have disregarded the possible influence of dietary and physical exercise factors. In this study, 30 patients with different anxiety disorders and 30 normal controls were compared for total cholesterol, low-density lipoprotein (LDL), and cholesterol high-density lipoprotein (HDL) ratio. Dietary and physical exercise habits were measured by self-rating questionnaires. Patients with anxiety disorders had significantly elevated total cholesterol, LDL, and cholesterol/HDL ratios. Patients showed borderline-high or high cholesterol levels almost 3 times as often as control participants. Anxiety-specific avoidance of physical exercise and special dietary habits of anxiety patients had a significant but minor impact on differences in cholesterol between both groups. Our data support the assumption that serum cholesterol elevations in anxiety disorder patients are within a clinically relevant range.

https://www.ncbi.nlm...pubmed/12211884
Can J Psychiatry. 2002 Aug;47(6):557-61.
Serum cholesterol level comparison: control subjects, anxiety disorder patients, and obsessive-compulsive disorder patients.
RESULTS:
Patients with anxiety disorders and OCD had elevated cholesterol levels, compared with normal control subjects. Cholesterol levels in OCD patients were comparable with those in patients with phobia.
CONCLUSIONS:
Our data support the assumption that elevation in cholesterol level is not a specific feature of panic disorder (as most assumed), but more generally associated with anxiety disorders. Increased cholesterol levels in patients with anxiety disorders and OCD may be of clinical relevance.

https://www.ncbi.nlm...pubmed/23197842
Psychosom Med. 2013 Jan;75(1):83-9. doi: 10.1097/PSY.0b013e318274d30f. Epub 2012 Nov 28.
Longitudinal relationship of depressive and anxiety symptoms with dyslipidemia and abdominal obesity.
RESULTS:
Baseline symptoms of depression or anxiety predicted a decrease in HDL cholesterol (adjusted β = -.062 [p = .003] and β = -.050 [p = .02], respectively) and an increase in waist circumference (adjusted β = .060 [p = .01] and β = .053 [p = .02], respectively) for 2 years. Reduction of symptoms of depression or anxiety over time did not coincide with an amelioration of lipid or waist circumference values.
CONCLUSIONS:
People with initially severe symptoms of depression or anxiety showed a subsequent decrease in HDL cholesterol levels and an increase in abdominal obesity over time, independent of a potential reduction in symptom severity in this period. Therefore, such people are at elongated and increasing risk for dyslipidemia and obesity, predisposing them to cardiovascular disease.

https://www.ncbi.nlm...pubmed/11778348
J Behav Med. 2001 Dec;24(6):517-36.
The impact of cholesterol lowering on patients' mood.
This study compared mood changes in 212 patients treated for hypercholesterolemia, as a function of their level of adherence to dietary recommendations. Assessments of mood (anxiety, depression, and hostility), measured by the Profile of Mood States, were obtained at baseline and 3-, 6-, and 12-month follow-up. Adherence to diet was categorized as low, medium, or high based on the Food Record Rating. Repeated-measures ANOVAs showed a significant decrease over time for anxiety, total cholesterol (TC), and low-density lipoproteins (LDL). A multiple regression was performed to determine if reductions in TC or LDL were associated with the anxiety decrease. The model for anxiety change was highly significant and included gender, baseline anxiety, number of stressful events, psychological stress, baseline level of adherence to diet, gender x adherence interaction, and change in TC x adherence interaction. In conclusion, cholesterol lowering did not negatively affect patients' moods. However, those who adhered poorly but nonetheless showed stable or reduced TC exhibited a greater decrease in anxiety.

https://www.ncbi.nlm.../pubmed/8884036
Can J Psychiatry. 1996 Sep;41(7):465-8.
Serum cholesterol levels in patients with generalized anxiety disorder (GAD) and with GAD and comorbid major depression.
RESULTS:
Significantly higher cholesterol and triglyceride levels were found in the GAD group.
CONCLUSION:
Increased noradrenergic activity may be responsible for elevations in lipid levels in patients with pure GAD.

https://www.ncbi.nlm...pubmed/11221492
Can J Psychiatry. 2001 Feb;46(1):68-71.
Serum lipid concentrations in patients with comorbid generalized anxiety disorder and major depressive disorder.
RESULTS:
All mean serum cholesterol concentrations are presented in Table 1. The mean serum total cholesterol concentration in patients with both GAD and MDD was significantly higher than in MDD-only patients, GAD-only patients, and control subjects. The triglyceride concentration was also significantly higher in patients with both GAD and MDD than in MDD-only patients, GAD-only patients, and control subjects. Patients with both GAD and MDD had a lower mean high-density lipoprotein cholesterol (HDL-C) concentration than did patients with GAD only and control subjects. The serum concentration of low-density lipoprotein cholesterol (LDL-C) was higher in patients with both GAD and MDD than in patients with MDD only and GAD only and healthy control subjects.
CONCLUSIONS:
Our findings indicate that the patients with both GAD and MDD have increased serum cholesterol, triglyceride, and LDL-C and reduced HDL-C levels. These patients may have a greater risk of mortality from coronary artery disease (CAD) than do patients with either depression or anxiety disorder.

https://www.ncbi.nlm...pubmed/21965991
Indian J Psychiatry. 1984 Jul;26(3):237-41.
Serum lipids in anxiety neurosis.
Mishra TK1, Shankar R, Sharma I, Srivastava PK.
Serum cholesterol, total triglycerides, HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, free cholesterol and total phospholipids were studied in 36 patients of anxiety neurosis and 24 control subjects. Serum triglycerides, VLDL-cholesterol and free-cholesterol were found to be significantly raised while esterified cholesterol WJS significantly lowered in anxiety neurosis. A significant negative correlation was observed between the anxiety score and free cholesterol in ferrule patients. The significance of these findings has been discussed.

https://www.ncbi.nlm...pubmed/10781707
J Affect Disord. 2000 May;58(2):167-70.
Serum cholesterol levels and panic symptoms in patients with panic disorder: a preliminary study.
RESULTS:
Stepwise regression analysis revealed a significant effect of the presence of the symptom 'fear of dying' on TC levels. Patients with a fear of dying had a significantly higher TC level than those without it.
LIMITATIONS:
The relatively small sample size may limit the generalizability of our findings.
DISCUSSION:
These data suggest that TC level may be associated.

No. 8
Low vitamin D linked to Anxiety
https://www.ncbi.nlm...pubmed/27149477
https://www.ncbi.nlm...pubmed/23395104
https://www.ncbi.nlm...pubmed/16850115
Vitamin D deficiency is common in fibromyalgia and occurs more frequently in patients with anxiety and depression.
https://www.ncbi.nlm...les/PMC4089018/
http://www.ncbi.nlm....pubmed/24226892
We found an association between serum 25(OH)D concentrations and symptoms of depression, but not anxiety and stress, in males

No. 9
Psoriasis linked to anxiety/sexual dysfunction
https://www.ncbi.nlm...pubmed/26702177
Patients with psoriasis have a clinically significant prevalence of depression, anxiety and perceived stress.

https://www.ncbi.nlm...pubmed/25387679
The findings indicated that HPA dysfunction may be present in psoriasis, as bedtime cortisol was correlated with psoriasis severity.

https://www.ncbi.nlm...pubmed/26131863
This study identifies body areas potentially related to sexual dysfunction

https://www.ncbi.nlm...pubmed/25266400
This is the first study identifying body areas other than genitals as potentially related to sexual dysfunction in psoriasis patients. The results suggest that the assessment of sexual dysfunction and the involvement of these body areas should be considered as disease severity criteria when deciding on treatment for psoriasis patients.
https://www.ncbi.nlm...pubmed/25424331
Scientific evidence shows that psoriasis patients have a higher risk of sexual dysfunction as compared to the general population. The risk of erectile dysfunction is also higher in psoriasis patients. The risk factors associated with sexual dysfunction in psoriasis patients are disease severity, female gender, psoriatic arthritis and age.
https://www.ncbi.nlm...pubmed/27270734
In conclusion, the higher prevalence of smoking and anxiety/depression among patients with moderate to severe psoriasis probably explains the higher prevalence of erectile dysfunction in this population.
https://www.ncbi.nlm...pubmed/22390686
Patients with psoriasis and atopic dermatitis show distinct anxiety profiles.
https://www.ncbi.nlm...pubmed/24692521
The rate of depression and anxiety is significantly higher in patients with PsA than in those with PsC. Depression and anxiety are associated with disease-related factors.
https://www.ncbi.nlm...pubmed/22243764
Pediatric patients with psoriasis had an increased risk of developing psychiatric disorders, including depression and anxiety, compared with psoriasis-free control subjects
https://www.ncbi.nlm...pubmed/23901577
[Psoriasis and sexual disorders].
And many more....
No. 10
Vitamin D treatment effect on HPA.

https://www.ncbi.nlm...pubmed/23986161
The two-compound topical suspension/gel containing calcipotriene plus betamethasone dipropionate may be applied once daily to extensive psoriasis vulgaris without generally causing adrenal suppression or disturbance of calcium homeostasis, consistent with previous findings. In a small number of patients with extensive psoriasis treated with large volumes of topical suspension, adrenal suppression may be observed. In the real-world setting, it is anticipated that systemic side-effects would occur in only a few cases within the general psoriasis patient population

https://www.ncbi.nlm...pubmed/20684147
Topical vit D did NOT suppress HPA function.

No. 11
Low Vit D and hypothyroidism

https://www.ncbi.nlm...les/PMC4012880/
Significantly low levels of vitamin D were documented in patients with AITDs that were related to the presence of anti thyroid antibodies and abnormal thyroid function tests, suggesting the involvement of vitamin D in the pathogenesis of AITDs and the advisability of supplementation. While VDR gene polymorphism was found to associate with autoimmune thyroid diseases (AITDs), few studies examined levels of vitamin D in these patients and those that did yielded conflicting results.

https://www.ncbi.nlm...les/PMC4616844/
We observed a lower serum vitamin D levels in AITD patients compared with controls. The lower the vitamin D level is, not vitamin D deficiency per se, the higher the risk for developing AITD will be. However, vitamin D does not have strong association with the titers of thyroid antibodies or the levels of thyroid hormones.

https://www.ncbi.nlm...les/PMC4563184/
Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

https://www.ncbi.nlm...les/PMC3936621/
25(OH)D3 level is an independent factor affecting the presence of TPOAb in AITDs. The causal effect of 25(OH)D3 deficiency to AITDs is to be elucidated.

https://www.ncbi.nlm...les/PMC3921055/
Our results indicated that patients with hypothyroidism suffered from hypovitaminosis D with hypocalcaemia that is significantly associated with the degree and severity of the hypothyroidism. That encourages the advisability of vit D supplementation and recommends the screening for Vitamin D deficiency and serum calcium levels for all hypothyroid patients.

No. 12
Vitamin D polymorpism linked to hypothyroisism.

https://www.ncbi.nlm...pubmed/25817800
The current first and preliminary results identified the association between VDR-FokI gene polymorphism and Hashimoto's thyroiditis in Serbian population. Results need to be supported by further investigations that define haplotype patterns for VDR gene polymorphisms in a larger group of HT patients of both sexes.

https://www.ncbi.nlm...les/PMC4804530/
Positivity to TPOA and VDR polymorphism FokI were strongly associated with concurrence of T1D and TD. These data collaborate to understanding the joint susceptibility genes for TD in T1DM.
https://www.ncbi.nlm...les/PMC4233376/
In conclusion, genetic differences in the VDR gene may be involved in the development of AITD and the activity of GD, whereas the genetic differences in the GC and CYP2R1 genes may be involved with the intractability of GD
NO. 13
VDR polymorphism linked to TC susceptability.

https://www.ncbi.nlm...pubmed/26869016
The polymorphisms in the VDR and VDBP genes appeared to be responsible for host susceptibility to human TB in a Taiwanese population.

http://journals.plos...al.pone.0083843
Based on the above results, we conclude that variants of the VDR gene that are homozygous for the FokI polymorphism might be more susceptible to tuberculosis in Chinese.

http://www.sciencedi...422763814000624
http://www.ncbi.nlm....pubmed/24571812
http://europepmc.org...cles/PMC3242999
http://www.hindawi.c...dm/2015/860628/
These articles indicate that vertain polymorphs can prevent or even treat TB depending on the VDR morph present.

http://www.vitamindw...s and Vitamin D
This article reflects on which polymorphs affect TB suceptability and or protection.

No. 14
VDR polymorphism linked to cytomeglavirus.

http://www.ncbi.nlm....pubmed/23044313
The recessive f allelic gene of VDR can be regarded as a risk factor of CMVD while FF recipients have lower incidence of CMVD

 


#4 FiveNotions

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Posted 30 June 2016 - 03:24 PM

Awesome research and summary, FH ... I'll plow through this, distill it further, and pass it along to my friend ... the vit. D / lipids connection is what leapt out at me as related to him ...

 

Have you tried explaining all  this to you doc yet?  :P  ;)


#5 fishinghat

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Posted 30 June 2016 - 03:32 PM

Actually saw my endocrinologist yesterday. I started to lay this all out to him and he informed me he attended a seminar in DC just 2 weeks ago given by one of the foremost authorities on Vit D deficiencies and related disorders. This dr had touched on most of this at the seminar. My dr had been promising to read up on these polymorph and the metabolism involved when I came in with this document. I though he was going to have a cow he was so excited. He had often noticed that the majority of his triglyceride patients had psoriasis but never new the details of the correlation. He read half the document while we talked. Tests are being set up now for me to take and determine a therapy regime. This could me major for me and help with several different conditions I suffer from. Can't wait to see what the blood tests show.


#6 FiveNotions

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Posted 30 June 2016 - 06:30 PM

This is wonderful news, FH ! Sure hope it leads to some progress / help for you !


#7 Carleeta

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Posted 30 June 2016 - 07:06 PM

Phenomenal....As it will take me some time to read all this, I'm sure it will be informative.  I for one believe Vitamin D is extremely important in our daily lives.  What I do know is it is extremely good to get a good night sleep.   I will find out more about this when I finish reading.  Thank you Fishinghat.  I'm hoping this will be a breakthrough for you....


#8 fishinghat

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Posted 15 August 2016 - 12:30 PM

Well I got back the blood test results and my Vitamin D is not low so it is not to blame for my low calcium, psoriasis or high triglycerides. Oh well, it was worth a shot. I did have my routine blood magnesium drawn a couple weeks ago and it was high. This would explain my low calcium. I have been dropping my magnesium intake a little at a time and repeating the blood test. As I drop it my calcium increases. I am now off the magnesium and hopefully at my next test on the 30th my calcium and magnesium will both be back to normal. This is why I always recommend people who are taking magnesium to have a blood magnesium test run every 6 months.


#9 gail

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Posted 15 August 2016 - 12:52 PM

Good for you Fisherman!

Question

When blood tests show that all is perfect, vitamin and mineral, should we supplement just the same?

I keep taking them, I wonder why? Vitamin B,C,D,E plus calcium with magnesium, I find this a pain. I would rather take nothing but the D because of our climate. D is a hormone, I remember that. Thanks!

#10 fishinghat

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Posted 15 August 2016 - 02:10 PM

I am not in favor of using a vitamin/mineral supplement if a CMP and blood cell count comes back normal. (Complete Metabolic Panel). I also understand about the need for a little extra D when you live up north like that although a few hours in a bikini in the snow on those sunny days would probably help. Just kidding. Extra vitamins/minerals over and above what you need can be harmful even without any symptoms. Some examples of this is iron, selenium, copper, some B vitamins, Vitamin E and many others. Now if your blood tests are not normal that is a different matter.

 

This is a good time to bring up going natural. The general rule is that a natural product is better than a pharmaceutical product. This is wrong. Typically both are bad. Let me explain. We all know about side effects of prescription meds as well as many natural products. I will not go into details here on that. First of all most(all?) prescription meds and natural health food store supplements contain added ingredients. This includes food colorings, sodium laurel sulfate, plastics, and so so many more. Examples of natural products are almond nuts which have zinc (and also cyanide). Nightshade will settle the stomach but also contains a deadly poison.

 

When I think of a natural product I think of something like calcium carbonate (the active ingredient in Tums). I do not use Tums because of the other ingredients. I purchase 100% calcium carbonate (food grade) and put the right amount in an empty vegetable gelatin capsule and use that for my antacid. Cheap, safe (as long as I routinely my blood calcium levels) and effective. As we all have seen before, some supplements, like tryptophan, are natural and very helpful to some while posing a serious health risk to others. Remember the teaspoon/teacup rule. If the dosage calls for a teacup full start with a teaspoonful. That way if you have any reactions they should be lighter and less severe.





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