4 replies to this topic

[FiveNotions]

Apologies to Fishinghat if he's already posted these....

Dulloxetiine Induced Diiscontiinuatiion Syndrome: A Case Report On Drug Safety
http://www.jcdr.net/...1619_6_4_11.pdf

AFirstLookatDuloxetine(Cymbalta| ina PostmortemLaboratory
http://jat.oxfordjou.../8/576.full.pdf

Eli Lilly: Developing Cymbalta
http://www.homeworkm.../case_study.pdf

Drug Secrets: What the FDA isn't telling.
http://webzoom.freew...ecrets main.pdf

Shock-Like Sensations Associated with Duloxetine Discontinuation
http://triggered.clo...401230802177664

DULOXETINE-RELATED PANIC ATTACKS
http://hrcak.srce.hr/file/114047

A possible explanation for dizziness following SSRI discontinuation
http://xa.yimg.com/k...e/dizziness.pdf

Mounting problems with discontinuing cymbalta
http://www.expertbri...nuing-cymbalta/

[thismoment]

FN

 

This excerpt is from the last article- Discontinuing Cymbalta.

 

"A one-page summary on dicontinuation “merely reports that in only a few trials were the doses tapered, and then only over two weeks. Lilly’s response may well be limited because neither the company nor the government has adequately studied how to discontinue patients comfortably and safely, or how to manage those patients in which withdrawal symptoms are severe or persistent.”

 

The upshot: ISMP concludes by writing that “a major lapse has occurred in the FDA-approved information for patients about the risks of stopping duloxetine. The information for prescribing physicians is somewhat better, but still inadequate about counseling patients; instructions for an adequate taper regime are omitted entirely. Furthermore, a major gap exists in our scientific understanding of the incidence and management of withdrawal syndrome cases that are severe and persistent.”"

[fishinghat]

Great work FN!! The first article and the last two should be of interest to the lawyers.

 

Like TM said the last article is amazing to read. Some of the original results from Eli Lilley show much higher discontinuation problems than their official position.

[FiveNotions]

My bet is the K-R firm has this journal research covered "like white on rice"..... but I was having trouble sleeping, and figured I'd do some "therapeutic digging" with my awake time....

Yeah, that last article, esp. the quote TM noted, was yet another eye opener..... like I've said before, there are special seats in Hell reserved for the Eli Lilly gang.....

[Limbo]

Wow. Those really are great articles to read, from good sources. I am slowly tapering from 60mg (I currently take out 90 beads from the 60mg pill) and it is going well, I have a headache today but that's to be expected, otherwise, no major breakdowns since I started the gradual approach (2mg/week). My eyes were opened reading this to how serious tapering is. I have had a few panic attacked that were very abnormal for me and I am starting to think Cymbalta was the cause of them, not my depression...although I didn't have as many as mentioned in the articles.

 

Further, I am worried about relapsing after withdrawal, and the first link had some good points about that, as quoted below:

 

"The confounding factors in the causality assessment were the 

possibility of relapse of depression and/or anxiety. Considering 

the symptoms that distinguish the antidepressant discontinuation 

syndrome from the relapse of depressive illness and anxiety (e.g., 

dizziness, “electric shock” sensations, “rushing” sensations in 

the head) and the complete resolution of the symptoms in one 

week (not characteristic of depressive relapse), [11] we made 

a diagnosis of discontinuation syndrome.

Depressive relapses  typically occur after two weeks or more

after the cessation of the medication and are most often marked

by the gradual worsening of depression, insomnia, and psychomotor

symptoms. "

 

Thanks FiveNations. I was looking for that kind of information!