Excellent review of past literature. A good read.
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Posted 03 March 2015 - 08:33 AM
Thanks for posting this, FH ... interesting and informative, and not so "researchy" as to make it impossible to penetrate ...
Here are 2 paragraphs that struck me as particularly important ... note, no definitive proof that anxiety is due to "disregulation" of neurotransmitters (i.e., serotonin, dopamine, etc.) ... and, CBT is still the best treatment for anxiety-related disorders ...
"Based on the available evidence, it appears that nutritional and herbal supplementation is an effective method for treating anxiety and anxiety-related conditions without the risk of serious side effects. There is the possibility that any positive effects seen could be due to a placebo effect, which may have a significant psychological impact on participants with mental disorders. However, based on this systematic review, strong evidence exists for the use of herbal supplements containing extracts of passionflower or kava and combinations of L-lysine and L-arginine as treatments for anxiety symptoms and disorders. Magnesium-containing supplements and other herbal combinations may hold promise, but more research is needed before these products can be recommended to patients. St. John's wort monotherapy has insufficient evidence for use as an effective anxiolytic treatment."
"To date, the biological explanations for many types of anxiety disorders remain inadequate. Postulations have implicated a dysregulation of specific neurotransmitters such as serotonin, dopamine and gamma-aminobutyric acid (GABA) as potential causes for both depression and anxiety disorders [4-6]. These hypotheses are based on the results of pharmacological treatments, but there are no definitive clinical trials that demonstrate the dysregulation of these neurotransmitters as causative factors of anxiety, potentially explaining why the treatment of anxiety with antidepressants is often ineffective. Thus far, cognitive behavioural therapy (CBT) has proven to be the most effective, long-term treatment for anxiety-related disorders."
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