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Cymbalta And Male Fertility

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#1 fishinghat


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Posted 28 December 2021 - 05:10 PM

Andrologia. 2021 Nov;53(10):e14207. doi: 10.1111/and.14207. Epub 2021 Aug 9.
Impact of duloxetine on male fertility: A randomised controlled clinical trial
This study assessed the impact of duloxetine (serotonin and norepinephrine reuptake inhibitor) on semen parameters, sperm DNA fragmentation and serum hormones. We performed a double-blind, placebo-controlled, randomised clinical trial of duloxetine 60mg or placebo daily for 6 weeks (5 weeks full dose and 1 week taper). Duloxetine was not associated with an increase in the proportion of participants with abnormal sperm DNA fragmentation terminal deoxynucleotidyl transferase dUTP nick-end labelling scores (>25%) on treatment (p = 0.09) or after treatment (p = 0.56), nor did median sperm DNA fragmentation increase on treatment. Compared with placebo, there were no changes in bulk semen parameters during treatment. Limited changes in hormonal values were detected. 
Note - A six weak test would be a short-term study and may not indicate any long-term effect.

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