Major Natural Human Supplements
SAMe - S-Adenosyl methionine is a common substrate involved in methylmethyl group transfers, transsulfuration, and aminopropylation. Although these reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids etc. The half-life is about 100 minutes. Wiki
Safety and side effects
Side effects from SAMe are rare and, if they occur, usually mild.
SAMe can cause:
⦁ Upset stomach
⦁ Mild insomnia
⦁ Diarrhea Mayo
Possible interactions include:
⦁ Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
⦁ Antipsychotics. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Amphetamines. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Dextromethorphan. Taking SAMe with this cough suppressant could increase the risk of serotonin syndrome.
⦁ Narcotics. Taking SAMe with meperidine (Demerol) or tramadol (Ultam, ConZip) could increase the risk of serotonin syndrome.
⦁ St. John's wort. Be cautious when taking this supplement with SAMe. The combination could cause serotonin syndrome.
S-Adenosyl methionine (SAM-e); In Depth
At least 40 studies in people have evaluated SAMe for depression, and many of them showed evidence of beneficial effects. However, most of these trials lasted only a few weeks, included a small number of participants, and were not of the highest scientific quality. Also, some studies used injected SAMe rather than an oral form (taken by mouth).
Detailed summary of scientific studies including safety, dose, interactions, etc.
Not useful in treating depression.
5-hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan (an essential amino acid that you get from food). After tryptophan is converted into 5-HTP, the chemical is changed into another chemical called serotonin (a neurotransmitter that relays signals between brain cells). 5-HTP dietary supplements help raise serotonin levels in the brain.
A 2002 review concluded that although the data evaluated suggests that 5-HTP is more effective than placebo in the treatment of depression, the evidence was insufficient to be conclusive due to a severe lack of high quality research. More and larger studies are needed to determine if 5-HTP is truly effective in treating depression. Wiki
5-HTP is POSSIBLY SAFE when taking by mouth appropriately. 5-HTP has been used safely in doses up to 400 mg daily for up to one year. However, some people who have taken it have developed a condition called eosinophilia-myalgia syndrome (EMS), a serious condition involving extreme muscle tenderness (myalgia) and blood abnormalities (eosinophilia). Some people think EMS might be caused by an accidental ingredient or contaminant in some 5-HTP products. However, there is not enough scientific evidence to know if EMS is caused by 5-HTP, a contaminant, or some other factor. Until more is known, 5-HTP should be used cautiously.
Other potential side effects of 5-HTP include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems.
5-HTP is POSSIBLY UNSAFE when taken by mouth in large doses. Doses from 6-10 grams daily have been linked to severe stomach problems and muscle spasms.
Special precautions & warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking 5-HTP if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Surgery: 5-HTP can affect a brain chemical called serotonin. Some drugs administered during surgery can also affect serotonin. Taking 5-HTP before surgery might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Tell patients to stop taking 5-HTP at least 2 weeks before surgery.
Are there interactions with medications?
Major Do not take this combination.
Medications for depression (Antidepressant drugs)
5-HTP increases a brain chemical called serotonin. Some medications for depression also increase serotonin. Taking 5-HTP along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking medications for depression.
Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.
Medications for depression (MAOIs)
5-HTP increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking 5-HTP with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Moderate Be cautious with this combination.
5-HTP can affect the brain. Carbidopa (Lodosyn) can also affect the brain. Taking 5-HTP along with carbidopa can increase the risk of serious side effects including rapid speech, anxiety, aggressiveness, and others.
Dextromethorphan (Robitussin DM, and others)
5-HTP can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking 5-HTP along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking dextromethorphan (Robitussin DM, and others).
5-HTP increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking 5-HTP along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.
5-HTP increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking 5-HTP along with pentazocine (Talwin) might increase serotonin too much. This might cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking pentazocine (Talwin).
Sedative medications (CNS depressants)
5-HTP might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking 5-HTP along with sedative medications might cause too much sleepiness.
Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
5-HTP increases a brain chemical called serotonin. Tramadol (Ultram) can also increase serotonin. Taking 5-HTP along with tramadol (Ultram) might cause too much serotonin in the brain and might result in side effects including confusion, shivering, stiff muscles, and others.
Are there interactions with herbs and supplements?
Herbs and supplements with sedative properties
5-HTP can cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, skullcap, valerian, yerba mansa, and others.
Herbs and supplements with serotonergic properties
5-HTP increases a brain chemical called serotonin. Taking 5-HTP along with other herbs and supplements that increase serotonin might lead to too much serotonin and cause side effects including heart problems, shivering and anxiety. Other herbs and supplements that increase serotonin levels include Hawaiian baby woodrose, L-tryptophan, S-adenosylmethionine (SAMe), and St. John's wort.
A total of 74 drugs (242 brand and generic names) are known to interact with 5-hydroxytryptophan.
55 major drug interactions
19 moderate drug interactions
For the complete list and to see what the interaction is go to:
No brain zaps in 5 days
I decided to stop taking it completely b/c I really didn't think it was doing much of anything for me/I wasn't withdrawl-ing and started taking 25 to 50 mg 5-HTP about a week ago. The 5-HTP doesn't really seem to be helping me. I am feeling more depressed...
The brain zaps are horrid, but 5-HTP really does ease them dramatically. I'm taking 100mg in the morning, and 50mg before bed. It really does help you sleep, and lifts your mood.
Tria - My head seems clearer and I just seem to feel more normal (knock on wood - don't want to jinx myself!) I can't say this is all due to the 5-HTP as she started me on a few other supplements as well but I only start one new supplement at a time, give it a couple weeks then start another, and my mood did improve after starting the 5-HTP.
AKAnole - I took 150mg of 5HTP every day for a few months. I stopped in December thinking I no longer needed it then over the holidays the depression came back suddenly.
brz - i am still not sure how best to take 5htp, it seems to work on a delayed "as needed" basis. does that make sense? it takes about a day to kick in but as soon as i get my anxiety under control it doesn't seem to be a problem to just stop. - which is not what i was expecting when i started last october. since many people take it on a regular basis, that is what i do. i take one 100mg time release pill every morning. just wanted to pass along my experience. however, while i have had good results from the 5htp for anxiety, i can't speak to its effectiveness as a sleep aid.
Analreland - Someone also suggested 5HTP, which is not for sale in Ireland
Penguin1982 - There was a post I read that even though the half life is only 12 hrs, it can stay in your liver and fat stores for months. Didn't realize that when I started supplementing with 200mg 5htp and 750mg GABA at night only to find myself peeing every ten min and shivering beyond control. After seeing that post I realized I was getting waaaay too much serotonin and creating serotonin syndrome for myself . I've since stopped both and seem to b coming back around .
AKAnole - 5 HTP to supplement the lack of serotonin that I was experiencing. It helped but didn't curb the anxiety I would experience at times. L-Tryptophan which I think works better for me mood wise but I can't take it at night or else it disrupts my sleep
brzghoff - most recently i've experimented with 5htp which has been effective.
FN - 5HTP worked/works great for me as well ... I did stop using it daily, and have been using it just once in a while, and was doing just fine ... however, I'm now actually considering going back on it daily, as I've been working a really stressful temp job, and I'm starting to feel a bit "unsteady" ...
There is a rebound effect from 5-htp if it is stopped cold turkey. Next time try phasing it out over a 2 week period and you will do a lot better
5thp information and discussion.
Detailed summary of scientific studies on 5HTP including anxiety and depression.
Lack of effectiveness and dangers of its use.
5-HTP is not found in the foods we eat, although tryptophan is. Eating foods with tryptophan does not increase 5-HTP levels very much, however. As a supplement, 5-HTP is made from the seeds of an African plant called Griffonia simplicifolia.
1. 5-HTP is changed into serotonin
2. Our body uses tryptophan to make 5-HTP
3. Vitamin B6, vitamin C, folic acid and magnesium are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption.
4. Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
5. Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
6. The following foods contain tryptophan: red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.
5-HTP can be a wonder drug for anxiety and depression but MUST be used correctly.
1st – Start out slow. Build slow
50 mg once per day for 3 days
50 mg twice a day for 3 days
50 mg three times per day for 3 days then
50-50-75 for 3 days
50-75-75 for 3 days
75-75-75 dor 3 dats and then
100- 3 times a day (maximum dose).
As you ramp up watch for stomach upset (stop at that point)
If at anytime your symptoms are minimal do not go up any more.
2nd – Absolutely do not take with a ssri/snri as it may cause seratonin syndrome (easily recognized by a fever over 102F.
3rd – Check list of incompatable drugs. Drugs.com
4th – After you have been emotionally stable for a couple weeks you need to slowly, slowly decrease the 5-HTP as your system may not need as much now that it has had a chance to catch up. Many people start out using 150 mg/day and feel fine and then taper down to 75 mg for the long haul. This is important as with long term usage 5-HTP can deplete some necessary nutrients in the body.
5th – 5-HTP can be gotten for our body by consuning foods rich in tryptophan along with a small supplement of Vitamin B6, vitamin C, folic acid and magnesium. Foods high in tryptophan include red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.
6th - Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
7th - Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
(puritan's pride) 200 mg capsules 2- 3/ day. I have been taking this prior to cymbalta detox. It helped me reduce my dosage of clonazepam. Within 20-30 mins I feel more calm. I do believe it is helping keep the anxiety in check.
Tinabee - For now I have started taking fish oil and a supplement called Theanine Serene that is supposed to help with anxiety. I know it sounds silly since I've only taken the anxiety supplement for a couple days but I really feel like it has helped.
200mg L-Theanine in the morning with a full glass of water on an empty stomach, you can take again in late afternoon 100 to 200 mg if needed (make sure it is suntheanine - it helps with headaches and pain as any painkiller I had just did not cut it)
Member's comments were generally favorable.
Page 1 and 2, detailed information on L theanine and its usage.
The research shows that all green tea leaves contain both L-theanine and D- theanine BUT only the special processing used by the manufacturer produces pure L-Theanine and is the choice of many of the research biologists.
Rapid Commun Mass Spectrom. 2004;18(3):251-6.
Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry.
Theanine, a naturally occurring non-proteinic amino acid found in tea leaves, has demonstrated wide-ranging physiological activity, from lowering blood pressure to enhancing the anti-tumor activity of chemotherapeutic drugs. The chiral nature of theanine suggests that enantiospecificity plays a significant role in its various pharmacological functions. Using the Chirobiotic T (teicoplanin) chiral stationary phase, native and derivatized theanine enantiomers were separated and detected via high-performance liquid chromatography (HPLC) coupled to atmospheric pressure ionization mass spectrometry (API-MS). With the use of flow rates compatible with each ionization source, native theanine standards achieved excellent sensitivity and detection limits (10 ng/mL) for both atmospheric pressure chemical ionization (APCI) and electrospray ionization (ESI). Optimum sensitivity and detection limits for derivatized theanine standards were achieved using ESI-MS. The enantiomeric composition of six commercially available L-theanine samples was evaluated using the high-flow APCI-MS method and confirmed with photodiode array detection. Five of the six products contained significant amounts of D-theanine. Only one product, SunTheanine, appeared to contain only the L-theanine enantiomer.
Note - Suntheanine is the pure ingredient and that is what you want. That is the pure L-theanine. D-theanine is not absorbed by our bodies.
L-theanine is an amino acid precursor to glutamate and glutamine.
It can cross the blood brain barrier. It is only produced by plants and fungi. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements.Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance in combination with caffeine. In combination with caffeine it may increase anxiety.
A National Standard monograph that reviews current research on theanine reports that it is likely safe in doses of 200–250 mg up to a maximum daily dose of 1,200 mg. Theanine is used to help with anxiety, blood pressure control, mood, and cognition. Natural Standard rates the evidence to support the usage for anxiety, blood pressure control, and mood as “unclear or conflicting scientific evidence” and the evidence for cognition as “fair negative scientific evidence.” Many of the studies of theanine were done in combination with caffeine as found in tea. While the studies found that the combination had some effect on mood, the studies found that theanine alone had little effect. More sufficiently designed studies in humans are warranted to further our understanding of the effects of theanine.
Effective, 400 mg/day
Not effective on anxiety, 200 mg/day
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.
"The basic metabolic process is ...
Tryptophan to 5HTP to seratonin to melatonin."
First of all assess if you may need additional dietary input.
"Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan." The most common of these seam to be the anxiety traits (eg. irritability) and the craving of carbohydrates.
Second determine what is needed for this process.
This includes Vitamin B6, vitamin C, folic acid and magnesium which are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption. A review of your diet can shed some light on how much of each is currently available to your body. Adding unneeded amounts of some of these can actually be detrimental. Blood test can be done for the B vitamins (a standard test for new psychiatric pstients with may pdocs). A blood test is also available for blood magnesium levels.
One complication is the interference of tyrosine and phenylalanine to the uptake of L-tryptophan. A recommended daily intake for phenylalanine and tyrosine is 25 mg per kilogram of body weight, or 11 mg per pound. For a 70 kg person this is 1750 mg (phenylalanine + tyrosine).
Unluckily these compounds are found in nearly the same food as L-Tryptophan. Tyrosine, which can also be synthesized in the body from phenylalanine, is found in many high-protein food products such as chicken, turkey, fish, milk, yogurt, cottage cheese, cheese, peanuts, almonds, pumpkin seeds, sesame seeds, soy products, lima beans, avocados, and bananas. For example, the white of an egg has about 250 mg per egg, while lean beef/lamb/pork/salmon/chicken/turkey contains about 1000 mg per 3 ounces (85 g) portion. So increasing you ingestion of these foods may not provide more L-tryptophan to your body and therefore a supplement might be considered.
Third, what else interfers with the conversion of tryptophan to serotonin.
Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes. So..no smoking, keep blood sugar levels in normal range, no drinking (alcoholic) and moderate protein ingestion. Again the excessive protein ingestion may cause interference by tyrosine and phenylalanine to the uptake of L-tryptophan.
How else to control seratonin levels.
The conversion of seratonin to melatonin at night helps our body deplete excessive seratonin and gives the brain a chance to rest/relax and repair. Once light dims below 25 watts the pineal gland in the brain begins to convert seratonin to melatonin which is used to cause sleepiness in the evenings. Many block ut the windows in there bedroom and regulate light levels carefully after 5 PM.
How to try to get L-tryptophan levels increased in the body.
Can not be synthsized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.
http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm (200 mg) per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs of white poultry meat per day with an upper limit of 4 lbs per day (not practical). I would suggest around 0.5 lbs of white poultry meat per day. Increasing the L-Tryptophan levels will give your body a chance to absorb additional amounnts if the interferences are minimal.
FH - Do I follow this diet? Yes I do. I can't say it has cured my anxiety but I do find it slightly improved and definitely more stable.
What if it is not effective.
If this regime is not effective then the substitution of L-Tryptophan supplements might be in order as described above. This would eliminate the risk of tyrosine and phenylalanine interference. Work with your dr and the schedule above to build up slowly and cut back once stabilized.
An amino acid. Tyrosine is a hydrophilic amino acid and is significantly less soluble in water than its precursor, phenylalinine.
L-phenylalinine is converted by the body to L-tyrosine which is changed to L-DOPA then to dopamine followed by norepiniphrine and finally epinephrine (adrenaline).
Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),but has little if any effect on mood in normal subjects. The effect on mood is noted in humans subjected to stressful conditions.
A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue, prolonged work and sleep deprivation, with reductions in stress hormone levels, reductions in stress-induced weight loss seen in animal trials, and improvements in cognitive and physical performance seen in human trials. Wiki
a neurostransmitter to help mental alertness and helps support glands especially the thyroid. I take 750 mg capsule 2x's/day
doriono - I was having anxiaty attacks all the time. I trid all sorts of supplements and finnally tried L-Tyrosine. It work like a miracle! I used NOW L-Tyrosine for 3 month and never got an attack again. It's been 6 months now.
Tomitsu - L-Tyrosine also helped me
Details the results of over 50 research articles on L-tyrosine.
No significant link found for L-tyrosine in fighting anxiety or depression.
L Tryptophan is an amino acid essential for human life and cannot be synthesized by our body, and therefore must be part of our diet. In addition, tryptophan functions as a biochemical precursor for Serotonin synthesized via tryptophan. Serotonin, in turn, can be converted to melatonin. Niacin is synthesized from tryptophan. L-tyrosine and phenylalanine compete with tryptophan for absorption.
If you don’t get enough l-tyrosine in your diet, or your body doesn’t properly convert it, you won’t be able to synthesize adequate dopamine. When looking for a supplement, consider n-acetyl-l-tyrosine. This is a highly absorbable form of l-tyrosine that readily enters the brain. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease. One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions. Webmd.com
Can not be synthesized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.
http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs od white poultry meat per day.
This supplement must be taken together with vitamin C, magnesium and B-complex vitamins to support the transformation of tryptophan into serotonin.
L tryptophan reacts with most antidepressants (seratonin syndrome), MAOIs, benzos and sedatives. There is an extensive number of drug interactions. Please research before use.
Tryptophan is a routine constituent of most protein-based foods or dietary proteins. It is particularly plentiful in chocolate, oats, dried dates, milk, yogurt, cottage cheese, red meat, eggs, fish, poultry, sesame, chickpeas, almonds, sunflower seeds, pumpkin seeds, buckwheat, spirulina, bananas, and peanuts. Contrary to the popular belief that turkey contains an abundance of tryptophan, the tryptophan content in turkey is typical of poultry.
Tryptophan (Trp) Content of Various Foods
[g/100 g of food] Protein
[g/100 g of food] Tryptophan/Protein [%]
egg white, dried 1.00 81.10 1.23
spirulina, dried 0.93 57.47 1.62
cod, atlantic, dried 0.70 62.82 1.11
soybeans, raw 0.59 36.49 1.62
cheese, Parmesan 0.56 37.90 1.47
sesame seed 0.37 17.00 2.17
cheese, cheddar 0.32 24.90 1.29
sunflower seed 0.30 17.20 1.74
pork, chop 0.25 19.27 1.27
turkey 0.24 21.89 1.11
chicken 0.24 20.85 1.14
beef 0.23 20.13 1.12
oats 0.23 16.89 1.39
salmon 0.22 19.84 1.12
lamb, chop 0.21 18.33 1.17
perch, Atlantic 0.21 18.62 1.12
chickpeas, raw 0.19 19.30 0.96
egg 0.17 12.58 1.33
wheat flour, white 0.13 10.33 1.23
baking chocolate, unsweetened 0.13 12.9 1.23
milk 0.08 3.22 2.34
rice, white, medium-grain, cooked 0.028 2.38 1.18
quinoa, uncooked 0.167 14.12 1.2
quinoa, cooked 0.052 4.40 1.1
potatoes, russet 0.02 2.14 0.84
tamarind 0.018 2.80 0.64
banana 0.01 1.03 0.87
L-tryptophan is possibly unsafe when taken by mouth. It has been linked to over 1500 reports of eosinophilia-myalgia syndrome (EMS) and 37 deaths. EMS is a neurological condition with symptoms that include fatigue; intense muscle pain; nerve pain; skin changes; baldness; rash; and pain and swelling affecting the joints, connective tissue, lungs, heart, and liver. Symptoms tend to improve over time, but some people may still experience symptoms up to 2 years after they develop EMS. Some people report that their symptoms have never gone away completely. Since the FDA has limited the doses available the occurrence of EMS has markedly dropped.
L-tryptophan can cause some side effects such as heartburn, stomach pain, belching and gas, nausea, vomiting, diarrhea, and loss of appetite. It can also cause headache, lightheadedness, drowsiness, dry mouth, visual blurring, muscle weakness, and sexual problems. This supplement must be taken together with vitamin C and B-complex vitamins to support the transformation of tryptophan into serotonin. Dosages range from 5 to 1000 mg/day.
brz - how well does the st john's wort work for anxiety? it makes it worse for me, same with L tryptophan. i checked into l tryptophan. after doing a lot of research i picked some up and took one 500 mg capsule tuesday night. within 20-30 min it kicked in. real mellow, i wasn't able to go to sleep right away, but was very comfortable for an hour before dozing off. slept all night the next day i felt great! wednesday night i took one 500 mg capsule. within 20-30 min i felt hyper, my heart rate went up and boom! anxiety! it was terrible. i was up for several hours
TM - The experiment with L-Tryptophan didn't work. That's okay-- forget about it. I'm old school: I'm suspicious of supplements and won't take any. I think they are another crap-shoot.
In formation on SAM-e, L-tryptophan and 5htp.
Metabolic limitations - All of these items mentioned above are 'natural' in our diets and/or body. However, each has to have certain enzymes, vitamins (such as B6, B12, Vit C, etc.), minerals or other components to be processes into dopamine, serotonin, adrenaline or other neurotransmitters. They may also have items which compete with them in the body such as tyrosine or phenylalanine. The reactions may or may not produce more or less of a neurotransmitter but will that even get to the brain? Many of these products just don't cross the blood brain barrier (a membrane around the brain) so even though they are produced they do no good for mood. Some require special enzymes, insulin, certain proteins, etc to cross the barrier and all these items have their own requirements and limitations. This becomes clearly evident in looking at all the individual comments on these supplements. The effects are all over the place. Each persons body is different and has its own nutritional shortages or overages and therefore it may be im possible to tell in advance what reaction may occur to one of these supplements.