Lion's Mane Mushroom

I finally decided to take the leap and get off this drug. I'm down to 20 mg and miserable but it's ok. I've been interesting in fungi as medicine for a while and started taking lion's mane supplements, as well as a few others. Has anyone else done this? I definitely notice a change in my mood and energy levels. I use the Fungi Perfecti product, fyi. I also found this article, if anyone is intetested.


https://www.ncbi.nlm...ubmed/24266378/



I will say though that perusing this forum is uplifting and depressing at the same time. Depressing bc I have a long road ahead but uplifting bc people do it Nd there's support here. Thanks y'all

Here's what I use


http://www.fungi.com...ules-120ct.html

One member, Blackbird, said he ordered some but never reported back if it worked or not. I really don't know how effective it will be.

Sorry

Hi Alpi,

I've not heard about this supplement, it would be interesting for you to come back and tell us about it. Thank you!

Well, Well, most interesting.

Lion's Mane Mushroom

(AKA Yamabushitake or H. erinaceum )

https://www.ncbi.nlm...pubmed/24506286
Lion's Mane Mushroom (LMM) contains Vitamin B12.

https://www.ncbi.nlm...pubmed/26559695
Our findings indicate the possibility that H. erinaceus exerts anti-inflammatory effects on macrophages through the inhibition of TLR4-JNK signaling and prevents or ameliorates adipose tissue inflammation associated with obesity.

https://www.ncbi.nlm...pubmed/23510212
Daily oral administration of H. erinaceus could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.

https://www.ncbi.nlm...pubmed/27481156
Anti-inflammatory, a protective agent in the treatment of IBDs (inflammatory bowel disease).

https://www.ncbi.nlm...pubmed/27481156
Anti-inflammatory, a protective agent in the treatment of Ulcerative Colitis.

https://www.ncbi.nlm...pubmed/29199560
This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive (pain) behavior and blocking the functional activity of P2R (calcium binding receptors).

https://www.ncbi.nlm...pubmed/28085076
These results suggested that H. erinaceum could be utilized in the development of natural antioxidant and anti-osteoporotic (fights osteoporosis) nutraceuticals and functional foods.

https://www.ncbi.nlm...les/PMC5237458/
In wild-type mice the oral supplementation with H. erinaceus induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that H. erinaceus induces a boost effect onto neuronal functions also in nonpathological conditions.

https://www.ncbi.nlm...les/PMC5133811/
Our findings provide experimental evidence that HE (H. erinaceus) may provide neuroprotective candidates for treating or preventing neurodegenerative diseases.

https://www.ncbi.nlm...les/PMC4895996/
Our results demonstrate that HEPS exhibit antioxidant and neuroprotective effects on Aβ-induced neurotoxicity in neurons.

https://www.ncbi.nlm...les/PMC4415743/
We observed that HE supplementation could restrain the hepatic damage caused by acute alcohol exposure.

https://examine.com/.../yamabushitake/
Yamabushitake, known as the Lion's Mane Mushroom, is a dietary mushroom that can be a supplement.

As the water soluble extract seems to be less potent than other fractions, it may be best to take Yamabushitake with meals if in supplemental form.

If itchy skin occurs, this may be related to an increase in Nerve Growth Factor and unless accompanied by signs of allergy should be benign.

Currently, the only human study has used an oral dose of 1,000mg Yamabushitake (96% purity extract) thrice daily for a cumulative total of 3,000mg extract. While it is unknown if this is the optimal dose or not, it appeared to be effective.

Yamabushitake has been noted to increase mRNA expression of nerve-growth factor (NGF) (Nerve growth factor is primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target nerve cells.) in isolated astrocytes to around 5-fold that of control at 100-150ug/mL of the ethanolic extract in a concentration dependent manner, with no efficacy noted in the water extract.

An increase in NGF mRNA has been detected in the hippocampus, but not cortex, of mice given 5% of the diet as yamabushitake for a period of seven days to around 1.3-fold of control. (Note - Interesting as Cymbalta heavily afects the hippocampus).

Neuronal excitability from glutamic acid appears to be attenuated in the presence of yamabushitake extracts.

Anxiety and Depressive symptoms have also been reduced in humans fed 2g of Yamabushitake, via cookies, over the course of 4 weeks. There was a significant difference between groups on the measurements of concentration and irritability, favoring the Yamabushitake group. Nagano M, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. (2010)

Yamabushitake may act as a PPARα agonist and reduce triglycerides without any apparent effect on cholesterol.

Although both the hot water and ethanolic extracts have been found inactive on cholesterol and HDL-C, an extract derived from the mycelium of yamabushitake (ethanolic extract which was then lyophilized) appeared to reduce LDL by 45.5% and improve HDL-C by 31.1% when taken at an oral dose of 200mg/kg with 50mg/kg also being somewhat active

Side Effects

There has been one case study of a 63 year old man who suffered acute respiratory failure, and the excess lymphocytes in his lungs showed high reactivity to Yamabushitake daily for 4 months in dosages commonly bought. The connection between the two, when rated, is seen as a 'probably' connection

https://nootropicsex...e/#dosage-notes

Dosage

Dosing of Lion’s Mane Mushroom depends on the strength of the extract. It’s available in capsule or powder form.
For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day.
Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.

Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement.

Side Effects

Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.
Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.

Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.

https://www.cabdirec...act/20103302738
Our results show that H. erinaceum intake has the possibility to reduce depression and anxiety.

file:///C:/Users/Neil/AppData/Local/Microsoft/Windows/INetCache/IE/K78IEYPO/solid-state-cultivation-of-hericium-erinaceus-biomass-and-erinacine-a-production-2155-9821.1000210.pdf

Erinacine A, isolated from the cultured mycelia of H. erinaceum, the main representative of this compounds group, has a strong enhancing effect on NGF synthesis, much stronger than epinephrine. Furthermore, this compound increases catecholamine and NGF content in the central nervous system of rats.

Erinacines and hericenons reduce anxiety as well as depression. For an accurate understanding of the overall mechanism of H. erinaceus diterpenoids action it requires additional clinical studies with physiological markers, such as hormones, or more profounded studies of autonomic nervous activity

https://www.thefreel...on.-a0430893147
Summary of the antianxiety/antidepressive effects of components of H. erinaceus.
 

Wow fishinghat! You did a lot of work there, thanks!

I have trouble with triglycerides so when I notice it can be used to treat that condition I jumped in with both feet. With all these supplements everyone is eager to do research on if they work and on what conditions BUT they do not want to do health effect studies. Only one study and that was on rats. I wish there was more info on safety.