I understood that you had finished your withdrawal (Yea!!). I was just supporting the information about your method. I also wanted everyone to realize that while some of us may not agree on all approaches that is great. All opinions are welcome and that is what makes this a good website.
I have added some information about the new water soluble "lorazepam" below. I think you will find it interesting.
Lorazepam is a nearly water insoluble compouind but recently the development of lorazepam glucuronide has been promoted by its manufacturer as a water soluble form of Lorazepam. Unluckily it is not a biologically active compound and has no effect on the CNS. This has lead to a lot of medical complications to those who try to use it for water titration during withdrawal. It has not been approved by the FDA for use in the United States.- Fishinghat
Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. In medicinal form, it is mainly available as tablets and a solution for injection, but, in some locations, it is also available as a skin patch, an oral solution, and a sublingual tablet.
It is a high-potency and an intermediate-acting benzodiazepine, and its uniqueness, advantages, and disadvantages are largely explained by its pharmacokinetic properties (poor water and lipid solubility, high protein binding and anoxidative metabolism to a pharmacologically inactive glucuronide form) and by its high relative potency (lorazepam 1 mg is equal in effect to diazepam 10 mg).
Lorazepam for injection formulated with polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative.
^ British Medical Association and Royal Pharmaceutical Society of Great Britain (March 2007). British National Formulary (v53 ed.). London: BMJ and RPS Pub. ISBN 0-85369-731-0.
Formulating a poorly water soluble drug into an oral solution suitable for paediatric patients; lorazepam as a model drug
Author links open overlay panelA.C.van der VossenaI.van der VeldeaO.S.N.M.SmeetsbD.J.PostmabM.EckhardtcA.VermesacB.C.P.KochacA.G.VultoaL.M.Hanffa
Lorazepam solubility in water - 0.0176 g/L
from Human Metabolome Database (HMDB)
Source: Human Metabolome Database (HMDB)
Soluble lorazepam is a 40-micrograms/ml admixture solution.
Am J Hosp Pharm. 1983 Mar;40(3):424-7.
Lorazepam solubility in and sorption from intravenous admixture solutions.
Newton DW, Narducci WA, Leet WA, Ueda CT.
*This would be impractacle for withdrawal.
Lorazepam is odourless or almost odourless . It is practically insoluble in water; sparingly soluble in alcohol; slightly soluble in chloroform (Reynolds, 1996).
Reynolds J (1996) Martindale, The Extra Pharmacopeia. 30th ed. The Pharmaceutical Press, London, 699-744.
Lorazepam-glucuronide is more water-soluble than its precursor, lorazepam. - Wiki
J Clin Psychiatry. 1978 Oct;39(10 Pt 2):16-23.
Clinical pharmacokinetics of lorazepam: a review.
Kyriakopoulos AA, Greenblatt DJ, Shader RI.
The clinical pharmacokinetics of lorazepam, a 3-hydroxy, 1,4-benzodiazepine, indicate that it is rapidly and readily absorbed, reaching peak concentrations in the blood proportional to the dose approximately 2 hours after oral administration. Blood levels decline thereafter, with an elimination half-life of about 12 hrs. Conjugation with glucuronic acid to form inactive lorazepam glucuronide is the major metabolic pathway. Seventy (70) to 75% of the administered dose is excreted as the glucuronide conjugate in the urine. On multiple-dose regimens, steady state blood levels directly proportional to the daily dose occur within 2--3 days and are maintained after several months of continuous treatment. The active drug and the glucuronide conjugate are completely eliminated from the blood within 1 week following the last dose.
Lorazepam glucuronide, the inactive metabolite, may be highly dialyzable.
Lorazepam glucuronide has no demonstrable CNS activity in animals. . - RxList
file:///C:/Users/Neil/AppData/Local/Microsoft/Windows/INetCache/IE/2V25RDCT/018140s041s042lbl.pdf (Ativan drug insert)
Lorazepam glucuronide is an inactive metabolite and is eliminated mainly by the kidneys.