This may not be news to older members of this forum, but I research Duloxetine in two medical journals I have subscriptions to.
The take away that struck me is from The Medical Letter, from 200 Issue 1193
CONCLUSION —
In the manufacturer’s clinical trials,
duloxetine
(Cymbalta)
, a new SNRI, was more effective
than placebo for treatment of depression, but in some
trials higher-than-approved doses of the drug were used
and the SSRI comparator was ineffective, raising ques-
tions about the validity of the results. Whether duloxetine
offers any advantage over venlafaxine
(Effexor)
or an
SSRI such as fluoxetine (
Prozac
, and others) remains to
be established. The manufacturer’s claim that duloxetine
is
the
antidepressant for painful physical symptoms
associated with depression is unsupported
Unsupported? Trials conducted by the manufacturer? These are red flags.