Jump to content



Photo

And The Answer To Your Question Is.....


  • Please log in to reply
13 replies to this topic

#1 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 05 August 2017 - 05:03 PM

I have just finished reading about 60,000 old posts on this site. My object is use this topic to post the reviews of all of our members concerning every drug, method, technique they have tried to handle their Cymbalta withdrawal. This will include their mistakes, successes, warnings, etc. My hope is that this can be a one stop shopping for information, especially new people.

 

If any of you have ANY suggestions. something you want to add, corrections, etc. just let me know and I will add it on to the posts. Lets make this as good as we can for everyone to use.

 

Sincerely

Fishinghat.


#2 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 05 August 2017 - 05:13 PM

Nausea Vertigo Treatments

 

Recommendations - Use of ginger root or other ginger product. No withdrawal or drug interactions and all natural. Member reviews are very positive. Second choice would be Original Dramamine.
 
Dimenhydrinate/Meclizine/Garlic and others - 8/7/17
Dimenhydrinate - an antihistamine - Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine, hydroxyzine).
 
Dramamine
71 member mentions.... 62 positive, 7 no help, 2 intermittent help, 13 says causes sleepiness,
Helps with lightheadedness, jolts, dizzy spells, sleep, nausea, brain swooshes, calming, motion sickness, brain zaps, Sloshy head, and anxiety.
 
Caution - some members state that "dramamine did..." but as listed below there is a difference in ingredients and dosing for different kinds of dramamine.  Dimenhydrinate is available in 98 products approved in the USA other than dramimine so please check label ingedients before using with other products .Nearly all nausea, cold, flu, sleep aides and dizziness medicines contain antihistamines and are incompatable with each other. Check ingredient list closely.
 
Seven members admit to taking two or more of these products at the same time OR taking double doses. This has lead to comments like...
"...and chucked my guts all day"
"and afterward had stomach cramps for hours"
 
Sarah noted "Dramamine II (not the original Dramamine) contains the same active ingredient as Bonine. Some places also sell generic Meclizine and I have found it at CVS. Some very closely related drugs are buclizine, and cyclizine.
Some brand names that contain meclizine, buclizine, or orcyclizine are:
Bonine
Bonamine
Dramamine II
Marezine
Marzine
Meclicot
Medivert"
 
Will NOT contribute to Serotonin Syndrome.
 
Tips from members -
1) Careful with the Benadryl and the Dramamine together. (causes you to be sick)
Also one member warned of 'DO NOT take both NyQuil and Dramamine.... '
2) Be careful taking dramamine during the day - it knocks me out!
3) Dramamine can also be doubled up at the initial dose. It all depends on your size and what you may or may not be sensitive to.
4) Take a low dose and I don't fall asleep
5) ORIGINAL FORMULA DRAMAMINE. (NOT THE NONDROWSY, just hypes you up and makes the dizziness worse.)
6) One said it can cause nightmares.
7) One said it does not cause nightmares
8) So, I was taking this ginger gravol and it did nothing for my nausea. I started taking half of a regular gravol and its finally working
9) 2 said - the ginger gravol version does not cause sleepiness
10) if taken on a regular basis, it stops working
 
Contents:
Original Dramamine - Active Ingredient (in each tablet) Dimenhydrinate 50 mg. Inactive ingredients anhydrous lactose, colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose.

Dramamine Motion Sickness Relief Less Drowsey Formula - Active Ingredient (in each tablet) Meclizine HCI 25 mg. Inactive Ingredients: Anhydrous Lactose, Corn Starch, Colloidal Silicon Dioxide, D&C Yellow 10 Aluminum Lake, Magnesium Stearate, Microcrystalline Cellulose.
 
Dramamine Non-Drowsy Naturals with Natural Ginger - Active ingredients - Ginger  Inactive Ingredients: Gelatin, Vegetable Magnesium Stearate, Silica
 
Dramamine All Day Less Drowsy Tab  - Meclizine 25 mg. Inactive Ingredients: Anhydrous Lactose, Corn Starch, Colloidal Silicon Dioxide, D&C Yellow 10 Aluminum Lake, Magnesium Stearate, Microcrystalline Cellulose.
 
Safety Warning
Do not give to children under 2 years of age unless directed by a doctor.
Ask a doctor before use if you have:
A breathing problem such as emphysema or chronic bronchitis.
Glaucoma.
Trouble urinating due to an enlarged prostate gland.
Ask a doctor or pharmacist before use if you are taking sedatives or tranquilizers.
When using this product:
Marked drowsiness may occur.
Avoid alcoholic drinks.
Alcohol, sedatives, and tranquilizers may increase drowsiness.
Be careful when driving a motor vehicle or operating machinery.
If pregnant or breast-feeding, ask a doctor before use.
----------------------------------------------------------------------------------------------------------
Meclizine
Taken for headaches, nausea, dizziness, brain zaps.
 
Meclizine (an antihistamine) is available in 104 products approved in the USA other than Bonine so please check label ingredients before using with other products.
 
Will NOT contribute to Serotonin Syndrome.
 
Tell your doctor about all medicines you use, and those you start or stop using during your treatment with meclizine, especially the antidepressants bupropion, duloxetine, fluoxetine, paroxetine, or sertraline.
 
Using meclizine together with DULoxetine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. (Drugs.com)
 
15 members have used this product, 6 positive, 4 negative, 4 helps intermittantly.
2 said it makes them sleepy/groggy.
 
Common side effects include blurred vision, dry mouth, constipation, dizziness, drowsiness, headache, vomiting, or tiredness
Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), high pressure in the eye (glaucoma), heart problems, high blood pressure, seizures, stomach/intestine problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate), liver problems, kidney problems.
 
Bonine - Active ingredients (in each tablet) Meclizine HCI 25 mg. Inactive ingredients:
Croscarmellose sodium, crospovidone, FD&C red #40 lake, lactose, magnesium stearate, raspberry flavor, silica, sodium saccharin, stearic acid, vanilla flavor.
 
Rugby Travel Med - Meclizine HCI 25 mg and they contain the artificial sweetener Aspartame, also contains Phenylalanine 0.28 mg per tablet (can cause anxiety and nervousness in some people). Inactive ingredients aspartame, croscarmellose sodium, dextrose, FD&C Red #40 Lake, magnesium stearate, maltodextrin, microcrystalline cellulose, natural and artificial flavors, silicon dioxide, sodium sulfate, sugar, tricalcium phosphate.
 
Truck Princess commented that "I have found that taking the Rugby travel sickness med 25mg took away ALL my withdrawal symptoms for the majority. I don't get any brain zaps, dizziness, head swooshing, none of that. Also with the Rugby it's 24hrs so you only take one or two. The Rugby I took because of the nausea was so bad and just discovered it really got rid of most of the withdrawals and I didn't get the crying spells like you and others have."
 
This may partly be due to the fact it also contains Phenylalanine which other members report as helping their symptoms. See cold and flu medicine section.
 
Caution - Many of the above products contain Lactose, a concern if you are lactose intolerant. They may also contain artificial colors that may irritate the nervous system and artificial sweeteners that can irritate the stomach in some people.
------------------------------------------------------------------------------------------------------------
Ginger
Helps with nausea and stomach issues.
 
24 positive remarks and 4 negative.
 
Tips from members...
FN - ginger tea (really strong), ginger ale (old home remedy for sure), and ... candied ginger, raw ginger.
Even it sounds disgusting, eating Ginger raw is the most effective way cured my nausea in 5-10 minutes
 
AH - Ginger root works very well for nausea. I have 550mg ginger root capsules, and this has helped with a lot of the nausea and stomach upset.I'd totally recommend buying the ginger root in capsule form at the health food store. Mine was $8.99 for 100 capsules, and I will take 2-3 whenever my stomach is upset. And of course we can't forget ginger tea. It is soothing, relaxing, and will also help your stomach feel better.
ta2ed - You can try ginger root... Wont make you tired.
 
Betty - I'd recommend trying ginger ale -- not Canada Dry but the real strong stuff, sometimes labeled Jamaican ginger ale or ginger beer. It's sold in four-packs here, in the health food or imported section of the store. I've had "irritable bowel" problems for years and have found this is real medicine, with no downside I can see! It also works for nausea.
 
FN - made a "tea concoction" of turmeric and ginger
Carleeta - yippee..The ginger works. ginger ale helps me a lot too at room temperature.
Considering - Ginger is good for nausea. If you don't have any tea, make some with either grated fresh ginger or dry ginger with a little honey added. This may help.
 
Anna - I thought I would give just smelling ginger a try. I put 2-3 drops of ginger essential oil on a cotton ball and my nausea pretty much disappeared almost instantly.
 
Tria - About the nausea, some weird things help mine - ice pops, room temperature root beer soda, and oatmeal. Ginger is a good herb for nausea. I cant stand ginger tea but some people swear by it. You can also buy ginger in capsules.
 
FCB - Dr. Sanjay Gupta's turmeric tea:
Ingredients
⦁ 1 cup almond milk (I'll try coconut milk too)
⦁ 1/2 tsp turmeric
⦁ 1 tsp cinnamon
⦁ 1 tsp honey (or maple syrup)
⦁ 1/4 tsp ginger
Directions: Heat the almond milk, stir in the spices and drizzle the honey on top.
 
Latte - ginger candy for nausea - I swear by it, particularly the Gin-Gin brand
Amberd - I tried ginger tea, but it only gave me indigestion on top of it all.
 
Travelcalm Natural -
Travacalm natural contains 100mg of dried root extract that offers faster relief in conjunction with 400mg of root powder that helps sustain the soothing effect. Each tablet contains: Zingiber officinale (ginger) 500mg as root powder 400mg and dried root extract equivalent to 100mg of root powder.
 
EOTR - I am taking 'Travelcalm' Natural - costs $4.50 for 10 tablets and ......it works!
------------------------------------------------------------------------------------------------
Misc. Nausea treatments
 
Vertigoheel (Caution - read carefully)
 
Composition: Tablets: 1 tablet cont.:
Anamirta cocculus D4 210 mg; is a Southeast Asian and Indian climbing plant. Its fruit, Cocculus indicus, is the source of picrotoxin, a poisonous alkaloid with stimulant properties.)
Conium maculatum D3, (hemlock or poison hemlock) is a highly poisonous biennial herbaceous flowering plant in the carrot family Apiaceae, native to Europe and North Africa. Since no specific antidote is available, prevention is the only way to deal with the production losses caused by the plant.
Ambra grisea D6, Ambergris, Latin: ambra grisea, Old French: ambre gris), ambergrease or grey amber, is a solid, waxy, flammable substance of a dull grey or blackish colour, produced in the digestive system of sperm whales.[1] It is illegal to possess or sell in many countries)
Petroleum rectificatum D8 (purified crude oil or petroleum is distilled, diluted with sulfuric acid, and succussed. The result is a very powerful homeopathic remedy that has a wide range of uses) 30 mg each.
 
http://www.biopathic...heet.pdf       Data sheet
History of the Heel Corporation
founding father, Dr. Hans-Heinrich Reckeweg. Established in Berlin in 1936,
 
FDA violations
In 1984 BHI received letters and warnings from the Food and Drug Administration that it was in violation of FDA regulations in regards to marketing of homeopathic remedies.[1] BHI was given multiple FDA citations and fines during the 1980s and early 1990s for violation of the Compliance Policy Guidelines labelling guidelines established by the FDA in 1988. These were corrected and have not recurred,[2][3] though in August 2013 the company again agreed to dial down its health claims tied to its over-the-counter remedies and pay a $1 million class settlement to resolve accusations that it exaggerated the products’ effectiveness to consumers.[4] (Wiki)

http://edzardernst.c...n-subsidiaries/
"Homeopathic manufacturer to close North American subsidiaries"
In the USA and Canada (Heel) has been confronted with accusations through class action lawsuits.  the Heel Group decided to focus on strengthening its excellent position in South America, Central Europe and Eastern Europe and to withdraw from business activities in the USA and Canada for the time being.
Heel’s operations in both the USA and Canada will accordingly be discontinued as of August 31, 2014.

<a href="http://vincentverhey...om/node/4#Heel"data-ipb="nomediaparse" data-cke-saved-href="http://vincentverheyen.com/node/4#Heel" s"="">http://vincentverheyen.com/node/4#Heel'sfortune comes from Nazi Germany: The Quandts were rich enough to escape the Nuremberg trials
Heel's fortune comes from Nazi Germany: The Quandts were rich enough to escape the Nuremberg trials
Unfortunately, the Quandt family has had a long history of concealing the truth and lying in favor of financial profits. Not particular important regarding pseudo-science, but ever so sadly: their family and its wealth is linked to Nazi Germany, providing weapons (e.g. via their German Weapons and Munitions public limited company & their Accumulatoren Fabrik AG Berlin-Hagen (AFA) (now VARTA)) & owning ±50,000 forced and/or concentration camp slave workers, as professor of history Joachim Scholtyseck
 
http://de.wikipedia....him_Scholtyseckhttp://de.wikipedia....im_Scholtyseck| University of Bonn has, during 3 years, researched in his (> 1000 pages) study "The rise of the Quandts"13. They even signed a contract with the SS to create the concentration camp KZ-Außenlager Hannover-Stöcken (Akkumulatorenwerke) at their factory to provide slaves from the Neuengamme concentration camp, to work under conditions which the company (explicitly written) expected to murder ± 80⁄month .131415 Direct Nazi relative Sven Quandt (Stefan Quandt's brother), the only member of the family who didn't decline interviews for the German documentary "The silence of the Quandts", even advised to forget the holocoust history of the Quandts, stating it is bad for Germany to remember the holocoust:
Heel announced to cease all its activities in North America. To me, its activities seem rather continued, covered up by a mere name-change
On 23/5/2014, Heel announced to close down its business activities in the United States and Canada, supposedly due to the accusations through class action lawsuits. It also said it was negotiating with a company called MediNatura® & that the transaction wouldn't include a number of Heel's products. Actually, Heel's products have just changed their names (cf. this picture159); and thus sadly enough, the products (including some of the products which supposedly were not to be transacted) are being still sold: on 30/5/2014, MediNatura® announced to be buying Heel and selling their discontinued products under different names. First of all, I have not been able to found any account of any existence of any company named MediNatura®, as anyhow related to medical products, before 2014. Secondly, Cliff Clive
https://www.linkedin.com/in/cliffclivehttps://www.linkedin.../in/cliffclive| https://twitter.com/cliffclive https://twitter.com/cliffclivehas been the CEO & general manager of Heel in the U.S.A for many years, right up until Heel changed its name to MediNatura® in 5/2014160, which is when Cliff Clive became the founder & CEO of MediNatura®161. Thirdly, the official address of MediNatura®, is the exact same address as Heel's: in an official notice of a meeting on 10/12/2014 of the Arizona State Board of Pharmacy162, it is noted that the address of MediNatura® is 10421 Research Road SE, Albuquerque, NM 87123. Guess what's Heel's official U.S.A address? So, the company MediNatura® is actually just registered at the building where Heel has been since 2003163164, in Albuquerque, where Heel has been since 1978165. Going to Heel's American website, actually just leads you to MediNatura®'s website.166 Further more, MediNatura even sells a whole line of products which are labeled "BHI", which is actually the name of yet another company of Heel. In fact, products in this line were sold identically by Heel in the U.S. (cf. the product on the far right159). Lastly, Heel has filled 2 trademark applications for the name MediNatura®, for which (by the way) the procedures started as early as 14/2/2014, far before the so-called "negotiations" with MediNatura®:
 
Uriel - Try a homeopathic called VERTIGOHEEL it really helped me out alot i took 3 a day you just let them melt under your tongue....
 
Medical Research on Vertigoheel.
https://www.ncbi.nlm...pubmed/20852360
https://www.ncbi.nlm.../pubmed/8414621
https://www.ncbi.nlm...pubmed/15750375
------------------------------------------------------------------------------------------------------


#3 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 09 August 2017 - 10:28 AM

Increasing your GABA production and efficiency
by proper diet and supplements. -
8/10/17

Summary - Eating foods high in GABA or taking GABA supplements have little success in treating anxiety or depression because while they enter the blood system they do NOT cross the Blood/Brain Barrier. However many flavinoids have been shown to facilitate GABA activity in the brain and help with anxiety and depression.
 
Recommendations - Gaba supplements provide little if any help. A better approach would be to use flavonoids. Try focusing of eating vegetables from the lists below and/or using flavonoid supplements Flavonoid supplements are varied and there is no standard dosage so  I would recommend a good bioflavonoid (citrus based) and start ut around 10% of the dosage recommended on the package and build up from there as tolerated.

GABA is a neurotransmitter that blocks impulses between nerve cells in the. Low levels of GABA may be linked to anxiety or mood disorders like depression, epilepsy and chronic pain. Researchers suspect that GABA may boost mood or have a calming, relaxing effect on the nervous system.
http://www.livestron...e-highest-gaba/
GABA is not an essential nutrient but has been used therapeutically for anxiety, insomnia, stress and hypertension. Some prescription depressant drugs and sleeping medications act on GABA by facilitating its ability to bind to receptor sites in the brain. This produces a calming effect and can induce sleep. Taking a commercial GABA supplement is ineffective for this purpose because it is unable to penetrate the barrier surrounding the brain. This is why more powerful prescription medications are used to stimulate existing GABA in the body.

Importance -
https://www.ncbi.nlm...les/PMC3412149/
Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. Many references
Low levels of GABA have been associated with insomnia, depression and anxiety; however, to date there are very few human studies demonstrating the anti-anxiety benefits of GABA supplementation.
Flavonoid-Rich Foods and GABA Receptors
Flavonoids are phytonutrients found in plant-based foods, tea and wine and are known to enhance GABA function.
Foods high in GABA - Cheese, kefir, miso, sauerkraut, tempeh, yogurt, soy sauce and Thai Fermented Shrimp (Kung-Som) have NOT been shown to fight anxiety or depression.
Many probiotics react to ferment foods and produce GABA but there is little evidence that these foods cross the blood brain barrier or has an effect on depression or anxiety.

A study published in 2011 in the British Journal of Pharmacology illustrates the impact flavonoids have on specific GABA receptors in the brain.

https://www.ars.usda...77Flavonoid.pdf
Detailed list of flavinoid containing foods.
General list of the Best Sources of Flavonoids
flavonols flavan-3-ols* flavones flavonones anthocyanidins
onions apples parsley oranges blueberries
apples bananas bell peppers grapefruit bananas
romaine lettuce blueberries celery lemons strawberries
tomatoes peaches apples tomatoes cherries
garbanzo beans pears oranges pears
almonds strawberries watermelon cabbage
turnip greens chili peppers cranberries
sweet potatoes cantaloupe plums
quinoa lettuce raspberries
garbanzo beans

Medical Research
https://www.ncbi.nlm...pubmed/25109791
citrus flavonoids ....including antidepressant (activity)

https://www.ncbi.nlm...pubmed/25656001
...the flavonoid fraction (F1C) with anxiolytic activity which is dose dependent, and has the ability to interact with the serotonergic system.

https://www.ncbi.nlm...pubmed/23596160
Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats.

https://www.ncbi.nlm...pubmed/24121702
Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder.

https://www.ncbi.nlm...pubmed/24679021
Purple grape juice as a protector against acute x-irradiation induced alterations on mobility, anxiety, and feeding behaviour in mice. This beneficial effect on short-term anxiety and mobility related activities could probably be included in the list of flavonoid bio-effects.

https://www.ncbi.nlm...pubmed/23603526
The experiments with different receptor blockers suggest an involvement of GABAergic system in the anxiolytic action of this bioflavonoid. However, this action is not seems to be mediated through serotonergic system.
https://www.ncbi.nlm...pubmed/26190180
https://www.ncbi.nlm...pubmed/25600371
https://www.ncbi.nlm...pubmed/21244373
https://www.ncbi.nlm...pubmed/25449359
These results suggest that spinosin exerts anxiolytic-like effects, and its mechanism of action appears to be modulated by GABAA and 5-HT1A (Serotonin) receptors.
https://www.ncbi.nlm...pubmed/21924247
Taken together, these data suggest that 3-OH-2'MeO6MF (a flavonoid) is an anxiolytic without sedative and myorelaxant effects acting through positive allosteric modulation of the α2β2/3γ2L and direct activation of α4β2/3δ GABA(A) receptor subtypes.

And many many more research articles show the anxiety fighting characteristics of various flavonoids.
https://www.ncbi.nlm...les/PMC4997290/
Higher flavonoid intakes may be associated with lower depression risk, particularly among older women.
https://www.ncbi.nlm...pubmed/23460966
https://www.ncbi.nlm...pubmed/24717328
https://www.ncbi.nlm...pubmed/24947870
And dozens more.

Members and foods they have consumed on the high flavinoid list.
garbanzo beans -1
NLFSS - Chickpeas (garbanzo beans), tofu, walnuts, sesame seeds, pumpkin seeds and almonds are just a few more items high on the food list that fight depression.

raspberries - 3

lettuce - 1

quinoa - 3
Anothermind - I already eat a lot of Red Quinoa (marvellous!)
Xiaojie - Red Peruvian quinoa. I thank God every day for his creating it. It is a protein-packed, vitamin and mineral-packed seed that you throw in your rice cooker and cook the same way you would cook rice (but I add a couple of tablespoons of coconut oil to it). Keeps you feeling energetic, and keeps your digestive system doing what it's meant to do, only more efficiently - so helps purge the body of crap - literally, lol. I HIGHLY recommend it eating a bowl of it every day. Sometimes I eat a bowl of it twice a day. I can tell by how good I feel after eating it that my body loves it. And it has weight loss benefits, as well. Eating lots of fresh vegetables, fish, nuts, coconut oil, and quinoa (very high in protein) daily.

sweet potatoes - 3
Lady Nancy - The sweating is a side effect of stopping the Crapalta, It messes with our hormone levels and the sudden drop in estrogen can be a cause. I found that eating sweet potatoes a couple of times a week really helped. They are a nature source of estrogen.

cantaloupe - 1

plums, cranberries, chili peppers, cabbage. peaches. romaine lettuce
None

turnip greens (Grrens in general) - 13
JDH - I put in just 20 minutes on my mini trampoline in the morning and down my fruits and greens and my days go a WAY better than when I didn't.
FCB - And I have also found eating salad greens and gourmet coleslaw mixes help
SSRI - Lots if leafy greens. ...help the zaps, but that's about it
Raphi - With no limits on the greens, I'm not hungry and was beginning to feel better.
Mendozen - Also, eat fruits and vegetables (I drank greens I got from a vitamin store). A well balanced diet truly helps with fogginess and fatigue
Tuke - friends told me about The Healing Diet. they recommend fresh pineapple, fresh greens(even cilantro and parsley), salmon, and lemon juice in tea or water whenever you can. (note - all contain flavinoids except the salmon.)

watermelon - 2
Sandlion - My husband got out the blender and made a mixture of mostly crushed ice with a tiny bit of watermelon blended in.... the ice felt so good, I was able to "drink" it down and the little bit of sugar from the watermelon gave me some energy. Second post - I woke up feeling nauseous again this morning so the first thing my husband did was make the watermelon drink... so far, so good....

strawberries - 4
JK61 - I use 2 Tablespoons of the Tart Cherry juice in my smoothie. I add a vegetable protein powder and strawberries and half of a banana. I just use water, some people use apple juice or other juices. When my depression was really bad and I couldn't eat I would have two of these a day.

almonds - 11
TM - First, foods rich in tyrosine are thought to stimulate the production of dopamine. These foods include bananas, almonds, avocados, low-fat dairy and meats, sesame seeds, and pumpkin seeds.
FN - then I started craving eggs....and prunes and almonds....
LadyNancy - but I am allergic to tree nuts with almonds and walnuts being deadly (I carry an Epi-pen because of it).
NoLonger - Foods highest in the tryptophan ratio are tofu, almonds and sesame seeds, sesame seeds being the highest. Chickpeas (garbanzo beans), tofu, walnuts, sesame seeds, pumpkin seeds and almonds are just a few more items high on the food list that fight depression.
KK - hopefully along with some dietary changes like adding lots of bananas and almonds to give you a quick boost in levels. This can apparently be accomplished by increasing the foods that raise dopamine levels, such as almonds, avocados, bananas, dairy products, lima beans, pumpkin seeds, and sesame seeds, and removing those things from my diet that cause dopamine levels to drop... such as alcohol, caffine, sugar, saturated fats, and refined foods.
Jeannie - I've been eating foods that support acetylcholine production such as peanuts, almonds, spinach, wheat germ, and whole eggs. Beef liver is also a good source of choline but who wants to eat that!
IAA - Food sources of dopamine increasing tyrosine include almonds, avocados, bananas, dairy products, lima beans, pumpkin seeds, and sesame seeds.
Michellah - I am also eating almonds and soup. The potato at night helps the body make its own serotonin and I highly encourage anyone going off to try the potato at night.
SarahJ - Also, raw almonds (without salt) are good filling food.

oranges - (Icluding the mention of citrus) - 9
WTKF - I drink a lot of water, take fish oil and eat protein and fruits/veggies without much carbs (apples, oranges, soups). The diet stuff seems to help.
LadyNancy - As far as the fruit goes you are better off with citrus like oranges or tropical like pineapple as long as your stomach can handle it. ...citrus fruit (oranges, lemons, limes) help the brain make GABA (the feel good neurotransmitter).
I am Who I Am - Poppy seeds, dates and citrus fruits are recommended as good remedies for vertigo.
tomatoes - 4
Rebecca - Two to three simple bananas and kiwi's, an egg-sandwich, 2-3 glasses of milk, a few tomatoes and an avocado a day provides many of the essential vitamins, (trace)minerals & amino acids you need on a daily base.
Jane -Eggs with tomatoes seems to be the best bet for me, followed off with a banana or applesauce.

apples - 8
WTKF - I drink a lot of water, take fish oil and eat protein and fruits/veggies without much carbs (apples, oranges, soups). The diet stuff seems to help.
CCOD - For instance, apples cause me to feel nauseated now.
MC - here are a couple of remedies that has helped my nausea in the past . Mint tea, peppermint tea, green apples and life saver 'wint-o-green' flavor.

cherries - 4
GK61 - I put the Tart Cherry in my morning smoothie for help with pain. It's been very beneficial for me.
Ctina - This week I had a strong craving for black cherries, due to my pregnancy. I discovered that they have an ingredient that helps with sleep patterns, Muscluler, and here is the kicker, skeletal pain!! I felt fantastic last night after drinking two glasses of cherrie soda. Which only after I drank it, I decided to look it up and discovered its benefits. It has meletonin to calm and help you sleep along with a natural pain reliever, called Anthocyanins. Many of us are suffering with pain and restlessness.
VV - In addition to the rhodiola, I increased intake of foods containing tryptophan. Tryptophan converts to 5-HTP which converts into serotonin. Thereby increasing my intake of tryptophan, increased my serotonin levels.

VV - Foods that help:
oatmeal
peanut butter
eggs
chicken
dark cherries
dark chocolate
yogurt
turkey
and many others if you search the web you can find them.

lemons - 2

celery - 3
Kitty - I also got three chinese herbal meds from the doc. Boswellia complex, Ligaplex 2, and Evergreen neck and shoulder chronic. Btw, all these meds are natural esp, Boswellia complex (main ingredients; turmeric powder, ginger, and celery seeds/ roots)

blueberries - 6
PPT - I also bought fresh blueberries: This lessened all my symptoms and gave me a little energy (who knows why)

bananas
BRZ -as for the nausea, since that is a direct symptom of anxiety - getting that under control would help, in the meantime, bananas work well for me.
TM - First, foods rich in tyrosine are thought to stimulate the production of dopamine. These foods include bananas, almonds, avocados, low-fat dairy and meats, sesame seeds, and pumpkin seeds.
aMarie - try b vitamins, multivitamins eggs, bananas, fish oils and red bull - this all helped greatly with my withdrawals.
LadyNancy -The bananas are good for when you have been throwing up sick or have bad diarhea or just can't eat much.
Anxiety Beating Treat
Banana chocolate dessert or spread -
2 very ripe bananas
1/8 to 1/4 cup unsweetened cocoa powder
Mash bananas then beat in cocoa until completely mixed and serve.
Irritableme - This is what I've taken to help feel a bit more human (thanks to this site): Res-Q fish oil capsules, vitamin B-12, multi-vitamin, lots of water, lots of healthy food (flaxseed ground up, Odwalla vitamin B juice, apples, bananas, salmon, fresh veges), lessened my caffeine intake, Claritin-D. I was already taking Vitamin D and magnesium before I stopped Cymbalta.
JWBH - Try to eat a bite of banana if you can. Bananas are a great source of potassium and serotonin which your brain is severely lacking after you quit Cymbalta.
Chimera - bananas are great little powerhouses when you feel weak!
Jenni - Rice cakes, bananas, nuts are working better for me than when I was eating cakes all the time - no surprise there! Also, try a regular anti-nausea medicine from the drugstore.
MixiePixie - Also, eating bananas and eggs, has helped me- which others on this site recommended.
MS -I swear to you that between a little exercise, a standard multi-vitamin that I was taking the whole time anyway, the protein whey, and a few extra bananas in my diet, I am kicking the Cymbalta withdrawals butt!
Lori - Since weaning off the Cymbalta, I have not had as much a craving for bananas, but I seem to have pain in my joints, sore muscles, and my back ITCHES!! I seem to be weaker physically, than what I used to be.

bell peppers - 1

grapefruit - (also see 'citrus' above) - 3
FH - Buspirone (Buspar) is a seratonin 5-HT1A receptor partial agonist and a dopamine antagonist at the D2 receptor, D3 receptor and D4 receptors. It functions as a weak anti-anxiety medication similar to diazepam in strength (a weak benzo). DO NOT take with grapefruit or grapefruit juice.
Member warnings
I think we would have to know more, like how much grapefruit juice has the potential to increase the levels in your system, depending on dose, other medications, etc. (False)
You aren't supposed to drink grapefruit juice while taking Cymbalta, because it changes how your body metabolizes it and increases the risk of Serotonin Syndrome, (False)
Just read that one should not drink grapefruit juice while taking Zoloft...bad interaction (True) See ...https://www.ncbi.nlm...pubmed/10890261for details.
Autimom - Did you know that GRAPEFRUIT products can cause an interaction with the following medications: Buspirone (BuSpar), Antiarrhythmia - Amiodarone (Cordarone), Antidepressant - Sertraline (Zoloft),
Antihistamine - Fexofenadine (Allegra),. Anti-seizure - Carbamazepine (Carbatrol, Tegretol), Calcium channel blocker (BP medication) - Nifedipine (Procardia), nimodipine (Nimotop), nisoldipine (Sular), Statin - Simvastatin (Zocor), lovastatin (Mevacor), atorvastatin (true)
rebecca - Avoid Grapefruit Juice. Grapefruit juice is an inhibitor of the cytochrome P-450 enzymes. These enzymes are known to metabolise (break down) (SSRI) antidepressants in the liver. Drinking grapefruit juice whilst you are taking an (SSRI) antidepressant can create a serious toxic reaction, because the (SSRI) antidepressant will build to toxic levels in the bloodstream! (only certain antidepressants) (true)
Note - Because both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism, potential exists for clinically important drug interactions when duloxetine is concurrently administered with CYP1A2 inhibitors, CYP2D6 inhibitors, and CYP2D6 substrates.1 (See Interactions.)( Drugs.com) while cytochrome P – 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. There is NO medical research to show that grapefruit juice interacts with Cymbalta. This is confirmed by the FDA ...
See https://www.fda.gov/...g/ucm093664.htm
https://www.ncbi.nlm...pubmed/10851844
Several actual examples on interactions with selective serotonin re-uptake inhibitors, HMG-CoA reductase inhibitors, mibefradil, sildenafil, protease inhibitors and with grapefruit juice are discussed.

parsley - 2
Chrism - So its been a lot of parsley, carrots, and especially broccoli. No luck.
onions (red) - 3

tea - A great many and will be addressed by types of tea tried.
chamomile flowers (tea) - 17
FN - chamomile tea helps some folks with the gastro issues (I wasn't one of them) but...helped me (with sleep) chamomile and valerian tea
FH - "There is a new sleep aide out called Somnapure. It is flying off the shelfs and being hailed as a wonder cure for insomnia. BUT.....As you can see the ingredients are listed below;

Supplement Facts
Serving Size: 2 Tablets
Servings Per Container: 30
Valerian (Valeriana Officinalis) Root Extract 500 mg*
Lemon Balm Extract Leaf 300 mg*
L Theonine 200 mg*
Hops Extract Strobile 120 mg*
Chamomile Flower Extract 50 mg*
Passion Flower Extract Aerial 50 mg*
Melatonin 3 mg*
* Daily Value not established.

All of these ingredients have strong drug interactions and/or side effects except for melatonin. There has been a rash of people landing in the hospital for reactions to this med, especially if they are on antidepressants. Use with caution."
Xanazul - *Lots of infusions (valerian, chamomile, limeflower...) all the day long, specially before going to bed.
TXC - Chamomile tea helps a little
Bahara - So yogurt, chamomile tea, orange juice helped me a lot.
CE - Chamomile tea seems to help the nausea and calms down any jitters I have. I practically live on it now.
Abbyg - The other thing that really helped was Chamomile tea.
Kate - Organic chamomile tea (especially helpful if you are prone to naseua or greater anxiety during the withdrawals)
GracesG - Also, the Chamomile Tea is helping me get to sleep.
Schmb - Chamomile Tea, or Sleepytime tea with Valerian (this helps me to sleep. I finally acquired a taste for chamomile tea, and that is soothing.
feverfew - 1
Tria - The herb Feverfew was given to me by a doctor but I was allergic to it.
Wiki - Long-term use of feverfew followed by abrupt discontinuation may induce a withdrawal syndrome featuring reb ound headaches and muscle and joint pains. Feverfew can cause allergic reactions, including contact dermatitis. Other side effects have included gastrointestinal upset such as nausea, vomiting, abdominal pain, diarrhea, and flatulence. When the herb is chewed or taken orally it can cause mouth ulcer and swelling and numbness of the mouth. Feverfew should not be taken by pregnant women. It may interact with blood thinners and increase the risk of bleeding, and may also interact with a variety of medications metabolized by the liver.
linden flowers - 2
mirmca - I did not try the apple vinegar, but I drank Linden Tea to calm my nerves at night so I could fall asleep.
cookie - Linden tea, as any other natural alternative brings very mild relief to anxiety.
passionflower - 6
LadyNancy - If you don't take any OTC sleeping aids you can also try some lemon balm or passionflower tea made quite strong at night. It helps relax the muscles which eases the pressure in the head. So far I have found that Lemon Balm, Passionflower and omega3 are very good. For nervousness, try Passionflower 2ml up to 3 times a day.
Mit90 - I had a couple of bad days when i got to 30 because i did the last drop a lttle fast but my naturopath gave me some passionflower which helped.
Freeme2 - The kava kava, passionflower, and Gaba really help keep me super calm.
cocoa (unsweetened dark cocoa only) -
BRZ - my new anti anxiety drug is Lindt's 90% cocoa chocolate
LadyNancy -
Anxiety Beating Treat
Banana chocolate dessert or spread -
2 very ripe bananas
1/8 to 1/4 cup unsweetened cocoa powder
Mash bananas then beat in cocoa until completely mixed and serve.

wine - 22 - Alcohol is dangerous when taking Cymbalta but small amounts may help GABA production after coming off Cymbalta.
FH - when they (cramps) get real bad she can take about 6 or 7 tablespoons of wine and in 15 minutes they are gone.
TFL - I am having wine at the moment cuz it helps!
Carletta - but should have stayed on one glass of wine, the other half had me feeling fidgety and crying.
Wagtail - I can feel the effects today & my balance is very bad so I have learned a lesson , NO wine whilst suffering w/d . I find that when I drink wine the side effects are worse
DonnaP - Be careful with the amount of wine tho. I think it's ok to have some wine to take the edge off,
Zappalta - I am 80% better -I do find if I get overtired or have a glass of wine I have some symptoms return-so no wine when i dine out for now.
Zazzed - slight buzzing had a glass of wine it went away.... go figure
LazyDaisey - Last night the anxiety lifted at about 8pm. I had 2 glasses of wine...not usually recommended, but I also watched a few funny panel shows I love so I was actually in great form. It was lovely to feel happy.
CV - There is nothing you can do (I found that a couple of glasses of red wine in the evening made a big and positive impact - which is ironic because one of the main reasons I came off Cymbalta was the weird increase in my cravings for alcohol, which turned me from a mild social imbiber into a hopeless drunk
Shaun - -a glass of wine every couple nights has helped me a lot
HZN - I only drink a small glass of wine occasionally. On March 19 I became so sick with nausea that I thougt 4 ounces might help. WRONG! It made me feel so much WORSE!
Drugfree - Alcohol is a definite no-no. I had a glass of wine a few days ago and had a horrible sleep followed by a full day of feeling hung over. One glass of wine should not make me hung over.
Jen - Someone on this board recommended red wine in the evening ... and absolute Godsend. The red wine took away the symptoms completely and helped me get to sleep.
Flavinoid supplements
...a typical person should consume 20 to 100 grams of flavonoids each day. Other sources say 250 to 750 milligrams per day (0.25 to 0.75 grams per day). It is recommended to start dosage low and build slowly until you are comfortable. As of this date NO medical research has been done to determine the daily requirement for flavonoid intake. There are over 4000 flavonoids that have been identified and each act at slightly different doses. Bioflavonooids (from citrus sources) help to facilitate Vitamin C usage but some are sensitive to them (1 member) and heartpounding, skip beats and other cardiac arrhythmias may occur. No studies have been done yet that determine which flavonoids work best for anxiety or depression.
Gaba Supplements
The only way to deliver GABA effectively is to circumvent the blood-brain barrier. Indeed, there are a small, limited number of over-the-counter supplements that are derivatives of GABA, such as phenibut and picamilon combines niacin and GABA and crosses the blood–brain barrier as a prodrug that later hydrolyzes into GABA and niacin.
Phenibut
There are numerous reports of withdrawal symptoms on Internet forums and blogs including "nervousness and shakiness, psychomotor agitation, feeling easily annoyed and irritated, fatigue, poor appetite, heart pounding and racing, nausea, insomnia, and feeling tense and keyed up", consistent with its GABAB agonist properties. There has been no systematic study of this problem. Very limited data to show it can be both anti-anxiety and antidepressant in nature.
http://www.ncbi.nlm....pubmed/23391959
http://www.ncbi.nlm....pubmed/21476277
http://www.ncbi.nlm....pubmed/20841974
http://www.ncbi.nlm....pubmed/19899708
http://www.ncbi.nlm....pubmed/19334514
http://www.ncbi.nlm....pubmed/18607733

Picamilon
Picamilon is able to cross the blood–brain barrier and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response. The second released component, niacin acts as a strong vasodilator, which might be useful for the treatment of migraine headaches. Very limited data to show it can be both anti-anxiety and antidepressant in nature.
Reported side effects include, but are not limited to, lightheadedness and decrease in blood pressure.
Phemibut has been researched more completely than picamilon. Neither are to be taken with benzos,
http://www.ncbi.nlm....pubmed/14558352
http://www.ncbi.nlm..../pubmed/2736292
Member comments on taking Gaba supplements...
pag - The doc increased my GABA intake
Turbolag - I take GABA, made by now. but it's been 1 a day. The instructions say 2-3 capsules daily. So I guess I could try going to 2?
1 capsule has 500mg of GABA and 2mg of vitamin B-6.
AKA -By the way, I'm taking 400mg of SAM-e in the morning and 500 of GABA once in the morning and once at night. I've been feeling pretty good mood wise for the last two weeks on this combination. My persistent issue is sleep disturbances.
FH - both SAM-e and GABA can cause sleep disturbances including constant dreaming, erratic sleep and disturbing dreams.
FN - Caution -Aspartame causes "The ATP stores [adenosine triphosphate] in the cells are depleted, indicating that low concentrations of glucose are present in the cells, and this in turn will indirectly decrease the synthesis of acetylcholine, glutamate and GABA (gamma-aminobutyric acid)."
Note - Indicates one should decrease the use of aspartame during withdrawal.
Flossy - Apparently xanax depletes your natural gaba. The gaba is actually helping a lot! I am so angry and agitated at the moment due to Cymbalta withdrawal and gaba is calming me a lot.
Note as mentioned above, benzos compete with gaba for the same receptors it does not deplete the gaba in your brain.
tt2k - They specialize in 5 htp, GABA, and other amino acids that totally help your body regulate and produce the chemicals your body needs to fight anxiety and depression. TOTALLY WAS A BLESSING!!!
Cez - The GABA acts as a balancer of other chemical processes in the brain and helps to reduce anxiety and induces relaxation and sleep. It was suggested taking 250 mg mid afternoon and late evening and working up if needed. TAKE THE FIRST DOSE AT HOME IN CASE IT MAKES YOU TOO SLEEPY TO DRIVE!! I only found 750 mg in the local GNC. I am splitting the capsules to lower the dosage until my mail order lower doses come.
phtech - How it works: Gaba is an inhibitory neurotransmitter that slows activity in th ebrain and makes it easier to fall asleep. How to use:Take 500mg to 1000 mg one hour before bedtime if you have trouble getting to sleep. IF your problem is that you wake in the middle of the night and cant go back to sleep, then take it then. Do not exceed recommended doses on the package. Do this for two weeks. If it doesn't help, talk to your doctor. Caution: combining GABA with prescription or over-the counter sleep aids can cause excessive sedation."
Cam - GABA - 250 mg when I'm feeling restless (helps your neurotransmitters kick in to relax,
GABA calm - 1 member
Contains magnesium, GABA, glycine, n-acetyl l-tyrosine and taurine also sorbitol, mannitol, stearic acid, modified cellulose gum, natural orange flavor, and magnesium stearate.

Gaba Plus - 1 member
maccacat - He started taking a supplement called Gaba Plus and told me he feels a difference.
Ingredients: GABA, glutamine, passionflower aerial parts, taurine and spirulina.

https://www.cymbalta...-advice-please/
Includes a detailed discussion on Gaba

Medicines that react with the Gaba receptors....
See ... https://en.wikipedia...eceptor_agonistAgonists which stimulate the gaba receptors.
and https://en.wikipedia...ptor_antagonistAntagonists which inhibit the gaba receptors.
FN - Trazadone works on the GABA receptors....
Note - to some extent bit it also reacts with over 20 other receptors.

See - https://www.ncbi.nlm...pubmed/15610924
Both klonopin and baclofen work on the GABA receptors Wiki

Drug Interactions
https://link.springe...?no-access=true

Not involved with Serotonin Syndrome
 
Vitamin C
https://www.ncbi.nlm...les/PMC2649700/
Ascorbate is proposed as a neuromodulator (effects the performance of other neurons) of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors.

Antihistamines
The H2 antihistamine receptor is found throughout the hypothalamus, thalamus and central nervous system including neurons (nerve cells). It stimulates formation of cAMP (a compound used to transport energy), protein formation, muscle contraction, blood pressure and much more. The receptor is found in neurons and when stimulated it acts to inhibit other neurotransmitter formation including dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.

Antidepressants -
http://www.ncbi.nlm....pubmed/15451391
In comparison with saline, citalopram (Celexa) produced a mean increase of 35% in relative brain GABA concentration in the occipital cortex.

https://www.ncbi.nlm...pubmed/25082715
Zolpidem (Ambien) increases GABA in depressed volunteers maintained on SSRIs.

https://www.ncbi.nlm...pubmed/11925309
A significant increase in occipital cortex GABA concentrations was seen after SSRI treatment.

Articles On How Anti-Depressants Effect Gaba
http://www.cymbaltaw...nts-effect-gaba

Other Supplements that efffect Gaba
Details on these supplements will be given in another section.
Thiamine (Vitamin B1) is used in the biosynthesis of the neurotransmitters acetylcholine and gamma aminobutyric acid (GABA). Humans must obtain it from their diet. Thiamine deficiency has a potentially fatal outcome if it remains untreated. There are no reports available of adverse effects from consumption of excess thiamine by ingestion of food and supplements. Thiamine increases the flow of glutamate into the cells for use in neurotransmitter formation. Wiki
Note - Use of thiamine supplements may increase gaba concentrations in the brain but it may also increase acetylcholine. This may account for the variety of responses by members.

No research found to indicate Thiamine is anxiolytic.
B6 (pyridoxine) is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gene expression. It is a factor in the biosynthesis of five important neurotransmitters: serotonin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid (GABA).
https://www.ncbi.nlm...pubmed/10746516
50 mg B6 with Mg
https://www.ncbi.nlm...pubmed/15554143
Magne-B6 (a magnesium lactate/pyridoxine combination), effective. 14 days to start.
Antihistamines
The H2 antihistamine receptor is found throughout the hypothalamus, thalamus and central nervous system including neurons (nerve cells). It stimulates formation of cAMP (a compound used to transport energy), protein formation, muscle contraction, blood pressure and much more. The receptor is found in neurons and when stimulated it acts to inhibit other neurotransmitter formation including dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin.

Benzodiazipines
https://www.ncbi.nlm...les/PMC2943829/
Based on collective findings in this benzodiazepine withdrawal-anxiety model, we propose a functional model illustrating the changes in glutamate receptor populations at excitatory synapses during benzodiazepine withdrawal.
(Physically alters GABA receptor shape and function during withdrawal.)
http://www.ncbi.nlm....les/PMC3494928/
Chronic BZ treatment results in allosteric uncoupling of the GABA and BZ binding sites, suggesting changes in receptor subunit composition and/or receptor function (reviewed in ref. 7). Chronic dosing of animals with BZ leads to a reduction in GABAAR synaptic inhibition (8\l "–10) and produces diverse changes in GABAAR transcripts across the brain (7). Direct comparison and interpretation of these and other studies assessing mRNA levels has been challenging due to differences in treatment paradigm (time and dose), brain regions assessed, and the BZ ligand used. Radioligand binding studies have reported mixed results, ranging from decreases to no change in CNS BZ binding sites, likely due to methodological limitations in assessing subtype-specific GABAAR changes.
(Multiple references to changes in the receptors)
Benzodiazepines enhance the effect of the GABA at the GABAAa receptor. Wiki
During withdrawal, fluoroquinolone-based antibiotics are best avoided if possible; they displace benzodiazepines from their binding site and reduce GABA function and, thus, may aggravate withdrawal symptoms.

L-theanine
L-theanine is an amino acid precursor to glutamate (involved in the synthesis of GABA) and glutamine. It can cross the blood brain barrier. It is only produced by plants and fungi and a component in some teas. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements. It is synthesized from glutamate using the enzyme glutamate decarboxylase and pyridoxal phosphate (which is the active form of vitamin B6) as a cofactor. This process converts glutamate, the principal excitatory neurotransmitter, into the principal inhibitory neurotransmitter (GABA).
http://en.wikipedia.org/wiki/Theanine

https://www.ncbi.nlm...pubmed/21208586
Effective, 400 mg/day
https://www.ncbi.nlm...pubmed/15378679
Not effective on anxiety, 200 mg/day
https://www.ncbi.nlm...les/PMC4137547/
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.


#4 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 14 August 2017 - 10:12 AM

                                                         Increasing production of Endorphins

When you are low in endorphins, you are more likely to feel anxious, depressed, stressed out, and unable to enjoy life or experience joy.

https://en.wikipedia...wiki/Endorphins
Endorphins are endogenous opioid neuropeptides and peptide hormones in humans and other animals. They are produced by the central nervous system and the pituitary gland. The principal function of endorphins is to inhibit the transmission of pain signals; they may also produce a feeling of euphoria (pleasure,happiness) very similar to that produced by other opioids.

How to increase endorphon levels

1. Sniff some vanilla or lavender - Vanilla causes an increase in production of endorphins. This is wht it can help so many with anxiety. The endorphins released when inhaling lavender creates a calming effect that may even enhance sleep and relieve depression.

https://www.ncbi.nlm...les/PMC4325408/
http://www.sciencedi...221169115001033
Ward, A., & Ward, K. (2006). U.S. Patent Application 11/609,330.

Vanilla Oil - Comments from Members

Plzhelp - i just recently learned that 'vanilla' is now something i am currently allergic to (i get headaches).
Lavender Oil - Members 12 positive and 1 negative comment.

SCL - I also have a sleep blend of Serenity, lavender, sandalwood, and bergamot. The calming blend even helped me with a headache without meds!

Gail - What helps me is bubble bath with lavender essential oil.

CurlyKate - The tips on bathing aren't working, my skin feels so tingly and creepy crawly that even my hair and clothing are painful...lavender and any other smells are triggering migraines...lost all appetite...can't sleep...this really sucks!

Gene - I agree 100% with the lavender scent, amazing how calming it is

Warning - Many essential oils are toxic to the liver and may collect there. Especially if taken orally or applied on the skin in large quantities or frequently.

The oils listed underneath are banned (FDA) and can cause toxicity if taken internally as well as dermally (eg. in a massage blend).
⦁ Almond butter
⦁ Boldo leaf
⦁ Calamus
⦁ Camphor
⦁ Horseradish
⦁ Jaborandi leaf
⦁ Mugwort
⦁ Mustard
⦁ Nightshade
⦁ Pennyoyal (both European and North American)
⦁ Rue
⦁ Sassafras
⦁ Savin
⦁ Southernwood
⦁ Stinging nettles
⦁ Tansy
⦁ Thuja
⦁ Wintergreen
⦁ Wormseed
⦁ Wormwood

http://essentialoils.../toxic-oils.htmgives details on each of these oils.
Medical research on DERMAL toxicity of essential oils.
https://www.ncbi.nlm...les/PMC3546250/
https://www.ncbi.nlm...pubmed/23663182
https://www.ncbi.nlm...pubmed/15771186
https://www.ncbi.nlm...pubmed/16324777
https://www.ncbi.nlm...pubmed/25272759
About lemon, ginger and clove toxicity.

https://www.ncbi.nlm...pubmed/15895251
Recent growth in aromatherapy sales has been accompanied by an unfortunate increase in accidental poisoning from these products. Clove oil warrants special attention.

2. take ginseng (red ginseng preferably)

https://www.ncbi.nlm...pubmed/16450289
http://muskrat.middl...ch/ginseng.html

Members - 6
Butterflygt - Combining that with breathing techniques, drinking lots of water and even green tea with ginseng and lemon it made everything bearable.

3. Exercise

https://www.ncbi.nlm...pubmed/18604371
Overtraining (OT) is a complex and multifactorial sport phenomenon, and there is no independent marker that can diagnose OT. The main stimulus for beta-end(1-31) secretion is to exercise because its secretion is volume/intensity dependent for both aerobic and anaerobic exercise. Excess training, however, may reduce beta-end(1-31) concentrations, thus altering its beneficial effects. Therefore, beta-end(1-31) could be used as an additional OT marker, mainly because its effects are strongly related to OT symptoms.

https://www.ncbi.nlm.../pubmed/1553453
https://www.ncbi.nlm.../pubmed/6091217
https://www.ncbi.nlm.../pubmed/9257407
and many more

As indicated by the first research article, the degree of exercise determines the quantities of endorphins. As many of our members related that light to moderate activities often made them feel better but heavy exercise often brought on an increase in withdrawal symptoms. Stretching also releases endorphins.

4. laughter

5. sex

6. chocolate (unsweetened cocoa) - One of the more unique neurotransmitters released by chocolate is phenylethylamine. This so called "chocolate amphetamine" causes endorphin levels to rise significantly.

https://www.ncbi.nlm.../pubmed/1805284
http://www.sciencedi...16503270600084X
https://www.elsevier...about-chocolate
and more.

Members on Cocoa - 4. all positive.

BRZ - my new anti anxiety drug is Lindt's 90% cocoa chocolate

Members on Chocolate - 18 comments, 6 mention dark unsweetened chocolate, and 4 negative comments about a sugar rush followed by a crash.

FN - for example, Lindt makes choco bars in different % ... the darkest is 90% chocolate ... bitter, but I've gotten to love it ... big boost.

Boot2 - i found if i combined chocolate (i am using unsweetened health food store kind now) and valerian- it feels like i am almost normal again...thought i;d pass that along.

7. music

8. Eat something spicy

Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a naturally occurring alkaloid derived from plants of the genus Capsicum, better known as chili pepper fruit. It is a member of the vanilloid family of compounds (e.g., vanillin from vanilla, eugenol from bay leaves, cloves, and zingerone from ginger) (Hayman and Kam, 2008).

https://www.research...ions_in_the_rat
http://www.phytochem...s/capsaicin.php
https://www.ncbi.nlm.../pubmed/2944026
http://www.rspublica.../april13/54.pdf
and many more articles.

9. Eat your very favorite food.

10. Meditation - 49 members tried it, 48 positive reviews and 1 negative review.

Meditation has been shown to in crease the production of endorphins.

https://www.ncbi.nlm.../pubmed/7669835
https://www.ncbi.nlm.../pubmed/9748098
Harte JL, Eifert GH, Smith R. The effects of running and meditation on beta-endorphin, corticotropin-releasing hormone and cortisol in plasma, and on mood. Biol Psychol. 1995;40:251–65. [PubMed]
Yadav RK, Magan D, Mehta N, Sharma R, Mahapatra SC. Efficacy of a short-term yoga-based lifestyle intervention in reducing stress and inflammation: preliminary results. J Altern Complement Med. 2012;18:662–7. [PubMed]
And more.

Member tips and comments

VanEttan - I've found drug-free methods like meditation that help a GREAT deal most of the time but like today, when I'm in panic mode to that extent,

CCod - Meditate daily for 20 minutes/day minimum. I use the Insight Timer app on my iPad or the Calm app. Use the Calm app if you have never tried meditation. Calm is really great if you have never meditated because she starts out with beginner instructions and short meditations that last 10minutes. It WORKS every single time. For headaches, anxiety, extreme anxiety, and yesterday, nausea got better. It is not religious or dogmatic; it's. Breathing.

Farkle - I gotta share with all here that the trauma based meditation approach is incredibly helpful as a coping mechanism for times like this,

FH - Meditation does help but only to a point. Once the anxiety gets too bad it becomes overwhelming.

Uriel - Just wondering if you all went cold turkey or did the weaning off slowly thing. It may sound bizarre but I have been doing meditation for 15 min a day to a meditation cd and its pretty amazing how the breathing calms your whole system.

Butterfly - The name of the app is "Relieve Depression Hypnosis-Guided meditation and Mental Health". There is a few different ones on the app store you can try and they are free, I really liked this one.

TM - I spent a few months listening to guided Mindfulness Meditation sessions at bedtime, and found it useful for winding down and falling asleep. You can find them on YouTube, on CD's, and elsewhere on the net.

considering - I think meditation has helped me deal with bouts of low grade depression that I've experienced in the last seven years since I've been on Cymbalta. So I would highly recommend it to anyone. But I recommend that you have a teacher, even if it's meditation CDs of teachings from Sharon Saltzberg or Pema Chodron.

Tinajuli - Somehow I have an anti-reaction when I think of relaxing methods like meditation and yoga. I tried them so much when I had that real depression and they didn't help, and I was despaired because they didn't help.

Karen - The guided meditation takes my anxiety down a lot. It might not be for you, but it really helped me
Check out this site: http://www.30minutem...meditation.html

Shanna - Go to http://www.self-compassion.org(my psychologist recommended this resource). Download the 'Loving Kindness / Self-Compassion' meditation and the 'Soften, Soothe, Allow' meditation - they are free and they are a great way to start cutting yourself a bit of slack and help you feel a bit more on top of yourself.

TXc - I also think meditation is helpful. There are some guided meditations you can download that are encouraging and reinforce the strength you have and can tap into to get through this. It's also nice when my senses are overly sensitive to shut down the noise, stay still, and focus on healing.

TBS - I'd also recommend a cd set by Buddhist teacher Jack Kornfield (Not to be confused with Jack Canfield!!!) called The Inner Art of Meditation. It's a workshop he ran with talks and short meditations and probably my favorite of all time.

Imdone - Meditation and visualization are powerful tools. I would recommend that everyone here practice visualization daily.

Zombie - I replaced the Cymbalta with Autogenics and Guided Meditations (not exotic meditation). My Pain Clinic has a psychologist who started me on Autogenics. I now do them daily. For guided meditations, I like this one: Susie Mantrell's Your Present: A Half-Hour of Peace. If you have access to a large library system, you will find many audio CDs on all of this so you can preview "programs" before buying CDs. Also, there are samples or mini-examples on youtube.

Chrism - And for me, meditation focused on breathing helps immensely, but that is not a skill you can pick up right away.

11. Increased exposure to sunlight.

https://www.ncbi.nlm...pubmed/24949966
https://www.ncbi.nlm...pubmed/26774381
https://www.ncbi.nlm...pubmed/16635689
https://www.ncbi.nlm...les/PMC2290997/
and more

There are numerous comments from members concerning getting enough sunlight each day. About half of the posts are in reference to the Vit D3 deficiency that member is suffering from and the rest are just general comments that sunlight is good for you especially if you have depression.

12. Certain touchs (hugs, massages...etc)

6 members mentioned messages in relation to their withdrawal. 5 positive. Many others got routine massages for their fibro and frequently mentioned how relaxed they were afterward.

TFL - Today was massage and am feeling better.

Paul - I ended up going to a spa and massage resort yesterday with the wife - didnt really find it relaxing at all!

13. Acupuncture

https://www.ncbi.nlm...pubmed/22073885
https://www.ncbi.nlm...pubmed/22073888
https://www.ncbi.nlm...pubmed/24215920
https://www.ncbi.nlm...pubmed/26896946
https://www.ncbi.nlm...pubmed/25595195
https://www.ncbi.nlm.../pubmed/7455665
and more

Member comments and tips - 15 reviews 14 positive.

FH - Many of my friends and family members have had acupuncture over the years. I think it is a great tool BUT there are a lot more idiots doing acupuncture than experts. In fact my family has only found one so far in the states that new what he was doing (I am sure there are others though).

Traceyish - I've been trying acupuncture, and a host of natural remedies but nothing is working.

GMI - I found a lot of relief from acupuncture in the early stages of withdrawal. I’ve mentioned in prior posts that I was never one to believe in acupuncture even though so many people have told me what wonders it's done for them. These types of acupuncture facilities are all over the country and one near you can be found on this link if you’re is interested in giving it a try: https://www.pocacoop...earch-by-state/

Zeus - However, my general practitioner thought different. She uses a combination of eastern and western medicine and suggested acupuncture. Wow what an improvement. I had one treatment this morning and no nausea since. Even the fatigue is better and I feel like eating again.

considering - Check out the U.S. network of Community Acupuncture Clinics. They are a great way to get low cost acupuncture treatment.

BCH - I used acupuncture, which helped amazingly well. Over a period of about 4 months I suffered very few side effect.

ECU - the auriculotherapy (like acupuncture, only done on the ear alone) was based on a 5 point protocol designed to treat heroin addicts in withdrawal, and got rid of all the physical symptoms (temporarily) and enabled me to function while my body adjusted.

cmonk - I had been going for acupuncture treatments and yes they are wonderful

Sarahj - Oh yeah, I realized how much acupuncture was helping me after the third treatment, I went once a week. So, I hope that it provides some benefit to you. One thing that I tried during the worst of the withdrawal is acupuncture. It really made a difference in my overall outlook on everything, not in a magic bullet kind of way, but my sense of being aware and wanting to take better care of myself seem to be heightened by the experience.

Rogerwilco -Acupuncture is definitely the best way I've found to treat withdrawal discomfort from pharma drugs. The thing about acupuncture is that it has side effects too... but they're all GOOD! I mean, like, WOW :!:

Ramona - acupuncture regularly now. It doesn't take away all the withdrawal symptoms, but it balances the systems in your body to help you feel better while you're going through this. Really calms down the anxiety, quiets your mind.

14. Deep breathing, sighs, yawns....

These activities cause an increase in the release of dopamine, endorphins and serotonin. This fact has been used by psychologists for decades to help control anxiety, depression and sleep. By causing yourself to yawn several time over a 10 or 15 minute period it will release enough of these neurotransmitters to help relax and induce sleep. Sighs work much in the same fashion but to a lesser degree, Breathing exercises are the most effective. A good psychologist should be used to teach the most effective techniques.

 

https://www.ncbi.nlm.../pubmed/9551709

Member comments and tips - deep breathes, breath(ing) - 22 comments all positive

Raven - Breathe it deep calming breaths and hold them for about 5 seconds before slowly letting them out.

Gail - you need to breathe, yes breathe in and out slowly.

Wagtail - Breathe deeply & slowly & DONT BE SCARED ..

FH - Deep breathing. Close your eyes—and try taking deep, slow breaths— making each breath even deeper than the last. If you have a psychologist who could teach you relaxation techniques, controlled breathing and heart rate, etc. These techniques really do work.

Raven - Just do you best to stay calm and use breathing techniques. My husband and FH have given me great tips on breathing when anxiety strikes. FH because he is a veteran and my husband because he has asthma.

Keys to breathing:
** Take slow deep breaths (breath in deeply and slowly)
** Hold for at least 15 secs if you can
** Exhale slowly
***repeat as needed*

FN - What helped me the most with this was yoga ...the breathing exercises ... once learned, they can be done anywhere, anytime .... the release of the built up anxiety in my body was tremendous ...

WAH - Some things that have helped me:

Practice breathing techniques. I'm one of those people who holds her breath a lot, and I don't even know that I'm doing it.

Janson - . i've learned a few breathing exercises via yoga and that helps immensely to calm down those nerves that are about to snap. even without knowledge of specific breathing exercises, just take deep full breaths with hands on your stomach and see your tummy rise on the breath in and then fully breath out. so simple, so effective.

Note - There must have been well over 100 members that had posts similar to the one below. Shortness of breath, heart pounding, skip beats, tightness in the chest or chest pain. These are classic anxiety symptoms and are the result of elevated adrenalin e levels. Adrenaline is a vasoconstrictor and bronchiole constrictor. These shallow rapid breaths allow CO2 to build in the lungs and worsens the symptoms. Alpha-agonists (eg. clonidine) and beta blockers (atenolol) work well t o block the effects of this excess adrenaline. Breathing exercises also help considerably in breaking this Cycle. As you can see below ZA got it really right.

Snap87 - Just scared with the shortness of breath and heart palpitations more than anything.

ZA - the 'out of breath' symptom is actually ;shallow breathing and I had that for about 2days it is very exhaustingas it cuauses your ozygen saturation to drop. what worked for me 'was awareness -slow deep breathing -then a little aerobics. it helped to up my b/p and neuteralize by blood gases

15. Conditioned Response -
One of the methods that can have a dramatic effect on anxiety is the development of a phrase in association with breathing exercises and relaxation techniques. This usually takes time to develop but is very effective. The process is begun by selecting a phrase...say the word "easy" for example. When you notice that you begin to get too anxious then lay down, close your eyes and begin your deep breathing exercises while also doing relaxation like 'progressive relaxation' all the time repeating the word 'easy' in your mind. With practice this becomes very effective and the need to lay down to achieve success is not necessary. You simply stop in place, close your eyes and say the word 'easy" to yourself while relaxing and breathing deeply. You then proceed on with your activities. This can be further used by your spouse to help you control your anxiety. If your spouse notices you becoming anxious they can simply develop a certain place she/he touches you gently as a signal that you need to stop, breath and relax. With practice this becomes automatic and can easily be done in public without drawing attention to your state of mind. The is a conditioned response so it MUST be practiced until it is a reflex action to be most helpful.

Three members report using this technique with excellent results.

Other Medical Research
https://www.ncbi.nlm...pubmed/15639542
it is suggested that melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by binding to its own receptors and increasing the release of beta-endorphin.

As well as ...
https://www.ncbi.nlm...pubmed/12579851
https://www.ncbi.nlm.../pubmed/3361078
https://www.ncbi.nlm.../pubmed/1668619
https://www.ncbi.nlm...les/PMC5038497/
and more.

Also....
https://www.ncbi.nlm...pubmed/12043836
Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina). Antidopaminergic activities of melatonin have been demonstrated in the striatum.

https://www.ncbi.nlm.../pubmed/6291701
The data of this study provide evidence for a further mechanism by which beta-endorphin may alter dopaminergic neurotransmission, namely by increasing dopamine reuptake into dopaminergic nerve endings.

https://www.ncbi.nlm.../pubmed/6263592
The data are consistent with the hypothesis that endorphins act at a presently unknown brain site(s) to increase the central sympathetic outflow to adrenal medulla and peripheral sympathetic nerve endings, thus stimulating peripheral catecholamine release and increasing plasma concentrations of epinephrine, norepinephrine, and dopamine.

https://www.ncbi.nlm.../pubmed/9588760
CSF (cerebrospinal fluid) levels of both neuropeptides (beta-endorphins and P factor) were observed to peak during the first year of life, and showed a negative correlation with increasing age. A significant positive correlation was observed between the CSF level of beta-endorphin and that of substance P.

https://www.ncbi.nlm...cles/PMC432218/
In cerebral cortex, brainstem, caudate nucleus, and thalamus, most responsive cells were inhibited by the peptides (endorphins) and by normorphine, while in hippocampus all responsive cells were excited. These results are consistent with the hypothesis that the endorphins and enkephalins may represent a new class of central neurotransmitters; among other functions, these peptides may play a role in the regulation of behavior and the expression of psychopharmacological agents such as the opiate alkaloids.
 


#5 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 28 August 2017 - 10:03 AM

                                                                            Increasing Dopamine levels
Summary;

 

⦁ The dopamine cycle is: tyrosine converts to L-Dopa to dopamine to norepinephrine and then epinephrine. Therefore caution should be used when trying to raise dopamine to treat depression. Begin with small doses until relief is obtained. Do not take larger doses as any extra unused dopamine will be changed to noradrenaline and adrenaline and the result could be anxiety.

⦁ An overabundance of bad bacteria leaves toxic byproducts called lipopolysaccharides which destroy the brain cells that make dopamine. (⦁ 14) Therefore a good probiotic should be used.
And don’t reach for artificial sweeteners. Aspartame decreases brain levels of both dopamine and serotonin, another important mood-boosting neurotransmitter. (⦁ 17)
L-tyrosine is the first dopamine supplement to consider. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease.
⦁ One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions.

Melatonin decreases dopamine and may make depression worse.

Bananas raise dopamine levels. Many members have relied on bananas to help with their depression and withdrawal symptoms.

 

Dopamine plays several important roles in the brain and body. It is synthesized from a molecule of L-Dopa, which is synthesized in the brain and kidneys. Some animals and humans make it via biosynthesis from the amino acid L-tyrosine. L-DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline) collectively known as catecholamines. The cycle is: tyrosine converts to L-Dopa to dopamine to norepinephrine and then epinephrine.

Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter - a chemical released by nerve cells to send signals to other nerve cells. The brain includes several distinct dopamine pathways, one of which plays a major role in reward-motivated behavior. Most types of rewards increase the level of dopamine in the brain, and many addictive drugs increase dopamine neuronal activity. Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones. It does not cross the blood brain barrier.

Dopamine deficiency can also manifest as certain psychiatric disorders including depression, addiction, attention deficit disorder (ADD), bipolar disorder, and Parkinson’s disease.

Major depressive disorder (MDD), The cause is believed to be a combination of genetic, environmental, and psychological factors. Risk factors include a family history of the condition, major life changes, certain medications, chronic health problems, and substance abuse. About 40% of the risk appears to be related to genetics. There is no laboratory test for major depression.

 

Testing, however, may be done to rule out physical conditions that can cause similar symptoms. Much scientific evidence links lack of dopamine to depression and sometimes anxiety.

Nicotine increases dopamine by 200%, cocaine 400%, and amphetamines a jaw-dropping 1,000%.

Few people realize that they are “self-medicating” to get a dopamine boost when they engage in potentially addictive and self-destructive behaviors. The use and abuse of caffeine, alcohol, sugar, drugs, shopping, sex, video games, online porn, power, and gambling are all effective, but temporary, dopamine boosters.

Here’s a list of foods, drinks, and spices known to increase tyrosine or dopamine directly: (6, 7, 8, 9, 10, 11, 12)
⦁ all animal products
⦁ almonds
⦁ apples
⦁ avocados
⦁ bananas
⦁ beets
⦁ chocolate
⦁ coffee
⦁ fava beans
⦁ green leafy vegetables
⦁ green tea
⦁ lima beans
⦁ oatmeal
⦁ olive oil
⦁ oregano
⦁ peanuts
⦁ rosemary
⦁ sea vegetables
⦁ sesame and pumpkin seeds
⦁ soy products
⦁ turmeric
⦁ watermelon
⦁ wheat germ

I’m going specifically mention bananas because they are a particularly good source of dietary dopamine. (13)

 

Surprisingly, the health of your intestinal flora impacts your production of neurotransmitters. An overabundance of bad bacteria leaves toxic byproducts called lipopolysaccharides which destroy the brain cells that make dopamine. (14) Therefore a good probiotic should be used.

Dopamine-Depleting Foods to Avoid
Eating a lot of saturated fat also decreases dopamine receptor sensitivity. (15)

Sugar has been found to boost dopamine, but this is a temporary, unhealthy boost that is more drug-like than food-like and ultimately contributes to deficiency. (16)

And don’t reach for artificial sweeteners instead. Aspartame decreases brain levels of both dopamine and serotonin, another important mood-boosting neurotransmitter. (17)

Here’s a look at some of the best supplements that raise dopamine levels naturally. Caution should be used when trying to raise dopamine to treat depressison. Begin with small doses until releif is obtained. Do not take larger doses as any extra unused dopamine will be changed to noradrenaline and adrenaline and the result could be anxiety.

L-tyrosine is the first dopamine supplement to consider.

This amino acid is the precursor to dopamine.
If you don’t get enough l-tyrosine in your diet, or your body doesn’t properly convert it, you won’t be able to synthesize adequate dopamine. When looking for a supplement, consider n-acetyl-l-tyrosine. This is a highly absorbable form of l-tyrosine that readily enters the brain. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease. One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions.

L-tyrosine can make headaches/migraines and existing thyroid issues worse. The body uses tyrosine to make thyroxine, a thyroid hormone. Tyrosine seems to be safe when used in doses up to 150 mg/kg per day for up to 3 months. Some people experience side effects such as nausea, headache, fatigue, heartburn, and joint pain. (Webmd)

Mucuna pruriens is a tropical legume that contains l-dopa, a dopamine precursor. Mucuna pruriens supplements are sold to enhance mood, memory, overall brain health, anti-aging, and libido. (19) This herb was found to work even better than levodopa medications for Parkinson’s, a disease characterized by low dopamine. (20) The plant contains relatively high (3–7% dry weight) levels of L-Dopa; some people are sensitive to L-DOPA and may experience nausea, vomiting, cramping, arrhythmias, and hypotension. The seeds of the plant contain about 3.1–6.1% L-Dopa,[14] with trace amounts of serotonin, nicotine, and bufotenine (a tryptamine related to aerotonin.)

Side effects include, if too high of a dosage is taken, users may experience vomiting, headaches, and sleeplessness. Other serious side effects, like high blood pressure, hair loss, and hallucinations are also possible. No more than 500 mg a day is generally necessary to experience all of Mucuna’s effects. If you take Mucuna too frequently, you may start to develop tolerances over time which cause you to increase dosage too quickly. https://nootriment.c...s-side-effects/

https://www.ncbi.nlm...pubmed/26058043
An average of 52.11% degradation of L-dopa was found in seeds of M. pruriens varieties. Since M. pruriens seeds and/or L-dopa are used for treatment of Parkinson's disease and as an aphrodisiac both in modern and/or traditional systems of medicine, the finding of high level of L-dopa degradation (in pure form and in M. pruriens extracts) into damaging quinones and ROS is very significant.

https://www.ncbi.nlm...les/PMC3942911/
Great review of this plant and its properties.

https://www.ncbi.nlm...les/PMC4213977/
Overview of its use in treating depression.

Curcumin is the main active ingredient in the spice turmeric. It readily crosses the blood-brain barrier where it boosts levels of dopamine. (21, 22, 23) Curcumin has been found to be as effective for treating depression as the popular antidepressant Prozac. (24) When buying a curcumin supplement look for one that contains piperine, a compound found in black pepper that increases curcumin absorption by a remarkable 2,000%. (25)

https://www.ncbi.nlm...pubmed/28074653
According to a 2017 review of over 120 studies, curcumin has not been successful in any clinical trial, leading the authors to conclude that "curcumin is an unstable, reactive, non-bioavailable compound and, therefore, a highly improbable lead".

https://www.ncbi.nlm...pubmed/26024538
In Phase I clinical trials, curcumin had poor bioavailability, was rapidly metabolized, retained low levels in plasma and tissues, and was extensively and rapidly excreted, factors that make its in vivo bioactivity unlikely and difficult to accurately assess.

https://www.ncbi.nlm...pubmed/26972530
Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats.

https://www.ncbi.nlm...pubmed/21928724
Curcumin increased both the swimming and climbing behavior in FST, thus its antidepressant like activity could be due to an increase in serotonin, norepinephrine and dopamine levels in the brain. Curcumin can be a useful antidepressant especially in cases which respond to drugs having mixed effects on serotonin and catecholamines levels in the brain.

https://www.ncbi.nlm...pubmed/20230279
Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway.
Our study suggests that the neuroprotective effect of curcumin is not related simply to its antiinflammatory and antioxidant properties, but involves other mechanisms, particularly by targeting the JNK pathway

https://www.ncbi.nlm...pubmed/18766332
Antidepressant activity of curcumin: involvement of serotonin and dopamine system.
The study provides evidences for mechanism-based antidepressant actions of curcumin. The coadministration of curcumin along with piperine may prove to be a useful and potent natural antidepressant approach in the management of depression.
And many other articles.

Side effects - Turmeric isn't approved by the U.S. Food and Drug Administration to treat any diseases, and taking turmeric supplements can cause unpleasant or dangerous side effects. The most common gastrointestinal side effects are stomachache, gas, nausea and indigestion and taking turmeric for long periods can cause ulcers in some people due to increasing stomach acid.
The curcumin in turmeric encourages the gallbladder to produce more bile, which may improve digestion. Because of the extra bile production, people who have gallstones or other conditions that block bile passages shouldn't take turmeric before consulting with their doctors. Turmeric may also contribute to the formation of kidney stones, particularly in people who have conditions that increase the risk of kidney stones.

Pregnant women shouldn't take turmeric as a supplement. According to MedlinePlus, the curcumin can stimulate the uterus or encourage the uterine lining to shed, which could increase the risk of miscarriage.

Because turmeric can increase stomach acid, it can interfere with the efficacy of drugs that reduce acid, such as acid reflux medications. The spice can also increase the effectiveness of some drugs, including blood thinners and diabetes medications. Taking turmeric with blood thinners can increase the risk of bleeding. This includes taking it with other herbs that act as blood thinners, including ginger, garlic, clove, ginseng and willow. Diabetics who take medication to help lower their blood sugar levels shouldn't take turmeric because it can drop blood sugar to potentially dangerous levels.

Ginkgo biloba is traditionally used for a variety of brain-related problems such as poor concentration, memory problems, headaches, fatigue, mental confusion, depression, and anxiety. (26) One of the ways ginkgo works is by raising dopamine. (27, 28)
Ginkgo LEAF EXTRACT is LIKELY SAFE for most people when taken by mouth in appropriate doses. It can cause some minor side effects such as stomach upset, headache, dizziness, constipation, forceful heartbeat, and allergic skin reactions.

There is some concern that ginkgo leaf extract might increase the risk of liver and thyroid cancers. However, this has only occurred in animals given extremely high doses of ginkgo. There is not enough information to know if it could happen in humans.

Ginkgo fruit and pulp can cause severe allergic skin reactions and irritation of mucous membranes. Ginkgo might cause an allergic reaction in people who are allergic to poison ivy, poison oak, poison sumac, mango rind, or cashew shell oil.

There is some concern that ginkgo leaf extract might increase the risk of bruising and bleeding. Ginkgo thins the blood and decreases its ability to form clots. A few people taking ginkgo have had bleeding into the eye and into the brain, and excessive bleeding following surgery. Ginkgo leaf extract can cause allergic skin reactions in some people.

The ROASTED SEED or CRUDE GINKGO PLANT is POSSIBLY UNSAFE when taken by mouth. Eating more than 10 roasted seeds per day can cause difficulty breathing, weak pulse, seizures, loss of consciousness, and shock. The FRESH SEED is even more dangerous. Fresh seeds are poisonous and are LIKELY UNSAFE. Eating fresh ginkgo seeds could cause seizures and death.

There isn't enough reliable information available to know if ginkgo is safe when applied to the skin.

Special Precautions & Warnings:
⦁ Pregnancy and breast-feeding: Ginkgo is POSSIBLY UNSAFE when taken by mouth during pregnancy. It might cause early labor or extra bleeding during delivery if used near that time. Not enough is known about the safety of using ginkgo during breast-feeding. Do not use ginkgo if you are pregnant or breast-feeding.

Infants and children: Ginkgo leaf extract is POSSIBLY SAFE when taken by mouth for a short time. Some research suggests that a specific combination of ginkgo leaf extract plus American ginseng might be safe in children when used short-term. Do not let children eat the ginkgo seed. It is LIKELY UNSAFE.

Bleeding disorders: Ginkgo might make bleeding disorders worse. If you have a bleeding disorder, don't use ginkgo.

Diabetes: Ginkgo might interfere with the management of diabetes. If you have diabetes, monitor your blood sugar closely.

Seizures: There is a concern that ginkgo might cause seizures. If you have ever had a seizure, don't use ginkgo.

Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD): Ginkgo might cause severe anemia in people have G6PD enzyme deficiency. Until more is known, use cautiously or avoid using ginkgo if you have G6PD deficiency.

Infertility: Ginkgo use might interfere with getting pregnant. Discuss your use of ginkgo with your healthcare provider if you are trying to get pregnant.

Surgery: Ginkgo might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using ginkgo at least 2 weeks before a scheduled surgery.

Drug Interactions

https://www.drugs.co...2&generic_only=
Ginkgo Biloba can react with over 500 different medications to primarily increase the risk of bleeding and seizures. Please review the list of meds at the above site to be sure you are not at risk of these interactions.

Talk to your doctor before using ginkgo together with DULoxetine. Some preparations of ginkgo biloba have caused seizures, and combining them with other medications that can also cause seizures such as DULoxetine may increase that risk.

Medical Research

https://www.ncbi.nlm...pubmed/25346240
Our results suggest that EGb 761 may be useful for reducing anhedonic depressive-like behavior.

https://www.ncbi.nlm...pubmed/21672588
It is suggested that EGb761 produces an antidepressant-like effect, and that an antioxidant effect against oxidative stress may be partly responsible for its observed neuroprotective effects.

https://www.ncbi.nlm...pubmed/20105177
The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
The present results demonstrate that chronic but not acute treatment with EGb 761 increased dopaminergic transmission in the PFC. This finding may be one of the mechanisms underlying the reported effects of G. biloba in improving cognitive function.

https://www.ncbi.nlm...pubmed/22784425
https://www.ncbi.nlm...pubmed/20411379

L-theanine is a unique compound found in green, black, and white teas.
It increases levels of dopamine as well as serotonin and the relaxing neurotransmitter GABA (gamma-aminobutyric acid). (29)

 

L-Theanine improves recall, learning, and positive mood. (30) You can get a dopamine boost by either taking an l-theanine supplement or by drinking tea.

See the section on "raising serotonin levels) for details on this supplement.

Phosphatidylserine acts as your brain’s “gatekeeper,” regulating nutrients and waste in and out of your brain. It can increase dopamine levels and improve memory, concentration, learning, and symptoms of ADHD. (32, 33, 34)

Boost Dopamine with Exercise

But you don’t need to exercise strenuously to enhance your brain. Taking walks, or doing gentle, no-impact exercises like yoga, tai chi, or qi gong all provide powerful mind-body benefits. (38, 39, 40, 41)

And if you can get your exercise outdoors, that’s even better. Sunlight can increase the number of dopamine receptors and create vitamin D which activates the genes that release dopamine. (42, 43)

Increase Dopamine with Meditation

The benefits of meditation have been proven in over 1,000 studies. (44) Regular meditators experience an enhanced ability to learn, increased creativity, and deep relaxation. It’s been shown that meditation increases dopamine, improving focus and concentration. (45) Creative hobbies of all kinds, including knitting, quilting, sewing, drawing, photography, woodworking, and home repair, bring the brain into a meditative state. These activities increase dopamine, ward off depression, and protect against brain aging. (46)

Music Gets Dopamine Flowing

Listening to music can cause release of dopamine. Brain scans show that the brain’s pleasure center lights up when listening to music similarly to when we eat, make love, or take drugs. (47)

Boost Dopamine with Touch

All kinds of pleasurable touch increase dopamine. A therapeutic massage increases dopamine and serotonin and reduces the stress hormone cortisol. (49, 50) Stroking your dog can give both you and your pet a boost of dopamine and a slew of other feel-good brain chemicals. (51) There’s evidence that having sex increases dopamine in lab rats. (52) This has yet to be proven in humans.

The Role of Dopamine and Sleep

Research has found that dopamine plays a bigger role in sleep regulation than previously believed. It controls the production of the sleep hormone melatonin. (53) Research suggests that lack of sleep may reduce the number of dopamine receptors. (54)

https://www.ncbi.nlm...pubmed/18057326
https://www.ncbi.nlm...pubmed/12043836
https://www.ncbi.nlm.../pubmed/7534345
and others
Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina).

Note - This would indicate that patients with depression may want to limit their use of melatonin due to possible lowering of dopamine and increased depression.

The Dopamine-Weight Loss Connection

There’s a strong link between obesity and dopamine dysfunction. (55) Interestingly, people who are obese have fewer dopamine receptors than average. (56) In fact, their brains behave much like that of a drug addict. (57) Thus, since dopamine is in charge of the brain’s pleasure center, obese people will receive less pleasure and satisfaction from eating, making them want to eat more. If you struggle with your weight, you may be caught in a vicious cycle.

Blast Dopamine with a Cold Shower

If you’re game, take a cold shower or at least end your shower with a cold blast.
Taking a shower with 14C°/57F° water can increase dopamine substantially — up to 250%! (58) Proponents of cold showers swear it boosts their mood and productivity all day, even more than drinking coffee

Acheiving Results

Dopamine is released when you achieve a goal, large or small.
If your big goal is to get organized, break it down into many small goals. Each goal can be as simple as organizing your emails, cleaning a closet, or emptying your junk drawer. Every time you cross one item off your to-do list, it gives you a nice spurt of dopamine.

Ideally, your goal should be hard — like quitting a bad habit or sticking with a budget to pay down your debt. The harder your goal, the more accomplishment you’ll feel, and that translates into more dopamine. Get a calendar, virtual or paper, and cross off each day that you’ve actively worked toward your goal. This “don’t break the chain” concept is a proven way to rewire your brain. Acknowledge and savor your victories every day for a daily dopamine boost.

A link to all references can be found at https://bebrainfit.c...rease-dopamine/
The remaining information came from either Wiki or NCBI medical abstracts.





 


#6 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 10 November 2017 - 11:36 AM

Effects of Various Over the Counter (OTC) Meds
Excedrin
Caution - Most Excedrin contains caffeine and may make anxiety worse.
 
TBH - Headaches - Advil and Excedrin made no difference
 
sanctuarie - Headaches - Nothing I've tried helps the headaches, motrin, tylenol, aspirin, excedrin, even norco gives me no relief.
 
CB - I took Excedrin Migraine today....no relief.
 
GW - mild occasional headache, which excedrin took care of.
 
Mjoy - and got a headache this afternoon that fortunately went away with some excedrin.
 
BF - By the end of the day yesterday I was getting really, really dizzy. I took an Excedrin and laid down. After a restful night's sleep I am feeling pretty good. The biggest problem overall with this withdrawal seems to be the dizziness. Taking Excedrin Migraine seems to help, but I don't wanna get caught in a trap of taking a bunch of Excedrin because I tend to get jittery from the caffeine if I take it too often.
 
ITWYS - but today (first time to try it) I took two extra strength excedrin for the headache and the brain zaps have subsided also. You might try this. It has worked so far!
 
BZ - the headache that will NOT go away (which right now is the worst part of it) Claritan D nor Excedrin are putting a dent in it.
 
GD - I was taking ibuprofen for pain, but it was adding to the nausea. I found that Excedrin helps best with dulling the pain and keeps me less nauseous
 
Extra Strength Excedrin - Acetaminophen 250 mg, Aspirin 250 mg, and Caffeine 65 mg.
Excedrin Migraine - Acetaminophen 250 mg, Aspirin 250 mg Caffeine 65 mg
Excedrin Tension Headaches - Acetaminophen 500 mg Caffeine 65 mg
--------------------------------------------------------------------------------------------------------
Activated charcoal capsules
 
https://www.ncbi.nlm...tacidsCymbalta
"Pharmacokinetic results from drug interaction studies show that activated charcoal decreases duloxetine exposure" (absorption)
 
Jillybean - Activated charcoal capsules- (Solaray brand name 280 mg I take 3 capsules twice a day. Lots of water or fluids, it is highly absorbable so it needs to be taken 2 hrs b4 or after other meds, vits etc. It helps to pull the poison from yours system. It may cause diarrhea or constipation hence another reason to boost fluids. Even though diarrhea is uncomfortable, do not take something to stop it as it is necessary to flush this poison out of your system. You can adjust amount based on how you feel.
 
Jillybean - I think the activated charcoal is working too as I am feeling better.
 
DonMH - One of the most harmless remedies for the stomach problems is capsules of Activated Charcoal. You can buy them over the counter. They are often used in overdose patients to prevent the absorption of ingested drugs. Completely natural and harmless - only side effect -your poop will turn black as the charcoal passes through your body. It works - I know!
 
FH - After reviewing the medical journal abstracts I found many research articles that looked at testing if activated charcoal would remove toxins from our body. None of the research showed beneficial effects. They are however very effective at absorbing (thus reducing) medicines and nutrients in the stomach.
----------------------------------------------------------------------------------------------------------
Bragg's Apple Cider Vinegar
 
Tfaff - I'm trying to " detox" by eating well, finding foods that help detox the liver. I drink that apple cider vinegar/ honey/cinnamon mix that came up in another post here.
 
Fivenotions - I took myself off completely a few months ago and went back to home remedies (ginger tea and ginger slices, as well as Bragg's vinegar) ... the home remedies work pretty well (not perfectly) for the acid reflux ... but the "stomach worms"/anxiety every so slowly started to ratchet up ...
Another "home remedy" that really helped me (still does, I'm still taking it) is Bragg's Apple Cider Vinegar ... it's also available in most health food stores, as well as from the internet (Amazon, and Bragg's directly) ... can be put in water, with honey, etc.... during early withdrawal, I drank it straight ... my food cravings were totally weird, and at the time it actually tasted great just like that ... blech ... there've been studies (which I now can't find, typical) that indicate it's a food that naturally increases serotonin levels ... it also cured my arthritis ... (Grandma knew more than I gave her credit for!)
The Bragg's ACV, which is unpasteurized and has what they call the "mother" in it...weird term, but that's the stuff that would otherwise be pasteurized out ....what starts to form when apple cider begins to go "hard" ....

Here's the link ...
http://bragg.com/

I started taking it early in withdrawal ... totally by self-discovery ... I was having an amazing craving for vinegar tasting stuff...like dill pickles...actually, the juice they come in...so I did some googling...

It was very helpful to me with the withdrawal ... seemed to help with the zaps, my constant tiredness and the body "shakes" I got .... now, I've found that it's pretty much cured my arthritis...
 
Equuswoman - Organic apple cider vinegar, raw honey and cinnamon mixed with water.been just a few days on this.
 
Fishinghat - By the way some have had very good success with Bragg's Apple Cider Vinegar for their fibro. There is some medical research that supports this. If you do a search on this site you will find several discussions about it. Be aware it is acidic so it can upset the stomach. The reason the Bragg's is the only Apple Cider Vinegar that works is that it is unpasteurized and therefore has all the original components. If you have any questions about the Braggs let me know and I will try to answer them.
 
Lady Nancy - I could not resist the urge to search and found several references to Bragg's Apple Cider Vinegar which is an unfiltered and unpasteurized apple cider vinegar. Many are unable to take it due to stomach issues in which case a good alternative is Malic Acid/Magnesium in pill form as it works the same.
The dose for the Bragg's is two teaspoons in a cup of water. It is much stronger than regular Apple Cider Vinegar which is probably why it causes stomach aches for some even with some sugar or honey added. I know that I would not be using sugar at all if possible as it actually adds to joint pain and feeds the inflammation. .
 
Fishinghat - A little caution on the vinegar, which has been shown effective, added vinegar ingestion by women has been linked to increases in vaginal infections due to changes in blood and vaginal pH.
katrand - I also add Bragg's apple cider vinegar to my orange juice every morning to aid in absorption of my thyroid meds and supplements.
 
TFL - Are you taking anything for the joint pain? I found that Apple Cider Vinegar (Braggs is the best - natural!) is a great help - you can mix a couple of spoonfuls in a cup of warm water with 1 spoon of honey and some cinnamon - almost tasty! I have arthritis and fibro and this really helps - give it a couple of weeks...
 
BJinFl - I have tried ACV, fishinghat, thank you. Unfortunately, I have one of those stomachs that can't stomach anything.
 
Fishinghat - For fibromyalgia I would try Braggs brand Apple Cider Vinegar. The dosage is 2 tablespoons in about a cup of cold water once a day. There has been some medical research that this juice has benefit for fibro and arthritis pain. This brand is the only one that works because it is the only one that is unfiltered and not pasteurized. Many find this solution to be too acidic for their stomach to handle, if you have that problem then buy some malic acid/magnesium tablets at your local health store. Malic acid and magnesium are the active ingredients in the Apple Cider vinegar.
 
Gail - ....each capsules contains 500mg apple cider vinegar powder, 300mcg potassium and 4mcg bore.
 
Cinders - I'm drinking apple cider vinegar (with must) with agave and cinnamon.
 
Fishinghat - He said to use a 50/50 blend of Braggs (sp) apple cider vinegar and water on the area on her back where the nerves are pinched. It may take a couple months to make a difference but will reduce the arthritis and the pain greatly. He recommends it to many of his patients as a way to reduce there use of pain meds for arthritis. I asked him if he has ever heard of using it on fibro and he said that the ACV worked better on the fibro than it did the arthritis.
 
http://www.ehow.com/...bromyalgia.html
This article explains the basics of using ACV to treat Fibro. I found maybe 50 articles or so that say basically the same thing and many forums that say it works.

http://www.ncbi.nlm..../pubmed/8587088
This research article demonstrates that malic acid is very beneficial in treating fibro. AND malic acid is one of the main ingredients in ACV. It is suggested that there must be magnesium present for it to work and there is nagnesium in ACV.
 
Natural diuretics include:
⦁ Apple cedar vinegar- it regulates the level of potassium in the body

Bragg Organic Apple Cider Vinegar is the type most often mentioned on the forums.

Gonnamakeit - Well, I decided to give this a try and started this morning with this recommended by Whycee a while back: "A cup of hot water, 1/2 teaspoon of cinnamon, two tablespoons of apple cider vinegar and a teaspoon of honey every morning" minus the cinnamon as I'm allergic and I have to say that it seems to be working! I had two servings this morning and this is the first good day since last Friday and I even woke up with my period in full force AGAIN--it just ended Sunday (apologies to the men!) and even those cramps are so much better.
 
FiveNotions -
Drinking to Cure: Apple Cider Vinegar and Cherry Juice for Arthritis?
http://www.healthlin...juice-arthritis

This isn't an article, but a collection of links to info about the ACV arthritis connection...also, we had an interesting discussion here a while back about tart cherry juice as a remedy for withdrawal... https://www.cymbalta...l=+tart+cherry

The healing powers of vinegar
http://www.dailymail...rs-vinegar.html

http://www.anyvitami...inegar-info.htm

Serotonin/tryptophan connection mentioned . . .
http://health.usnews...e-cider-vinegar

This is an interesting discussion about ACV from the Social Anxiety Forum....
http://www.socialanx...a-relief-47323/
 
Wagtail - I think it was Fivenotions that recommended the apple cider vinegar , so I decided to try it . I can't say if it's a coincidence or not , but I do feel better since I've been taking it ... Less s/e's & more energy .. I'm happy with that !..:-)
 
Carleeta - Holy Moly...Apple cider vinegar...wow...I use it daily with Iceberg lettuce...I use it on my fish and on my potatoes..Also, I mix apple cider with fresh caused garlic and fresh ground black pepper, place it in a small bowl and dip pieces of meat (steak, pork chops) on it and eat them...I also soak crispy friend pork rinds in the bowl mixture and eat them...I guess I use apple cider vinegar a lot. It's possible this is what keeps me going forward...I like that it does burn fat also... So great to know it's helping you out with your cymbalta withdrawl....
 
JBhibbard - Drink lots and lots of water. Have you tried the apple cider vinegar detox? I believe it helps.
Andreamarie - For supplements I'm taking B Complex, Omega 3s, and apple cider vinegar.
 
Whychee - A cup of hot water, 1/2 teaspoon of cinnimon, two tablespoons of apple cider vinegar (Braggs) and a teaspoon of honey every morning.
 
plezhelp - i cannot say what will work for you but i continue to try different things = being open to change as the fkn side-effects change too! the best thing i am still doing is tepid Epsom-salt baths with baking soda, and apple cider vinegar - which has helped a lot with the itching; i have no idea which one of those things are the best/better 'healing' but know that they are all currently helping me.
 
happyzappynot - I found that adding a teaspoon of cider vinegar to a glass of water helped my gut.
andie - I have bought some omega 3 6 9 and taking apple cider vinegar. everything has been very bearable so far so good xx
 
Nmood2talk - I started taking apple cider vinegar over a week ago to help with metabolism and weight issues - it does - more energy than ever - less appetite but amazing result is how I didn't know it helped get off
Cymbalta - I tried before because when I didn't have money for meds at times I had terrible brain zaps(like electric shocks in my head) and terrible nightmares- and the pain in my legs got so much worse -
the apple cider vinegar has worked 3rd day off minimal leg discomfort - no brain zaps - no nightmares - have felt better than I can remember ever - look up apple cider vinegar on Web MD and other places - don't drink straight as it will irritate throat - harsh to teeth - look to see if any side effects - says it could interact with meds ... just research it - but I'm telling you - it's an answer for me so far when I thought there were no answers - apple cider vinegar - look it up - nothing fancy although they say organic is better - got mine at the dollar store and like I said took it initially for weight loss - which it is curbing my appetite and making me feel so much better and I'm losing weight but the off cymbalta without terrible withdrawals was the unexpected unbelievable finding - look it up - research it - and let me know
 
IamwhoIam - Prepare a mixture of apple cider vinegar and honey. Consume this mixture; this home remedy is highly effective in relieving vertigo.
----------------------------------------------------------------------------------------------------------
Imodium AD
 
Fishinghat - If the dry heaves are bothering her you might try a half dose of Imodium. It helps relax the GI muscles but don't use it if constipation is an issue. In the case of constipation you can have her suck on a peppermint lozenge. This relaxes the esophagus/stomach but does not affect the lower intestines and does not aggravate constipation or diarrhea. Be sure it has real peppermint not peppermint flavoring. I have occasional esophageal spasms (a weaker form of dry heaves) and they work well for me. I buy mine at a health food store for about $3 for 10 lozenges.
When I went through mine I lived off of Imodium and Pepto for the digestive issues.
 
LauraM - I can't sleep all I can do is run to the bathroom. Imodium isn't helping.
 
TFL - I used Pepto-Bismol for the nausea and Imodium for the diarrhea. It did the trick.
Fivenotions - ...new arrivals of urinary incontinence and diarrhea ( for which I've got no immediate remedies, except Imodium) ...
 
Equuswoman - The GI symptoms are rough. I took OTC Imodium and sipped G2.
 
kirksd55 - I also had big problems with diarrhea. Imodium helped pretty good but took until about a week ago.
 
Baclaker - I also took imodium for the first time last night and it has greatly helped my nausea.
Houdi - Imodium - for diarrhea
-----------------------------------------------------------------------------------------------------------
pepto
 
Fishinghat - I know I lived off of pepto, Imodium and antacids. I had some good success with Pepto. I used it for occasional relief as too much can cause constipation and ringing in the ears.
 
FiveNotions - I tried the pepto, Gas-X, and a few other OTC remedies, but they didn't help (each of us is so different, frustrating that we seem to have to try different stuff until we hit what works)
 
Sandinanth - I did have a LOT of stomach/bowel issues as a symptom of getting off the Cymbalta. I won't go into detail but it was a full month's worth of not so pleasant bathroom visits and LOTS of Pepto Bismol.
 
silverseed - I've eating Tums and drinking Pepto like it's going out of style.
 
amberd - Ladies, I am sorry if this is TMI. I will call my doctor on Monday if this persist through tomorrow. Some of you have said you have had diarrhea. Mine started Thursday. Tonight it is black. Like, BLACK. I have always heard black means blood is in it. I have been drinking pepto since yesterday. Wondering if it has anything to do with it, but now I am worried. On the bright side, less dizziness and nausea today.I actually ate soup and it stayed down. (Note - FH - yes, pepto can turn your stools black.)
cse - I think I drank half a bottle of Pepto to put the fire out.
 
TFL - I used Pepto-Bismol for the nausea
 
Writeratheart - When my stomach is really, really bothering me, I take some Pepto Bismol, but it tends to make me sleepy, so I make sure it's at a time when I'll be able to take a good hour-long nap.
 
lexini - I am throwing up and nausouis all day long. I am taking pepto bismol and ginger ale, but it isn't alleviating anything.
 
jgbounds - I am so nausiated and the vertigo seem like its getting worse. Pepto Bismo helps, pepperment candy helps
 
ebudae - is there anything that will help get rid of this nausea? I have tried Pepto...nope...
 
Carla - There is one thing that has helped my stomach and bowel problems. The doctor told me to take Pepto Bismol pills...you swallow them...three x three a day and ordered me some prescription Lomotil as the Immodium wasn't helping. Those have helped somewhat.
 
gippos - Hopefully the nausea and dizziness will go away soon - pepto bismol doesn't seem to help with that.
 
vickster - I live on Pepto Bismo and Antacids.
--------------------------------------------------------------------------------------------------------
epsom salts
 
Merete - My go-to solutions are Epsom salt baths and mint tea to sooth aches and calm the body and mind. The salts can also help with the itchy, crawly skin sensations. The only caution is if you have acute nerve pain (pins and needles or sharp stinging) in hands and feet then the warm salty water can make the feeling worse
.
Gran - Drink a lot of water, take epsom salts baths, and I massage my stomach when it feels like it's squeezing.
 
Fivenotions - Have you tried Epsom Salts hot soaks? That did wonders for me, along with the chelated magnesium ...
 
Sis - I also strongly recommend Epsom salt baths, especially in the evening. I had a hard time believing that we absorb and properly process magnesium through out skin, we do but the concentration has to be fairly high. I routinely add 2 cups of epsom and a couple drops of Lavender
 
Lundilez - I've tried Epsom salt bath which helps a little.
 
ShadyLady - .I bought a 20lb bag of epsom salts and 5lbs of baking soda, yep, more is better thinking, and it does help with the fibro pain. The problem is, even with the baking soda added, I have to take a shower and rinse off or I am itching up a storm! I have looked up the amount of salts to use and the baking powder is supposed to be a natural skin softener, but still come out itchy and shriveled up like a raisin. So far, it is more work with all that soaking and showering, I end up exhausted from the energy spent to ease the pain:( Good Lord, we will try anything for relief)
 
Buzzbuzz - I just remembered that my mother used to say that soaking in a hot bath with Epsom Salt before bed is helpful.
 
bobbie - 4) Warm baths with epsom salts help.
 
plezhelp - the best thing i am still doing is tepid Epsom-salt baths with baking soda, and apple cider vinegar - which has helped a lot with the itching; i have no idea which one of those things are the best/better 'healing' but know that they are all currently helping me.
 
freeme2 - My legs hurt the other day, maybe from all the new walking I have done. I took a nice bath with Epsom salts and I felt much better.
 
Cab - 2. Epsom salts baths helped. Since I am having extreme hot flashes since withdrawing it was hard to get in a tub of hot water so I made it lukewarm and it helped relax me.
 
chauceriangirl - I do soak with epsom salts, and it helps some.
 
imwmn - soaking in "detox baths". 1 cup epsom salts 1 cup baking soda and ESSENTIAL Lavender. I took a long detox bath every day
 
sickandtiredofit - A great therapy for the muscle aches and pains that is cheap. Run a warm bath and place 2-4 cups of epsom salt in the bath water. Add a cap of olive oil to the water. Epsom salt and oilve oil are suppose to be great fro sore achy muscles and it really helps. I also place a little drop of lavendar oil to help me relax.
 
mkhackler - I soaked last night with 2 cups of epsom salt and perfume oil.........ahhhhhhhhh.
 
schmb - I have filled the tub with hot water, 1 cup of Epsom Salts, and a few drops of patchouli oil, and just soaked until the water got cool. I read a book, and just let go. It quieted my head, eased the aches and pains, and smelled really good! (You can use whatever fragrance you like, and use oils sparingly.)
------------------------------------------------------------------------------------------------------
diaper rash cream (most contain zinc oxide)
 
Pitbullmama- The diaper rash cream actually helped soothe the itch some.
 
Runni - Anyway, back to itching I found that Calamine Lotion was helpful, Pure Aloe Vera gel was very cooling and also cream that can be bought for diaper rash in babies is especially good.
 
Vickif - hey even diaper rash cream works(by generic it cheaper)
--------------------------------------------------------------------------------------------------------
Dr Redwig R22
 
Lynn - One thing she gave me too take 3x daily was Dr Redwig R22 drops for mood.
Fishinghat - WOW, WOW and WOW again. You guys have got to read the details at the end of this information about 2 of the ingredients.

http://dkonatural.co...41&categoryId=7
R22 Reckeweg Nervous Disorders
Active ingredients:
Grindelia X4, Lachesis mutus X12, Naja tripudians X12, Ethanol, Aqua purificata.

Inactive ingredients:
36-37 vol.-% alcohol, distilled water.

Suggested Use:
Generally 10-15 drops in some water 3 times daily before meals. Reduce dosage gradually after improvement, but continue treatment for several months.

** Please read all label information on delivery.

https://www.my-ayurv...heart-medicines
DR. RECKEWEG R22 - Najasthen Drops for Nervous Disorder Anginous Condition 22 ml
Indications:
Nervous disturbance, oppression and suffocation, also following flatulence.
Anginous condition of the heart.
Ingredients:

MODE OF ACTION OF MAIN INGREDIENTS:

Naja trip: Soreness at forehead and temples due to the anginous condition of the heart. Palpitations of the heart, oppression, general nervousness. Cardiac weakness and irritations caused by nervous coughing, acute condition.

Grindelia rob.: Feels as if heart were too large for thoracic cavity, cardiac and pulmonary weakness, sensation of suffocation in bed.

Lachesis: Nervousness, spiritual animosity, headaches especially above the left eye, palpitations with sensation of suffocation, symptoms worse at bed time and by warmth.

http://homeopathictr...vous-disorders/
Same as above reference.

http://www.reckeweg-...com/company.php
Dr.Roshanlal Aggarwal & Sons Pvt.Ltd. Representing Dr.Reckeweg in India, Nepal & Bangladesh
Pioneers in Homoeopathy for over 60 years

https://homeomart.ne...isorders-drops/
Dr. Reckeweg R22 Drops for nervous disorders (anginous condition of the heart) indicated for Chest pain that is typically described as heaviness, squeezing, pressure, tightness or pain (Anginous condition of the heart). R 21 treats nervous disturbances, headaches, rapid heartbeat due to exertion (oppression) and suffocation, also following flatulence. Sense of suffocation in bed due to pulmonary weakness

A search of the medical journals has shown no scientific research has been done on this specific product.
Ingredient review:
Naja tripudians X12 - An extract from the venom of The monocled cobra.
The major toxic components in cobra venoms are postsynaptic neurotoxins, which block the nerve transmission by binding specifically to the nicotinic acetylcholine receptor, leading to flaccid paralysis and even death by respiratory failure. The major α-neurotoxin in Naja kaouthia venom is a long neurotoxin, α-cobratoxin; the minor α-neurotoxin is different from cobrotoxin in one residue. The neurotoxins of this particular species are weak. The venom of this species also contains mtotoxins and cardiotoxins.
Purchase of cobra venom and its extracts require federal permits before the products can be marketed. Current permit limitations are very restrictive and do not include medicinal applications except for antivenom use.
No medical journal information on this material other than its toxic effects.

Grindelia Robusta -
Both Grindelia Robusta and Grindelia Robusta squarrosa have been used for the symptoms here recorded. There is practically no difference in their action, although the G. Squarrosa is credited with more SPLENIC symptoms, dull pains and fullness in left hypochondrium; chronic malaria; gastric pains associated with splenic congestion. Induces paralysis, beginning in extremities. Its action is shown on the heart first quickening, then retarding it.
Acts on the cardiopulmonary distribution of the pneumo gastric in dry catarrh (tart Emetic in muco-purulent). Produces a paresis of the pneumo-gastric, interfering with respiration. Smothering after falling asleep. Asthmatic conditions, chronic bronchitis. Bronchorrhea with tough mucus, difficult to detach. Raises the blood pressure. Nausea and retching of gastric ulcer. Sugar in urine An effective antidote to Rhus-poisoning, locally and internally; also for burns, blisters, vaginal catarrh and herpes zoster. Hyperchlorhydria when attended with asthmatic and other neurotic symptoms. Hyperaemia of gastric mucous membrane with difficult respiration.

https://www.ncbi.nlm...pubmed/24603350
"Since the health-promoting effects of natural phenolic compounds against brain disorders is of increasing interest, HT and HME were also tested against oxygen and nitrogen reactive species and against enzymes related with Alzheimer's disease and depression. Extracts displayed strong in vitro scavenging activity and monoamine oxidase-A (MAO-A) inhibitory activity. The anti-MAO-A capacity was observed at non-toxic concentrations for SH-SY5Y human neuroblastoma cell line, reinforcing the benefits of G. robusta HT."
 
https://www.ncbi.nlm...pubmed/21031629
The results suggest that G. robusta extract possesses an antiinflammatory therapeutic potential through its capacity to reduce the accumulation of inflammatory mediators and MMPs.
 
https://www.ncbi.nlm...pubmed/19278665
The flavonoid pattern of an acetonic extract of Grindelia robusta Nutt. was investigated in detail. The flavonoids were enriched by CC. In addition to twelve known methylated exudate flavonols four compounds were identified for the first time in G. robusta. Several substances of the flavonoid complex, among them the main compounds quercetin-3-methylether and 6-OH-kaempferol-3,6-dimethylether, were tested for their activity to inhibit neutrophil elastase. Quercetin-3-methylether was shown to be most active with an IC(50) of 19 microM, thus obviously contributing to the anti-inflammatory activity of the drug.
 
https://www.ncbi.nlm.../pubmed/2236296
Certain components in the leaves break down red blood cells.

Lachesis mutus (The Bushmaster) - An extract of a venomous pit viper from South America.
http://natural-heali...hesis-mutus.htm
The poison of the bushmaster, a greatly feared snake native to Central and South America, is deadly if it enters the human bloodstream. It can paralyze the heart and central nervous system and disrupt the blood-clotting process. If the poison is injected into a muscle, it can induce server swelling. These reactions are why many people find it surprising that this snake venom is used in homeopathic medicine to treat various circulatory and nervous-system disorders. But the remedy, Lachesis mutus, is so dilute that only almost undetectable amounts of the poison remain. Like other homeopathic remedies, it is considered most effective in people who have particular modes of behavior. Before prescribing Lachesis mutus, the homeopath will look for such personality traits as strong self-confidence and a tendency toward envy and vengefulness. In addition, the remedy is often prescribed when symptoms of any ailments start on the left side and worsen after waking.
Lachesis mutus type
Two types of people are most likely to benefit from Lachesis mutus: One is slim and pale but energetic; the other is somewhat obese with a blotchy, reddish, complexion. Both types share a strong dislike of tight cloths, particularly around the neck.
To determine if you're a Lachesis mutus type, Check those characteristics that apply to you.
⦁ You are afraid of water.
⦁ You are very jealous.
⦁ Your symptoms are aggravated by grief.
⦁ You act erratically, can't concentrate or lose your train of thought.
⦁ You sometimes feel as if you're suffocating or not getting enough air.
⦁ Your symptoms are worse on hot days or in stuffy rooms.
If you checked more than 3 times, turn to the back of the card for additional information about the benefits of Lachesis mutus.
Therapeutic effect
The most important effect of Lachesis mutus is its blood-thinning, or anticoagulant, function. This action enbances blood flow and facilitates the bealing process by bastening the removal of toxins from the blood. The remedy is effective against many bleeding disorders.
------------------------------------------------------------------------------------------------------------
AproDerm Emollient cream
 
Katherine - (Red Face Rash) If anyone else is suffering from this I just wanted to give hope that this side effect only lasted a few days and that I eased it with AproDerm Emoillent cream,
Ingredients:
White soft paraffin, liquid paraffin, cetostearyl alcohol, macrogol cetostearyl ether, ceteareth-20, purified water, sodium hydrogen phosphate, euxyl PE 9010, phosphoric acid / sodium hydroxide.
------------------------------------------------------------------------------------------------------------
Zofran (is a medication used to prevent nausea and vomiting) It is a serotonin 5-HT3 receptor antagonist (reduces the activity of serotonin receptors). Decreases serotonin production in the intestinal tract.
 
ConnieStar - I have a medication called Zofran (ondansetron) which is working very well for nausea. I recommend it.
 
Nancydear - My doctor said zofran and bonnie for the dizziness and to call if need too.
 
Cymsufferer - I got a message from my pharmacy that Zofran was finally filled. I've been taking it for 2 weeks now. It's helped with the nausea, but the diarrhea and overall gag feeling is still around.
sanctuarie - And finally zofran 8mg odt, which is doing *nothing* for my nausea.
 
Lundetz - Also bad nausea. The doctor had given me Zofran so I tried one today. It helped a lot.
 
Equuswoman - Nausea has a biggie for me mostly. But I am able to control that w/generic Zofran.
 
TheComposer - 1. Nausea: Daily and inconsistent. Benedryl/Dramamine help sometimes, but not always.
Zofran (anti nausea medication used for chemo) completely ineffective.
 
Justmyreality - They gave me Zofran, same drug they give to chemo patients to deal with nausea and vomitting. It worked but I worried it may be masking bigger issues so i only took it a couple days.
 
Crazycatgirl - I've noticed that generic zofran helps a lot with the nausea. I used to use this when I was pregnant and it seems to help a lot now.
 
autimomforever - ask your doc for a prescription for zofran (it helps nausea/vomitting)..
 
MissAmber - I also had a prescription for Zofran and used it when i couldn't take the Dramamine because I needed to not be drowsy for work. It seemed to help too, but often gave me headaches.
 
watchdog - The Zofran is keeping the nausea in check,
 
JustJulz - However, Zofran is a nice one, dissolves in your mouth, and does not mess with your center of well-being (serotonin, etc.). I had no problems at all when I needed to stop using it. Only drawback is that it is constipating.
 
cymthia - My doctor gave me zofran for the nausea which has helped.
 
kelpme2 - My md prescribed Zofran and it has helped a little but I have no desire to eat (which has been going on) and the nausea still there a bit but better I guess.
 
patches - They gave me Zofran in IV and it stopped the non-stop nausea and intermittant cramping. I was able to eat a solid food that night after a good two months of broth and crackers and soft foods. What a nightmare.
 
Caution - 5.3 Serotonin Syndrome
The development of serotonin syndrome has been reported with 5-HT3 receptor antagonists alone. Most reports have been associated with concomitant use of serotonergic drugs (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and intravenous methylene blue). Some of the reported cases were fatal. Serotonin syndrome occurring with overdose of ZOFRAN alone has also been reported. The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.
 
Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, with or without gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of ZOFRAN and other serotonergic drugs. If symptoms of serotonin syndrome occur, discontinue ZOFRAN and initiate supportive treatment. Patients should be informed of the increased risk of serotonin syndrome, especially if ZOFRAN is used concomitantly with other serotonergic drugs [see Drug Interactions (7.1), Overdosage (10)].
 
Medical research articles which show that Zofran can help with anxiety.
https://www.ncbi.nlm...pubmed/26188166
https://www.ncbi.nlm...pubmed/22374255
https://www.ncbi.nlm...pubmed/25284215
https://www.ncbi.nlm.../pubmed/9151286
https://www.ncbi.nlm...pubmed/10650519
and more....
----------------------------------------------------------------------------------------------------------
Pseudoephedrine/Phenylephrine containing meds
Caution - Pseudoephedrine can raise blood pressure and cause nervousness in some people.
 
Tylenol Cold and Flu
Active ingredients
Dextromethorphan HBr 10 mg in each caplet
Guaifenesin 200 mg in each caplet
Phenylephrine HCl 5 mg in each caplet
Not to be taken with Cymbalta
 
gail - Tylenol flu is good for the brain zaps.
 
hailsmarie - Tylenol Cold and Flu completely took away my brain zaps,
 
dstanek - My husband said try some Nyquil I didn't have any but tried tylenol cold nighttime. In 20 min symptoms disappeared. I slept great no soaking night sweats. No nightmares. Zaps gone, I even had to shake my head to be sure. Woke up this morning feeling normal. I am going to get non drowsy version today and see if this truly is the miracle helper.
 
Caution - tylenol cold nighttime contains
Acetaminophen 325 mg in each 15 mL
Dextromethorphan HBr 10 mg in each 15 mL
Doxylamine succinate 6.25 mg in 15 mL
Phenylephrine HCl 5 mg in each 15 mL
As such it should not be taken with Cymbalta (because of the Dextromethorphan) or diphenhydramine (because of Doxylamine).

Mucinex D
Active Ingredients: Guaifenesin (600 mg), Pseudoephedrine HCl (60 mg).
 
Coastgirl - Just wanna say I ran out of Mucinex D and got Advil Cold And Flu (behind the counter with pseudophedrine) and it also works to combat the brain zaps for me. My vertigo and zaps are 98% gone.
 
Sudafed PE
Dextromethorphan HBr 10 mg
Guaifenesin 100 mg
Phenylephrine HCl 5 mg
 
Caution -As such it should not be taken with Cymbalta (because of the Dextromethorphan)
 
Coastgirl - Tried to not take sudafed this morning and I feel so messed up! Just dizzy and can't think straight. I feel so out out of it.
(I mentioned in another post the Sudafed helps with the brain zaps....unfortunately it doesn't help too much with the mild nausea feeling).
 
Houdi - some days I had to take sudafed, the REAL sudafed and only 1/2 the dose cuz it reves me up.
 
Johnnyz - earlier today I read a topic in here about pseudoephedrine and its supposed effectiveness to alleviate SSRI withdrawal symptoms. I take 12-hour sudafed (the real, behind the counter sudafed) 1-2x daily as I have persistent nasal congestion. Yesterday evening, soon after the morning sudafed tab had worn off, I had a very stressful situation which caused an emotional low that had me sitting for 10 minutes feeling very depressed. I was able to talk myself out of that stupor and continue on in a neutrally emotional state until bedtime. I took a 12-hr sudafed around 11pm and woke up at 6am this morning feeling very good physically and emotionally, like I had a decent sleep. My point here is that, looking back at the previous 5 days of my Cymbalta/ Trintillex withdrawal plan and its relative low and tolerable symptoms, I wonder how much my daily use of sudafed has been a factor in my light symptoms.

Claritin-D 24 hour extended release tablets
10 mg loratadine for immediate release
240 mg pseudoephedrine sulfate is released slowly allowing for once-daily administration.

ittybittysmitty - WHAM, today I got blasted with three times as much dizziness and zapping...I feel zombie-like. Thinking it was part allergy symptoms I took a Claritin...that helped somewhat...less dizziness while seated.
 
irritableme - I started taking a Claritin-D and that seems to help. When I don't take the Claritin-D the brain swooshes and zaps return.

Advil Cold & Sinus
Ibuprofen 200 mg
Pseudoephedrine Hydrochloride 30 mg
Chlorpheniramine Maleate 2 mg
 
Chlorpheniramine (over the counter) is an antihistamine {H(1)R antagonist} used to treat allergy symptoms. It does cause sleepiness like other antihistamines and has significant anxiolytic effects. Caution - It has also been shown to function as an ssri and snri. As such it should never be taken in combination with those medications as it can cause seratonin syndrome. Due to its anticholenergic effects it frequently causes constipation. As with diphenhydramine do not take with other medicines that can cause sleepiness. Recommended dose is 4 mg every 4 to 6 hrs not to exceed 32 mg/day. Widely sold as an allergy treatment.
Begins working in 30 minutes to an hour
Peak levels - 2 to 4 hrs
Half Life – 12 to 43 hrs
 
https://www.ncbi.nlm...les/PMC3854398/
(8mg dose)
https://www.ncbi.nlm...pubmed/16876927
https://www.ncbi.nlm...pubmed/16156843
https://www.ncbi.nlm...pubmed/12951198
https://www.ncbi.nlm...pubmed/10541737

Coastgirl - Just wanna say I ran out of Mucinex D and got Advil Cold And Flu (behind the counter with pseudophedrine) and it also works to combat the brain zaps for me. My vertigo and zaps are 98% gone.
 
Carleeta - Have been taking advil cold and sinus daily..Seems to work.
 
Heartfeatherss - Try taking 4 ( yes 4) Advil LIQUID BLUE GELCAPs with a Coke. It has to be the blue gel caps and it cannot be a diet Coke. My neurologist told me to do this and I was so miffed, thinking he was just not understanding how bad it hurt... but dang! It works!! Hope this gives you relief.
 
Contains ibuprofen and dihydramine. Should not be taken with other amines like benadryl.

Medical information on ingredients of above meds
 
Dextromethorophan
 
FiveNotions - I didn't check, but my bet is that Tylenol Cold contains DMX -- "dextromethorphan" .... it's a serotonin agonist (enhancer - reuptake inhibitor) ...
Nyquil contains a lot of it, which is why someone taking Cymbalta (duloxetine) or any other SSRI shouldn't use Nyquil ... there are case studies about the combo causing severe serotonin syndrome ...

Loratadine

https://www.ncbi.nlm...pubmed/10444229
Loratadine, No effect on 'mood'.

While this is the only research I found it is interesting to note that around 4% of people taking loratadine report anxiety as a side effect. This is about the same number of diphenhydramine (Benadryl) users that report depression as a side effect. (FDA)

From Drugs.com
Cardiovascular side effects have included hypertension, hypotension, palpitation, supraventricular tachyarrhythmias, syncope and tachycardia.

Wiki
As a "nonsedating" antihistamine, loratadine causes less (but still significant, in some cases) sedation and psychomotor retardation than the older antihistamines because it penetrates the blood/brain barrier to a smaller extent.
 
Note - inability to significantly penetrate the blood brain barrier would make it an unlikely anxiolytic medicine.
 
Do not take with Tagamet or other antihistamines.
 
Half life - 8 hours.
 
Metabolism
Loratadine is an H1 receptor antagonist (blocks the action of histamine on the H1 histamine receptor). Does NOT cross the blood brain barrier.
Diphenhydramine is an potent H1 receptor inverse agonist (blocks the action of histamine on the H1 receptors but crosses the blood brain barrier readily. Has been shown to reduce anxiety.
Hydroxyzine is a potent H1 receptor inverse agonist as well and has been shown to have substantial effect on anxiety and readily crosses the blood brain barrier.
 
Pseudoephedrine
Wiki
Patients who are prone to anxiety or panic attacks should use pseudoephedrine with caution, as anxiety and restlessness are common side effects, mostly due to the drug's stimulant properties.
http://www.sciencedi...080552323624882
Can cause anxiety as a side effect.

http://research.omic...Pseudoephedrine
Adverse effects
Common adverse drug reactions (ADRs) associated with pseudoephedrine therapy include: CNS stimulation, insomnia, nervousness, excitability, dizziness and anxiety. Infrequent ADRs include: tachycardia or palpitations.

https://www.ncbi.nlm...pubmed/10999495
"...the drug tended to increase anxiety scores (p=0.092). Depth resulted in a significant increase in anxiety scores (p=0.021) and a significant decrease in verbal fluency test scores (p=0.041)"

https://www.ncbi.nlm...les/PMC4518702/
Over-the-counter cold preparations contain phenylpropylamine and pseudoephedrine, obvious stimulants. Yet patients with unexplained dyspnea may believe they have allergies and take these medications frequently in order to treat their anxiety symptom, further exacerbating their dyspnea and anxiety symptoms. The use of energy drinks with combinations of both caffeine and stimulants is another important example.
And many more research articles....

http://www.ehealthme...loride/anxiety/
(FDA website)
140 people reported to have side effects when taking Pseudoephedrine Hydrochloride.
Among them, 12 people (8.57%) had Anxiety as a side effect.

Pseudoephedrine: Pseudoephedrine is an agonist at both alpha- and, to a lesser degree, beta-adrenergic receptors. Like ephedrine, pseudoephedrine also has an indirect effect by releasing norepinephrine from its storage sites. By stimulating alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine shrinks swollen nasal mucous membranes; reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. Also, drainage of sinus secretions is increased, and obstructed eustachian ostia may be opened. Oral administration of pseudoephedrine usually produces negligible effects on blood pressure. In some patients, especially those with preexisting cardiac disease receiving higher doses, pseudoephedrine may increase blood pressure or irritability of the heart muscle and may affect ventricular conduction. Wiki
Phenylephrine is a selective alpha1-adrenergic receptor agonist (stimulates adrenaline receptors) used primarily as a decongestant, as an agent to dilate pupils, and to increase blood pressure. Wiki
 
Medical research emphasizing that phenylephrine can cause anxiety.
https://www.ncbi.nlm...pubmed/20937329
https://pubchem.ncbi...d/phenylephrine
https://everipedia.o.../Phenylephrine/
People with a history of anxiety or panic disorders, or on anticonvulsant medication for epilepsy should not take this substance.
--------------------------------------------------------------------------------------------------------
Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is a sympathomimetic drug, which means that it mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha receptors which cause blood vessels to constrict. Phenylephrine may cause side effects such as headache, reflex bradycardia, excitability, restlessness and cardiac arrhythmias. Phenylephrine is not suggested for use in patients with hypertension.
Available as Oral and nasal spray.

While considerable medical research indicates that Phenylephrine can cause anxiety the following research indicates differently.

https://www.ncbi.nlm...pubmed/20937329
Helps with anxiety

https://mdanderson.i...amatergic-synap
https://mdanderson.i...tially-regulate
https://www.ncbi.nlm...les/PMC4252518/
Increases the release of gaba.

---------------------------------------------------------------------------------------------------------------------------------------


naproxin, advil, tylenol, ibuprofen, allevee, aspirin, motrin, acetaminophen, excedrin and other over the counter analgesics do not fair well for body aches and headaches. Just as many say they don't work as say they help. No clear cut option here.
---------------------------------------------------------------------------------------------------------
Himalaya Herbal Healthcare StressCare

http://www.cymbaltaw...elps#entry65192
----------------------------------------------------------------------------------------------------------
Ylang-ylang
Note - Cananga odorata, known as the cananga tree is a tropical tree. It is valued for the perfume extracted from its flowers, called ylang-ylang which is an essential oil used in aromatherapy.
 
Carleeta - Ylang-ylang is still one of my favorites....it's wonderful for lifting your mood...and helps with positivity....
 
mimmie - Dill oil on my wrists and Joy oils (mixture of Bergamot, Ylang Ylang, Geranium and others) on my chest right over my heart.
 
sarahj - Ylang Ylang for in the day, for the beauty of the smell also. You can just smell them straight from the bottle, or put some in your bathwater.
-------------------------------------------------------------------------------------------------------------
Zantac (Ranitidine) is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.

http://www.cymbaltaw...tion#entry66071
Zantac (Ranitidine) For Anxiety And Depression

FiveNotions - I've stumbled onto the discovery that Zantac, which I'd been taking for severe acid reflux, seems to help my post-crapalta anxiety ... did some research, and found a number of old (really old) articles that seem to confirm this ... here's one of the freely available ones ...
jimmcg - Now, with a week on the Zantac, I feel much more in control of these feelings. I may wake up worrying about something in the middle of the night, but, unlike before, I can talk myself through it and go back to sleep.
 
Caution : but be aware that new research is showing that extended use of Zantac, and / or use of the highest dose, may cause kidney/liver damage.
 
http://pmj.bmj.com/c...03/353.full.pdf
Effect of the H2-receptor antagonist ranitidine on depression and anxiety in duodenal ulcer patients
Depression and anxiety were measured during the course of a double-blind, placebo-controlled trial
of the histamine H2-receptor antagonist, ranitidine (150 mg twice daily), in patients suffering from
duodenal ulcer but free of systemic disease. There were 25 patients in the ranitidine group (mean age: 33-2 years) and 28 in the placebo group (mean age: 37-2 years). In both groups there was a highly significant and progressive decrease in depression and anxiety scores over the 4 weeks of treatment. There were no instances of mental confusion. In our group of otherwise physically healthy patients, ranitidine appeared to be free of neuropsychiatric complications.

https://www.ncbi.nlm.../pubmed/9833631

The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes.
In summary, these findings show that H1- and H2-receptor antagonists differentially modulate reinforcement and fear-related processes in the NBM and thus, provide the first evidence for a behavioral relevance for the histaminergic innervation of this brain site.

https://www.ncbi.nlm...les/PMC3854398/

H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
As well as...
https://www.ncbi.nlm...pubmed/18275952
https://www.ncbi.nlm...pubmed/17109942
https://www.ncbi.nlm...pubmed/16600315
https://www.ncbi.nlm...pubmed/23535246
https://www.ncbi.nlm...pubmed/22952484
Plus many more....

Drug interactions -
Caution - Zantac (Ranitidine) may significantly increase the blood levels of loperamide (Imodium). This can lead to serious and potentially fatal complications such as irregular heart rhythm and cardiac arrest, especially if you use more than the recommended doses of loperamide.
 
Zantac CAN be taken with Benadryl. They are different types of antihistamines. Drugs.com
-------------------------------------------------------------------------------------------------------------
http://www.cymbaltaw...tion#entry37106
Kratom information and discussion.
-------------------------------------------------------------------------------------------------------------
Benadryl -Antihistamine and sleep aide containing 50 mg diphenhydramine
 
Diphenhydramine, (over the counter) also known as Benadryl, is an antihistamine and as such is not only used for allergies/colds but also as a sleep aide. It does have a mild anxiolytic effect. May lower blood pressure and cause irregular heartbeats. Long-term use of Benadryl often affects mental cognition, especially in the elderly. Your body does build up tolerance to it after a few weeks. There is evidence of dependence in cases of long-term heavy uses, It is a histamine H(1)R antagonist in the brain. Do not take this medicine with any other medicine that can cause sleepiness including benzos, most blood pressure medicines, ssri/snri, buspar and others. Please check for compatibility before using. This medicine has many drug interactions.
Begins working in 15 to 30 minutes
Peak levels - 2 to 2.5 hrs
Half Life – 4 to 6 hrs
 
https://www.ncbi.nlm...pubmed/24530460
Moderately effective
https://www.ncbi.nlm...pubmed/19415242
(50mg dose)
https://www.ncbi.nlm...pubmed/16156843
Effective
https://www.ncbi.nlm...pubmed/16111835
Effective
Can cause dependence with constant heavy use. Some moderate withdrawal symptoms possible.

Diphenhydramine should NOT be taken with hydroxyzine. Drugs.com
 
Use by members for anxiety releif and to help sleep is too numerous to mention.
Products containing diphenhydramine...
Brand names
⦁ Aler-Dryl®
⦁ Allergia-C®⦁ ¶
⦁ Allermax®⦁ ¶
⦁ Altaryl®⦁ ¶
⦁ Banophen®⦁ ¶
⦁ Ben Tann®⦁ §
⦁ Benadryl®
⦁ Bromanate AF®⦁ ¶
⦁ Compoz Nighttime Sleep Aid®⦁ ¶
⦁ Dicopanol®⦁ §
⦁ Diphedryl®⦁ ¶
⦁ Diphen®⦁ ¶
⦁ Diphenadryl®⦁ ¶
⦁ Diphenhist®
⦁ Diphenylin®⦁ ¶
⦁ Dytan®⦁ ¶
⦁ Hydramine®⦁ ¶
⦁ Nytol®
⦁ Pardryl®⦁ ¶
⦁ PediaCare Children's Allergy®
⦁ Siladryl®
⦁ Silphen®
⦁ Sominex®
⦁ Unisom®
Brand names of combination products
⦁ Advil PM® (containing Diphenhydramine, Ibuprofen)
⦁ Alahist LQ® (containing Diphenhydramine, Phenylephrine)
⦁ Aldex CT® (containing Diphenhydramine, Phenylephrine)
⦁ Aleve PM® (containing Diphenhydramine, Naproxen)
⦁ Anacin P.M. Aspirin Free® (containing Acetaminophen, Diphenhydramine)⦁ ¶
⦁ Bayer Aspirin PM® (containing Aspirin, Diphenhydramine)
⦁ Benadryl-D Allergy Plus Sinus® (containing Diphenhydramine, Phenylephrine)
⦁ Children's Dimetapp Nighttime Cold and Congestion® (containing Diphenhydramine, Phenylephrine)
⦁ Doans PM® (containing Diphenhydramine, Magnesium Salicylate)⦁ ¶
⦁ Endal HD® (containing Diphenhydramine, Phenylephrine)⦁ §
⦁ Excedrin PM® (containing Acetaminophen, Diphenhydramine)
⦁ Goody's PM® (containing Acetaminophen, Diphenhydramine)
⦁ Legatrin PM® (containing Acetaminophen, Diphenhydramine)
⦁ Masophen PM® (containing Acetaminophen, Diphenhydramine)⦁ ¶
⦁ Midol PM® (containing Acetaminophen, Diphenhydramine)
⦁ Motrin PM® (containing Diphenhydramine, Ibuprofen)
⦁ PediaCare Children's Allergy and Cold® (containing Diphenhydramine, Phenylephrine)
⦁ Robitussin Night Time Cough and Cold® (containing Diphenhydramine, Phenylephrine)
⦁ Sudafed PE Day/Night Cold® (containing Acetaminophen, Dextromethorphan, Diphenhydramine, Guaifenesin, Phenylephrine)
⦁ Sudafed PE Day/Night Congestion® (containing Diphenhydramine, Phenylephrine)
⦁ Sudafed PE Severe Cold® (containing Acetaminophen, Diphenhydramine, Phenylephrine)
⦁ Tekral® (containing Diphenhydramine, Pseudoephedrine)⦁ §
⦁ Theraflu Nighttime Severe Cold and Cough® (containing Acetaminophen, Diphenhydramine, Phenylephrine)
⦁ Triaminic Night Time Cold and Cough® (containing Diphenhydramine, Phenylephrine)
⦁ Tylenol Allergy Multi-Symptom Nighttime® (containing Acetaminophen, Diphenhydramine, Phenylephrine)
⦁ Tylenol Severe Allergy® (containing Acetaminophen, Diphenhydramine)
⦁ Unisom with Pain Relief® (containing Acetaminophen, Diphenhydramine)

------------------------------------------------------------------------------------------------------
Omeprazole
 
Significant drug interactions.
omeprazole ↔ citalopram
Applies to:omeprazole and Celexa (citalopram)
Talk to your doctor before using citalopram together with omeprazole. Combining these medications may increase the blood levels of citalopram and increase the risk of certain side effects, including an irregular heart rhythm that may be serious or life-threatening.
 
Omeprazole causes the increased absorption of nearly 500 medications. It should NOT be taken with.....
Benzos, Atenolol, Celexa, Lexapro and many other ssri and snri, st. john's wort,
------------------------------------------------------------------------------------------------------
Baking soda
 
Shady Lady - I hate baths, but needed fast relief and the epsom salt baths, I also pour in a half to one cup of baking soda for softness as the bath salts made me itchy, another pesky issue.
 
FiveNotioins - I'd also add in baking soda/water ... I made a paste of it, and put it on the worst welted/itchy/scratchy parts of my skin ... then rinse of with cool water ..
 
plezhelp - i am still doing is tepid Epsom-salt baths with baking soda, and apple cider vinegar - which has helped a lot with the itching;
 
freeme2 - I took a nice hot bath with baking soda and Epson salts The baking soda really calms down the skin.
 
sage - I had digestion issues with Cymbalta as well, especially as I've started weaning off of it. The two things that seem to totally work (for me) are dill pickles with garlic (and sipping the juice!)... and 1/2 tsp of baking soda mixed with a little water (instant appeasement of symptoms, which means Cymbalta has probably made my stomach more acidic?).
 
irnwmn - They suggested soaking in "detox baths". 1 cup epsom salts 1 cup baking soda and ESSENTIAL Lavender.
Many members use baking soda as an antacid as well.
------------------------------------------------------------------------------------------------------------
probiotics
http://www.cymbaltaw...rove#entry45197
It begins on post #68 and continues to post #73.
Info and discussion on probiotics.

http://www.cymbaltaw...ics/?hl=improve
Great Details on benefits of probiotics.

probiotic and serotonin,
https://www.ncbi.nlm...pubmed/28607543
After probiotic supplementation, we observed a significant increase in concentration of serum serotonin (P = .008) and a decreased level of tryptophan in plasma.
https://www.ncbi.nlm...les/PMC5102282/
Summary of the effects of pro and prebiotics on psychiatric functions.
https://www.huffingt...4b064e1b4b3a842
A layman's summary of the effects of pro and prebiotics on psychiatric functions.
https://www.ncbi.nlm...pubmed/25470391
https://www.ncbi.nlm...pubmed/24554471
https://www.ncbi.nlm...pubmed/20974015
https://www.ncbi.nlm...pubmed/21983070
https://www.ncbi.nlm...pubmed/25879690
https://www.ncbi.nlm...pubmed/23384445
and many more
----------------------------------------------------------------------------------------------------------
Phosphatidylserine (Theoretically reduces corticol.)
 
Phosphatidylserine is an important phospholipid cellular membrane component which plays a key role in cell cycle signaling, specifically in relationship to apoptosis (programmed cell death). When the Phosphatidylserine in the cell membrane turns around (The head of the molecule pointing out and the tail pointing in) it acts as a signal for macrophages to engulf the cell.
In May, 2003 the FDA gave "qualified health claim" status to phosphatidylserine thus allowing labels to state "consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly" along with the disclaimer "very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. FDA concludes that there is little scientific evidence supporting this claim.
Originally acquired from the bovine brain, mad cow disease put an end to that. Most is now extracted from soybeans. Phosphatidylserine can cause side effects including insomnia and stomach upset, particularly at doses over 300 mg.

http://www.ncbi.nlm....pubmed/24759145
Involved in the formation of clots.

http://www.ncbi.nlm....pubmed/23312676
Well tolerated.

http://www.ncbi.nlm....pubmed/24172938
Those with elevated levels of phosphatidylserine are more likely to form thrombosis (blood clots).

http://www.ncbi.nlm....pubmed/23926688
Phosphatidylserine is critical in the production of good quality sperm.

http://www.ncbi.nlm....pubmed/23723695
safe for human consumption.

http://www.ncbi.nlm....pubmed/21807480
Well tolerated

http://www.ncbi.nlm....pubmed/12385596
Soy derived Phosphatidylserine is safe for human consumption.

http://www.ncbi.nlm....les/PMC4237891/
A Phosphatidylserine/phosphatidic acid complex normalized the hypothalmus-pituatary-adrenal axis in acutely stressed males. It normalized cortisol levels. They used PAS 200 (200 mg of both compounds) and PAS 400 (400 mg of both compounds). Only the PAS 400 showed the beneficial response.


http://www.ncbi.nlm....les/PMC2503954/
Reduces cortisol levels after exercise.


Several of these studies showed that the compound Phosphatidylserine had no effect on blood pressure or pulse. With the combination (PAS) returning the hypothalmus-pituatary-adrenal axis to normal function in the chronically fatigued. Adrenaline increases and cortisol decreases with an increase in energy levels. This increase in energy is what causes the insomnia side effect. Should be taken in the morning.
Not compatable with adrenergic agonists (eg. Clonidine). Most reviews of this product are positive but do reflect that it is an adaptogen (your body adapts to it in time and begins reducing its natural production). Many reviews state it only helps for a couple months at a time. There are many who say it makes them sleep like a baby and many who say it causes insomnia. This is probably due to whether or not the person is suffering from a chronic adrenergic state (stress over a long period of time elevating adrenaline levels) OR from adrenal fatigue which is due to a relatively short term intense stress which causes a burst of adrenaline followed by a drop in adrenaline. This is what causes the knees to shake and a person to feel exhausted after say a car accident.

http://www.cymbaltaw...rove#entry59862

Ramona - I've read that there is a supplement called Phosphatidylserine that reduces the amount of cortisol your adrenals are over-producing. Anyone familiar with this? I checked with a pharmacist over the weekend and he said I shouldn't take Seriphos while on Cymbalta.

Bethhalffull - I saw a new shrink. She recommended ... phosphatidylserine. When I investigated the second ingredient it is supposed to limit cortisol.
Seriphos - Phosphorylated Serine - An amino acid not to be confused with Phosphatidylserine although similar in structure and action and is mostly used to improve clotting and cognition. Taking it with Cymbalta reduces the essential amino acid serine in the body and should be avoided. NCBI

I could find no medical journal article associating Phosphorylated Serine with lower cortisol levels. I did find several articles on its effects on the adrenal gland but no reference to its efficacy for either anxiety or depression.
----------------------------------------------------------------------------------------------------------
Rescue Remedy
 
Ingredients
Active Ingredients: 5 x dilution of:- Prunus cerasifera HPUS (Crab Apple), Clematis vitalba HPUS (Clematis), Impatiens glandulifera HPUS (Impatiens), Helianthemum nummularium HPUS (Rock Rose), Ornithogalum umbellatum HPUS (Star of Bethlehem). Inactive Ingredients: 27% Alcohol
 
Uriel - You can get Rescue Remedey from the health food store its a tincture you put under your tongue for anxiety. It helps the body cope well.
-------------------------------------------------------------------------------------------------------
Genius Joy
INGREDIENTS

Serving Size: 4 Delayed Release Veggie Capsules
Servings Per Container: 25

Amount Per Serving

Vitamin B Energy Complex

Vitamin B1 (as Thiamine HCL) – 1.5mg
Vitamin B2 (as Riboflavin 5 Phosphate) – 1.7mg
Vitamin B3 (as Niacinamide) – 20mg
Vitamin B5 (as D-Calcium Pantothenate) – 10mg
Vitamin B6 (as pyridoxal-5-phosphate) – 2mg
Vitamin B12 (as methylcobalamin) – 6mcg
Vitamin D3 (as cholecalciferol) – 1000IU

S-adenosylmethionine (SamE) – 1000mg
N-Acetyl L Tyrosine – 350mg
Rhodiola5Plus Rhodiola rosea [root](std. 3% Rosavins and 2% Salidrosides) – 300mg
Red Panax Ginseng Powder – 250mg
HTPurity 5-hydroxytryptophan Griffonia simplicifolia [seed] (Std. 98% 5-HTP) – 100mg
Neuro Factor Coffea Arabica [Fruit] Extract – 100mg
TheaKalm Natural L-Theanine – 100mg
 
mimi - I'm still only taking 2 Genius Joy supplements when I first get up and by 10am I can do all that I wish to accomplish for the day, I can be outside without itching, I can drive safely, I can do my household finances and communicate effectively.
 
While this product contains many components that may be benificial they may also be incopatable with a variety of drugs and other natural remedies. You should closely check for drug interactions before use.
-----------------------------------------------------------------------------------------------------------


#7 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 15 December 2017 - 01:28 PM

                                                                Other OTC Products

Standard Process

TFL - I found the Min Tran on Amazon -- 90 tabs for 11.97 -- Brand is Standard Process. Suggested dosage 4 tabs w/each meal.
Jessielee - Here are some vitamins & other things that are helping me.
*Standard Process Vitamins: Min-Chex (9/day) & Cataplex G (6/day)

Dawson - I take all natural, whole food supplements that I got from my Doctor. The brand name is Standard Process, and I take several to help restore the balance as well as replenish the minerals that cymbalta has robbed my liver of. I have been on them several months now, and feel really good, however, like I said in my posting, I was off the cymbalta for a week, and was a mess! So who knows what, if anything, is making me feel better?

Jeff - Standard Process Brands is a whole food supplement of really high quality. I get it from my Chiropractor. You cannot get it at a store, check online for resources.
---------------------------------------------------------------------------------------------------------------------------
Gatorade

Amysgarden - I've increased my protein and salt intake and also b vitamins and electrolyte drinks such as Gatorade and Vitalyte. It's helping, but I think with our entire systems being under so much stress from withdrawal and healing, we just have to slow down for awhile and pay close attention to how our bodies respond to nutrient intake.

Fivenotions - I also drank an awful lot of Gatorade during the first weeks.

Carleeta -.For me, I always carry a bottle of gatorade with me where ever I go..

ZappAlta - Eat light but eat often -get some gatorade -keep fluids in most important.

Kindorf - Also I have been avoiding caffeine so I cut out my coffee and sweet tea.
I replaced then with fruit juice, ( mainly apple juice ) water and Gatorade. Today no stomach cramps I think they are done. No diarrhea, Lord I hope that is gone. No dizzy spells today and that felt good.

shvarner - I've been drinking a lot of water & gatorade,

Uriel - I am eating good healthy meals and also drinking gatorade.

Judy - I knew that Gatorade helped with the light-headed, "floating brain" feelings.

watchdog - Drinks LOTS of GREEN gatorade..... don't know what the deal is, but it helps.

wiraz - Drink at least one G2 Gatorade a day – stay away from the full sugar version, leads to a higher chance of diarrhea. I drink one 32 oz bottle every day plus tons of water!!

caroline - Vit E also for head and joints and then Gatorade's G2. I didn't want the sugars so I went with the G2

Rafael - I have mild brain zaps but I believe the omega 3 Fish Oil and Gatorade are helping.

Sandlion - I took fish oil/other Omega 3 and also found that Gatorade helped -- maybe it's the salt replacement after all the nightsweats.

guppie - I'm a month off the drug so only minor zaps now and then. Whoever gave the gatorade advice is a genius. That treats them instantly (make sure you get the low calorie gatorade since regular is high calorie). Brain zaps are minor. I grab a gatorade and that gets rid of those for a bit (electrolytes).

Alisha - gatorade-had one of the big bottles yesterday and it did seem to help,

mkhackler - I have started drinking a ton of G2, the lighter version of Gatorade because I think I'm getting dehydrated as well.

Summary - Many members medtioned drinking Gatorade for the electrolytes after diarrhea, night sweats and when having brain zaps. G2 was often mentioned because it has no sugar (not true, see below). Also, it was suggested that one should not just rely on Gatorade alone for hydrated but should also drink plenti of water. Green Gatorade is highly recommended by some members. Vitylite and Powerade wer also mentioned a couple times for electrolytes. I would also recommend Isopure as it comes with and without sugars and proteins with a similar amount and type of electrolytes as Gatorade.


Original Gatorade - One 12.5 fl oz bottle contains 21 grams sugar. It also contains 160 mg sodium (sodium is a stimulant to some people, raising bp and and metabolism). It contains no phosphorus, calcium or magnesium.
Lemon/lime has same ingredients as other Gatorade except it has Yellow #5.

G2 Gatorade - It has the same amount of sugar as regular Gatorade and nearly all the same ingredients and electrolytes.

Gatorade Fierce Green Apple Sports Drink - This may be the "green gatorade" that members spoke of. It contains malic acid, the active ingredient in apple cider vinager which has proved so helpful to other members. Other ingredients are the same.

Isopure Zero Carbs - No sugar, with some calcium. Contains Malic acid
Isopure Mass - With sugar and proteins, with calcium, Contains Malic acid
Isopure zero carb with proteins - no sugar, contains proteins. With calcium Contains Malic acid

-----------------------------------------------------------------------------------------------------------------------
valerian root

Fishinghat - A caution for those who use or are considering using valerian root. It greatly slows down the bodies ability to process and eliminate benzos. This allows the benzos to build to very high values in the body. Caution should be used when taking the two at the same time.

Fivenotions - Ditto to the valerian caution.....I tried it as tea....wasn't using benzos, but it whacked me out somehow....a tip I got from Fishinghat is to start whatever it is you're trying....amino, herb, etc....in very small amounts/doses....and work up gradually....

Boot2 - i found if i combined chocolate (i am using unsweetened health food store kind now) and valerian- it feels like i am almost normal again...thought i;d pass that along.

LadyNancy - I had a reaction to valerian but then that is nothing new for me.

RussellSprout - The valerian/mag combo (when I remember to do both) doesn't act like a sleeping pill or anything of that sort, but it does physically relax me so I can drift to sleep more easily. Unfortunately, the valerian smells like death.

Hornet - I too am enjoying the dreams. Additionally, I have been taking Valerian root to help sleep and it exacerbates the dreams.

brzghoff - valerian works for some, gives me a headache.

jillybean - I also use valerian root (from puritan's pride) 450 mg capsules 1 capsule late afternoon and 1 before bed. This is considered nature's valium and though it does not make me drowsy I do feel it is helping with anxiety. I missed the late afternoon dose yesterday and had one hell of a panic attack. I won't do that again.

Albergo - Made things worse: Valerian root (really bad reaction - BIG WARNING), benzodiazepines (clonozepam .5mg, took 1-2 weeks to recover from),

Around 20 members mention taking valerian, especially in their SleepyTime Tea. I would estimate around 60% said it helped with around 40% saying no. Several had bad reactions/interactions with it.

Drug.com list 581 drug interactions for Valerian, including sleep aides, benzos, cold medicines, and more.
---------------------------------------------------------------------------------------------------------------------------
damiana tea

FiveNotions - Instead of valerian, I use damiana tea...from the fresh herb.....but a caution there....it can lower blood pressure, esp. Systolic....that's a benefit for me, but not if you already run low or take meds for bp.....

Fishinghat - Interesting. I couldn't find anything about damiana (Turnera diffusa) treating anxiety in the medical journals. But I found several articles on Turnera aphrodisiac being as effective as diazepam. The active ingredient on Turnera aphrodesiacis, Apigenin, which works on benzo receptors. (see reference below )

Kumar, S; Madaan, R; Sharma, A (2008), "Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca", Indian Journal of Pharmaceutical Sciences, 70: 740–4, doi:10.4103/0250-474X.49095, PMC 3040867  , PMID 21369434
Apigenin is a potent inhibitor of CYP2C9 an enzyme responsible for the metabolism of many pharmaceutical drugs in the body. Ingestion of this substance would significantly reduce the absorption of medicines and supplements absorbed via the CYP2C9 enzyme. It also effects opiod and adenosine receptors as well. It can increase testosterone levels, decrreases cortisol levels, (See reference below for source references).
https://examine.com/...ments/apigenin/

Many references state that Turnera diffusa and T. aphrodisiaca are generally regarded as the same plant in herbal commerce. This may explain why some supplements have a better reputation than others. Many mention that damiana is also an aphrodesiac but again this is not damianas but Turnera aphrodisiac.

Research;

http://www.ncbi.nlm....pubmed/16635964
http://www.ncbi.nlm....pubmed/15864356
http://www.ncbi.nlm....les/PMC1062162/


http://www.herbaldb....iolytic-action/
The article here talks about the anti-anxiety properties of damianas in research BUT the research they quote was done on Turnera aphrodesiac not Turnera diffusa (damianas).
-------------------------------------------------------------------------------------------------------------------
essential oils

Tea tree oil
kmrek - Some things I tried when I weaned the first time: tea tree oil under my nose (for some reason, the smell was calming),

Ylang-ylang
Note - Cananga odorata, known as the cananga tree is a tropical tree. It is valued for the perfume extracted from its flowers, called ylang-ylang which is an essential oil used in aromatherapy.

Carleeta - Ylang-ylang is still one of my favorites....it's wonderful for lifting your mood...and helps with positivity....

mimmie - Dill oil on my wrists and Joy oils (mixture of Bergamot, Ylang Ylang, Geranium and others) on my chest right over my heart.

sarahj - Ylang Ylang for in the day, for the beauty of the smell also. You can just smell them straight from the bottle, or put some in your bathwater.

Sniff some vanilla or lavender - Vanilla causes an increase in production of endorphins. This is why it can help so many with anxiety. The endorphins released when inhaling lavender creates a calming effect that may even enhance sleep and relieve depression.
https://www.ncbi.nlm...les/PMC4325408/
http://www.sciencedi...221169115001033
Ward, A., & Ward, K. (2006). U.S. Patent Application 11/609,330.

Vanilla Oil -
Plzhelp - i just recently learned that 'vanilla' is now something i am currently allergic to (i get headaches).

Lavender Oil - Members 12 positive and 1 negative comment.
SCL - I also have a sleep blend of Serenity, lavender, sandalwood, and bergamot. The calming blend even helped me with a headache without meds!

Gail - What helps me is bubble bath with lavender essential oil.

CurlyKate - The tips on bathing aren't working, my skin feels so tingly and creepy crawly that even my hair and clothing are painful...lavender and any other smells are triggering migraines...lost all appetite...can't sleep...this really sucks!

Gene - I agree 100% with the lavender scent, amazing how calming it is

Warning - Many essential oils are toxic to the liver and may collect there. Especially if taken orally or applied on the skin in large quantities or frequently.
The oils listed underneath are banned (FDA) and can cause toxicity if taken internally as well as dermally (eg. in a massage blend).
⦁ Almond butter
⦁ Boldo leaf
⦁ Calamus
⦁ Camphor
⦁ Horseradish
⦁ Jaborandi leaf
⦁ Mugwort
⦁ Mustard
⦁ Nightshade
⦁ Pennyoyal (both European and North American)
⦁ Rue
⦁ Sassafras
⦁ Savin
⦁ Southernwood
⦁ Stinging nettles
⦁ Tansy
⦁ Thuja
⦁ Wintergreen
⦁ Wormseed
⦁ Wormwood

http://essentialoils...c-oils.htmgivesdetails on each of these oils.
Medical research on DERMAL toxicity of essential oils.
https://www.ncbi.nlm...les/PMC3546250/
https://www.ncbi.nlm...pubmed/23663182
https://www.ncbi.nlm...pubmed/15771186
https://www.ncbi.nlm...pubmed/16324777
https://www.ncbi.nlm...pubmed/25272759
About lemon, ginger and clove toxicity.

https://www.ncbi.nlm...pubmed/15895251
Recent growth in aromatherapy sales has been accompanied by an unfortunate increase in accidental poisoning from these products. Clove oil warrants special attention.

RevTom - Yes, we had some empty veggie caps lying around, for essential oils.

Carleeta - Rosemary oil rubbed on your temples makes you think clearer

FiveNotions - I found the scent of lavender to be very soothing, helpful to me for getting calmed down and drifting off to sleep .

Fishinghat - A caution on the essential oils. Being oils they are absorbed readily through the skin into the blood stream where (along with other oils and fats) and can contribute to non-alcoholic fatty liver disease. I know they are real popular right now but the FDA is considering a warning on topical use. Lemon oil is the only one tested to not contribute to this condition. These oils combine with cholesterol and triglycerides in fat/oil saturation of the liver.
You might consider just putting them on your collar or label for the aroma.

smacoy - I am using Young Living Essentil Oils. There are so many oils to use for so many things. I diffuse them, take them orally, apply them topically. My favorite right now is the supplement called Ningxia Red. It's a mixture of fruit juices and essential oils. It gives me energy and even curbs my appetite some. It's also great for your immune system. I also have lavender, frankincense and lemon which are supposed to be great for depression. I have a pendant that I'm going to put them in and wear them so that I'm inhaling them all day

CatLeeJones - What I've come across for the pain is absolutely amazing. It is called 'oil pulling'. Oil pulling is putting about a tablespoon of oil in your mouth, gently swishing it through for about 20 minutes. Then you spit it out. I did this for the first time yesterday with 3 sessions and it is nothing short of a miracle in how it released my pain. I've just started this process, with others I've read up on stating their pain is completely gone. There are so many more benefits from this process. This is something Im sure big pharma doesn't want too popular. The oils recommended are sesame seed oil, olive oil and coconut oil. I used organic sesame seed oil. I've read that sesame seed oil has properties that is most beneficial for fibromyalgia sufferers. It will take a bit to get used to but I'd rather do this than take pills that poison my body.

https://www.ncbi.nlm...pubmed/25584309
Oil pulling with sesame oil is equally efficacious as chlorhexidine in reducing oral malodor (bad breath) and microbes causing it. It should be promoted as a preventive home care therapy.

https://www.ncbi.nlm...pubmed/27084861
The Effect of Coconut Oil pulling on Streptococcus mutans Count in Saliva in Comparison with Chlorhexidine Mouthwash.

https://www.ncbi.nlm...pubmed/27966509
Oil pulling for bad breath.

And many more articles all dealing with oil pulling for bad breath and oral bacterial control.

https://www.ncbi.nlm...pubmed/29070291
https://www.ncbi.nlm...pubmed/24429325
https://www.ncbi.nlm...pubmed/26518258
lipoid pneumonia caused by repeated sesame oil pulling
Note - he membranes in the mouth are very adept at absorbing materials. This would be a way to directly absorb oils (especially if exposed for 20 minutes, directly into the blood stream without digestion.

grtree - the next step was to meet with an aromatherapist,she performed a thorough intake survey,we tried several different essential oils to see how I responded,then she mixed them and put into an inhaler(absolutely fantastic!)Then I kept pushing back the time I took the meds daily,just kept waiting until the zaps and dizzy feelings were getting to me,over the course of three weeks,I gained a full two days in time so to speak,then one day my body said...enough.The first 72 hours were a breeze,then things got ugly with the withdrawal symptoms.

I am who I am - To relieve dizziness or vertigo symptoms you can even opt for aromatic essential oils like lavender, peppermint, etc. Gentle forehead massage with the essential oils will be helpful in restoring normalcy and improves blood circulation.

SCL - have a calming blend of doTerra Serenity, frankinsence, and something else (someone made it for me). I also have a sleep blend of Serenity, lavender, sandalwood, and bergamot. The calming blend even helped me with a headache without meds! It could all be in my head, but I don't care.

---------------------------------------------------------------------------------------------------------------------------
Jujube (also called San Zao Ren) (Genera Ziziphus)


FH - San Zao Ren is the same thing as Jujube. It does have anxiolytic effects but can also reduce bp so please monitor carefully.
Geebers - She gave me an herbal powder called San Zao Ren (Chao). This is to help with the anxiety and sleep.
https://www.ncbi.nlm...pubmed/19260286
The alcohol extracts of Semen Ziziphi Spinosae have the anti-anxiety effects instinctively. Its mechanism may be related to increasing the GABA and expression of GABAAR1 and reducing the Glu and expression of NMDAR1.

https://www.ncbi.nlm...pubmed/19101585
It is concluded that sanjoinine A may have anxiolytic-like effects in the elevated plus-maze, hole-board test and open field test, and these effects may be mediated by GABAergic transmission.
https://www.ncbi.nlm...pubmed/19505549
ZE (jujube) with the 5-HT(1B) (serotonin) receptor.

https://www.ncbi.nlm...pubmed/10996283
https://www.ncbi.nlm...pubmed/14531016
All the above mention anxiolytic effects.

https://examine.com/...iziphus-jujuba/
Traditional usage of Jujube is taking 50g of the fruits (20 individual 2-2.5cm diameter fruits) and doing a hot water extract, either a soup of a beverage.
There currently is not enough evidence in humans to establish an effective oral dose of Zizyphus Jujube supplements but estimating from animal studies finding benefits with 500mg/kg for anxiety reduction, an estimated human dose would be:
⦁ 5,500 mg for a 150lb person
⦁ 7,300 mg for a 200lb person
⦁ 9,000 mg for a 250lb person
The seeds of Ziziphus jujube have been implicated in reducing anxiety, in accordance with their traditional usage. Oral administration of 0.5, 1, and 2g/kg of the ethanolic seed extract in mice was able to exert anxiolytic effects, and although it was equally effective as Buspirone and Diazepam (2mg/kg and 1mg/kg, respectively) at a black and white test (anxiety model) at 500mg/kg, it appeared to become less potent at anxiolysis at 1 and 2g/kg while becoming more sedative in nature.
Highly regarded as a sedative in traditional chinese medicine with minimal Western trials on its efficacy, it appears to induce sedation in a relatively dose dependent manner and is synergistic with 5-HTP in this regard.
Good for constipation. May be acutely anti-fertility, but there is limited evidence to support this notion.
Above reference contains support references.
As no human toxicity tests have been performed care should be used when taking this supplement.
---------------------------------------------------------------------------------------------------------------------------
Multivitamins

Caution -Vitamin Toxicity. More than 60,000 instances of vitamin toxicity are reported annually to US poison control centers.
USP – A sign of synthesized vitamins. Most vitamins can be purchased as natural food vitamins.

Vitamins should always be consumed with at least a small amount of foods which contain the same vitamin. This way any natural covitamins, enzymes or poteins needed to process the vitamin will be available.

A (β-carotene) is a group of unsaturated nutritional organic compounds, that includes retinol, retinal, retinic acid and several provitamin A carotenoids, among which beta-catotene is the most important. Vitamin A has multiple functions: it is important for growth and development, for the maintenance of the immune system and good vision. Vitamin A is needed by the retina of the eye in the form of retinal. Vitamin A also functions as retinoic acid which is an important hormone-like growth factor for epithelial and other cells. Recommended Daily Allowance is from 600 to 900 micrograms/day (Maximum is 1700 to 3000 micrograms/day). Vitamin A toxicity is very serious and as it is fat soluble it may be stored in the human body. Consult with physician before taking Vitamin A supplements. Anxiety is a side effect of Vitamin A deficiency and as such Vitamin A will bring the anxiety under control but it is recommended that this be done by dietary changes rather than by supplements due to the risk of toxicity. Vitamin A allergy is rare.

https://www.ncbi.nlm...pubmed/21521362
Not anxiolytic.
https://www.ncbi.nlm...pubmed/24777547
RA not anxiolytic.
https://www.ncbi.nlm...pubmed/17727954
Causes anxiety

Hypervitaminosis A (elevated Vitamin A levels)
Toxicity results from ingesting too much preformed vitamin A from foods (such as fish or animal liver), supplements, or prescription medications and can be prevented by ingesting no more than the recommended daily amount.
Diagnosis can be difficult but there are effective tests available. Hypervitaminosis A is usually treated by stopping intake of the offending food(s), supplement(s), or medication. Most people make a full recovery.

Wiki

"Per tablespoon (13.6 g), cod liver oil contains 136% of the established daily Tolerable Upper Intake Level (UL) for Preformed Vitamin A (Retinol). Vitamin A accumulates in the liver, and can reach harmful levels sufficient to cause hypervitaminosis A. Pregnant women may want to consider consulting a doctor when taking cod liver oil because of the high amount of natural forms of vitamin A such as retinol.

The risks of fatty acid oxidation, hypervitaminosis, and exposure to environmental toxins are reduced when purification processes are applied to produce refined fish oil products."

The environmental toxins are important, especially mercury, other heavy metals and pesticides.
http://ajcn.nutritio...t/83/2/191.full
In developed nations, the increasing availability of and interest in fortified foods and supplements resulted in a large percentage of the population with preformed vitamin A intakes higher than recommended. Indeed, observational studies suggest that more than 75% of people may be routinely ingesting more than the recommended dietary allowance (RDA) for vitamin A, much of it as preformed vitamin A

https://www.ncbi.nlm...t00572-0157.pdf
Chronic hypervitaminosis A may exist for many years among members of the general
public without recognition, resulting eventually in hepatocellular (liver) damage and hepatic fibrosis. Pre-existing liver disease may also affect the capacity of the organ to transport the vitamin into the circulation, thus potentiating its hepatotoxicity..

Symptoms may include:
Abnormal softening of the skull bone (in infants and children)
Blurred vision
Bone Pain or swelling Bulging of the soft spot in an infant's skull
Changes in alertness or consciousness
Devreased Appitite
Dizziness
Double vision (in young children)
Drowsiness
Hair changes, such as hair loss and oily hair
Headache
Irritability
Liver damage
Nausea
Poor weight gain (in infants and children)
Skin changes, such as cracking at corners of the mouth, higher sensitivity to sunlight, oily skin, peeling, itching, and yellow color to the skin
Vision changes
Vomiting

Dosages -
Liver is high in vitamin A. The liver of certain animals are particularly toxic. Supplements - usually when taken above recommended dosages - can be toxic. Cod Liver Oilis particularly high in vitamin A.

http://nutritiondata...-and-oils/628/2
One tablespoon of Cod Liver oil contains 13,500 IU (4,500 μg/day) which exceeds the tolerable upper limit for an adult human by 50% for daily intake.

Most Vitamin A supplements deliver 5,000 to 25,000 IU (which is 1,667 to 8,333 μg/day)
Amazon

https://www.ncbi.nlm...ooks/NBK222318/
The half-life o0f Vitamin A is 128 days and allows for rapid build up of toxic levels.

Daily Tolerable Upper Level
Life stage group category Upper Level (μg/day)
Infants
0–6 months
7–12 months
600
600
Children
1–3 years
4–8 years
600
900
Males
9–13 years
14–18 years
19 – >70 years
1700
2800
3000
Females
9–13 years
14–18 years
19 – >70 years
1700
2800
3000
Pregnancy
<19 years
19 – >50 years
2800
3000
Lactation
<19 years
19 – >50 years
2800
3000
Source for above information is wiki

B complex is a class of water-soluble vitamins that play important roles in cell metabolism. Though these vitamins share similar names, research shows that they are chemically distinct vitamins that often coexist in the same foods. In general, supplements containing all eight are referred to as a vitamin B complex. General side effects, (usually transient) may include restlessness, nausea and insomnia. Vitamin B allergies are rare and are usually associated with Vitamin B 3, 6 and 12. Some allergic reactions can be severe. See individual B vitamin. The raw form of B vitamins are difficult to absorb. The methylated or phosphated forms (sometimes referred to as coenzyme form)is more readily absorbed. Since the B vitamins are so essential in our handling of stress many psychiatrists begin new patients off with a vitamin B blood assessment. There is little evidence that B vitamins are effective against anxiety but only helps protect against the effect of further stress.

FH - One caution to add. If this is your first time taking B vitamins start with a low dose and work up from there. I was put on B complex when I was first diagnosed with anxiety and had a severe allergic reaction to it.. Allergy to B vitamins is uncommon but does happen. I can't even take the little kiddy pills without nausea and vomiting.

FN - Also, take them in the morning.....I learned that if I take a b complex any later than noon, it seems to interfere with my sleep....they seem to give me an energy boost, which isn't what I need at nighttime.....I've read that this is the case for quite a few people....

http://www.ncbi.nlm....pubmed/23738221
Used Max Stress B, effective, 30 days to start

Caution – Max Stress B contains many more active ingredients than just B Vitamins.

https://www.ncbi.nlm...pubmed/21905094
B complex not effective

B1 (thiamine) is the most active form is thiamine pyrophosphate (TPP), a coenzyme in the breakdown of sugars and amino acids. Synthetically thiamin is usually marketed as thiamin hydrochloride or thiamin mononitrate and is a made from Grewe diamine (a coal tar derivative) processed with ammonia and other chemicals.
Thiamine is used in the biosynthesis of the neurotransmitters acetocholine and gamma=aminobutyric Acid (GABA). Humans must obtain it from their diet. Thiamine deficiency has a potentially fatal outcome if it remains untreated. The RDA is set at about 1.0 mg. There are no reports available of adverse effects from consumption of excess thiamine by ingestion of food and supplements. Vitamin B1 toxicity is very rare but high doses can lower other vitamins.
No research found to indicate Thiamine is anxiolytic.

B2 (riboflavin) has reactions including activation of other vitamins. There is no evidence for riboflavin toxicity produced by excessive intakes, as its low solubility keeps it from being absorbed in dangerous amounts within the digestive tract. Allergic reactions are rare.
No research found to indicate riboflavin is anxiolytic.

B3 (niacin) is changed to NAD and NADP which are used in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis. Niacin is involved in both DNA repair and the production of steroid hormones in the adrenal gland. Due to high energy use in the brain it is the most susceptible organ for niacin deficiency. RDA is 14 to 16 mg/day. Intake should not exceed 35 mg/day. Extended release tablets increase the risk of liver toxicity. The FDA does not recommend the taking of niacin supplements. Niacinamide does not seem to cause gastrointestinal upset or hepatotoxicity that the synthetic time-released niacin can cause.

It comes in 3 forms (nicotinic acid, niacinamide and nicotinamide). Taking niacin also might worsen allergies, gallbladder disease and symptoms of certain thyroid disorders. If you have diabetes, niacin can interfere with blood glucose control. Use niacin with caution if you have the complex form of arthritis gout. Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout. (Mayo Clinic)

No research found to indicate niacin is anxiolytic.

FH - Niacin is a B Vitamin (B2) and like so many B vitamins it can help with anxiety. CAUTION....Niacin can build up in the system and cause flushing, liver toxicity and really agitate your stomach. I would start with low doses around 0.25 to 0.5 mg per day and see how you handle it.

B5 (pantothenic acid) is a water soluble vitamin that is essential to synthesize and metabolize proteins, carbohydrates, and fats. The RDA is 5mg/day. There is no upper limit for consumption. Extremely high doses have been found to produce panic attacks. Synthetic pantothenic acid is processed with formaldehyde (a strong cancer causing agent. It exists in 2 other forms; pantotheno and calcium pantothenate.
No research found to indicate pantothenic acid is anxiolytic.

B6 (pyridoxine) is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gebe expression. It is a factor in the biosynthesis of five important neurotransmitters: serotoniin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid (GABA). The RDA is 1 – 3 mg/day. Doses of pyridoxine in excess of the RDA over long periods of time result in painful and ultimately irreversible neurological problems. There are 7 forms; Pyridoxine (most common), Pyridoxine 5'-phosphate, Pyridoxal, Pyridoxa 5'-phosphate, the metabolically active form (sold as 'P-5-P' vitamin supplement) Pyridoxamine (PM), Pyridoxamine 5'-phosphate (PMP) and 4-Pyridoxic acid (PA). Due to its half life of up to 25 days it is easy to buildup mtoxic amounts in the blood stream. Vitamin B6 toxicity is on the rise in the USA.

Vitamin B6 Toxicity

https://www.ncbi.nlm...pubmed/26417231
Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice. Our data showed that fenugreek has anti neuropathic effect and restores the function of nerve fibers
The German Commission E monograph recommends 6 grams per day, which can be taken all at once or divided between three meals. Since most fenugreek capsules are available in either 580 or 610 milligrams, a common dosing scheme would be 2-3 capsules three times a day.

https://www.ncbi.nlm.../pubmed/6308447
We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.

https://www.ncbi.nlm...ooks/NBK114313/
Half-Life is 15 to 24 days.

https://www.ncbi.nlm.../pubmed/3041185
Pyridoxine neuropathy.
A case of sensory neuropathy in a young woman due to long-term ingestion of pyridoxine, with subsequent recovery, is described. Pyridoxine neuropathy may occur after the long-term ingestion of doses as low as 200 mg a day. Because of its widespread use in the community, both the general public and the medical community need to be aware of this recently described complication of megavitamin therapy.

https://www.ncbi.nlm.../pubmed/3630649
A newly recognized neurotoxic syndrome due to pyridoxine (B6) overdose is described. It is the largest series of B6 intoxication hitherto reported. A raised serum B6 level was present in 172 women of whom 60% had neurological symptoms, which disappeared when B6 was withdrawn and reappeared in 4 cases when B6 was restarted. The mean dose of B6 in the 103 women with neurological symptoms was 117 +/- 92 mgs, compared with 116.2 +/- 66 mgs in the control group. There was a significant difference (P less than 0.01) in the average duration of ingestion of B6 in the neurotoxic group of 2.9 +/- 1.9 years compared with 1.6 +/- 2.1 years in controls. The symptoms were paraesthesia, hyperaesthesia, bone pains, muscle weakness, numbness and fasciculation, most marked on the extremities and predominantly bilateral unless there was a history of previous trauma to the limb. These women were taking a lower dose of B6 than previously described (1,2), which may account for the complete recovery within 6 months of stopping B6.

https://www.ncbi.nlm...pubmed/10746516
50 mg B6 with Mg
https://www.ncbi.nlm...pubmed/15554143
Magne-B6 (a magnesium lactate/pyridoxine combination), effective. 14 days to start.
A total of four articles were found linking vitamin B6 to the treatment of anxiety and/or depression.
https://www.livestro...icity-symptoms/
Vitamin B-6 toxicity cannot occur from eating natural foods, but it can occur from supplementing with its synthetic form, pyridoxine. The recommended dietary allowance of vitamin B-6 for adults is no more than 2 mg daily, but toxicity is not thought to occur until ingesting at least 100 mg daily, if not 500 mg daily, for many weeks consecutively. Some people do mega-dose pyridoxine for long enough to cause toxicity, which leads to symptoms ranging from temporarily irritating to permanent and disabling.

https://www.ncbi.nlm...pubmed/16320662
Vitamin B6 (pyridoxine) causes neuropathy at intakes of 1000 mg per day or more, which is about 800 times the daily intake from foods. There have also been occasional reports of toxicity at intakes of 100-300 mg per day. The US authorities set the no-observed-adverse-effect-level at 200 mg per day and the safe upper limit at 100 mg per day.

https://www.ncbi.nlm...pubmed/25137514
Supplementation with pyridoxine at doses greater than 50 mg/d for extended duration may be harmful and should be discouraged.
https://www.ncbi.nlm...pubmed/25056196

B7 (Biotin) no reported side effects or toxicity.
No research found to indicate biotin is anxiolytic.

B9 (Folic acid, folate) is essential for numerous bodily functions. Humans cannot synthesize folic acid, therefore, folic acid has to be supplied through the diet to meet their daily requirements. Folic acid is not found naturally but folate is. Some recent research has indicated that synthetic folic acid may interfer with the bodies ability to process folate. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy. Children and adults both require folate to produce healthy red blood cells and prevent anemia. Low risk of toxicity. RDA is 400micrograms/day and not to exceed 1000.
http://www.ncbi.nlm....pubmed/22528830

B12 (methylcobalamin) (do not use cyanocobalamin, contains cyanide molecule.) oral use may lead to several allergic reactions such as hives; difficult breathing; swelling of the face, lips, tongue, or throat. Less-serious side effects may include headache, nausea, stomach upset, diarrhea, joint pain, itching, or rash. Cyanocobalamin is synthetically manufactured but the body can convert it to all forms of vitamin B12. Vitamin B12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.

http://www.ncbi.nlm....pubmed/12796225
Not anxiolytic.

Vitamin C (ascorbic acid ) is a cofactor in at least eight enzyme reactions, including several collagen synthesis reactions that, when dysfunctional, cause the most severe symptoms of scurvy. In animals, these reactions are especially important in wound-healing and in preventing bleeding from capillaries. Vitamin C may also act as an antioxidant against oxidative stress. The functions of Vitamin C include the synthesis of collagen, carnitine, and neurotransmitters (norepinephrine from dopamine); the synthesis and catabolism of tyrosine; and the metabolism of microsome. RDA is 75 to 90 mg/day with no more than 2000 mg/day maximum. The signs and symptoms of overdose is nausea, vomiting, diarrhea, flushing of the face, headache, fatigue and disturbed sleep. Vitamin C's anxiolytic properties is beleived to primarily be from its ability to repair oxidative effects from stress.

http://www.ncbi.nlm....pubmed/24511708
Effective at 1000 mg/day
http://www.ncbi.nlm....les/PMC2885294/
Effective
https://www.ncbi.nlm...pubmed/24979594
Effective
https://www.ncbi.nlm...pubmed/21036190
Effective and lowers cortisol levels.
https://www.ncbi.nlm...les/PMC2649700/
Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors.
https://www.ncbi.nlm...les/PMC3964749/
A paper explaining the relationship between oxidative stress and anxiety.

Vitamin D - Cholecalciferol and ergocalciferol
No Research shows Vitamin D, in any form, anxiolytic.

FH - You are definitely correct about taking the D3 with the calcium but would caution about watching out for immediate changes in behavior, clarity of thought, (not that I am sure I could tell right now lol), constipation, nausea and vomiting as these are symptoms of an allergic reaction that require immediate medical attention. If taking vit d3 you should have your calcium and D3 levels checked each 6 months. Long term use can cause hypercalcemia (too high calcium levels).

Vitamin E refers to a group of compounds that include both tocopherols and tocotrienols. Regular consumption of more than 1,000 mg (1,500 IU) of tocopherols per day may be expected to cause hypervitaminosis E with an associated risk of vitamin K deficiency and consequently of bleeding problems. Vitamin E has many biological functions, the antioxidant function being the most important and best known. Other functions include enzymatic activities, gene expression, and neurological function(s). RDA is 15 mg/day.

Hypervitaminosis E is a state of vitamin E toxicity. Since vitamin E can act as an anticoagulant[citation needed] and may increase the risk of bleeding problems, many agencies have set a tolerable upper intake levels (UL) for vitamin E at 1,000 mg (1,500 IU) per day.[1] This UL was established due to an increased incidence of hemorrhaging with higher doses of supplemental vitamin E. Doses of vitamin E above the UL can also magnify the antiplatelet effects of certain drugs such as anti-coagulant medications and aspirin, which can cause life-threatening symptoms in ill patients. Hypervitaminosis E may also counteract vitamin K, leading to a vitamin K deficiency.

http://jn.nutrition....138925.full.pdf
Half life is 2 - 3 days.

http://www.ncbi.nlm....pubmed/24511708
Not effective

https://www.ncbi.nlm...pubmed/21036190
Effective

Members comments

Many used vitamins without any real comment on their perceived effectiveness.
One member did recommend Vitamin B complex.
And two stated that Vit B complex may have caused increased anxiety.
Another stated....."B Vitamins - "
"Some of the recommendations I've heard are: stay away from Vitamin B as it ramps up the nervous system and can actually increase anxiety."

Resources
Major sources of information includes NCBI, webmd, emedicine and drugs.com.
--------------------------------------------------------------------------------------------------------------------
Centrum Forte

Lady nancy - A really good vitamin & mineral supplement (I used Centrum Forte) has helped me.

Nutrient Info
Select a vitamin or mineral to learn more.
Vitamins
Vitamin A
1,000 IU
Beta- Carotene
3,000 IU
Vitamin E
50 IU
Vitamin C
90 mg
Folate
0.4 mg
Vitamin B1
2.25 mg
Vitamin B2
3.2 mg
Niacinamide
15 mg
Vitamin B6
5 mg
Vitamin B12
20 mcg
Vitamin D
600 IU
Biotin
45 mcg
Pantothenic Acid
10 mg
Vitamin K1
25 mcg
Minerals
Calcium
200 mg
Iodine
0.15 mg
Iron
10 mg
Magnesium
50 mg
Copper
1 mg
Manganese
5 mg
Potassium
80 mg
Chromium
35 mcg
Molybdenum
45 mcg
Selenium
55 mcg
Zinc
7.5 mg
Other Ingredients
Lutein
500 mcg
Lycopene
600 mcg

-------------------------------------------------------------------------------------------------------------------------
Calms Forte

Arcelus - Right now I'm also taking 300mg of chelated magnesium and I might take calms forte for sleep as well.
Uriel - Different things work for different people I have found a homepathic called Calms Forte for me they work great for the anxiety and down moods while i went thru withdrawl.

Active Ingredients | Purposes:
Avena Sativa 4X HPUS: stress, nervousness
Calcarea Phosphorica 3X HPUS: restlessness
Chamomilla 4X HPUS: nervous irritability
Ferrum Phosphoricum 3X HPUS: nervousness
Humulus Lupulus 4X HPUS: occasional sleeplessness
Kali Phosphoricum 3X HPUS: irritability
Magnesia Phosphorica 3X HPUS: mental anxiousness
Natrum Phosphoricum 3X HPUS: anxiousness
Passiflora 4X HPUS: restless sleep from exhaustion

Caution - Carefully investigate the possibility of interactions with your medications.

 


#8 gail

gail

    God-like

  • Site Supporter
  • 4,259 posts
  • LocationSherbrooke, PQ
  • why_joining:
    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 16 December 2017 - 09:44 AM

Oh wow! I just saw this.

I think that we should ask Ken to add another, short of English words here, subject line called Different Medical information or something like that. We get lost searching for different info.

You could put all those info in there with links. This subject would be without possible posts from us. And add below Different Medical Information another subject called Questions About Medical Information. That would be great.

What do you think Fishinghat? I'm excited about this possibility. Thank you sir!

#9 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 16 December 2017 - 10:33 AM

Gail, could you give me a small sample of an outline for these two threads? I am having a hard time putting this together in my mind. When the last of my info us loaded on the current thread I was going to reformat the information anyway. For right now any member can go to this thread and do a search for a symptoms (eg. zaps), supplement (eg magnesium) or other term and find the information fairly easily but to just set down and read it is difficult for sure.


#10 gail

gail

    God-like

  • Site Supporter
  • 4,259 posts
  • LocationSherbrooke, PQ
  • why_joining:
    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 17 December 2017 - 10:29 AM

Fishingbrain, I do find that Different medical information would be a good title. Most important, it would be for us impossible to post back on this because we'll be lost again and again and if Ken can arrange this, that must be possible.

Example, when you gave me the difference between Dyskenisia and the two others, I don't remember in what category it was. But I wrote it all down, thank God! This post should be in Different Medical information.

Just below this different medical info, the title should be questions about DMI. I'm not sure that I answered your question here. Of course you can answer people about DMI on any posts, but this information should be reposted on DMI.

Lots of work? In a way, it would prevent you of repeating and repeating. And refer them to DMI. On that, a good Sunday to you and your so loving wife.

#11 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 17 December 2017 - 11:12 AM

Very interesting. O understand your approach. Here is what I am going to do.

 

1) Finish entering my info on the existing thread.

 

2) Reorganize my information on that thread.

 

3) Deveolp an outline for that thread.

 

4) Rename the thread

 

5) Return to the subject of how to better present the info with you and other members and possible get Ken to help if we decide to go that route.

 

6) Reread the posts for 'other medical information' like the one on muscle movement syndromes and incorporate them as well.

 

This will take some time but with everyone's input we can make a good document out of this.

 

Thanbk you for your input Gail and let me know of this sounds reasonable.


#12 gail

gail

    God-like

  • Site Supporter
  • 4,259 posts
  • LocationSherbrooke, PQ
  • why_joining:
    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 20 December 2017 - 11:43 AM

Sounds great Fishinghat, sorry for the late reply. Exhaustion took over my body. Normal, as the oncologist said yesterday.

Yes, a lot of work, I really think that this would be beneficial for all members. And as I said, prevent you of repeating. Prevent me from losing my mind while searching. And there is so many valuable informations, we need this! Like a plant that needs watering!

Perhaps we can get the members here also, to get their output. Thismoment, we could use your thoughts about this, where ever you are! Smoking a cigar in Italy??

#13 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 23 December 2017 - 01:03 PM

                                          Reading Material and Treatment Programs

                  Informational Reading

     A Mind Of Your Own

blanam - A great book is Kelly Brogan's "A Mind Of Your Own".
FH - Kelly Brogan, MD is absolutely correct. I remember my crying spell. It lasted about 3 or 4 weeks. I remember going for long walks in the park and crying every step, for no apparent reason. Everyone was asking me if I was OK. I waited for those spells to end before I went walking again.
blanam - Kelly Brogan, MD suggests that it can take from 6 month to 2 years for the brain/body to recalibrate.
kr15sy - I have been focusing on going Paleo to get healthy and lose weight, and after reading Dr. Kelly Brogan's A Mind of Your Own, and Dr. Perlmutter's Grain Brain, found out about the connection between your gut and your brain.

     The Gifts of Imperfection
FN - If you're a reader, I highly recommend Brene Brown's The Gifts of Imperfection.

AngryinHouston - If you're a reader, I highly recommend Brene Brown's The Gifts of Imperfection.

     The Antidepressant Solution

Jekaufman - BUY THE BOOK- "THE ANTIDEPRESSANT SOLUTION" By. Joseph Glenmullen. He writes a step-by-step guide to overcoming Antidepressant Withdrawl, Dependence and Addiction!
Unitedwecan - This book, The Antidepressant Solution, was written in 2005. It is by Joseph Glenmullen, M.D.. He also wrote Prozac Backlash. He teaches at Harvard Medical School. This book tells of the way money and power have corrupted the pharmecutical companies, the FDA and everyone involved. It also has a 5 step program that basically says to GO SLOW when weaning off these drugs.
pheonixjazzmine - I would like to suggest a book called "The Antidepressant Solution" by Joseph Glenmullen, M.D. Dr. According to Glenmullen, many doctors these days do not taper patients off of SSRI's slowly enough. His book guides people off of these drugs through verrrry gradual tapering schedules.
agrace - I have a book called "The Antidepressant Solution" by a Dr. Glenmullen which devotes a whole chapter on determining whether a symptom is that of an actual illness or just withdrawal. It's very good, although I don't think he goes nearly far enough in discussing the long term implications of these symptoms, although he briefly mentions that they have been documented to continue past a year,and he has a chart of over fifty side effects that cover everything from physical to mental/emotional to neurological.
Norther - In Joseph Glenmullen's book, 'The Antidepressant Solution' (devoted to withdrawal), he states the situation very clearly, on p.97:
"Q. Can antidepressants be taken every other day as part of tapering off them?
A. None of the short acting antidepressants should be taken every other day as a method of tapering them. Because of their short half-lives, the every other day schedule can result in roller coaster levels of the drugs and roller coaster levels of withdrawal symptoms."
However, patients seem to be told, time after time, to withdraw by alternating doses or missing out days - a surefire recipe for destabilising drug levels, and putting the patient through needless physiological chaos and withdrawal nightmares
rogerwilco - I found Dr Glenmullen's book very revealing of the situation I find myself in, and you can find it at addall.com.

     Full Catastrophe Living

Gail - Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain and Illness (Delta, 1991);
This book treats all ailments the same way. Depression, anxiety, cancer, fibromalgia, anything, you name it.
Same (remedy) applies to all, mindfulness.
A really interesting book. Step by step. Easy to understand,

xanaxul - I forgot, I agree with you "Full catastrophe living..." Other of the John Kabat-Zinn books offers many cues for trauma survivors to cope and begin to rebuilt from the emotional wreckage that trauma lefts behind.
Limbo - A book that has always helped me is Dr. Jon Kabatt-Zinn's books. He has a mindfullness-based stress reduction program that is extremely helpful for chronic pain and depression. He runs these programs in hospitals but you can buy the books and audio CDs.
http://www.amazon.co...nn/e/B000AQ12GA
http://www.umassmed....t.aspx?id=41252

     Walking with God through Pain and Suffering

IBS - I'm not sure what you like to read but I am reading a great book on suffering by Timothy Keller..called 'Walking with God through Pain and Suffering' It's completely biblical, based on the foundation you mentioned and I highly recommend it.

     The Ragamuffin Gospel
SL - Praying like never before & have deriving the most comfort from (other than the Psalms) a book called 'The Ragamuffin Gospel' by Brennan Manning (awesome, you might wanna check it out) 'written for the bedraggled, beat up & burnt out.'

     Anatomy of an Epidemic
TM - I introduced the topic because the no-proof-for-serotonin-deficiency is high on the list of SSRI critics; Robert Whitaker's book, Anatomy of an Epidemic is representative of this, and I recommend it.
BHF - One of the things I would like to share is the books that I have learned from. One of my favorites is Anatomy of an Epidemic by Robert Whittaker. I felt that the references to research let me use my own judgement to reach conclusions. He studied a wide range of psychotropic drugs. I bought copies of his book to lend and/or give away. I am particularly worried about some of my son's teenaged friends who are ripe for the industry to chew up. I also appreciated Unhinged and The Emperors New Drugs.
Papin - For anyone interested in learning more about recent research on long-term anti-depressant use, check out the book Anatomy of an Epidemic, by Robert Whitaker. He goes into a lot of detail about the history of psychotropic drugs and the efforts the APA goes to in order to cover up evidence that these drugs are, in fact, doing more harm than good.
Imdone - I encourage everyone to read Whitaker's "Anatomy of an Epidemic" and Breggin's "Your Drug May Be Your Problem."
Jesselee - Also, educate yourself and uplift yourself. I found the book, "Anatomy of an Epidemic" by Robert Whitaker to be helpful,

     The Mood Cure

K65 - You may find the book "The Mood Cure" helpful. It addresses the underlying diet and medical causes (for me, hypothyroidism) of pain (both mental and physical). I have found it to be very useful in understanding and learning about natural and dietary means of treating that pain. The book also references 5HTP, as well as other supplements, as being helpful for people weaning off of antidepressants.

 

     At Last A Life

Jennifer - I have read Claire Weekes and got a lot of helpful info there but the book that is truly helping me is At Last A Life by Paul David. It's up to date and hit the nail on the head on everything I am going through. He suffered for 10 years with severe anxiety and has gotten his life back.

     The Healing Power of Vitamins, Minerals, and Herbs

Tria - It has info on most of the more common vitamins and supplements - The Healing Power of Vitamins, Minerals, and Herbs by Reader's Digest. I don't think it's in print anymore, but you may be able to find used copies online.

     Essential Help for the nerves
Gail - If you have a chance to get her book, it will soothe you, at least for a while. Title ESSENTIAL HELP FOR YOUR NERVES.

     Various Suggested reading by members
http://www.cymbaltaw...book#entry41552

     Suggested readings

TM
Anatomy of an Epidemic, Robert Whitaker (2010)
Let Them Eat Prozac, David Healey (2006)
Pharmageddon, David Healey (2013)

Boundaries
IBS -I'm reading the book "Boundaries" by Cloud and Townshend...it's a great read...should have read a decade ago, but that's okay...

Surviving Panic Disorder: What You Need to Know
TM - Here's a link to a book you might wish to look into.
http://www.amazon.co...disordershipko

The Power of Anxious Thinking
BRZ - i highly recommend his latest podcast, The Power of Anxious Thinking: http://www.anxietygu...xious-thinking/its about an hour, the first 6 min or so is just chit chat, but then he gets into the meat of his topic. there is an article and then at the bottom a link for the podcast on that topic. the actual podcast section is the archives - also good stuff in there.
-------------------------------------------------------------------------------------------------------------
                                       Programs
http://www.theroadba...withdrawal.aspx
The Road Back is put out by the Church of Scientology

http://www.cymbaltaw...tion#entry45468
http://www.cymbaltaw..."the road back"
Discussions and information on the Road Back program.

http://www.cymbaltaw...book#entry44953
A discussion and information on TheRoadBackProgram.

Tinajuli - something that might be a joke, I don't know: Have you heard about The Road Back Programme? It might be just using the desperation of people who feel very silly afterwards but I thought screw it and ordered the stuff. They advise to take a supplement that kind of calms the reactions that take place in your body as soon as you take an anti-depressant, and when you go into withdrawal. It has to do with the JNK gene. (If you know whether that company is a joke, let me know!) What are ALA supplements? I really need something to help me with that fatigue, because work gets really hard when you're constantly extremely tired.

LadyNancy - I know someone who used The Road Back program to try to get off of Cymbalta and the last time I had any contact with her she was doing everything the book said to do and taking all the supplements and still not off it so unless you just like to pray a lot then in my opinion you should just go out and buy some Omega 3, a good Vitamin B complex and drink lots of water.
I haven't found anyone who had severe symptoms that found the program very helpful in actually getting through withdrawal symptoms.
-------------------------------------------------------------------------------------------------------------
                                   Psychological treatments
     General
FH - Psychiatrists only regulate meds but a good psychologist can help you control the anxiety without meds. They can teach you relaxation techniques, control your heart rate and breathing and much more. I would highly recommend one. These techniques can help you greatly reduce your need for meds. Pick a psychologist who has experience with Cognitive Behavioral Therapy or Mindfulness. These seem to be the best techniques for anxiety.
Way to many members recommended a good psychologist to list all quotes here.

     REBT
brzghoff - my therapist who specializes in REBT, rational emotive behavioral therapy,
FN - You're young, and there are lots of other good alternatives for managing depression, anxiety and any other issues that landed you on the meds in the first place ... CBT and REBT are two ...
http://rebtnetwork.o...rary/ideas.html
REBT Website

FN - What is Rational Emotional Behavior Therapy (REBT)?
Understanding the Approach by Considering the Four Elements of its Name
Wyndy Dryden, Goldsmith's University of London
http://windydryden.c...nts_article.pdf

Excellent overview and introduction to REBT.

Brz -
1) go to http://rebtnetwork.org/library.html
2) look on the right hand side
3) scroll down in the box "news"
4) look for "New ebook released" How to Conquer Your Frustrations by Dr. William J. Knaus. the link is right there and says in blue hypertext "download the free ebook.

EQ - i would like to share a downloadable booklet i found last night that is free. great stuff. check it out if you like. its called "How To Conquer Your Frustrations" http://www.rebtnetwo...strations.pdf
it can be found on a web site i haven't been to in a long time: www.rebtnetowork.org .
https://www.ncbi.nlm.../pubmed/9479090
The results suggest that the treatment approach was successful in modifying irrational beliefs and anxiety.

https://www.ncbi.nlm...les/PMC5036761/
The findings revealed significant effects of a REHCT intervention program on problematic assumptions, death anxiety, and psychological distress reduction among the cancer patients and their family caregivers at the end of the intervention.
https://www.ncbi.nlm...les/PMC5428629/
REBC is a time-efficient and solution-focused therapeutic modality for assisting occupationally stressed employees

Scientific research into the efficacy of this method is limited.

      Cognative Behavioral Therapy

FH - Therapy is a must. I was blessed with a dr who was adept at cognitive behavioral therapy (mindfulness therapy is also good). She taught me how to do breathing exercises, reduce heart rate, refocus my thinking from obsessive thoughts, and many more coping mechanism. It has proved very beneficial.
Brz - i also highly recommend seeing a therapist who specializes in cognitive behavioral therapy - and visit on as regular basis as much as you can possibly afford - like once a week. that combined with a conservative tapering schedule can be the difference between self destruction and preserving the relationships with those you love. i won't say there will be no struggle - because there will - but the idea is to minimize suffering and avoid permanent or long term damage.
Brz - i got good sleep and deployed some good cognitive strateges and things started to improve a little.

https://www.ncbi.nlm...pubmed/24314926
Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach
Manual based psychotherapies remain a treatment option, with the most compelling evidence for cognitive behavioral therapy.

https://www.ncbi.nlm...pubmed/25433401
Systematic review of management for treatment-resistant depression in adolescents.
The combination of antidepressant medication and psychotherapy should be recommended for adolescents who present with treatment-resistant depression.

https://www.ncbi.nlm...pubmed/24458008
The integrative management of treatment-resistant depression: a comprehensive review and perspectives.
Evidence suggests that cognitive therapy (CT) is an effective strategy for TRD.

https://www.ncbi.nlm...pubmed/26635099
Treatment-resistant panic disorder: a systematic review.
Augmentation of the pharmacological treatment with cognitive-behavioral therapy demonstrated some short-term efficacy in treatment-resistant PD.

https://www.ncbi.nlm...pubmed/16847460
Treatment-resistant anxiety disorders.
Anxiety disorders are treatable conditions and respond to the front-line interventions such as serotonin reuptake inhibitors and cognitive behavioral therapy.
Acceptance and Commitment Therapy for Generalized Anxiety Disorder in Older Adults: A Preliminary Report (full text)
Behavioral Therapy, March 2011

http://www.ncbi.nlm....les/PMC3496779/

Abstract excerpt: Some evidence suggests that acceptance-based approaches such as Acceptance and Commitment Therapy (ACT) may be well-suited to geriatric generalized anxiety disorder (GAD). The primary goal of this project was to determine whether ACT was feasible for this population. Seven older primary-care patients with GAD received 12 individual sessions of ACT; another 9 were treated with cognitive-behavioral therapy. No patients dropped out of ACT, and worry and depression improved. Findings suggest that ACT may warrant a large-scale investigation with anxious older adults.

Cathill - I just finished up with 4 months of cognitive behavioral therapy to help with my life long battle of depression. I have been on and off antidepressants for most of my adult life (usually very low levels). I have been on Cymbalta for over two years now, 40mg once a day, and now that I am armed with my new tools that I learned in therapy, fianlly ready to say good bye to this drug. I have tried getting off in the past, so I am well aware of the hell you go through getting off.
gsmommy - I did have anxiety and panic attacks nearly 10 years ago and took a med for it, paxil. I went through very aggressive cognitive behavioral therapy and weaned from the med and have not had panic attack since.
There are dozens and dozens of medical research articles showing the benefit of CBT on anxiety treatment primarily but also more limitedly on depression as well.

     Mindfulness

Xana - JON KABAT-ZINN, PH.D., is founding Executive Director of the Center for Mindfulness in Medicine, Health Care, and Society at the University of Massachusetts Medical School. He is also the founding director of its renowned Stress Reduction Clinic and Professor of Medicine emeritus at the University of Massachusetts Medical School. He teaches mindfulness and Mindfulness-Based Stress Reduction (MBSR) in various venues around the world. He received his Ph.D. in molecular biology from MIT in 1971 in the laboratory of Nobel Laureate, Salvador Luria.

He is the author of numerous scientific papers on the clinical applications of mindfulness in medicine and health care, and of a number of books for the lay public: Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain and Illness (Delta, 1991); Wherever You Go, There You Are: Mindfulness Meditation in Everyday Life (Hyperion, 1994); Coming to Our Senses: Healing Ourselves and the World Through Mindfulness (Hyperion, 2005); and Arriving at Your Own Door: 108 Lessons in Mindfulness (Hyperion, 2007). He is also co-author, with his wife Myla, of Everyday Blessings: The Inner Work of Mindful Parenting (Hyperion, 1997); and with Williams, Teasdale, and Segal, of The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Guilford, 2007). Overall, his books have been translated into over 30 languages.

I did the training (half of it as I told you) with a former Z Segal PhD student. The book I've is the one by Williams, Teasdale, Segal and Kabat-Zinn, that comes with a CD with all the exercises guided by Kabat-Zinn. The book is about mindfulness applied to prevent depression relapse, but since it was written Minfulness that was developed as a technique to cope with stress by J Kabat-Zinn, has proven to be equally efective in treating the whole spectrum of anxiety disorders.

Pepe - The following technique (which I picked up from a book) has worked for me to slow down this constant train of thoughts and anxiety several times, and it still does.
1) Make yourself as comfortable as you can (sit or or lie down and close your eyes)
2) Try to get your respiration under control (inhale deep through your nose for 4 seconds, keep the air in for 3 seconds exhale for 7 seconds)
3) When your respiration has stabilized,try to observe yourself as a silent 'spectator'
4) You are NOT your thoughts or feelings, your thoughts and feelings should not kidnap you as a person. Try to observe your thoughts/feelings without any judgement. Just try to observe them. Don't ask yourself any questions regarding these thoughts/feelings.
5) Realize you are *observing* your thoughts/feelings. You, as a full person, are observing 'some thoughts/feelings' which are....just there.
6) Realize that these thoughts/feelings are just a (small) part of you, they are NOT you.
7) If you are able to objectively observe your thoughts/feelings they will gradually decrease in strength and speed.

TM - I spent a few months listening to guided Mindfulness Meditation sessions at bedtime, and found it useful for winding down and falling asleep. You can find them on YouTube, on CD's, and elsewhere on the net.
considering - I think meditation has helped me deal with bouts of low grade depression that I've experienced in the last seven years since I've been on Cymbalta. So I would highly recommend it to anyone. But I recommend that you have a teacher, even if it's meditation CDs of teachings from Sharon Saltzberg or Pema Chodron.

newbeginning - Im hoping just to try to relax do some relaxation techniques from my mindfulness tape, and not to think this is what my life will always be like. ive never realised how bad anxiety can be as ive manly suffered depression and ocd thinking.
turbolag - I work with a therapist, that works with me on mindfulness and meditation, I also use Gert's anxiety CD course.
jimmcg -The good news is that all the work I've been doing — therapy, mindfulness study, meditation and reading — has paid dividends in other areas of my life, especially my personal relationships.
IBS - One therapy I've benefited from is DBT...it incorporates mindfulness and was designed by Dr. Marsha Linehan for people with Borderline personality disorder...so i better get going on it.

TM - 1. The Mindfulness & Acceptance Workbook for Depression by Kirk D. Strosahl and Patricia J. Robinson.
2. The Mindfulness & Acceptance Workbook for Anxiety by George H. Elfert and John P. Forsyth.
These books come with CD, guided imagery, and Mindfulness exercises. As a strategy for broadening your Mindfulness understanding and practice, look into Mindfulness classes in your area. You might inquire through your therapist, medical community, community college, night classes, or university. Search on YouTube for Vipassana Mindfulness Meditation
TM - Start with something to keep the anxiety down-- that's the wild card! I could not imagine using Mindfulness to intervene in a skyrocketing episode of anxiety or rage. Impossible!
I agree that the physical symptoms occupy too much band-width to enable Mindfulness or other therapy to be up-loaded early on in discontinuation-- there's just too much activity in your head at this time.
brz - i wish i could find the web site i found with a good description, but a great technique i use is sensory mindfulness. focus on one of your five senses, like sound. just listen to all the sounds around you, , don't judge them, just let them come and go and be aware of them. do that for 5-10 minutes, then switch to a different sense, sight - notice all the imgaes before you, again, don't judge them, just notice them and be aware - you can do the same with touch , taste - chew something flavorful like chocolate, savor it, note the subtleties. the idea is to take your focus away from the intrusive thoughts. same with focusing on your breath, in out, full but normal breathing. don't hyperventilate. just feel your breath go in and out, no judgement. it takes practice. i work on it ALL the time, so when the anxiety isn't as strong, it is easier and it can become a habit.
anothermind - are you referring to Prof Mark Williams - he has researched mindfulness and happiness? ... https://www.youtube....h?v=WY08aXxor20( here's a great talk from him at Alain de Botton's School of Life in London)
Andrew Solomon is another amazing speaker on anxiety and depression: http://www.ted.com/t...secret_we_share
and dozens of others with positive things to say about mindfulness therapy.
There are large amount of research showing the benefits of mindfulness for both anxiety and depression.
----------------------------------------------------------------------------------------------------------
                                                 Home Care
     Sleep

Many members recommend sleeping as much as possible during withdrawal.

http://www.cymbaltaw...elps#entry72205
The document "How to sleep better"

FN - Sound machine/radio - I pick out which of the sounds (often I have high and low pitch, hissing, humming, and whirring all at the same time) I find most pleasing ... and somehow that helps me drift off to sleep ... It helps cover up outside noises.
Raven - I also sometimes find that putting headphones on and listening to your favorite music as loud as you can stand it helps drown out anything that might make you panic, it might even help you fall asleep.

https://www.ncbi.nlm...pubmed/26047492
This meta-analysis indicates that short and long sleep duration was significantly associated with increased risk of depression in adults.

https://www.ncbi.nlm...pubmed/26179204
Geriatric Depression Scale and Geriatric Anxiety Inventory scores are both significantly correlated with sleep disturbance. Geriatric Depression Scale scores are uniquely associated with daytime dysfunction, and Geriatric Anxiety Inventory scores are uniquely associated with perceived sleep quality, sleep latency, and global Pittsburgh Sleep Quality Index scores.

https://www.ncbi.nlm...les/PMC3900629/
Contributions to depressive symptoms increase at both short and long sleep durations.
Many articles exist that show this relationship of sleeping to much or to little contributes to anxiety and depression symptoms.
There are many studies that reflect the fact that withdrawal decreases sleep and increases withdrawal symptoms. Many studies also reflect that by increasing sleep by use of natural or prescription drugs help with withdrawal sympotoms.

     Diet

Please refer to previous sections on diet to improve serotonin, endorphin and dopamine levels.

Increase protein intake to help body to heal. Protein is very big in helping to overcome any illness. Can be added as a powder to a smoothie or other liquid.

FN - the amino acids ... just be very cautious, and research every single thing he/she tells you on your own ... they're powerful, and if not used with great care and caution, can be harmful.

     Blood pressure monitoring
FH - Just wanted to pass along a growing trend in a new way drs can get accurate feedback on your anxiety levels and how to adjust your medicine.

As we have discussed many times on this site most antidepressants and especially antianxiety drugs will lower you blood pressure to some degree. Ever wonder why a dr will start you out on a low dose of a medicine first and then slowly increase it as needed? Well part of the reason is to be sure you do not take any more meds then necessary. The other part is to make sure your body has a chance to adjust to any changes in blood pressure. Any dr who puts you on a full dose to begin with is doing you no favors unless you are just desperate for help. By ramping up slowly you can see if you will develop any significant side effects before they overwhelm you; you can see if you have a reaction to a medicine before you get carried away with a full dose and to give your body a chance to adjust to any changes in BP.

What drs are doing now (and we can do this as well) is to monitor the systolic part of our blood pressure. The systolic is the top large number of our blood pressure. So if your bp is 120/80 then the 120 is the systolic number. The general guidelines are that if the systolic is over 120 then the anxiety levels are to high and an increase in meds may be necessary. If the systolic drops to near 90 (say 90/50) then this indicates that there is more medicine in your system than you need and the dr may cut back on a dose.
Now drs are using this method along with the information on how you feel to determine if any changes are needed. Of course you don't always carry a dr around in your back pocket so it is important to realize that you can use this method as well.
As many of you know I take clonidine and hydroxyzine to control my anxiety. Both of course can affect bp but have no withdrawal. So by monitoring my bp I can tell when I need to get more medicine in my body (systolic over 120) or to drop a little in medicine dose (systolic near 90). By the way if you get dizzy when you stand up too fast this is an indication your bp is getting low and you need to check it. This is also a way to determine if you are stable enough to start weaning again. As your bp drops it indicates your stress levels are decreasing and it may be time to start weaning again. If your bp starts to go over 120 on the systolic then it may be time to slow down or pause a little bit BEFORE it gets too bad.

PLEASE READ; Important.
Blood pressure must be taken the same way each time. You must be sitting or lying still for 2 minutes or more. This is called a resting blood pressure. If you choose to set then it must always be taken in a setting position each time. DO NOT base any of your decisions on one single bp. Bp fluctuates due to many factors. Activity around you, your health, when and what you eat, etc. So when I need to check things out I take 2 or 3 blood pressures during the day. You are looking for a pattern. I have found that at least in my case it is easy to quickly determine that my bp is rising or falling after a few bp readings. Do not take a bp within 5 minutes of another blood pressure. It takes the vessels in the arm or wrist time to adjust back to normal. It is best to wait 10 minutes if you need to try and get another bp.
I know for me this has helped as a early warning system on when my withdrawal is ramping up and gives me better control. I hope it helps you all as well.

     Taking Meds

FH - At this point, like with most medicines I would recommend the teaspoon tea cup rule. For those new to the site this is the safety approach to taking a new medicine to avoid allergic reactions, severe side effects or incompatible reactions. If the medicine calls for, example, 100 mg every 8 hours start with 10 mg (part of a tablet), then 20 then 50 then 75, etc. Some sort of step mechanism to be sure your body can handle the medicine appropriately before going to a full dose. This helps avoid a lot of needless suffering.

     Mediatation

See section earlier in this thread.

     GI Disturbances

FH - Remember if your stomach is an issue you shouldn't drink anything hot or cold as this caused the muscles to tighten even more. Slightly warm water is the best and sometimes a hot pad on the stomach help calms it as well.

FH - It is like the old question, which came first the chicken or the egg. Anxiety causes an increase in adrenaline and serotonin activity. Adrenaline affects the heart and serotonin in the stomach and intestines. What most people do not realize is that the heart and stomach are controlled by the vagus nerve. So if anxiety increases then the stomach problems increase and vice versa, if stomach problems increase then anxiety increases. Anxiety increases due to feed back from the stomach and the vagus nerve. Old drs use to call this the head/gut connection. Stomach issues are also another stressor for the body and any time you can reduce a source of stress your anxiety will improve. Consider when you have had a bad case of the flu. You are tired and sick but also irritable, agitated, etc. The flu makes you stressed. As the flu subsides your psychological symptoms reduce as well. Chronic long-term stress usually causes IBS (irritable bowel syndrome) because of constant increase in serotonin activity in the GI tract.

Jim - He put me on 150 mg of Zantac twice a day in order to reduce production of stomach acid. Within 2 hours of taking the first dose I was shocked to feel my anxiety reduce by probably 75%. I was astonished at how my stomach was exacerbating my anxious feelings. Sometimes even when I didn't feel particularly anxious about anything, my stomach would well up and I would suddenly feel like I was about to go into the most important job interview on my life.

FH - Stomach issues, IBS, acid refux, etc have long been correlated to the severity of anxiety. During my own withdrawal I found that relief of heartburn by zantac and antacids would not only relieve my heartburn but also reduce my anxiety levels some. You need to realize that stomach ailments are a source of more stress on the body and would add to your anxiety symptoms. It is also believed that by returning the acid levels in the stomach to normal allows your medicine to be absorbed more efficiently and therefore it does a better job.

FN - I remembered this discussion, and I had some Zantac on hand. So, I figured I'd try an experiment to see how it works on anxiety .... I'm having no acid reflux/GERD symptoms of the sort that tell me I need to take it ... and I haven't associated my weird stomach sensation with acid reflux ...
Anyway, I took 75 mg...about 7 a.m.... and amazingly, shortly thereafter, the anxiety stuff dropped down several notches ... so, at about 9 a.m. I took another 75 mg tab (can't take more than two in a 24 hr period) ...
Well, the anxiety/weird stomach stuff that I call "anxiety" totally cleared up ... I mean totally ....
https://draxe.com/gu...ain-connection/
A fairly good overview of the brain/gurt connection.

FH - Basically with stress proper digestion and acid production changes. Bad bacteria in the stomach are able to better compete with good bacteria. With poor digestion improper nutrition increases to the body and has an inflamatory effect on many organs including the brain. Stress reduction, probiotics and a good diet are essential in bringing things back into balance. See the section on probiotics for details on what conditions can be caused by this inproper digestion. See the earlier section in this thread on Probiotics.

     Peppermint

Fishinghat -You can have her suck on a peppermint lozenge. This relaxes the esophagus/stomach but does not affect the lower intestines and does not aggravate constipation or diarrhea. Be sure it has real peppermint not peppermint flavoring. I have occasional esophageal spasms (a weaker form of dry heaves) and they work well for me. I buy mine at a health food store for about $3 for 10 lozenges. Peppermint contains menthol, which has an antispasmodic effect that relaxes the muscles of the digestive tract.

notsobad - I've had issues with motion sickness (that I didn't have when I was a kid)...and I wonder if it's all connected somehow. I went through phases with ginger and chewing peppermint gum, which made the situation survivable but still unpleasant.
MC - here are a couple of remedies that has helped my nausea in the past . Mint tea, peppermint tea, green apples and life saver 'wint-o-green' flavor.

Many members mention the GI benefits they recieve from using peppermint. Peppermint contains high amounts of menthol which is an antispasmotic and smooth muscle relaxant.

     Keeping a Journal
Many members promote the keeping of aq journal. You will find that this type of record is much more accurate trhan our memories plus it is a good reference when talking to the dr or going back to look for similar experiences. My journal has helped me immensely over the years.

     Cravings

Chart: what do food cravings mean (nutrient shortage indicated by cravings)... scroll down the page, chart is at bottom)
http://betterraw.com...-you-chart.html

Members frequently mention cravings during withdrawal. Ten mention craving sugar, 7 mention craving carbs, 3 salt, 2 coffee, and they also mention ice, ice cream, oranges and orange juice, pineapple.

It is interesting that these items has a unique dietary profile.
Coffee raises tyrosine and dopoamine
Salt and ice cream are high in sodium, calcium and magnesium (electrolytes)
Oranges, orange juice and pineapple are high in bioflavanoids and vitamin C as well as sugar.
The sugar craving may be because of low blood sugar during withdrawal which has been mentioned by many members.

16 members mention developing low blood sugar during withdrawal, usually associated with headaches or dizziness. 2 members mentioned that their blood sugar readings were like a rollercoaster during withdrawal and 4 mentioned it stayed normal. I could not find any research articles linking Cymbalta withdrawal to hypoglycemia.

     Stimulants (Make anxiety worse)

Caffeine
Over-the-counter cold preparations contain phenylpropylamine and pseudoephedrine*
Sleep deprivation
m*********
Magnesium*
MSG
Alcohol
Stress
amphetamines
ecstasy
nicotine
Ginseng
L-Tyrosine
B Vitamins*
aspartame
Coconut Oil
Taurine
DHEA
Ginkgo
Iodine
Arginine
Sugar
Kava
* - Only some people have this reaction.

Things containing caffeine..
Coffee, Espresso, Cappuccino, some Teas, Low calorie, non-cola soda containing aspartame, Low calorie colas containing aspartame or saccharine, Energy drinks, Some types of alcoholic drinks.
Chocolate ....Baking, Dark, Sweet and semisweet, Pudding, Cereals, Fudge , Milk chocolate, Syrup, Mousse, Soymilk, Fat free cookies, Cookies, Cake, Frozen Yogurt, Ice cream, Frosting, and Shakes .
Java Pops, Chai Mints, Green Tea, Warp Mints, Penguin mints, and cinnamons. Caffeinated Energy Strips, Caffeinated Fruity Lollipops, HyDrive Energy Chews, Caffeinated Nixie Tubes, Foosh Energy Mints, Atomic Energy Bites, Buzz Bites, KickBricks, Energy Chews, Reload Energy Strips, Movit Gummies, Caffeinated jellybeans, Morning Spark, Oatmeal, Sumseeds (caffeinated sunflower seeds), Lightning Rods (beef sticks), Engobi "Energy Go Bites" (crispy snacks), Jolt Gum, Blitz Energy Gum, Think Gum Stay Alert, Vibe Black, Black Go Fast!, Dozens and dozens of herbal supplements.
https://www.caffeine...ffeine-database
List of energy drinks with caffiene. (over 100)

FCB - Air, I'd think coffee is better than the diet coke! Those artificial sweeteners can really mess with your body and mind (anxiety-creating, among other effects) plus the other junk that is in pop. Coffee on the other hand, has been found to have health benefits. Dark roast coffee has less caffeine. Sweeten it with honey or maple syrup - they have a medium glycemic index and have other health benefits, and sweeter than sugar so you use less (or try stevia, I heard the body does not process stevia as a sugar).

http://www.cymbaltaw...ety/?hl=improve
What makes anxiety worse.

     Depressants (Make depression worse)

Oxalic acid is found in members of the spinach family and cabbage, broccoli, brussels sprouts, chives and lamb's quarters are high in oxalates, as are sorrel and parsley. Rhubarb leaves contain about 0.5% oxalic acid.
Can cause depression, lack of minerals, kidney stones, and more. Cooking does not affect oxalic acid. People with kidney disease, a history of kidney stones or suffer from depression should avoid these foods.

Aspartame
Gluten
High Fat Dairy
Sugar
alcohol
Trans fats
Sodium
Caffiene
Pesticide residue on foods
GHB
Organic solvents (paint, varnish, stains, cleaning solvents, paint thinner, etc).
------------------------------------------------------------------------------------------------------
                             Mammalian diving reflex

The diving reflex, also known as the diving response and mammalian diving reflex is a response to immersion that overrides the basic homeostatic reflexes, which is found in all air-breathing vertebrates. It optimizes respiration by preferentially distributing oxygen stores to the heart and brain which allows staying underwater for extended periods of time. It is exhibited strongly in humans, in particular babies up to 6 months old. The greatest bradycardia effect is induced when the subject is holding breath with face submerged.

Method description - The Dive Reflex, originally noted in cold water diving, is a first rate vagus nerve stimulation method capable of rapidly chilling down anxiety, panic, stress and body-wide inflammation as well as elevating moods. At first the dive reflex was done by dipping the face from the lips to the scalp line into very cold water for 30 seconds to 1 minute. This would quickly melt away anxiety and stress. Later it was found that a large zip-lock plastic bag filled with ice or ice cubes applied to the face from the scalp line to the lips would perform as well without leaving the user appearing like they just emerged from a river. The Dive Reflex, because of its ability to stimulate the vagus nerve, has proved helpful for:

Swift reduction of all forms of anxiety.
Rapidly dampening down a panic attack.
Performance anxiety, test anxiety, and phobia work.
Reducing body-wide inflammation.
Use in lowering intense fight/flight in PTSD work.
Reducing stress.
Lowering anger.
Thwarting worry and rumination.
Elevating moods.

https://www.ncbi.nlm...les/PMC3768097/
Harnessing the suprabulbar circuits of origin that control diving physiology may promote feedback therapies designed to remedy high HR and hypertension associated with anxiety.
------------------------------------------------------------------------------------------------------------

 


#14 fishinghat

fishinghat

    God-like

  • Active Members
  • PipPipPipPipPipPipPipPip
  • 7,169 posts
  • LocationMissouri

Posted 26 December 2017 - 04:20 PM

                                                   Major Natural Human Supplements

SAMe - S-Adenosyl methionine is a common substrate involved in methylmethyl group transfers, transsulfuration, and aminopropylation. Although these reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids etc. The half-life is about 100 minutes. Wiki

Safety and side effects

Side effects from SAMe are rare and, if they occur, usually mild.
SAMe can cause:
⦁ Upset stomach
⦁ Nausea
⦁ Mild insomnia
⦁ Dizziness
⦁ Irritability
⦁ Anxiety
⦁ Sweating
⦁ Constipation
⦁ Diarrhea Mayo

Possible interactions include:

⦁ Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
⦁ Antipsychotics. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Amphetamines. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Dextromethorphan. Taking SAMe with this cough suppressant could increase the risk of serotonin syndrome.
⦁ Narcotics. Taking SAMe with meperidine (Demerol) or tramadol (Ultam, ConZip) could increase the risk of serotonin syndrome.
⦁ St. John's wort. Be cautious when taking this supplement with SAMe. The combination could cause serotonin syndrome.
Mayo

https://nccih.nih.go...upplements/SAMe
S-Adenosyl methionine (SAM-e); In Depth
At least 40 studies in people have evaluated SAMe for depression, and many of them showed evidence of beneficial effects. However, most of these trials lasted only a few weeks, included a small number of participants, and were not of the highest scientific quality. Also, some studies used injected SAMe rather than an oral form (taken by mouth).

https://examine.com/...syl-methionine/
Detailed summary of scientific studies including safety, dose, interactions, etc.
Great info.

https://www.ncbi.nlm...pubmed/27727432
Not useful in treating depression.

-------------------------------------------------------------------------------------------------------
5HTP
http://www.umm.edu/h...tryptophan-5htp
Overview
5-hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan (an essential amino acid that you get from food). After tryptophan is converted into 5-HTP, the chemical is changed into another chemical called serotonin (a neurotransmitter that relays signals between brain cells). 5-HTP dietary supplements help raise serotonin levels in the brain.
A 2002 review concluded that although the data evaluated suggests that 5-HTP is more effective than placebo in the treatment of depression, the evidence was insufficient to be conclusive due to a severe lack of high quality research. More and larger studies are needed to determine if 5-HTP is truly effective in treating depression. Wiki

Safety

5-HTP is POSSIBLY SAFE when taking by mouth appropriately. 5-HTP has been used safely in doses up to 400 mg daily for up to one year. However, some people who have taken it have developed a condition called eosinophilia-myalgia syndrome (EMS), a serious condition involving extreme muscle tenderness (myalgia) and blood abnormalities (eosinophilia). Some people think EMS might be caused by an accidental ingredient or contaminant in some 5-HTP products. However, there is not enough scientific evidence to know if EMS is caused by 5-HTP, a contaminant, or some other factor. Until more is known, 5-HTP should be used cautiously.

Other potential side effects of 5-HTP include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems.

5-HTP is POSSIBLY UNSAFE when taken by mouth in large doses. Doses from 6-10 grams daily have been linked to severe stomach problems and muscle spasms.

Special precautions & warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking 5-HTP if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Surgery: 5-HTP can affect a brain chemical called serotonin. Some drugs administered during surgery can also affect serotonin. Taking 5-HTP before surgery might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Tell patients to stop taking 5-HTP at least 2 weeks before surgery.

Are there interactions with medications?

Major Do not take this combination.
Medications for depression (Antidepressant drugs)
5-HTP increases a brain chemical called serotonin. Some medications for depression also increase serotonin. Taking 5-HTP along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking medications for depression.

Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.

Medications for depression (MAOIs)
5-HTP increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking 5-HTP with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Moderate Be cautious with this combination.

Carbidopa (Lodosyn)
5-HTP can affect the brain. Carbidopa (Lodosyn) can also affect the brain. Taking 5-HTP along with carbidopa can increase the risk of serious side effects including rapid speech, anxiety, aggressiveness, and others.

Dextromethorphan (Robitussin DM, and others)
5-HTP can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking 5-HTP along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking dextromethorphan (Robitussin DM, and others).

Meperidine (Demerol)
5-HTP increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking 5-HTP along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.

Pentazocine (Talwin)
5-HTP increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking 5-HTP along with pentazocine (Talwin) might increase serotonin too much. This might cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking pentazocine (Talwin).

Sedative medications (CNS depressants)
5-HTP might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking 5-HTP along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Tramadol (Ultram)
5-HTP increases a brain chemical called serotonin. Tramadol (Ultram) can also increase serotonin. Taking 5-HTP along with tramadol (Ultram) might cause too much serotonin in the brain and might result in side effects including confusion, shivering, stiff muscles, and others.

Are there interactions with herbs and supplements?

Herbs and supplements with sedative properties

5-HTP can cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, skullcap, valerian, yerba mansa, and others.

Herbs and supplements with serotonergic properties
5-HTP increases a brain chemical called serotonin. Taking 5-HTP along with other herbs and supplements that increase serotonin might lead to too much serotonin and cause side effects including heart problems, shivering and anxiety. Other herbs and supplements that increase serotonin levels include Hawaiian baby woodrose, L-tryptophan, S-adenosylmethionine (SAMe), and St. John's wort.

A total of 74 drugs (242 brand and generic names) are known to interact with 5-hydroxytryptophan.
55 major drug interactions
19 moderate drug interactions
For the complete list and to see what the interaction is go to:
http://www.drugs.com...3&generic_only=

Member comments

No brain zaps in 5 days

I decided to stop taking it completely b/c I really didn't think it was doing much of anything for me/I wasn't withdrawl-ing and started taking 25 to 50 mg 5-HTP about a week ago. The 5-HTP doesn't really seem to be helping me. I am feeling more depressed...

The brain zaps are horrid, but 5-HTP really does ease them dramatically. I'm taking 100mg in the morning, and 50mg before bed. It really does help you sleep, and lifts your mood.

Tria - My head seems clearer and I just seem to feel more normal (knock on wood - don't want to jinx myself!) I can't say this is all due to the 5-HTP as she started me on a few other supplements as well but I only start one new supplement at a time, give it a couple weeks then start another, and my mood did improve after starting the 5-HTP.

AKAnole - I took 150mg of 5HTP every day for a few months. I stopped in December thinking I no longer needed it then over the holidays the depression came back suddenly.

brz - i am still not sure how best to take 5htp, it seems to work on a delayed "as needed" basis. does that make sense? it takes about a day to kick in but as soon as i get my anxiety under control it doesn't seem to be a problem to just stop. - which is not what i was expecting when i started last october. since many people take it on a regular basis, that is what i do. i take one 100mg time release pill every morning. just wanted to pass along my experience. however, while i have had good results from the 5htp for anxiety, i can't speak to its effectiveness as a sleep aid.

Analreland - Someone also suggested 5HTP, which is not for sale in Ireland

Penguin1982 - There was a post I read that even though the half life is only 12 hrs, it can stay in your liver and fat stores for months. Didn't realize that when I started supplementing with 200mg 5htp and 750mg GABA at night only to find myself peeing every ten min and shivering beyond control. After seeing that post I realized I was getting waaaay too much serotonin and creating serotonin syndrome for myself . I've since stopped both and seem to b coming back around .

AKAnole - 5 HTP to supplement the lack of serotonin that I was experiencing. It helped but didn't curb the anxiety I would experience at times. L-Tryptophan which I think works better for me mood wise but I can't take it at night or else it disrupts my sleep

brzghoff - most recently i've experimented with 5htp which has been effective.

FN - 5HTP worked/works great for me as well ... I did stop using it daily, and have been using it just once in a while, and was doing just fine ... however, I'm now actually considering going back on it daily, as I've been working a really stressful temp job, and I'm starting to feel a bit "unsteady" ...

There is a rebound effect from 5-htp if it is stopped cold turkey. Next time try phasing it out over a 2 week period and you will do a lot better

http://www.cymbaltaw...5-htp/?hl=helps
5thp information and discussion.

https://examine.com/supplements/5-htp/
Detailed summary of scientific studies on 5HTP including anxiety and depression.

https://www.ncbi.nlm...les/PMC3415362/
Lack of effectiveness and dangers of its use.

5-HTP is not found in the foods we eat, although tryptophan is. Eating foods with tryptophan does not increase 5-HTP levels very much, however. As a supplement, 5-HTP is made from the seeds of an African plant called Griffonia simplicifolia.
Source: http://www.umm.edu/a...m#ixzz2Q0VyOr4w

1. 5-HTP is changed into serotonin
2. Our body uses tryptophan to make 5-HTP
3. Vitamin B6, vitamin C, folic acid and magnesium are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption.
4. Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
5. Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
6. The following foods contain tryptophan: red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.

5-HTP can be a wonder drug for anxiety and depression but MUST be used correctly.
1st – Start out slow. Build slow
50 mg once per day for 3 days
50 mg twice a day for 3 days
50 mg three times per day for 3 days then
50-50-75 for 3 days
50-75-75 for 3 days
75-75-75 dor 3 dats and then
100-75-75
100-100-75
100- 3 times a day (maximum dose).
As you ramp up watch for stomach upset (stop at that point)
If at anytime your symptoms are minimal do not go up any more.

2nd – Absolutely do not take with a ssri/snri as it may cause seratonin syndrome (easily recognized by a fever over 102F.
3rd – Check list of incompatable drugs. Drugs.com
4th – After you have been emotionally stable for a couple weeks you need to slowly, slowly decrease the 5-HTP as your system may not need as much now that it has had a chance to catch up. Many people start out using 150 mg/day and feel fine and then taper down to 75 mg for the long haul. This is important as with long term usage 5-HTP can deplete some necessary nutrients in the body.
5th – 5-HTP can be gotten for our body by consuning foods rich in tryptophan along with a small supplement of Vitamin B6, vitamin C, folic acid and magnesium. Foods high in tryptophan include red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.
6th - Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
7th - Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
-----------------------------------------------------------------------------------------------------------
L-theanine:

Member's comments

(puritan's pride) 200 mg capsules 2- 3/ day. I have been taking this prior to cymbalta detox. It helped me reduce my dosage of clonazepam. Within 20-30 mins I feel more calm. I do believe it is helping keep the anxiety in check.

Tinabee - For now I have started taking fish oil and a supplement called Theanine Serene that is supposed to help with anxiety. I know it sounds silly since I've only taken the anxiety supplement for a couple days but I really feel like it has helped.

200mg L-Theanine in the morning with a full glass of water on an empty stomach, you can take again in late afternoon 100 to 200 mg if needed (make sure it is suntheanine - it helps with headaches and pain as any painkiller I had just did not cut it)

Member's comments were generally favorable.

http://www.cymbaltaw...page-2?hl=helps
Page 1 and 2, detailed information on L theanine and its usage.

Research

The research shows that all green tea leaves contain both L-theanine and D- theanine BUT only the special processing used by the manufacturer produces pure L-Theanine and is the choice of many of the research biologists.

https://www.ncbi.nlm...pubmed/22214254
https://www.ncbi.nlm...pubmed/16759779
https://www.ncbi.nlm...pubmed/14755608

Rapid Commun Mass Spectrom. 2004;18(3):251-6.
Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry.
⦁ Abstract
Theanine, a naturally occurring non-proteinic amino acid found in tea leaves, has demonstrated wide-ranging physiological activity, from lowering blood pressure to enhancing the anti-tumor activity of chemotherapeutic drugs. The chiral nature of theanine suggests that enantiospecificity plays a significant role in its various pharmacological functions. Using the Chirobiotic T (teicoplanin) chiral stationary phase, native and derivatized theanine enantiomers were separated and detected via high-performance liquid chromatography (HPLC) coupled to atmospheric pressure ionization mass spectrometry (API-MS). With the use of flow rates compatible with each ionization source, native theanine standards achieved excellent sensitivity and detection limits (10 ng/mL) for both atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI). Optimum sensitivity and detection limits for derivatized theanine standards were achieved using ESI-MS. The enantiomeric composition of six commercially available L-theanine samples was evaluated using the high-flow APCI-MS method and confirmed with photodiode array detection. Five of the six products contained significant amounts of D-theanine. Only one product, SunTheanine, appeared to contain only the L-theanine enantiomer.

https://www.ncbi.nlm...les/PMC3049752/
Note - Suntheanine is the pure ingredient and that is what you want. That is the pure L-theanine. D-theanine is not absorbed by our bodies.
L-theanine is an amino acid precursor to glutamate and glutamine.

Key Points

It can cross the blood brain barrier. It is only produced by plants and fungi. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements.Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance in combination with caffeine. In combination with caffeine it may increase anxiety.

Scientific Information

A National Standard monograph that reviews current research on theanine reports that it is likely safe in doses of 200–250 mg up to a maximum daily dose of 1,200 mg. Theanine is used to help with anxiety, blood pressure control, mood, and cognition. Natural Standard rates the evidence to support the usage for anxiety, blood pressure control, and mood as “unclear or conflicting scientific evidence” and the evidence for cognition as “fair negative scientific evidence.” Many of the studies of theanine were done in combination with caffeine as found in tea. While the studies found that the combination had some effect on mood, the studies found that theanine alone had little effect. More sufficiently designed studies in humans are warranted to further our understanding of the effects of theanine.

https://www.ncbi.nlm...pubmed/21208586
Effective, 400 mg/day
https://www.ncbi.nlm...pubmed/15378679
Not effective on anxiety, 200 mg/day
https://www.ncbi.nlm...les/PMC4137547/
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.


Recommendations

"The basic metabolic process is ...
Tryptophan to 5HTP to seratonin to melatonin."

First of all assess if you may need additional dietary input.

"Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan." The most common of these seam to be the anxiety traits (eg. irritability) and the craving of carbohydrates.

Second determine what is needed for this process.

This includes Vitamin B6, vitamin C, folic acid and magnesium which are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption. A review of your diet can shed some light on how much of each is currently available to your body. Adding unneeded amounts of some of these can actually be detrimental. Blood test can be done for the B vitamins (a standard test for new psychiatric pstients with may pdocs). A blood test is also available for blood magnesium levels.

One complication is the interference of tyrosine and phenylalanine to the uptake of L-tryptophan. A recommended daily intake for phenylalanine and tyrosine is 25 mg per kilogram of body weight, or 11 mg per pound. For a 70 kg person this is 1750 mg (phenylalanine + tyrosine).

Unluckily these compounds are found in nearly the same food as L-Tryptophan. Tyrosine, which can also be synthesized in the body from phenylalanine, is found in many high-protein food products such as chicken, turkey, fish, milk, yogurt, cottage cheese, cheese, peanuts, almonds, pumpkin seeds, sesame seeds, soy products, lima beans, avocados, and bananas. For example, the white of an egg has about 250 mg per egg, while lean beef/lamb/pork/salmon/chicken/turkey contains about 1000 mg per 3 ounces (85 g) portion. So increasing you ingestion of these foods may not provide more L-tryptophan to your body and therefore a supplement might be considered.

Third, what else interfers with the conversion of tryptophan to serotonin.

Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes. So..no smoking, keep blood sugar levels in normal range, no drinking (alcoholic) and moderate protein ingestion. Again the excessive protein ingestion may cause interference by tyrosine and phenylalanine to the uptake of L-tryptophan.

How else to control seratonin levels.

The conversion of seratonin to melatonin at night helps our body deplete excessive seratonin and gives the brain a chance to rest/relax and repair. Once light dims below 25 watts the pineal gland in the brain begins to convert seratonin to melatonin which is used to cause sleepiness in the evenings. Many block ut the windows in there bedroom and regulate light levels carefully after 5 PM.

How to try to get L-tryptophan levels increased in the body.

Can not be synthsized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.

http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm (200 mg) per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs of white poultry meat per day with an upper limit of 4 lbs per day (not practical). I would suggest around 0.5 lbs of white poultry meat per day. Increasing the L-Tryptophan levels will give your body a chance to absorb additional amounnts if the interferences are minimal.

FH - Do I follow this diet? Yes I do. I can't say it has cured my anxiety but I do find it slightly improved and definitely more stable.

What if it is not effective.

If this regime is not effective then the substitution of L-Tryptophan supplements might be in order as described above. This would eliminate the risk of tyrosine and phenylalanine interference. Work with your dr and the schedule above to build up slowly and cut back once stabilized.

-------------------------------------------------------------------------------------------------------------
L- tyrosine

An amino acid. Tyrosine is a hydrophilic amino acid and is significantly less soluble in water than its precursor, phenylalinine.
L-phenylalinine is converted by the body to L-tyrosine which is changed to L-DOPA then to dopamine followed by norepiniphrine and finally epinephrine (adrenaline).

Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),but has little if any effect on mood in normal subjects. The effect on mood is noted in humans subjected to stressful conditions.

A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue, prolonged work and sleep deprivation, with reductions in stress hormone levels, reductions in stress-induced weight loss seen in animal trials, and improvements in cognitive and physical performance seen in human trials. Wiki

Member Comments

a neurostransmitter to help mental alertness and helps support glands especially the thyroid. I take 750 mg capsule 2x's/day
doriono - I was having anxiaty attacks all the time. I trid all sorts of supplements and finnally tried L-Tyrosine. It work like a miracle! I used NOW L-Tyrosine for 3 month and never got an attack again. It's been 6 months now.

Tomitsu - L-Tyrosine also helped me

https://examine.com/...nts/l-tyrosine/
Details the results of over 50 research articles on L-tyrosine.

No significant link found for L-tyrosine in fighting anxiety or depression.
-------------------------------------------------------------------------------------------------------------
L Tryptophan is an amino acid essential for human life and cannot be synthesized by our body, and therefore must be part of our diet. In addition, tryptophan functions as a biochemical precursor for Serotonin synthesized via tryptophan. Serotonin, in turn, can be converted to melatonin. Niacin is synthesized from tryptophan. L-tyrosine and phenylalanine compete with tryptophan for absorption.

If you don’t get enough l-tyrosine in your diet, or your body doesn’t properly convert it, you won’t be able to synthesize adequate dopamine. When looking for a supplement, consider n-acetyl-l-tyrosine. This is a highly absorbable form of l-tyrosine that readily enters the brain. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease. One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions. Webmd.com

Key Points

Can not be synthesized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.

http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs od white poultry meat per day.

This supplement must be taken together with vitamin C, magnesium and B-complex vitamins to support the transformation of tryptophan into serotonin.

L tryptophan reacts with most antidepressants (seratonin syndrome), MAOIs, benzos and sedatives. There is an extensive number of drug interactions. Please research before use.

Scientific Information

Dietary sources

Tryptophan is a routine constituent of most protein-based foods or dietary proteins. It is particularly plentiful in chocolate, oats, dried dates, milk, yogurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, almonds, sunflower seeds, pumpkin seeds, buckwheat, spirulina, bananas, and peanuts. Contrary to the popular belief that turkey contains an abundance of tryptophan, the tryptophan content in turkey is typical of poultry.

Tryptophan (Trp) Content of Various Foods
Food Tryptophan
[g/100 g of food] Protein
[g/100 g of food] Tryptophan/Protein [%]
egg white, dried 1.00 81.10 1.23
spirulina, dried 0.93 57.47 1.62
cod, atlantic, dried 0.70 62.82 1.11
soybeans, raw 0.59 36.49 1.62
cheese, Parmesan 0.56 37.90 1.47
sesame seed 0.37 17.00 2.17
cheese, cheddar 0.32 24.90 1.29
sunflower seed 0.30 17.20 1.74
pork, chop 0.25 19.27 1.27
turkey 0.24 21.89 1.11
chicken 0.24 20.85 1.14
beef 0.23 20.13 1.12
oats 0.23 16.89 1.39
salmon 0.22 19.84 1.12
lamb, chop 0.21 18.33 1.17
perch, Atlantic 0.21 18.62 1.12
chickpeas, raw 0.19 19.30 0.96
egg 0.17 12.58 1.33
wheat flour, white 0.13 10.33 1.23
baking chocolate, unsweetened 0.13 12.9 1.23
milk 0.08 3.22 2.34
rice, white, medium-grain, cooked 0.028 2.38 1.18
quinoa, uncooked 0.167 14.12 1.2
quinoa, cooked 0.052 4.40 1.1
potatoes, russet 0.02 2.14 0.84
tamarind 0.018 2.80 0.64
banana 0.01 1.03 0.87


L-tryptophan is possibly unsafe when taken by mouth. It has been linked to over 1500 reports of eosinophilia-myalgia syndrome (EMS) and 37 deaths. EMS is a neurological condition with symptoms that include fatigue; intense muscle pain; nerve pain; skin changes; baldness; rash; and pain and swelling affecting the joints, connective tissue, lungs, heart, and liver. Symptoms tend to improve over time, but some people may still experience symptoms up to 2 years after they develop EMS. Some people report that their symptoms have never gone away completely. Since the FDA has limited the doses available the occurrence of EMS has markedly dropped.

L-tryptophan can cause some side effects such as heartburn, stomach pain, belching and gas, nausea, vomiting, diarrhea, and loss of appetite. It can also cause headache, lightheadedness, drowsiness, dry mouth, visual blurring, muscle weakness, and sexual problems. This supplement must be taken together with vitamin C and B-complex vitamins to support the transformation of tryptophan into serotonin. Dosages range from 5 to 1000 mg/day.

http://www.ncbi.nlm....les/PMC3195213/
http://www.ncbi.nlm....les/PMC2908021/

brz - how well does the st john's wort work for anxiety? it makes it worse for me, same with L tryptophan. i checked into l tryptophan. after doing a lot of research i picked some up and took one 500 mg capsule tuesday night. within 20-30 min it kicked in. real mellow, i wasn't able to go to sleep right away, but was very comfortable for an hour before dozing off. slept all night the next day i felt great! wednesday night i took one 500 mg capsule. within 20-30 min i felt hyper, my heart rate went up and boom! anxiety! it was terrible. i was up for several hours

TM - The experiment with L-Tryptophan didn't work. That's okay-- forget about it. I'm old school: I'm suspicious of supplements and won't take any. I think they are another crap-shoot.

General Comments

http://www.cymbaltaw...rove#entry72249
In formation on SAM-e, L-tryptophan and 5htp.

Special Note

Metabolic limitations - All of these items mentioned above are 'natural' in our diets and/or body. However, each has to have certain enzymes, vitamins (such as B6, B12, Vit C, etc.), minerals or other components to be processes into dopamine, serotonin, adrenaline or other neurotransmitters. They may also have items which compete with them in the body such as tyrosine or phenylalanine. The reactions may or may not produce more or less of a neurotransmitter but will that even get to the brain? Many of these products just don't cross the blood brain barrier (a membrane around the brain) so even though they are produced they do no good for mood. Some require special enzymes, insulin, certain proteins, etc to cross the barrier and all these items have their own requirements and limitations. This becomes clearly evident in looking at all the individual comments on these supplements. The effects are all over the place. Each persons body is different and has its own nutritional shortages or overages and therefore it may be im possible to tell in advance what reaction may occur to one of these supplements.




 





0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users