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Summary Of Cymbalta Withdrawal Information


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#1 fishinghat

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Posted 08 July 2018 - 05:07 PM

This document is an effort to summarize everything that members have tried in order to reduce their withdrawal symptoms. It includes, where available, what worked and what didn't work, medical research, health warnings, compatibilities, and much more.

 

It would be appreciated if ANY errors in typing or content be pointed out so that this document can be corrected.

 

Any suggestions for improvement would be appreciated.


#2 fishinghat

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Posted 08 July 2018 - 05:19 PM

Table of Contents

 

Over the Counter Medications used to treat Cymbalta Withdrawal
Dramamine
Bonine -
Rugby Travel Med
Zofran
Excedrin
Naproxin, advil, tylenol, ibuprofen, aleve, aspirin, motrin, acetaminophen, excedrin and other over the counter analgesics
Imodium AD
Pepto
Diaper Rash Cream
AproDerm Emoillent cream
----------------------------------------------------------------------------------------------------------
Cold and Flu Medications
Pseudoephedrine/Phenylephrine containing meds;
Tylenol Cold and Flu
Mucinex D
Sudafed PE
Claritin-D 24 hour extended release tablets
Advil Cold & Sinus
Zyrtec
Advil LIQUID BLUE GELCAPs Cocktail
Dextromethorophan
Loratadine
Pseudoephedrine
Phenylephrine
Zantac
Diphenhydramine
Omeprazole (Prilosec)
Phosphatidylserine
-------------------------------------------------------------------------------
Natural Treatments for Cymbalta Withdrawal Symptoms
Rescue Remedy
Genius Joy
Omega 3
Omega-6 fatty acids
Ginger
Travelcalm Natural
Min Tran
Baking Soda
Himalaya Herbal Healthcare StressCare
Dr Redwig R22
Epsom Salts
Activated Charcoal Capsules
Bragg's Apple Cider Vinegar
Vertigoheel
Melatonin
Gatorade
Vitylite and Powerade
Isopure
Ylang-ylang
Kratom
Valerian root
Damiana tea
Jujube
NAC - N-acetylcysteine - Strong antioxidant.
Rockstar Energy Drink
Vicks
Lion's Mane Mushroom
Sweet Fennel Tea
St. John's wort
Camphor
Eucalyptus oil
Ashwagandha
------------------------------------------------------------------------------------------------------------
Vitamins
Vitamin A
B complex
B1
B2 (riboflavin)
B3 (niacin)
B5 (pantothenic acid)
B6 (pyridoxine)
B7 (Biotin)
B9 (Folic acid, folate)
B12 (methylcobalamin)
Vitamin C (ascorbic acid )
Vitamin D - Cholecalciferol and ergocalciferol
Vitamin E
----------------------------------------------------------------------------------------------------------
Multivitamins
Centrum Forte
Calms Forte
Nutricalm
Natural Calm
-----------------------------------------------------------------------------------------------------------

Increasing Your GABA Production
Flavonoid-Rich Foods and GABA Receptors
Lemon Balm Tea
Feverfew
Linden flowers
Passionflower
Flavonoid supplements
Gaba Supplements
Medicines that react with the Gaba receptors....
Vitamin C
Antihistamines
Antidepressants -
Supplements that effect Gaba
Thiamine (Vitamin B1)
B6 (pyridoxine)
Benzodiazepines
L-theanine
--------------------------------------------------------------------------------------------------------
Increasing Production of Endorphins
Vanilla or lavender
Essential oils
Ginseng
Exercise
Laughter
Sex
Chocolate (unsweetened cocoa)
Music
Eat something spicy
Eat your very favorite food.
Meditation
Increased exposure to sunlight.
Certain touches (hugs, massages...etc)
Acupuncture
Deep breathing, sighs, yawns....
Conditioned Response
------------------------------------------------------------------------------------------------------------
Increasing Dopamine Levels
List of foods, drinks, and spices known to increase tyrosine or dopamine directly:
Dopamine-Depleting Foods to Avoid
L-tyrosine
Mucuna pruriens
Curcumin
Ginkgo biloba
L-theanine
Phosphatidylserine
Exercise
Meditation
Music
Touch
Sleep
Inhibition of dopamine release by melatonin
Dopamine-Weight Loss Connection
Cold Shower
Achieving Results
-------------------------------------------------------------------------------------------------------------------
Essential oils
Tea tree oil
Ylang-ylang
Vanilla or Lavender
Vanilla Oil -
Lavender Oil -
Toxic Essential Oils
Oil Pulling
---------------------------------------------------------------------------------------------------------------------------

Reading Material and Treatment Programs
Informational Reading
A Mind Of Your Own
The Gifts of Imperfection
The Antidepressant Solution
Full Catastrophe Living
Walking with God through Pain and Suffering
The Ragamuffin Gospel
Anatomy of an Epidemic
The Mood Cure
At Last A Life
The Healing Power of Vitamins, Minerals, and Herbs
Essential Help for the nerves
Other Various Suggested reading by members
Boundaries
Surviving Panic Disorder: What You Need to Know
The Power of Anxious Thinking
------------------------------------------------------------------------------------------------------------
Programs
The Road Back
------------------------------------------------------------------------------------------------------------
Psychological Therapies
General
REBT (rational emotive behavioral therapy)
Cognitive Behavioral Therapy
Mindfulness
----------------------------------------------------------------------------------------------------------
Home Care
Sleep
Diet
Blood pressure monitoring
Taking Meds
GI Disturbances
Keeping a Journal
Cravings
Stimulants (Make anxiety worse)
Things containing caffeine..
Depressants (Make depression worse)
Mammalian diving reflex
Reiki
------------------------------------------------------------------------------------------------------------

Major Natural Human Supplements
SAMe - S-Adenosyl methionine
5HTP
L-theanine:
L-Tryptophan
L- Tyrosine
------------------------------------------------------------------------------------------------------------

Nutritional Causes of Anxiety and Depression
Amino Acids
Tryptophan
Threonine
Isoleucine
Methionine
Phenylalanine
Tyrosine
Vitamins
Vitamin C
Vitamin D
Vitamin E
B Vitamins
Thiamine (B1)
Niacin (B3)
Vitamin B6 (pyridoxine)
Folate (Folic Acid, Vitamin B9)
Vitamin B12 (cobalamin)
Pantothenic Acid (Vitamin B5)
Choline
Minerals/Metals
Calcium
Iron
Magnesium
Potassium/Sodium
Zinc
Manganese
Selenium
Fluoride
Cholesterol /Triglyceride
------------------------------------------------------------------------------------------------------------
Nutritional Blood Tests for Causes for Anxiety and/or Depression.
-------------------------------------------------------------------------------------------------------
Competition of Minerals and Vitamins in the body.
-------------------------------------------------------------------------------------------------------
List of Medical/Medicinal Causes of Anxiety not Including Stress
------------------------------------------------------------------------------------------------------------
List of causes of Depressive symptoms
------------------------------------------------------------------------------------------------------
Prescription Meds
Cimetidine – (Tagamet)
Clonidine
Hydroxyzine, (Vistaril, Atarax)
Atenolol
Buspirone (Buspar)
Benzodiazepines and Z-Drugs
-----------------------------------------------------------------------------------------------------------
Effects of Cymbalta on the Body
Restless Leg Syndrome
Pregnancy
Heart
High blood pressure
Cymbalta's Damages/Effects
Bone metabolism
Organ development
Cardiovascular growth factor
Damaged red blood cells
Cymbalta downregulates the activity of the bladder control nerves.
Cymbalta did not cause DNA damage.
Cymbalta regulates DNA product manufacturing in the frontal lobe and hippocampus.
Change the structure of Glutamate receptors in the prefrontal cortex
Alcohol
Hyperglycemia
Mania/Sexual effects while taking Cymbalta.
Liver
Skin
Seizures and Sodium
Cymbalta's effect on neurotransmitters in the brain.
Cymbalta Fat soluble & tissue absorption.
PSSD (Post ssri Sexual Dysfunction)
-----------------------------------------------------------------------------------------------------------
What is Anxiety?
Chronic Adrenergic State
Conditions Associated with a Chronic Adrenergic State
Symptoms
Definitions
History
Aggravating Agents and Vulnerability
Chemistry
Physiology
Genetics
Treatments
--------------------------------------------------------------------------------------------------------
Methods of Getting off Cymbalta
Cold turkey
Cross tapering
Bead counting
DURATION OF WITHDRAWAL
SUPPORT
Cross Tapering Details
Gov guidelines
New Zealand Guidelines
Australian Guidelines
-----------------------------------------------------------------------------------------------------------
Compounding Pharmacies
----------------------------------------------------------------------------------------------------------
Post Acute Withdrawal Syndrome: (Also Called Protracted Withdrawal)
Causes, Symptoms, Treatment
What is post-acute withdrawal syndrome (PAWS)?
-----------------------------------------------------------------------------------------------------------
Probiotics
Introduction
Research
Allergies
Diarrhea
Antibiotic-associated Diarrhea
Lactose intolerance
Cholesterol
Blood pressure
Immune Function and Infections
Helicobacter pylori
Inflammation
Irritable Bowel Syndrome and Colitis
Necrotizing Enterocolitis
Vitamin Production
Eczema
Bacterial Vaginosis
Side Effects
Member Discussions
Probiotic and Serotonin,
----------------------------------------------------------------------------------------------------------
Repetitive Transcranial Magnetic Stimulation (rTMS).
Anxiety
Depression
Members Comments
-----------------------------------------------------------------------------------------------------------
ECT - Electroconvulsive therapy
Members Comments
---------------------------------------------------------------------------------------------------------
Feedback Mechanisms
Neurofeedback
Biofeedback
Research
----------------------------------------------------------------------------------------------------------
NAMI - National Alliance on Mental Illness
Area Agencies for Aging
----------------------------------------------------------------------------------------------------------
Peripheral Neuropathy
Omega 3 Supplements
Neurovascular Support/Nerve Health/Brain Health Supplements
Vitamins and Minerals
Notes
----------------------------------------------------------------------------------------------------------
Adrenal insufficiency
Symptoms
----------------------------------------------------------------------------------------------------------
Adrenal fatigue
Definition
Dr. Tracy
----------------------------------------------------------------------------------------------------------
Treatment Resistant Anxiety/Depression.
-----------------------------------------------------------------------------------------------------------
Blood Brain Barrier
-------------------------------------------------------------------------------------------------------------
Brain Zaps
-----------------------------------------------------------------------------------------------------------
Genetics
------------------------------------------------------------------------------
Phantosmia
------------------------------------------------------------------------------------------------------------
SSRIs and Vision
-------------------------------------------------------------------------------------------------------------
Research Articles on ssris being Anxiogenic
-------------------------------------------------------------------------------------------------------------
Tachyphylaxis
-------------------------------------------------------------------------------------------------------------
Tardive Dyskinesia
-------------------------------------------------------------------------------------------------------------
Trazodone
-------------------------------------------------------------------------------------------------------------
Trintellix Withdrawal
-------------------------------------------------------------------------------------------------------------
Valsartan
-------------------------------------------------------------------------------------------------------------
Zoloft and Hypothyroidism and Leucopenia
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Zoloft Withdrawal
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#3 fishinghat

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Posted 08 July 2018 - 05:22 PM

Over the Counter Medications used to Treat Cymbalta Withdrawal Symptoms
7/8/18

 

Dramamine
71 member mentions.... 62 positive, 7 no help, 2 intermittent help, 13 says causes sleepiness,
Helps with lightheadedness, jolts, dizzy spells, sleep, nausea, brain swooshes, calming, motion sickness, brain zaps, Sloshy head, and anxiety.
 
Active Ingredient
Dimenhydrinate - an antihistamine - Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opiod pain or cough relievers (such as codeine, hydrocodone), alcohol, drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine, hydroxyzine).

Caution - some members state that "dramamine did..." but as listed below there is a difference in ingredients and dosing for different kinds of dramamine. Please follow label directions. Dimenhydrinate is available in 98 products approved in the USA other than dramamine so please check label ingredients before using with other products. Nearly all nausea, cold, flu, sleep aides and dizziness medicines contain antihistamines and are incompatible with each other. Check ingredient list closely. These drugs Will NOT contribute to Serotonin Syndrome.

Seven members admit to taking two or more of these products at the same time OR taking double doses. This has lead to comments like...
"...and chucked my guts all day"
"and afterward had stomach cramps for hours"

Tips from members -
1) Careful with the Benadryl and the Dramamine together. (causes you to be sick)
Also one member warned of 'DO NOT take both NyQuil and Dramamine.... '
2) Be careful taking dramamine during the day - it knocks me out!
3) Dramamine can also be doubled up at the initial dose. It all depends on your size and what you may or may not be sensitive to.
4) ORIGINAL FORMULA DRAMAMINE. (NOT THE NONDROWSY), just hypes you up and makes the dizziness worse.)
5) One said it can cause nightmares.
6) One said it does not cause nightmares
7) So, I was taking this ginger gravol and it did nothing for my nausea. I started taking half of a regular gravol (same as Dramamine) and its finally working
8) 2 said - the ginger gravol version does not cause sleepiness
9) if taken on a regular basis, it stops working

Contents:
Original Dramamine - Active Ingredient (in each tablet) Dimenhydrinate 50 mg.
Dramamine Motion Sickness Relief Less Drowsey Formula - Active Ingredient (in each tablet) Meclizine HCI 25 mg.
Dramamine Non-Drowsy Naturals with Natural Ginger - Active ingredients - Ginger 1000 mg.Take 2 capsules; do not take more than 4 capsules in 24 hours.
Dramamine All Day Less Drwsy Tab Size 8 Ct Dramamine Less Drwsy - Extended release Meclizine 25 mg.

Bonine -
Active ingredients (in each tablet) Meclizine HCI 25 mg.

Meclizine
Taken for headaches, nausea, dizziness, brain zaps.

Meclizine (an antihistamine) is available in 104 products approved in the USA other than Bonine so please check label ingredients before using with other products.
Will NOT contribute to Serotonin Syndrome.

Caution - Tell your doctor about all medicines you use, and those you start or stop using during your treatment with meclizine, especially the antidepressants bupropion, duloxetine, fluoxetine, paroxetine, or sertraline.

Using meclizine together with duloxetine may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. (Drugs.com)

15 members have used this product, 6 positive, 4 negative, 4 helps intermittently.
2 said it makes them sleepy/groggy.

Common side effects include blurred vision, dry mouth, constipation, dizziness, drowsiness, headache, vomiting, or tiredness.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, emphysema), high pressure in the eye (glaucoma), heart problems, high blood pressure, seizures, stomach/intestine problems (such as ulcers, blockage), overactive thyroid (hyperthyroidism), difficulty urinate, liver problems, kidney problems.

Sarah noted "Dramamine II (not the original Dramamine) contains the same active ingredient as Bonine. Some places also sell generic Meclizine and I have found it at CVS. Some very closely related drugs are buclizine, and cyclizine.

Some brand names that contain meclizine, buclizine, or cyclizine are:
Bonine
Bonamine
Dramamine II
Marezine
Marzine
Meclicot
Medivert"

Rugby Travel Med
Meclizine HCI 25 mg and they contain the artificial sweetener Aspartame, also contains Phenylalanine 0.28 mg per tablet (can cause anxiety and nervousness in some people).

Truck Princess commented that "I have found that taking the Rugby travel sickness med 25mg took away ALL my withdrawal symptoms for the majority. I don't get any brain zaps, dizziness, head swooshing, none of that. Also with the Rugby it's 24hrs so you only take one or two. The Rugby I took because of the nausea was so bad and just discovered it really got rid of most of the withdrawals and I didn't get the crying spells like you and others have."

This may partly be due to the fact it also contains Phenylalanine which other members report as helping their symptoms.

Caution - Many of the above products contain Lactose, a concern if you are lactose intolerant. They may also contain artificial colors that may irritate the nervous system and artificial sweeteners that can irritate the stomach in some people.

Zofran (is a medication used to prevent nausea and vomiting)
It is a serotonin 5-HT3 receptor antagonist (reduces the activity of serotonin receptors). Decreases serotonin production in the intestinal tract.
Most members commented that the Zofran was very helpful with their nausea.

JustJulz - However, Zofran is a nice one, dissolves in your mouth, and does not mess with your center of well-being (serotonin, etc.). I had no problems at all when I needed to stop using it. Only drawback is that it is constipating.

From the drug insert for Zofran;
Caution - 5.3 Serotonin Syndrome
The development of serotonin syndrome has been reported with 5-HT3 receptor antagonists alone. Most reports have been associated with concomitant use of serotonergic drugs (e.g., selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and intravenous methylene blue). Some of the reported cases were fatal. Serotonin syndrome occurring with overdose of ZOFRAN alone has also been reported. The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post-anesthesia care unit or an infusion center.

Symptoms associated with serotonin syndrome may include the following combination of signs and symptoms: mental status changes (e.g., agitation, hallucinations, delirium, and coma), autonomic instability (e.g., tachycardia, labile blood pressure, dizziness, diaphoresis, flushing, hyperthermia), neuromuscular symptoms (e.g., tremor, rigidity, myoclonus, hyperreflexia, incoordination), seizures, with or without gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea). Patients should be monitored for the emergence of serotonin syndrome, especially with concomitant use of ZOFRAN and other serotonergic drugs. If symptoms of serotonin syndrome occur, discontinue ZOFRAN and initiate supportive treatment. Patients should be informed of the increased risk of serotonin syndrome, especially if ZOFRAN is used concomitantly with other serotonergic drugs [see Drug Interactions (7.1), Overdosage (10)].

Medical research articles which show that Zofran can help with anxiety.
https://www.ncbi.nlm...pubmed/26188166
https://www.ncbi.nlm...pubmed/22374255
https://www.ncbi.nlm...pubmed/25284215
https://www.ncbi.nlm.../pubmed/9151286
https://www.ncbi.nlm...pubmed/10650519
and more....

Excedrin
Caution - Most Excedrin contains caffeine and may make anxiety worse.
Extra Strength Excedrin - Acetaminophen 250 mg, Aspirin 250 mg, and Caffeine 65 mg.
Excedrin Migraine - Acetaminophen 250 mg, Aspirin 250 mg Caffeine 65 mg
Excedrin Tension Headaches - Acetaminophen 500 mg Caffeine 65 mg

Naproxin, advil, tylenol, ibuprofen, aleve, aspirin, motrin, acetaminophen, excedrin and other over the counter analgesics do not fair well for body aches and headaches. Just as many say they don't work as say they help. No clear cut option here.

Imodium AD
Members report it is very effective for dry heaves and diarrhea.

Fishinghat - If the dry heaves are bothering her you might try a half dose of Imodium. It helps relax the GI muscles but don't use it if constipation is an issue. In the case of constipation you can have her suck on a peppermint lozenge. This relaxes the esophagus/stomach but does not affect the lower intestines and does not aggravate constipation or diarrhea. Be sure it has real peppermint not peppermint flavoring. I have occasional esophageal spasms (a weaker form of dry heaves) and they work well for me. I buy mine at a health food store for about $3 for 10 lozenges.

When I went through mine I lived off of Imodium and Pepto for the digestive issues.

Pepto
Fishinghat - I know I lived off of pepto, Imodium and antacids. I had some good success with Pepto. I used it for occasional relief as too much can cause constipation, black stools and ringing in the ears.
Many members report using it successfully for stomach issues including nausea, cramping, and diarrhea.

Diaper Rash Cream
(most contain zinc oxide)

Pitbullmama- The diaper rash cream actually helped soothe the itch some.
Runni - Anyway, back to itching I found that Calamine Lotion was helpful, Pure Aloe Vera gel was very cooling and also cream that can be bought for diaper rash in babies is especially good.
Vickif - hey even diaper rash cream works(by generic it cheaper)

AproDerm Emoillent cream
Katherine - (Red Face Rash) If anyone else is suffering from this I just wanted to give hope that this side effect only lasted a few days and that I eased it with AproDerm Emoillent cream,

Ingredients:
White soft paraffin, liquid paraffin, cetostearyl alcohol, macrogol cetostearyl ether, ceteareth-20, purified water, sodium hydrogen phosphate, euxyl PE 9010, phosphoric acid / sodium hydroxide.
----------------------------------------------------------------------------------------------------------
Cold and Flu Medications
 
Pseudoephedrine/Phenylephrine containing meds
Used to treat nearly all withdrawal symptoms.
Caution - Pseudoephedrine can raise blood pressure and cause nervousness in some people.
 
Tylenol Cold and Flu
Active ingredients
Dextromethorphan HBr 10 mg in each caplet
Guaifenesin 200 mg in each caplet
Phenylephrine HCl 5 mg in each caplet

Not to be taken with Cymbalta

gail - Tylenol flu is good for the brain zaps.
hailsmarie - Tylenol Cold and Flu completely took away my brain zaps,
dstanek - My husband said try some Nyquil I didn't have any but tried tylenol cold nighttime. In 20 min symptoms disappeared. I slept great no soaking night sweats. No nightmares. Zaps gone, I even had to shake my head to be sure. Woke up this morning feeling normal. I am going to get non drowsy version today and see if this truly is the miracle helper.

Caution - Tylenol cold nighttime contains
Acetaminophen 325 mg in each 15 mL
Dextromethorphan HBr 10 mg in each 15 mL
Doxylamine succinate 6.25 mg in 15 mL
Phenylephrine HCl 5 mg in each 15 mL
As such it should not be taken with Cymbalta (because of the Dextromethorphan) or diphenhydramine (because of Doxylamine).

Mucinex D
Active Ingredients: Guaifenesin (600 mg), Pseudoephedrine HCl (60 mg).

Coastgirl - Just wanna say I ran out of Mucinex D and got Advil Cold And Flu (behind the counter with pseudophedrine) and it also works to combat the brain zaps for me. My vertigo and zaps are 98% gone.
Sudafed PE
Dextromethorphan HBr 10 mg
Guaifenesin 100 mg
Phenylephrine HCl 5 mg

Caution -As such it should not be taken with Cymbalta (because of the Dextromethorphan)

Coastgirl - Tried to not take sudafed this morning and I feel so messed up! Just dizzy and can't think straight. I feel so out out of it.
(I mentioned in another post the Sudafed helps with the brain zaps....unfortunately it doesn't help too much with the mild nausea feeling).
Houdi - some days I had to take sudafed, the REAL sudafed and only 1/2 the dose cuz it reves me up.
Johnnyz - earlier today I read a topic in here about pseudoephedrine and its supposed effectiveness to alleviate SSRI withdrawal symptoms. I take 12-hour sudafed (the real, behind the counter sudafed) 1-2x daily as I have persistent nasal congestion. Yesterday evening, soon after the morning sudafed tab had worn off, I had a very stressful situation which caused an emotional low that had me sitting for 10 minutes feeling very depressed. I was able to talk myself out of that stupor and continue on in a neutrally emotional state until bedtime. I took a 12-hr sudafed around 11pm and woke up at 6am this morning feeling very good physically and emotionally, like I had a decent sleep. My point here is that, looking back at the previous 5 days of my Cymbalta/ Trintillex withdrawal plan and its relative low and tolerable symptoms, I wonder how much my daily use of sudafed has been a factor in my light symptoms.

Claritin-D 24 hour extended release tablets
10 mg loratadine for immediate release
240 mg pseudoephedrine sulfate is released slowly allowing for once-daily administration.

ittybittysmitty - WHAM, today I got blasted with three times as much dizziness and zapping...I feel zombie-like. Thinking it was part allergy symptoms I took a Claritin...that helped somewhat...less dizziness while seated.
irritableme - I started taking a Claritin-D and that seems to help. When I don't take the Claritin-D the brain swooshes and zaps return.

Advil Cold & Sinus
Ibuprofen 200 mg
Pseudoephedrine Hydrochloride 30 mg
Chlorpheniramine Maleate 2 mg

Coastgirl - Just wanna say I ran out of Mucinex D and got Advil Cold And Flu (behind the counter with pseudophedrine) and it also works to combat the brain zaps for me. My vertigo and zaps are 98% gone.
Carleeta - Have been taking advil cold and sinus daily..Seems to work.
Zertec - Cetirizine HCl 10 mg (antihistamine)

https://www.ncbi.nlm...pubmed/23673913
Cetirizine linked to depression.

Advil LIQUID BLUE GELCAPs Cocktail
Heartfeatherss - Try taking 4 ( yes 4) Advil LIQUID BLUE GELCAPs with a Coke. It has to be the blue gel caps and it cannot be a diet Coke. My neurologist told me to do this and I was so miffed, thinking he was just not understanding how bad it hurt... but dang! It works!! Hope this gives you relief. Contains ibuprofen and dihydramine. Should not be taken with other amines like benadryl.

Indian J Exp Biol. 2003 Nov;41(11):1322-4.
Influence of acidic beverage (Coca-Cola) on pharmacokinetics of ibuprofen in healthy rabbits.
https://www.ncbi.nlm...pubmed/15332505
The Cmax and AUC0-alpha of ibuprofen were significantly increased after single and multiple doses of Coca-Cola, thereby indicating increased extent of absorption of ibuprofen. The results warrant the reduction of ibuprofen daily dosage, frequency when administered with Coca-Cola.

Note - This sure sounds like it puts a lot of Advil into the system. The articles I read from migraine users all say the same thing it must be coke a cola and name brand Advil liquicaps.

Information on the cold and flu medicine ingredients
Chlorpheniramine (over the counter) is an antihistamine {H(1)R antagonist} used to treat allergy symptoms. It does cause sleepiness like other antihistamines and has significant anxiolytic effects. Caution - It has also been shown to function as an ssri and snri. As such it should never be taken in combination with those medications as it can cause seratonin syndrome. Due to its anticholenergic effects it frequently causes constipation. As with diphenhydramine do not take with other medicines that can cause sleepiness. Recommended dose is 4 mg every 4 to 6 hrs not to exceed 32 mg/day. Widely sold as an allergy treatment.
Begins working in 30 minutes to an hour
Peak levels - 2 to 4 hrs
Half Life – 12 to 43 hrs
https://www.ncbi.nlm...les/PMC3854398/
(8mg dose)
https://www.ncbi.nlm...pubmed/16876927
https://www.ncbi.nlm...pubmed/16156843
https://www.ncbi.nlm...pubmed/12951198
https://www.ncbi.nlm...pubmed/10541737

Dextromethorophan
FiveNotions - I didn't check, but my bet is that Tylenol Cold contains DMX -- "dextromethorphan" .... it's a serotonin agonist (enhancer - reuptake inhibitor) ...
Nyquil contains a lot of it, which is why someone taking Cymbalta (duloxetine) or any other SSRI shouldn't use Nyquil ... there are case studies about the combo causing severe serotonin syndrome ...

Loratadine

https://www.ncbi.nlm...pubmed/10444229
Loratadine, No effect on 'mood'.

While this is the only research I found it is interesting to note that around 4% of people taking loratadine report anxiety as a side effect. This is about the same number of diphenhydramine (Benadryl) users that report depression as a side effect. (FDA)

From Drugs.com
Cardiovascular side effects have included hypertension, hypotension, palpitation, supraventricular tachyarrhythmias, syncope and tachycardia.

Wiki
As a "nonsedating" antihistamine, loratadine causes less (but still significant, in some cases) sedation and psychomotor retardation than the older antihistamines because it penetrates the blood/brain barrier to a smaller extent.[14]

Note - Inability to significantly penetrate the blood brain barrier would make it an unlikely anxiolytic medicine.
Do not take with Tagamet or other antihistamines.

Half life - 8 hours.

Metabolism
Loratadine is an H1 receptor antagonist (blocks the action of histamine on the H1 histamine receptor). Does NOT cross the blood brain barrier.

Pseudoephedrine
Wiki
Patients who are prone to anxiety or panic attacks should use pseudoephedrine with caution, as anxiety and restlessness are common side effects, mostly due to the drug's stimulant properties. Pseudoephedrine should not be taken with beta-blockers.

http://www.sciencedi...080552323624882
Can cause anxiety as a side effect.

http://research.omic...Pseudoephedrine
Adverse effects
Common adverse drug reactions (ADRs) associated with pseudoephedrine therapy include: CNS stimulation, insomnia, nervousness, excitability, dizziness and anxiety. Infrequent ADRs include: tachycardia or palpitations.

https://www.ncbi.nlm...pubmed/10999495
"...the drug tended to increase anxiety scores. Depth resulted in a significant increase in anxiety scores and a significant decrease in verbal fluency test scores."

https://www.ncbi.nlm...les/PMC4518702/
Over-the-counter cold preparations contain phenylpropylamine and pseudoephedrine, obvious stimulants. Yet patients with unexplained dyspnea may believe they have allergies and take these medications frequently in order to treat their anxiety symptom, further exacerbating their dyspnea and anxiety symptoms. The use of energy drinks with combinations of both caffeine and stimulants is another important example.
And many more research articles....

http://www.ehealthme...loride/anxiety/
(FDA website)
140 people reported to have side effects when taking Pseudoephedrine Hydrochloride.
Among them, 12 people (8.57%) had Anxiety as a side effect.

Pseudoephedrine is an agonist at both alpha- and, to a lesser degree, beta-adrenergic receptors. Like ephedrine, pseudoephedrine also has an indirect effect by releasing norepinephrine from its storage sites. By stimulating alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine shrinks swollen nasal mucous membranes; reduces tissue hyperemia, edema, and nasal congestion; and increases nasal airway patency. Also, drainage of sinus secretions is increased, and obstructed eustachian ostia may be opened. Oral administration of pseudoephedrine usually produces negligible effects on blood pressure. In some patients, especially those with preexisting cardiac disease receiving higher doses, pseudoephedrine may increase blood pressure or irritability of the heart muscle and may affect ventricular conduction. Wiki
Phenylephrine is a selective α1-adrenergic receptor agonist of the phenethylamine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Phenylephrine is a sympathomimetic drug, which means that it mimics the actions of epinephrine (commonly known as adrenaline) or norepinephrine. Phenylephrine selectively binds to alpha receptors which cause blood vessels to constrict. Phenylephrine may cause side effects such as headache, reflex bradycardia, excitability, restlessness and cardiac arrhythmias. Phenylephrine is not suggested for use in patients with hypertension.
Available as Oral and nasal spray.

Medical research emphasizing that phenylephrine can cause anxiety.
https://www.ncbi.nlm...pubmed/20937329
https://pubchem.ncbi...d/phenylephrine
https://everipedia.o.../Phenylephrine/
People with a history of anxiety or panic disorders, or on anticonvulsant medication for epilepsy should not take this substance.

While considerable medical research indicates that Phenylephrine can cause anxiety the following research indicates differently.
https://www.ncbi.nlm...pubmed/20937329
Helps with anxiety

https://mdanderson.i...amatergic-synap
https://mdanderson.i...tially-regulate
---------------------------------------------------------------------------------------------------------


#4 gail

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    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 09 July 2018 - 06:52 AM

Fishinghat,

I'm losing my feathers here. This is unbelievable research. Thank you so much for all your implication.

I got stuck with the Coke thing, really interesting. Might buy some!

Just one thing, Coke and Advil, is that for anxiety? Love you.

#5 fishinghat

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Posted 09 July 2018 - 08:40 AM

Just for pain Gail. Sorry. This thread will replace the "answer to your question thread.." so many more posts to make.


#6 fishinghat

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Posted 09 July 2018 - 02:29 PM

Zantac
Contains Ranitidine is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach.
http://www.cymbaltaw...tion#entry66071
Zantac (Ranitidine) For Anxiety And Depression
FiveNotions - I've stumbled onto the discovery that Zantac, which I'd been taking for severe acid reflux, seems to help my post-crapalta anxiety ... did some research, and found a number of old (really old) articles that seem to confirm this ... here's one of the freely available ones ...
jimmcg - Now, with a week on the Zantac, I feel much more in control of these feelings. I may wake up worrying about something in the middle of the night, but, unlike before, I can talk myself through it and go back to sleep.

Sparkybird - FYI I some research on Zantac and found it was the source of the depression and anxiety I had this morning. This might help others along te way.

https://www.ehealthm...tac/depression/
54,938 people reported to have side effects when taking Zantac.
Among them, 1,859 people (3.38%) have Depression

https://www.ehealthm...zantac/anxiety/
54,938 people reported to have side effects when taking Zantac.
Among them, 2,370 people (4.31%) have Anxiety


Caution : but be aware that new research is showing that extended use of Zantac, and / or use of the highest dose, may cause liver damage.
https://livertox.nlm.../Ranitidine.htm

http://pmj.bmj.com/c...03/353.full.pdf
Effect of the H2-receptor antagonist ranitidine on depression and anxiety in duodenal ulcer patients
(150 mg twice daily0 In both groups there was a highly significant and progressive decrease in depression and anxiety scores over the 4 weeks of treatment.

https://www.ncbi.nlm.../pubmed/9833631

The H1- and H2-histamine blockers chlorpheniramine and ranitidine show that H1- and H2-receptor antagonists differentially modulate reinforcement and fear-related processes in the NBM and thus, provide the first evidence for a behavioral relevance for the histaminergic innervation of this brain site.

https://www.ncbi.nlm...les/PMC3854398/

H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
As well as...
https://www.ncbi.nlm...pubmed/18275952
https://www.ncbi.nlm...pubmed/17109942
https://www.ncbi.nlm...pubmed/16600315
https://www.ncbi.nlm...pubmed/23535246
https://www.ncbi.nlm...pubmed/22952484
Plus many more....

Drug interactions -
Zantac (Ranitidine) may significantly increase the blood levels of loperamide (Imodium). This can lead to serious and potentially fatal complications such as irregular heart rhythm and cardiac arrest, especially if you use more than the recommended doses of loperamide.
Zantac CAN be taken with benadryl. They are different types of antihistamines. Drugs.com

Diphenhydramine, (over the counter) also known as Benadryl, is an antihistamine and as such is not only used for allergies/colds but also as a sleep aide. It does have a mild anxiolytic effect. May lower blood pressure and cause irregular heartbeats. Long-term use of Benadryl often affects mental cognition, especially in the elderly. Your body does build up tolerance to it after a few weeks. There is evidence of dependence in cases of long-term heavy uses, It is a histamine H(1)R antagonist in the brain. Do not take this medicine with any other medicine that can cause sleepiness including benzos, most blood pressure medicines, ssri/snri, buspar and others. Please check for compatibility before using. This medicine has many drug interactions.
Begins working in 15 to 30 minutes
Peak levels - 2 to 2.5 hrs
Half Life – 4 to 6 hrs
Use by members for anxiety releif and to help sleep is too numerous to mention.
https://www.ncbi.nlm...pubmed/24530460
Moderately effective
https://www.ncbi.nlm...pubmed/19415242
(50mg dose)
https://www.ncbi.nlm...pubmed/16156843
Effective
https://www.ncbi.nlm...pubmed/16111835
Effective
Can cause dependence with constant heavy use. Some moderate withdrawal symptoms possible.

Diphenhydramine should NOT be taken with hydroxyzine. Drugs.com

http://www.cymbaltaw...elps#entry68017
Technical information on Diphenhydramine (Benadryl)
serendipity - I found Benadryl to produce hangover effects, and cause palpitations when taken long term. Even if you wake up in the middle of the night, and can't get back to sleep, even a teeny amount (say, 15mg) can induce sleep again.
Schmb - Benadryl worked on a limited basis for me, because sometimes it makes me jittery, and that only made the zaps much worse, so just use some caution in case you are sensitive to it.
FH - One caution on benadryl. It is famous for bad reactions with other medicine so check your compatability closely. The maximum dosage of benadryl is 25 to 50 mg every 4 to 6 hours and do not surpass 300 mg in a day.
Benadryl Total
Medicinal ingredients:
•Acetaminophen, 500 mg
•Diphenhydramine Hydrochloride, 25 mg
•Pseudoephedrine Hydrochloride, 30 mg

It contains diphenhydramine which is the active ingredient in regular Benadryl and also pseudoephedrine which is common in most cold medicines. The Diphenhydramine helps with sleep and anxiety and the pseudoephedrine helps block the action of adrenaline which produces a calming effect.
Brand Name: Tavist NightTime Allergy
Generic Drug: diphenhydramine-pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: tablet
Route Description: oral
Tavist NightTime Allergy Strength Description: 25 mg-60 mg
Note - Twice as much pseudoephedrine as Benadryl Total.
Brand Name: Benylin Multi-Symptom
Generic Drug: diphenhydramine-pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: liquid
Route Description: oral
Benylin Multi-Symptom Strength Description: 12.5 mg-30 mg/ 5 mL
Note - Contains half of the diphenhydramine than Benadryl Total
Brand Name: Benadryl Allergy Decongestant
Generic Drug: diphenhydramine- pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Descriptions: liquid; tablet
Route Description: oral
Benadryl Allergy Decongestant Strength Descriptions: 12.5 mg-30 mg/ 5 mL; 25 mg-60 mg
Note - Same as the two above.
Brand Name: Actifed Allergy Day/ Night
Generic Drug: diphenhydramine-pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: tablet
Route Description: oral
Actifed Allergy Day/ Night Strength Description: 25 mg-30 mg
Same as Benadryl Total

Brand Name: Benadryl Childrens Allergy and Cold
Generic Drug: diphenhydramine- pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: tablet, disintegrating
Route Description: oral
Benadryl Childrens Allergy and Cold Strength Description: 12.5 mg-30 mg
Note - Contains half of the diphenhydramine than Benadryl Total

Brand Name: Benadryl Child Allergy and Sinus
Generic Drug: diphenhydramine- pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: liquid
Route Description: oral
Benadryl Child Allergy and Sinus Strength Description: 12.5 mg-30 mg/ 5 mL
Note - Contains half of the diphenhydramine than Benadryl Total
Brand Name: Benadryl Allergy Sinus
Generic Drug: diphenhydramine-pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: tablet
Route Description: oral
Benadryl Allergy Sinus Strength Description: 25 mg-60 mg
Note - Twice as much pseudoephedrine as Benadryl Total.
Brand Name: Benadryl Allergy Sinus Fastmelt
Generic Drug: diphenhydramine- pseudoephedrine
Active Ingredients: diphenhydramine hydrochloride; pseudoephedrine hydrochloride
Dose Form Description: tablet, disintegrating
Route Description: oral
Benadryl Allergy Sinus Fastmelt Strength Description: 12.5 mg-30 mg
Note - Contains half of the diphenhydramine than Benadryl Total
There re at least 75 products sold in the USA that contain diphenhydramine.

Omeprazole (Prilosec)
Significant drug interactions.
omeprazole ↔ citalopram
Applies to omeprazole and Celexa (citalopram)
Talk to your doctor before using citalopram together with omeprazole. Combining these medications may increase the blood levels of citalopram and increase the risk of certain side effects, including an irregular heart rhythm that may be serious or life-threatening.
Caution - Omeprazole causes the increased absorbtion of nearly 500 medications. It should NOT be taken with.....
Benzos, Atenolol, Celexa, Lexapro and many other ssri and snri, st. john's wort, etc.
Phosphatidylserine (Theoretically reduces corticol.)
Phosphatidylserine is an important phospholipid cellular membrane component which plays a key role in cell cycle signaling, specifically in relationship to apoptosis (programmed cell death). When the Phosphatidylserine in the cell membrane turns around (The head of the molecule pointing out and the tail pointing in) it acts as a signal for macrophages to engulf the cell.

In May, 2003 the FDA gave "qualified health claim" status to phosphatidylserine thus allowing labels to state "consumption of phosphatidylserine may reduce the risk of dementia and cognitive dysfunction in the elderly" along with the disclaimer "very limited and preliminary scientific research suggests that phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly." FDA concludes that there is little scientific evidence supporting this claim.

Originally acquired from the bovine brain, mad cow disease put an end to that. Most is now extracted from soybeans. Phosphatidylserine can cause side effects including insomnia and stomach upset, particularly at doses over 300 mg.

http://www.ncbi.nlm....pubmed/23312676
Well tolerated.

http://www.ncbi.nlm....pubmed/23723695
safe for human consumption.

http://www.ncbi.nlm....pubmed/21807480
Well tolerated

http://www.ncbi.nlm....pubmed/12385596
Soy derived Phosphatidylserine is safe for human consumption.

http://www.ncbi.nlm....les/PMC4237891/
A Phosphatidylserine/phosphatidic acid complex normalized the hypothalmus-pituatary-adrenal axis in acutely stressed males. It normalized cortisol levels. They used PAS 200 (200 mg of both compounds) and PAS 400 (400 mg of both compounds). Only the PAS 400 showed the beneficial response.

http://www.ncbi.nlm....les/PMC2503954/
Reduces cortisol levels after exercise.

Several of these studies showed that the compound Phosphatidylserine had no effect on blood pressure or pulse. With the combination (PAS) returning the hypothalmus-pituatary-adrenal axis to normal function in the chronically fatigued. Adrenaline increases and cortisol decreases with an increase in energy levels. This increase in energy is what causes the insomnia side effect. Should be taken in the morning.

Not compatable with adrenergic agonists (eg. Clonidine). Most reviews of this product are positive but do reflect that it is an adaptogen (your body adapts to it in time and begins reducing its natural production). Many reviews state it only helps for a couple months at a time. There are many who say it makes them sleep like a baby and many who say it causes insomnia. This is probably due to whether or not the person is suffering from a chronic adrenergic state (stress over a long period of time elevating adrenaline levels) OR from adrenal insufficiency which is due to a relatively short term intense stress which causes a burst of adrenaline followed by a drop in adrenaline. This is what causes the knees to shake and a person to feel exhausted after say a car accident.

http://www.cymbaltaw...rove#entry59862

Ramona - I've read that there is a supplement called Phosphatidylserine that reduces the amount of cortisol your adrenals are over-producing. Anyone familiar with this? I checked with a pharmacist over the weekend and he said I shouldn't take Seriphos while on Cymbalta.

Bethhalffull - I saw a new shrink. She recommended ... phosphatidylserine. When I investigated the second ingredient it is supposed to limit cortisol.
Seriphos - Phosphorylated Serine - An amino acid not to be confused with Phosphatidylserine although similar in structure and action and is mostly used to improve clotting and cognition. Taking it with Cymbalta reduces the essential amino acid serine in the body and should be avoided. NCBI

I could find no medical journal article associating Phosphorylated Serine with lower cortisol levels. I did find several articles on its effects on the adrenal gland but no reference to its efficacy for either anxiety or depression.
============================================================

#7 fishinghat

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Posted 09 July 2018 - 02:36 PM

Natural Treatments for Cymbalta Withdrawal Symptoms
Rescue Remedy
Ingredients
Active Ingredients: 5 x dilution of:- Prunus cerasifera HPUS (Crab Apple), Clematis vitalba HPUS (Clematis), Impatiens glandulifera HPUS (Impatiens), Helianthemum nummularium HPUS (Rock Rose), Ornithogalum umbellatum HPUS (Star of Bethlehem). Inactive Ingredients: 27% Alcohol

Uriel - You can get Rescue Remedey from the health food store its a tincture you put under your tongue for anxiety. It helps the body cope well.

Genius Joy
INGREDIENTS
Serving Size: 4 Delayed Release Veggie Capsules
Servings Per Container: 25
Amount Per Serving

Vitamin B Energy Complex

Vitamin B1 (as Thiamine HCL) – 1.5mg
Vitamin B2 (as Riboflavin 5 Phosphate) – 1.7mg
Vitamin B3 (as Niacinamide) – 20mg
Vitamin B5 (as D-Calcium Pantothenate) – 10mg
Vitamin B6 (as pyridoxal-5-phosphate) – 2mg
Vitamin B12 (as methylcobalamin) – 6mcg
Vitamin D3 (as cholecalciferol) – 1000IU

S-adenosylmethionine (SamE) – 1000mg
N-Acetyl L Tyrosine – 350mg
Rhodiola5Plus Rhodiola rosea [root](std. 3% Rosavins and 2% Salidrosides) – 300mg
Red Panax Ginseng Powder – 250mg
HTPurity 5-hydroxytryptophan Griffonia simplicifolia [seed] (Std. 98% 5-HTP) – 100mg
Neuro Factor Coffea Arabica [Fruit] Extract – 100mg
TheaKalm Natural L-Theanine – 100mg
mimi - I'm still only taking 2 Genius Joy supplements when I first get up and by 10am I can do all that I wish to accomplish for the day, I can be outside without itching, I can drive safely, I can do my household finances and communicate effectively.
While this product contains many components that may be beneficial they may also be incompatable with a variety of drugs and other natural remedies. You should closely check for drug interactions before use.
Omega 3
Sources
Table 2: Selected Food Sources of ALA, EPA, and DHA
Food Grams per serving
ALA DHA EPA
Flaxseed oil, 1 tbsp 7.26
Chia seeds, 1 ounce 5.06
Flaxseed, whole, 1 tbsp 2.35
Salmon, Atlantic, farmed cooked, 3 ounces 1.24 0.59
Salmon, Atlantic, wild, cooked, 3 ounces 1.22 0.35
Herring, Atlantic, cooked, 3 ounces* 0.94 0.77
Canola oil, 1 tbsp 1.28
Sardines, canned in tomato sauce, drained, 3 ounces* 0.74 0.45
Mackerel, Atlantic, cooked, 3 ounces* 0.59 0.43
Salmon, pink, canned, drained, 3 ounces* 0.04 0.63 0.28
Soybean oil, 1 tbsp 0.92
Trout, rainbow, wild, cooked, 3 ounces 0.44 0.40
Black walnuts, 1 ounce 0.76
Mayonnaise, 1 tbsp 0.74
Oysters, eastern, wild, cooked, 3 ounces 0.14 0.23 0.30
Sea bass, cooked, 3 ounces* 0.47 0.18
Edamame, frozen, prepared, ½ cup 0.28
Shrimp, cooked, 3 ounces* 0.12 0.12
Refried beans, canned, vegetarian, ½ cup 0.21
Lobster, cooked, 3 ounces* 0.04 0.07 0.10
Tuna, light, canned in water, drained, 3 ounces* 0.17 0.02
Tilapia, cooked, 3 ounces* 0.04 0.11
Scallops, cooked, 3 ounces* 0.09 0.06
Cod, Pacific, cooked, 3 ounces* 0.10 0.04
Tuna, yellowfin, cooked 3 ounces* 0.09 0.01
Kidney beans, canned ½ cup 0.10
Baked beans, canned, vegetarian, ½ cup 0.07
Ground beef, 85% lean, cooked, 3 ounces** 0.04
Bread, whole wheat, 1 slice 0.04
Egg, cooked, 1 egg 0.03
Chicken, breast, roasted, 3 ounces 0.02 0.01
Milk, low-fat (1%), 1 cup 0.01
*Except as noted, the USDA database does not specify whether fish are farmed or wild caught.
**The USDA database does not specify whether beef is grass fed or grain fed.
Flax seed products, canola oil, soy products, walnuts, mayonaise, edamine, most beans, beef, bread and low fat milk, contain only ALA and no EPA and DHA and as such would be less effective during Cymbalta withdrawal.
Dose - Omega 3 is recommended at 2000 mg/day EPA and DHA for anxiety, give or take a couple hundred depending on what research you read. It has been shown that only the EPA and DHA components effect anxiety. Any other omega 3 fatty acids don't do anything for anxiety. Life Extensions, Mega EPA/DHA, is distilled (molecularly purified) so you don't get any impurities with your product plus it contains no mercury. Some even provide a certificate of analysis if requested. They also have ones that are enteric coated now that will not irritate the digestive track and has no fish burbs to them.

http://www.cymbaltaw...elps#entry67706
This thread contains a detailed discussion on use of Omega 3.

Also this thread....
http://www.cymbaltaw...elps#entry68036

Fishinghat - Omega 3 fish oils can be very high in mercury depending on the type of fish used. Some have tested at over 300 ppm mercury. There are brands out there that are mercury free or low mercury guaranteed. Something to think about. If you have thyroid issues they usually contain high iodine concentrations also. One member had an episode of high iodine toxicity I couldn't find a iodine free product. If your thyroid is fine then this should not be an issue.
FH - Cod liver oil you buy in the store may be high in mercury and pesticides. The liver is the pollutant filter for the body. Cod livers are from the top of the food chain and pollutant levels are usually significant. Be sure to get one that is purified and verified mercury free. But I don't believe there is one verified pesticide free. Great care must be used in selecting one. It also contains fairly significant levels of vitamin A and D and toxic doses are known to occur. Routine blood analysis for Vit A and D should be done every 6 months if using Cod Liver Oil or any Fish oil.
Heavy metal poisoning by the body's accumulation of traces of heavy metals, in particular mercury, lead, nickek, arsenic and cadmium is a possible risk from consuming fish oil supplements. Also, other contaminants (PCBs, Furans, dioxins, and PBDEs) might be found, especially in less-refined fish oil supplements. However, heavy metal toxicity from consuming fish oil supplements is highly unlikely, because heavy metals selectively bind with protein in the fish flesh rather than accumulate in the oil. An independent test in 2005 of 44 fish oils on the US market found all of the products passed safety standards for potential contaminants.
http://www.ncbi.nlm....pubmed/25708183
Global fish stocks are, in some cases, contaminated with heavy metals.

http://www.ncbi.nlm....pubmed/20104234
Dioxins, polychlorinated biphenyls, methyl mercury and omega-3 polyunsaturated fatty acids as biomarkers of fish consumption.

http://dspace.knust..../123456789/1406
Levels of some heavy metals in omega-3 food supplements.

http://www.nejm.org/...56/NEJMoa020157
Mercury, Fish Oils, and the Risk of Myocardial Infarction

http://www.nova.edu/...avy-metals.html
Production of oil and omega 3 from algae but it was found that they absorb heavy metals such as lead, chromium, copper, zinc and nickel.

https://www.ncbi.nlm...les/PMC4145306/
DHA deficiency may be the cause of many disorders such as depression, inability to concentrate, excessive mood swings, anxiety, cardiovascular disease, type 2 diabetes, dry skin and so on.

https://www.ncbi.nlm...pubmed/24189320
We also observed that omega-3 FA intake may play a preventive role in Hg-induced nephrotoxicity. Additional studies are warranted to determine the sources, exposure routes, and forms of Hg most responsible for observed associations.

https://www.ncbi.nlm...pubmed/20633905
Species that are high in omega-3s and low in mercury include salmon, trout, and shrimp. Species with both high levels of mercury and omega-3 fatty acids include tuna, shark, and halibut, swordfish, and sea bass.
And many many more including pesticides and organic toxins.
Omega 3 supplements
http://www.livestron...il-supplements/
List of Mercury Levels in Fish Oil Supplements
http://consumereview...a 3 supplements

Warning
Arrhythmias
Omega 3
60. Raitt MH, Connor WE, Morris C, et al. Fish oil supplementation and risk of ventricular tachycardia and ventricular fibrillation in patients with implantable defibrillators. A randomized controlled trial. JAMA 2005;293:2884-91
3 Grams of omega 3 per day can worsen cardiac arrtymias.

https://dailymed.nlm...cc-f106f614c9f0
Note - The items below are copied from the drug insert for Lovaza (prescription strength Omega 3)
Warning and Precautions
There is a possible association between LOVAZA and more frequent recurrences of symptomatic atrial fibrillation or flutter in patients with paroxysmal or persistent atrial fibrillation, particularly within the first months of initiating therapy.
5.3 Recurrent Atrial Fibrillation (AF) or Flutter
In a double-blind, placebo-controlled trial of 663 subjects with symptomatic paroxysmal AF (n = 542) or persistent AF (n = 121), recurrent AF or flutter was observed in subjects randomized to LOVAZA who received 8 grams per day for 7 days and 4 grams per day thereafter for 23 weeks at a higher rate relative to placebo. Subjects in this trial had median baseline triglycerides of 127 mg per dL, had no substantial structural heart disease, were taking no anti-arrhythmic therapy (rate control permitted), and were in normal sinus rhythm at baseline.
At 24 weeks, in the paroxysmal AF stratum, there were 129 (47%) first recurrent symptomatic AF or flutter events on placebo and 141 (53%) on LOVAZA [primary endpoint, HR 1.19; 95% CI: 0.93, 1.35]. In the persistent AF stratum, there were 19 (35%) events on placebo and 34 (52%) events on LOVAZA [HR 1.63; 95% CI: 0.91, 2.18]. For both strata combined, the HR was 1.25; 95% CI: 1.00, 1.40. Although the clinical significance of these results is uncertain, there is a possible association between LOVAZA and more frequent recurrences of symptomatic atrial fibrillation or flutter in patients with paroxysmal or persistent atrial fibrillation, particularly within the first 2 to 3 months of initiating therapy.
LOVAZA is not indicated for the treatment of AF or flutter.

http://www.accessdat...4977s000lbl.pdf
The same exact warnings are given for OMTRYG.

http://www.accessdat...04/21654lbl.pdf
Omacor
Adverse Reactions
CARDIOVASCULAR SYSTEM: arrhythmia, bypass surgery, cardiac arrest,
hyperlipemia, hypertension, migraine, myocardial infarct, myocardial ischemia,
occlusion, peripheral vascular disorder, syncope, and tachycardia.

https://www.ncbi.nlm...pubmed/24574493
A U-shaped association between consumption of marine n-3 fatty acids and development of atrial fibrillation/atrial flutter-a Danish cohort study.
We found a U-shaped association between consumption of marine n-3 PUFA and risk of incident AF, with the lowest risk close to the median intake of total marine n-3 PUFA (0.63 g/day).

https://www.ncbi.nlm...pubmed/24169465
U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery.
The results suggest a 'U-shaped' relationship between RBC DHA levels and POAF incidence. The possibility of increased risk of POAF (Atrial fibrilation) at high levels of DHA suggests an upper limit for n-3 LC-PUFAs (Omega 3's) in certain conditions.
Three of our members have experienced the symptoms of increased cardiac arythmias when using Omega 3.

High levels of Omega 3 fatty acids can cause anxiety
https://www.ncbi.nlm...pubmed/17991818

Omega 3 deficiency linked to depression.
https://www.ncbi.nlm...pubmed/23890734
https://www.ncbi.nlm...pubmed/21838665
https://www.hindawi....cl/2014/313570/
and other articles as well.
This is an increasingly common occurance in advanced societies that no longer consume significant levels of fish or seafood.

EPA
https://academic.oup...5/3/244/1448354
High levels of EPA are linked to anxiety. Rare

DHA
https://www.nih.gov/...itary-personnel
Study links low DHA levels to suicide risk among U.S. military personnel. Increasing in occurance.

Omega-6 fatty acids
https://www.scienced...50525161319.htm
High levels of Omega 6 linked to depression. Rare

Testing
http://www.questdiag...dc=TS_Omega_3_6
Blood sampling for individual Omega 3 and 6 components.

#8 fishinghat

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Posted 09 July 2018 - 02:38 PM

Natural Treatments for Cymbalta Withdrawal Symptoms (cont.)
Ginger
Helps with nausea and stomach issues.
25 positive remarks and 4 negative.
Tips from members...
FN - ginger tea (really strong), ginger ale (old home remedy for sure), and ... candied ginger, raw ginger.
Even it sounds disgusting, eating Ginger raw is the most effective way cured my nausea in 5-10 minutes
AH - Ginger root works very well for nausea. I have 550mg ginger root capsules, and this has helped with a lot of the nausea and stomach upset. I'd totally recommend buying the ginger root in capsule form at the health food store. Mine was $8.99 for 100 capsules, and I will take 2-3 whenever my stomach is upset. And of course we can't forget ginger tea. It is soothing, relaxing, and will also help your stomach feel better.
ta2ed - You can try ginger root... Wont make you tired.
Betty - I'd recommend trying ginger ale -- not Canada Dry but the real strong stuff, sometimes labeled Jamaican ginger ale or ginger beer. It's sold in four-packs here, in the health food or imported section of the store. I've had "irritable bowel" problems for years and have found this is real medicine, with no downside I can see! It also works for nausea.
Anna - I thought I would give just smelling ginger a try. I put 2-3 drops of ginger essential oil on a cotton ball and my nausea pretty much disappeared almost instantly.
Latte - ginger candy for nausea - I swear by it, particularly the Gin-Gin brand
Amberd - I tried ginger tea, but it only gave me indigestion on top of it all.
Vinvin - The Fierce Green Apple Gatorade, Dramamine and Boylan's Ginger Ale seem to help out as well

Travelcalm Natural
Travacalm Natural contains 100mg of dried ginger root extract that offers faster relief in conjunction with 400mg of root powder that helps sustain the soothing effect. Each tablet contains: Zingiber officinale (ginger) 500mg as root powder 400mg and dried root extract equivalent to 100mg of root powder.
EOTR - I am taking 'Travelcalm' Natural - costs $4.50 for 10 tablets and ......it works!

Standard Process
TFL - I found the Min Tran on Amazon -- 90 tabs for 11.97 -- Brand is Standard Process. Suggested dosage 4 tabs w/each meal.
Jessielee - Here are some vitamins & other things that are helping me.
*Standard Process Vitamins: Min-Chex (9/day) & Cataplex G (6/day)

Dawson - I take all natural, whole food supplements that I got from my Doctor. The brand name is Standard Process, and I take several to help restore the balance as well as replenish the minerals that cymbalta has robbed my liver of. I have been on them several months now, and feel really good, however, like I said in my posting, I was off the cymbalta for a week, and was a mess! So who knows what, if anything, is making me feel better?

Jeff - Standard Process Brands is a whole food supplement of really high quality. I get it from my Chiropractor. You cannot get it at a store, check online for resources.
http://www.brainrese...t.com/min-tran/
Min-Tran includes the following ingredients: Kelp, Alfalfa, Water, Calcium Lactate, Calcium Stearate, and Magnesium Citrate.

Baking Soda
Many members found baking soda baths very effective for itching,
FiveNotioins - I'd also add in baking soda/water ... I made a paste of it, and put it on the worst welted/itchy/scratchy parts of my skin ... then rinse of with cool water ..
sage - I had digestion issues with Cymbalta as well, especially as I've started weaning off of it. The two things that seem to totally work (for me) are dill pickles with garlic (and sipping the juice!)... and 1/2 tsp of baking soda mixed with a little water (instant appeasement of symptoms, which means Cymbalta has probably made my stomach more acidic?).
Many members use baking soda as an antacid as well.
Himalaya Herbal Healthcare StressCare

http://www.cymbaltaw...elps#entry65192

Dr Redwig R22
Lynn - One thing she gave me too take 3x daily was Dr Redwig R22 drops for mood.
Fishinghat - WOW, WOW and WOW again. You guys have got to read the details at the end of this information about 2 of the ingredients.

http://dkonatural.co...41&categoryId=7
R22 Reckeweg Nervous Disorders
Active ingredients:
Grindelia X4, Lachesis mutus X12, Naja tripudians X12, Ethanol, Aqua purificata.

Inactive ingredients:
36-37 vol.-% alcohol, distilled water.

Suggested Use:
Generally 10-15 drops in some water 3 times daily before meals. Reduce dosage gradually after improvement, but continue treatment for several months.

** Please read all label information on delivery.

https://www.my-ayurv...heart-medicines
DR. RECKEWEG R22 - Najasthen Drops for Nervous Disorder Anginous Condition 22 ml
Indications:
Nervous disturbance, oppression and suffocation, also following flatulence.
Anginous condition of the heart.
Ingredients:

MODE OF ACTION OF MAIN INGREDIENTS:

Naja trip: Soreness at forehead and temples due to the anginous condition of the heart. Palpitations of the heart, oppression, general nervousness. Cardiac weakness and irritations caused by nervous coughing, acute condition.

Grindelia rob.: Feels as if heart were too large for thoracic cavity, cardiac and pulmonary weakness, sensation of suffocation in bed.

Lachesis: Nervousness, spiritual animosity, headaches especially above the left eye, palpitations with sensation of suffocation, symptoms worse at bed time and by warmth.

http://homeopathictr...vous-disorders/
Same as above reference.

http://www.reckeweg-...com/company.php
Dr.Roshanlal Aggarwal & Sons Pvt.Ltd. Representing Dr.Reckeweg in India, Nepal & Bangladesh
Pioneers in Homoeopathy for over 60 years

https://homeomart.ne...isorders-drops/
Dr. Reckeweg R22 Drops for nervous disorders (anginous condition of the heart) indicated for Chest pain that is typically described as heaviness, squeezing, pressure, tightness or pain (Anginous condition of the heart). R 21 treats nervous disturbances, headaches, rapid heartbeat due to exertion (oppression) and suffocation, also following flatulence. Sense of suffocation in bed due to pulmonary weakness

A search of the medical journals has shown no scientific research has been done on this specific product.
Ingredient review:
Naja tripudians X12 - An extract from the venom of The monocled cobra.
The major toxic components in cobra venoms are postsynaptic neurotoxins, which block the nerve transmission by binding specifically to the nicotinic acetylcholine receptor, leading to flaccid paralysis and even death by respiratory failure

Purchase of cobra venom and its extracts require federal permits before the products can be marketed. Current permit limitations are very restrictive and do not include medicinal applications except for antivenom use.
No medical journal information on this material other than its toxic effects.

Grindelia Robusta -
Both Grindelia Robusta and Grindelia Robusta squarrosa have been used for the symptoms here recorded. There is practically no difference in their action, although the G. Squarrosa is credited with more SPLENIC symptoms, dull pains and fullness in left hypochondrium; chronic malaria; gastric pains associated with splenic congestion. Induces paralysis, beginning in extremities. Its action is shown on the heart first quickening, then retarding it.
Acts on the cardiopulmonary distribution of the pneumo gastric in dry catarrh (tart Emetic in muco-purulent). Produces a paresis of the pneumo-gastric, interfering with respiration. Smothering after falling asleep. Asthmatic conditions, chronic bronchitis. Bronchorrhea with tough mucus, difficult to detach. Raises the blood pressure. Nausea and retching of gastric ulcer. Sugar in urine. An effective antidote to Rhus-poisoning, locally and internally; also for burns, blisters, vaginal catarrh and herpes zoster. Hyperchlorhydria when attended with asthmatic and other neurotic symptoms. Hyperaemia of gastric mucous membrane with difficult respiration.

https://www.ncbi.nlm.../pubmed/2236296
Certain components in the leaves break down red blood cells.

Lachesis mutus (The Bushmaster) - An extract of a venomous pit viper from South America.
http://natural-heali...hesis-mutus.htm
The poison of the bushmaster, a greatly feared snake native to Central and South America, is deadly if it enters the human bloodstream. It can paralyze the heart and central nervous system and disrupt the blood-clotting process. These reactions are why many people find it surprising that this snake venom is used in homeopathic medicine to treat various circulatory and nervous-system disorders. But the remedy

Therapeutic effect
The most important effect of Lachesis mutus is its blood-thinning, or anticoagulant, function. This action enbances blood flow and facilitates the healing process by hastening the removal of toxins from the blood. The remedy is effective against many bleeding disorders.

Epsom Salts
Many members report success using it for cramping, itching and even withdrawal symptoms.
Merete - My go-to solutions are Epsom salt baths and mint tea to sooth aches and calm the body and mind. The salts can also help with the itchy, crawly skin sensations. The only caution is if you have acute nerve pain (pins and needles or sharp stinging) in hands and feet then the warm salty water can make the feeling worse.
Fivenotions - Have you tried Epsom Salts hot soaks? That did wonders for me, along with the chelated magnesium ...
Sis - I also strongly recommend Epsom salt baths, especially in the evening. I had a hard time believing that we absorb and properly process magnesium through out skin, we do but the concentration has to be fairly high. I routinely add 2 cups of epsom and a couple drops of Lavendar
plezhelp - the best thing i am still doing is tepid Epsom-salt baths with baking soda, and apple cider vinegar - which has helped a lot with the itching; i have no idea which one of those things are the best/better 'healing' but know that they are all currently helping me.
sickandtiredofit - A great therapy for the muscle aches and pains that is cheap. Run a warm bath and place 2-4 cups of epsom salt in the bath water. Add a cap of olive oil to the water. Epsom salt and oilve oil are suppose to be great fro sore achy muscles and it really helps. I also place a little drop of lavendar oil to help me relax.
Activated Charcoal Capsules
https://www.ncbi.nlm...tacidsCymbalta
"Pharmacokinetic results from drug interaction studies show that activated charcoal decreases duloxetine exposure" (absorbtion)
Jillybean - Activated charcoal capsules- (Solaray brand name 280 mg I take 3 capsules twice a day. Lots of water or fluids, it is highly absorbable so it needs to be taken 2 hrs b4 or after other meds, vits etc. It helps to pull the poison from yours system. It may cause diarrhea or constipation hence another reason to boost fluids. Even though diarrhea is uncomfortable, do not take something to stop it as it is necessary to flush this poison out of your system. You can adjust amount based on how you feel.
Jillybean - I think the activated charcoal is working too as I am feeling better.
DonMH - One of the most harmless remedies for the stomach problems is capsules of Activated Charcoal. You can buy them over the counter. They are often used in overdose patients to prevent the absorption of ingested drugs. Completely natural and harmless - only side effect -your poop will turn black as the charcoal passes through your body. It works - I know!
FH - After reviewing the medical journal abstracts I found many research articles that looked at testing if activated charcoal would remove toxins from our body. None of the research showed benificial effects. Caution - They are however very effective at absorbing (thus reducing) medicines and nutrients in the stomach.

Bragg's Apple Cider Vinegar
Used for detox, fibromyalgia, arthritis, zaps, fatigue, shakes, muscle aches and pains.
Tfaff - I'm trying to " detox" by eating well, finding foods that help detox the liver. I drink that apple cider vinegar/ honey/cinnamon mix that came up in another post here.
Fivenotions - I took myself off completely a few months ago and went back to home remedies (ginger tea and ginger slices, as well as Bragg's vinegar) ... the home remedies work pretty well (not perfectly) for the acid reflux ... but the "stomach worms"/anxiety every so slowly started to ratchet up ...
Another "home remedy" that really helped me (still does, I'm still taking it) is Bragg's Apple Cider Vinegar ... it's also available in most health food stores, as well as from the internet (Amazon, and Bragg's directly) ... can be put in water, with honey, etc.... during early withdrawal, I drank it straight ... my food cravings were totally weird, and at the time it actually tasted great just like that ... blech ... there've been studies (which I now can't find, typical) that indicate it's a food that naturally increases serotonin levels ... it also cured my arthritis ... (Grandma knew more than I gave her credit for!)
The Bragg's ACV, which is unpasteurized and has what they call the "mother" in it...weird term, but that's the stuff that would otherwise be pasteurized out ....what starts to form when apple cider begins to go "hard" ....

Here's the link ...
http://bragg.com/

I started taking it early in withdrawal ... totally by self-discovery ... I was having an amazing craving for vinegar tasting stuff...like dill pickles...actually, the juice they come in...so I did some googling...

It was very helpful to me with the withdrawal ... seemed to help with the zaps, my constant tiredness and the body "shakes" I got .... now, I've found that it's pretty much cured my arthritis...
Fishinghat - By the way some have had very good success with Bragg's Apple Cider Vinegar for their fibro. There is some medical research that supports this. If you do a search on this site you will find several discussions about it. Be aware it is acidic so it can upset the stomach. The reason the Bragg's is the only Apple Cider Vinegar that works is that it is unpasteurized and therefore has all the original components. If you have any questions about the Braggs let me know and I will try to answer them.
Lady Nancy - I could not resist the urge to search and found several references to Bragg's Apple Cider Vinegar which is an unfiltered and unpasteurized apple cider vinegar. Many are unable to take it due to stomach issues in which case a good alternative is Malic Acid/Magnesium in pill form as it works the same.
The dose for the Bragg's is two teaspoons in a cup of water. It is much stronger than regular Apple Cider Vinegar which is probably why it causes stomach aches for some even with some sugar or honey added. I know that I would not be using sugar at all if possible as it actually adds to joint pain and feeds the inflammation. .
Fishinghat - A little caution on the vinegar, which has been shown effective, added vinegar ingestion by women has been linked to increases in vaginal infections due to changes in blood and vaginal pH.
katrand - I also add Bragg's apple cider vinegar to my orange juice every morning to aid in absorption of my thyroid meds and supplements.
TFL - Are you taking anything for the joint pain? I found that Apple Cider Vinegar (Braggs is the best - natural!) is a great help - you can mix a couple of spoonfuls in a cup of warm water with 1 spoon of honey and some cinnamon - almost tasty! I have arthritis and fibro and this really helps - give it a couple of weeks...
BJinFl - I have tried ACV, fishinghat, thank you. Unfortunately, I have one of those stomachs that can't stomach anything.
Fishinghat - For fibromyalgia I would try Braggs brand Apple Cider Vinegar. The dosage is 2 tablespoons in about a cup of cold water once a day. There has been some medical research that this juice has benefit for fibro and arthritis pain. This brand is the only one that works because it is the only one that is unfiltered and not pasteurized. Many find this solution to be too acidic for their stomach to handle, if you have that problem then buy some malic acid/magnesium tablets at your local health store. Malic acid and magnesium are the active ingredients in the Apple Cider vinegar.
Gail - ....each capsules contains 500mg apple cider vinegar powder, 300mcg potassium and 4mcg bore.
Fishinghat - He said to use a 50/50 blend of Braggs (sp) apple cider vinegar and water on the area on her back where the nerves are pinched. It may take a couple months to make a difference but will reduce the arthritis and the pain greatly. He recommends it to many of his patients as a way to reduce there use of pain meds for arthritis. I asked him if he has ever heard of using it on fibro and he said that the ACV worked better on the fibro than it did the arthritis.
http://www.ehow.com/...bromyalgia.html
This article explains the basics of using ACV to treat Fibro. I found maybe 50 articles or so that say basically the same thing and many forums that say it works.

http://www.ncbi.nlm..../pubmed/8587088
This research article demonstrates that malic acid is very beneficial in treating fibro. AND malic acid is one of the main ingredients in ACV. It is suggested that there must be magnesium present for it to work and there is nagnesium in ACV.
Natural diuretics include:
⦁ Apple cedar vinegar- it regulates the level of potassium in the body

Bragg Organic Apple Cider Vinegar is the type most often mentioned on the forums.

Gonnamakeit - Well, I decided to give this a try and started this morning with this recommended by Whycee a while back: "A cup of hot water, 1/2 teaspoon of cinnamon, two tablespoons of apple cider vinegar and a teaspoon of honey every morning" minus the cinnamon as I'm allergic and I have to say that it seems to be working! I had two servings this morning and this is the first good day since last Friday and I even woke up with my period in full force AGAIN--it just ended Sunday (apologies to the men!) and even those cramps are so much better.
FiveNotions -
Drinking to Cure: Apple Cider Vinegar and Cherry Juice for Arthritis?
http://www.healthlin...juice-arthritis

This isn't an article, but a collection of links to info about the ACV arthritis connection...also, we had an interesting discussion here a while back about tart cherry juice as a remedy for withdrawal... https://www.cymbalta...l=+tart+cherry

The healing powers of vinegar
http://www.dailymail...rs-vinegar.html

http://www.anyvitami...inegar-info.htm

Serotonin/tryptophan connection mentioned . . .
http://health.usnews...e-cider-vinegar

This is an interesting discussion about ACV from the Social Anxiety Forum....
http://www.socialanx...a-relief-47323/
Wagtail - I think it was Fivenotions that recommended the apple cider vinegar , so I decided to try it . I can't say if it's a coincidence or not , but I do feel better since I've been taking it ... Less s/e's & more energy .. I'm happy with that !..:-)
Carleeta - Holy Moly...Apple cider vinegar...wow...I use it daily with Iceberg lettuce...I use it on my fish and on my potatoes..Also, I mix apple cider with fresh caused garlic and fresh ground black pepper, place it in a small bowl and dip pieces of meat (steak, pork chops) on it and eat them...I also soak crispy friend pork rinds in the bowl mixture and eat them...I guess I use apple cider vinegar a lot. It's possible this is what keeps me going forward...I like that it does burn fat also... So great to know it's helping you out with your cymbalta withdrawl....
JBhibbard - Drink lots and lots of water. Have you tried the apple cider vinegar detox? I believe it helps.
Andreamarie - For supplements I'm taking B Complex, Omega 3s, and apple cider vinegar.
Whychee - A cup of hot water, 1/2 teaspoon of cinnimon, two tablespoons of apple cider vinegar (Braggs) and a teaspoon of honey every morning.
plezhelp - i cannot say what will work for you but i continue to try different things = being open to change as the *** side-effects change too! the best thing i am still doing is tepid Epsom-salt baths with baking soda, and apple cider vinegar - which has helped a lot with the itching; i have no idea which one of those things are the best/better 'healing' but know that they are all currently helping me.
happyzappynot - I found that adding a teaspoon of cider vinegar to a glass of water helped my gut.
andie - I have bought some omega 3 6 9 and taking apple cider vinegar. everything has been very bearable so far so good xx
Nmood2talk - I started taking apple cider vinegar over a week ago to help with metabolism and weight issues - it does - more energy than ever - less appetite but amazing result is how I didn't know it helped get off Cymbalta - I tried before becasue when I didn't have money for meds at times I had terrible brain zaps(like elctric shocks in my head) and terrible nightmares- and the pain in my legs got so much worse -
the apple cider vinegar has worked 3rd day off minimal leg discomfort - no brain zaps - no nightmares - have felt better than I can remember ever - look up apple cider vinegar on Web MD and other places - don't drink straight as it will irritate throat - harsh to teeth - look to see if any side effects - says it could interact with meds ... just research it - but I'm telling you - it's an answer for me so far when I thought there were no answers - apple cider vinegar - look it up - nothing fancy although they say organic is better - got mine at the dollar store and like I said took it initially for weight loss - which it is curbing my appetite and making me feel so much better and I'm losing weight but the off cymbalta without terrible withdrawals was the unexpected unbelievable finding - look it up - research it - and let me know
IamwhoIam - Prepare a mixture of apple cider vinegar and honey. Consume this mixture; this home remedy is highly effective in relieving vertigo.
Vertigoheel
Composition:
Anamirta cocculus D4 210 mg; is a Asian and Indian climbing plant. Its fruit, Cocculus indicus, is the source of picrotoxin, a poisonous alkaloid, with stimulant properties.
Conium maculatum D3, (hemlock or poison hemlock) is a highly poisonous plant in the carrot family, native to Europe and North Africa. Since no specific antidote is available, prevention is the only way to deal with the plants poisonous effects.
Ambra grisea D6, Ambergris, is a solid, waxy, flammable substance of a dull grey or blackish colour, produced in the digestive system of sperm whales It is illegal to possess or sell in most countries).
Petroleum rectificatum D8 (purified crude oil or petroleum is distilled, diluted with sulfuric acid, and succussed (shaken vigorously). The result is a very powerful homeopathic remedy that has a wide range of uses) 30 mg each.
http://www.biopathic... Fact Sheet.pdfData sheet
Heel Corporation
FDA violations
In 1984 BHI received letters and warnings from the Food and Drug Administration that it was in violation of FDA regulations in regards to marketing of homeopathic remedies. BHI was given multiple FDA citations and fines during the 1980s and early 1990s for violation of the Compliance Policy Guidelines labelling guidelines established by the FDA in 1988. These were corrected and have not recurred, though in August 2013 the company again agreed to dial down its health claims tied to its over-the-counter remedies and pay a $1 million class settlement to resolve accusations that it exaggerated the products’ effectiveness to consumers.(Wiki)
http://edzardernst.c...n-subsidiaries/
Homeopathic manufacturer to close North American subsidiaries
In the USA and Canada, manufacturers of OTC homeopathic medicinal products have been confronted with accusations through class action lawsuits. Heel Inc., the Heel Group’s U.S.-based subsidiary, was also faced with two such attempts recently. Both cases have been settled without conceding the allegations. The financial burden on Heel Inc., however, was substantial.
In a subsequent risk-benefit analysis of its global activities, the Heel Group decided to focus on strengthening its excellent position in South America, Central Europe and Eastern Europe and to withdraw from business activities in the USA and Canada for the time being.
Heel’s operations in both the USA and Canada will accordingly be discontinued as of August 31, 2014.
http://vincentverhey...m/node/4#Heel'sOR http://web.archive.o...ntVerheyen.com/
Heel's fortune comes from Nazi Germany: The Quandts were rich enough to escape the Nuremberg trials. They now produce Vertigoheel.
Uriel - Try a homeopathic called VERTIGOHEEL it really helped me out alot i took 3 a day you just let them melt under your tongue....
Medical Research on Vertigoheel.
https://www.ncbi.nlm...pubmed/20852360
https://www.ncbi.nlm.../pubmed/8414621
https://www.ncbi.nlm...pubmed/15750375

Melatonin
FH - a research article where it was shown that taking 3 mg of melatonin under the tongue (sublingual) helps with anxiety. Place it under the tongue until dissolved and gone. In case you are not familiar with melatonin it is the chemical your body produces in the evening to make you sleepy and ready for bed.
Several other areas mention melatonin. A search of this topic for the word Melatonin yeilds much more information.

Gatorade

Many members found Gatorade to be considerable help in fighting most withdrawal symptoms, especially the green gatorade.

Kindorf - Also I have been avoiding caffeine so I cut out my coffee and sweet tea.
I replaced then with fruit juice, ( mainly apple juice ) water and Gatorade. Today no stomach cramps I think they are done. No diarrhea, Lord I hope that is gone.

Judy - I knew that Gatorade helped with the light-headed, "floating brain" feelings.

watchdog - Drinks LOTS of GREEN gatorade..... don't know what the deal is, but it helps.

wiraz - Drink at least one G2 Gatorade a day – stay away from the full sugar version, leads to a higher chance of diarrhea. I drink one 32 oz bottle every day plus tons of water!!

caroline - Vit E also for head and joints and then Gatorade's G2. I didn't want the sugars so I went with the G2

Rafael - I have mild brain zaps but I believe the omega 3 Fish Oil and Gatorade are helping.

Sandlion - I took fish oil/other Omega 3 and also found that Gatorade helped -- maybe it's the salt replacement after all the nightsweats.

guppie - I'm a month off the drug so only minor zaps now and then. Whoever gave the gatorade advice is a genius. That treats them instantly (make sure you get the low calorie gatorade since regular is high calorie). Brain zaps are minor. I grab a gatorade and that gets rid of those for a bit (electrolytes).

Alisha - gatorade-had one of the big bottles yesterday and it did seem to help,

Vinvin - The Fierce Green Apple Gatorade, Dramamine and Boylan's Ginger Ale seem to help out as well

Summary - Many members medtioned drinking Gatorade for the electrolytes after diarrhea, night sweats and when having brain zaps. G2 was often mentioned because it has no sugar (not true, see below). Also, it was suggested that one should not just rely on Gatorade alone for hydrated but should also drink plenti of water. Green Gatorade is highly recommended by some members. Vitylite and Powerade were also mentioned a couple times for electrolytes. I would also recommend Isopure as it comes with and without sugars and proteins with a similar amount and type of electrolytes as Gatorade.

Original Gatorade - One 12.5 fl oz bottle contains 21 grams sugar. It also contains 160 mg sodium (sodium is a stimulant to some people, raising bp and and metabolism). It contains no phosphorus, calcium or magnesium.
Lemon/lime has same ingredients as other Gatorade except it has Yellow #5.

G2 Gatorade - It has the same amount of sugar as regular Gatorade and nearly all the same ingredients and electrolytes.

Gatorade Fierce Green Apple Sports Drink - This may be the "green gatorade" that members spoke of. It contains malic acid, the active ingredient in apple cider vinager which has proved so helpful to other members. Other ingredients are the same.

Isopure Zero Carbs - No sugar, with some calcium. Contains Malic acid
Isopure Mass - With sugar and proteins, with calcium, Contains Malic acid
Isopure zero carb with proteins - no sugar, contains proteins. With calcium Contains Malic acid


Ylang-ylang
Note - Cananga odorata, known as the cananga tree is a tropical tree. It is valued for the perfume extracted from its flowers, called ylang-ylang which is an essential oil used in aromatherapy.
Carleeta - Ylang-ylang is still one of my favorites....it's wonderful for lifting your mood...and helps with positivity....
mimmie - Dill oil on my wrists and Joy oils (mixture of Bergamot, Ylang Ylang, Geranium and others) on my chest right over my heart.
sarahj - Ylang Ylang for in the day, for the beauty of the smell also. You can just smell them straight from the bottle, or put some in your bathwater.
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#9 fishinghat

fishinghat

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Posted 09 July 2018 - 03:38 PM

Natural Treatments for Cymbalta Withdrawal Symptoms (cont.)

http://www.cymbaltaw...tion#entry37106
Kratom information and discussion.

Kratom is a tropical evergreen tree in the coffee family native to Southeast Asia.
As of 2018, little is known of kratom's worth or safety as a therapeutic agent, since research into its use has been of poor quality. In February 2018, the Food and Drug Administration (FDA) stated that there is no evidence kratom is safe or effective for treating any condition. Some people take it for managing chronic pain, for treating opioid withdrawal symptoms, or – more recently – for recreational purposes. Onset of effects typically begins within 5 to 10 minutes and lasts 2 to 5 hours.
Common minor side effects may include nausea, vomiting, and constipation. More severe side effects may include respiratory depression (decreased breathing), seizure, addiction, and psychosis. Other side effects may include high heart rate and blood pressure, trouble sleeping, and, rarely, liver toxicity. When use is stopped, withdrawal symptoms may occur. Deaths have occurred with kratom both by itself and mixed with other substances. Between 2011 and 2017, 44 kratom-related deaths occurred, only one of which involved kratom alone. Nine kratom-related deaths occurred in Sweden in 2011 and 2012, all involving a mixture of kratom with a prescription opioid analgesic.
The U.S. Drug Enforcement Administration has issued a "Drugs of Abuse Resource Guide", which states "Kratom is not controlled under the Federal Controlled Substances Act; however, there may be some State regulations or prohibitions against the possession and use of kratom. Alabama, for example, outlawed the use and possession of kratom in May 2016, and all stores in Alabama were ordered to immediately remove all kratom products from their shelves. In addition, DEA has listed kratom as a Drug and Chemical of Concern." There is no FDA-approved medical use for kratom in the United States.
On June 9, 2015, the Food and Drug Administration (FDA) announced an import alert for kratom, issuing guidance that shipments are to be seized without physical examination from several vendors listed due to concerns that there is no evidence that Kratom does not pose an unnecessary risk of illness or injury, further stating that "[C]onsumption of kratom can lead to a number of health impacts, including respiratory depression, nervousness, agitation, aggression, sleeplessness, hallucinations, delusions, tremors, loss of libido, constipation, skin hyperpigmentation, nausea, vomiting, and severe withdrawal signs and symptoms."(Wiki)
http://www.ncbi.nlm....pubmed/20798544
Seizures and coma;

http://www.ncbi.nlm....pubmed/20411370
The more I read the more it sounds like a drug similar to the alkoids in opium.

Great caution should be exercised before use of this product. It reacts with the same receptors as opium. Immediate deaths have occured with taking it. Most commercial (internet) products contain codiene, pseudoephrine, caffiene and other stimulants with the Kratom. Some foreign countries are using this like you would an opiod pain killer. It is addictive and you can build up tolerance to it.

http://www.ncbi.nlm....pubmed/24325774
http://www.ncbi.nlm....pubmed/23846544
http://www.ncbi.nlm....pubmed/23212430
http://www.ncbi.nlm....pubmed/23206666
http://www.ncbi.nlm....pubmed/23082895
http://www.ncbi.nlm....pubmed/22018854
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Valerian root

Fishinghat - A caution for those who use or are considering using valerian root. It greatly slows down the bodies ability to process and eliminate benzos. This allows the benzos to build to very high values in the body. Caution should be used when taking the two at the same time.
Fivenotions - Ditto to the valerian caution.....I tried it as tea....wasn't using benzos, but it whacked me out somehow....a tip I got from Fishinghat is to start whatever it is you're trying....amino, herb, etc....in very small amounts/doses....and work up gradually....

Boot2 - i found if i combined chocolate (i am using unsweetened health food store kind now) and valerian- it feels like i am almost normal again...thought i;d pass that along.

LadyNancy - I had a reaction to valerian but then that is nothing new for me.

RussellSprout - The valerian/mag combo (when I remember to do both) doesn't act like a sleeping pill or anything of that sort, but it does physically relax me so I can drift to sleep more easily. Unfortunately, the valerian smells like death.

Hornet - I too am enjoying the dreams. Additionally, I have been taking Valerian root to help sleep and it exacerbates the dreams.

brzghoff - valerian works for some, gives me a headache.

jillybean - I also use valerian root (from puritan's pride) 450 mg capsules 1 capsule late afternoon and 1 before bed. This is considered nature's valium and though it does not make me drowsy I do feel it is helping with anxiety. I missed the late afternoon dose yesterday and had one hell of a panic attack. I won't do that again.

Albergo - Made things worse: Valerian root (really bad reaction - BIG WARNING), benzodiazepines (clonozepam .5mg, took 1-2 weeks to recover from),

Around 20 members mention taking valerian, especially in their SleepyTime Tea. I would estimate around 60% said it helped with around 40% saying no. Several had bad reactions/interactions with it.

Drug.com list 581 drug interactions for Valerian, including sleep aides, benzos, cold medicines, and more.

Damiana tea
FiveNotions - Instead of valerian, I use damiana tea...from the fresh herb.....but a caution there....it can lower blood pressure, esp. Systolic....that's a benefit for me, but not if you already run low or take meds for bp.....
Fishinghat - Interesting. I couldn't find anything about damiana (Turnera diffusa) treating anxiety in the medical journals. But I found several articles on Turnera aphrodisiac being as effective as diazepam. The active ingredient on Turnera aphrodesiacis, Apigenin, which works on benzo receptors. (see reference below )
Kumar, S; Madaan, R; Sharma, A (2008), "Pharmacological evaluation of Bioactive Principle of Turnera aphrodisiaca", Indian Journal of Pharmaceutical Sciences, 70: 740–4, doi:10.4103/0250-474X.49095, PMC 3040867  , PMID 21369434
Apigenin is a potent inhibitor of CYP2C9 an enzyme responsible for the metabolism of many pharmaceutical drugs in the body. Ingestion of this substance would significantly reduce the absorption of medicines and supplements absorbed via the CYP2C9 enzyme. It also effects opiod and adenosine receptors as well. It can increase testosterone levels, decreases cortisol levels, (See reference below for source references).
https://examine.com/...ments/apigenin/

Many references state that Turnera diffusa and T. aphrodisiaca are generally regarded as the same plant in herbal commerce. This may explain why some supplements have a better reputation than others. Many mention that damiana is also an aphrodesiac but again this is not damianas but Turnera aphrodisiac.

Research;

http://www.ncbi.nlm....pubmed/16635964
http://www.ncbi.nlm....pubmed/15864356
http://www.ncbi.nlm....les/PMC1062162/


http://www.herbaldb....iolytic-action/
The article here talks about the anti-anxiety properties of damianas in research BUT the research they quote was done on Turnera aphrodesiac not Turnera diffusa (damianas).

Jujube (also called San Zao Ren) (Genera Ziziphus)
FH - San Zao Ren is the same thing as Jujube. It does have anxiolytic effects but can also reduce bp so please monitor carefully.
Geebers - She gave me an herbal powder called San Zao Ren (Chao). This is to help with the anxiety and sleep.
https://www.ncbi.nlm...pubmed/19260286
The alcohol extracts of Semen Ziziphi Spinosae have the anti-anxiety effects instinctively. Its mechanism may be related to increasing the GABA and expression of GABAAR1 and reducing the Glu and expression of NMDAR1.

https://www.ncbi.nlm...pubmed/19101585
It is concluded that sanjoinine A may have anxiolytic-like effects in the elevated plus-maze, hole-board test and open field test, and these effects may be mediated by GABAergic transmission.

https://www.ncbi.nlm...pubmed/19505549
ZE (jujube) with the 5-HT(1B) (serotonin) receptor.

https://www.ncbi.nlm...pubmed/10996283
https://www.ncbi.nlm...pubmed/14531016
All the above mention anxiolytic effects.

https://examine.com/...iziphus-jujuba/
Traditional usage of Jujube is taking 50g of the fruits (20 individual 2-2.5cm diameter fruits) and doing a hot water extract, either a soup of a beverage.
There currently is not enough evidence in humans to establish an effective oral dose of Zizyphus Jujube supplements but estimating from animal studies finding benefits with 500mg/kg for anxiety reduction, an estimated human dose would be:
⦁ 5,500 mg for a 150lb person
⦁ 7,300 mg for a 200lb person
⦁ 9,000 mg for a 250lb person
The seeds of Ziziphus jujube have been implicated in reducing anxiety, in accordance with their traditional usage. Oral administration of 0.5, 1, and 2g/kg of the ethanolic seed extract in mice was able to exert anxiolytic effects, and although it was equally effective as Buspirone and Diazepam (2mg/kg and 1mg/kg, respectively) at a black and white test (anxiety model) at 500mg/kg, it appeared to become less potent at anxiolysis at 1 and 2g/kg while becoming more sedative in nature.
Highly regarded as a sedative in traditional chinese medicine with minimal Western trials on its efficacy, it appears to induce sedation in a relatively dose dependent manner and is synergistic with 5-HTP in this regard.
Good for constipation. May be acutely anti-fertility, but there is limited evidence to support this notion.
Above reference contains support references.
As no human toxicity tests have been performed care should be used when taking this supplement.

NAC - N-acetylcysteine - Strong antioxidant.
https://www.ncbi.nlm...pubmed/18534556
NAC appears a safe and effective augmentation strategy for depressive symptoms in bipolar disorder.
https://www.ncbi.nlm...pubmed/25004186
the study provides only limited support for the role of NAC as a novel adjunctive therapy for MDD.
https://www.ncbi.nlm...pubmed/21719110
These open label data demonstrate a robust decrement in depression scores with NAC treatment
https://www.ncbi.nlm...pubmed/22891797
There were no significant between-group differences in recurrence or symptomatic outcomes during the maintenance phase of the trial;
https://www.ncbi.nlm...pubmed/27725170
The anxiolytic effects of NAC were comparable to diazepam.

Freeme - I have been taking milk thistle to detox the liver and zertex. I put benadryl spray on my arms at night. I am taking also x3 NAC which cleanses the liver too. These both will calm down my itchy to nothing.
3 members reported a positive experience with this product.

Rockstar Energy Drink
4 members mention using it for dehydration, brain zaps and fog as well as an energy drink,
https://www.walgreen...6020233-product
The world's most powerful energy drink. Enhanced with the potent herbal blend of guarana, ginkgo, ginseng and milk thistle. Scientifically formulated to provide an incredible energy boost for those who lead active and exhausting lifestyles-from athletes to rock stars. Enjoy this fully refreshing, lightly carbonated beverage super chilled. Double strength & size.
Not Recommended For Children, pregnant or nursing women Or Those Sensitive To Caffeine.

https://en.wikipedia...drink)#Contents
Rockstar products in the US have two levels of caffeine content - either 10 mg of caffeine per ounce, or 15 mg of caffeine per ounce. Rockstar Energy Drink Original contains 160 mg of caffeine per 16 ounce can, while the Rockstar Punched energy drink contain 360 mg of caffeine per 24 ounce can.
Besides caffeine and sugar, Rockstar Energy Drink contains a variety of herbs, including panax ginseng, ginko bilobe, milk thistle extract, and guarana seed. The amount of guarana used to be higher, but "after being criticized for including guarana once health concerns about the herb were publicized, the amount in the drink was significantly reduced." It also includes 1000 mg of tqurine.
Rockstar can cause jitteriness, head aches, anxiety, and high blood sugar levels. If mixed with alcohol it may also mask the level of alcohol intoxification.

https://www.ncbi.nlm...les/PMC5015039/
a study in which blood pressure and heart rate responses to a sugar-sweetened ED (Rockstar, Rockstar, Inc.; 240 mg caffeine and ∼62 g sugar) resulted in significantly elevated blood pressure values (systolic blood pressure: +6.6 mm Hg; diastolic blood pressure: +4.2 mm Hg) compared with a sugar-matched placebo.

Vicks
3 members found Vicks Vapor Rub calming.
TOC - At night I put vicks on my sinus areas, it soothes me and calms me.
https://vicks.com/en...opical-ointment
Regular:Camphor (synthetic) 4.8% (Cough suppressant and topical analgesic)
Eucalyptus oil 1.2% (Cough suppressant)
Menthol 2.6% (Cough suppressant and topical analgesic)
Some versions contain lavendar oil which has been found to help releive anxiety.

Lion's Mane Mushroom
(AKA Yamabushitake or H. erinaceum )
https://www.ncbi.nlm...pubmed/24506286
Lion's Mane Mushroom (LMM) contains Vitamin B12.
https://www.ncbi.nlm...pubmed/23510212
Daily oral administration of H. erinaceus could promote the regeneration of injured rat peroneal nerve in the early stage of recovery.

https://www.ncbi.nlm...pubmed/27481156
Anti-inflammatory, a protective agent in the treatment of IBDs (inflammatory bowel disease).

https://www.ncbi.nlm...pubmed/29199560
This study demonstrates novel characteristics of H. erinaceus in reducing nociceptive (pain) behavior and blocking the functional activity of P2R (calcium binding receptors).

https://www.ncbi.nlm...les/PMC5237458/
In wild-type mice the oral supplementation with H. erinaceus induces, in behaviour test, a significant improvement in the recognition memory and, in hippocampal slices, an increase in spontaneous and evoked excitatory synaptic current in mossy fiber-CA3 synapse. In conclusion, we have produced a series of findings in support of the concept that H. erinaceus induces a boost effect onto neuronal functions also in nonpathological conditions.

https://www.ncbi.nlm...les/PMC5133811/
Our findings provide experimental evidence that HE (H. erinaceus) may provide neuroprotective candidates for treating or preventing neurodegenerative diseases.

https://www.ncbi.nlm...les/PMC4895996/
Our results demonstrate that HEPS exhibit antioxidant and neuroprotective effects on Aβ-induced neurotoxicity in neurons.

https://examine.com/.../yamabushitake/
Yamabushitake, known as the Lion's Mane Mushroom, is a dietary mushroom that can be a supplement.
As the water soluble extract seems to be less potent than other fractions, it may be best to take Yamabushitake with meals if in supplemental form.
If itchy skin occurs, this may be related to an increase in Nerve Growth Factor and unless accompanied by signs of allergy should be benign.
Currently, the only human study has used an oral dose of 1,000mg Yamabushitake (96% purity extract) thrice daily for a cumulative total of 3,000mg extract. While it is unknown if this is the optimal dose or not, it appeared to be effective.
Yamabushitake has been noted to increase mRNA expression of nerve-growth factor (NGF) (Nerve growth factor is primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target nerve cells.) in isolated astrocytes to around 5-fold that of control at 100-150ug/mL of the ethanolic extract in a concentration dependent manner, with no efficacy noted in the water extract
An increase in NGF mRNA has been detected in the hippocampus, but not cortex, of mice given 5% of the diet as yamabushitake for a period of seven days to around 1.3-fold of control. (Note - Interesting as Cymbalta heavily afects the hippocampus).
Neuronal excitability from glutamic acid appears to be attenuated in the presence of yamabushitake extracts.
Anxiety and Depressive symptoms have also been reduced in humans fed 2g of Yamabushitake, via cookies, over the course of 4 weeks. There was a significant difference between groups on the measurements of concentration and irritability, favoring the Yamabushitake group. Nagano M, et al. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. (2010)
Yamabushitake may act as a PPARα agonist and reduce triglycerides without any apparent effect on cholesterol.
Although both the hot water and ethanolic extracts have been found inactive on cholesterol and HDL-C, an extract derived from the mycelium of yamabushitake (ethanolic extract which was then lyophilized) appeared to reduce LDL by 45.5% and improve HDL-C by 31.1% when taken at an oral dose of 200mg/kg with 50mg/kg also being somewhat active
Side Effects
There has been one case study of a 63 year old man who suffered acute respiratory failure, and the excess lymphocytes in his lungs showed high reactivity to Yamabushitake daily for 4 months in dosages commonly bought. The connection between the two, when rated, is seen as a 'probably' connection
https://nootropicsex...e/#dosage-notes
Dosage
Dosing of Lion’s Mane Mushroom depends on the strength of the extract. It’s available in capsule or powder form.
For Lion’s Mane 10:1 extract (30% polysaccharide), daily dosage is 500 – 1,000 mg taken 1 to 3 times per day.
Other retail extract dosage of Lion’s Mane ranges from 300 mg to 3000 mg dosed 1 – 3 times per day. Check the label and see what the manufacturer recommends. And when first using the supplement, start with the lowest dose and see how your body reacts.
Start at 500 mg per day and see how it works for you. If you don’t experience a benefit, boost Lion’s Mane in small increments of 250 mg per day until you notice an improvement.
Side Effects
Lion’s Mane Mushroom is non-toxic and considered very safe. So there are very few side effects reported.
Some neurohackers report itchy skin from higher doses. Likely attributable to a boost in Nerve Growth Factor.
Lion’s Mane has been tested in animals showing no side effects or toxicity even up to 5 grams per kilogram.
https://www.cabdirec...act/20103302738
Our results show that H. erinaceum intake has the possibility to reduce depression and anxiety.

file:///C:/Users/Neil/AppData/Local/Microsoft/Windows/INetCache/IE/K78IEYPO/solid-state-cultivation-of-hericium-erinaceus-biomass-and-erinacine-a-production-2155-9821.1000210.pdf
Erinacine A, isolated from the cultured mycelia of H. erinaceum, the main representative of this compounds group, has a strong enhancing effect on NGF synthesis, much stronger than epinephrine. Furthermore, this compound increases catecholamine and NGF content in the central nervous system of rats.
Erinacines and hericenons reduce anxiety as well as depression. For an accurate understanding of the overall mechanism of H. erinaceus diterpenoids action it requires additional clinical studies with physiological markers, such as hormones, or more profounded studies of autonomic nervous activity
https://www.thefreel...on.-a0430893147
Summary of the antianxiety/antidepressive effects of components of H. erinaceus.

BK Yang et al., “Hypolipidemic effect of an Exo-biopolymer produced from a submerged mycelial culture of Hericium erinaceus," Bioscience, Biotechnology, and Biochemistry, vol. 67, no. 6 (June 2003): 1292–1298.
A cell wall polysaccharide produced by a special, submerged culture of lion’s mane mushroom was found in an animal study to lower cholesterol by 32%, LDL cholesterol by 45.4%, and triglycerides by 34.3%, and to raise the “good” HDL cholesterol by 31%.9 The researchers proposed that the mushroom’s constituents helped to lower cholesterol production via the hepatic HMG-CoA reductase pathway, reducing the amount of this enzyme by 20%.

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Sweet Fennel Tea

Numerous members used Sweet Fennel Tea to improve sleep and to treat edema.

Drinking fennel tea may increase your skin's sensitivity to sunlight, notes Drugs.com.
People who have a known allergy to carrots, celery or mugwort are at an increased risk of developing an allergic reaction upon exposure to fennel. Symptoms associated with an allergic reaction may be life-threatening and include facial swelling, difficulty swallowing or breathing, hives or dizziness. Seek prompt care from your medical provider if you exhibit any of these side effects after drinking a cup of fennel tea.
Consumption of fennel tea should also be avoided by people with a personal history of a seizure disorder, such as epilepsy, as this herbal treatment may increase your risk of experiencing seizures.
Do not consume fennel if you are also taking birth control pills or any estrogen-based therapeutic drugs, as fennel may reduce the efficacy of such drugs. Concomitant use of fennel tea and ciprofloxacin or tamoxifen should also be avoided. Fennel may make it harder for your body to properly absorb these medications.

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St. John's wort
Classified as a ssri.
Special Precautions & Warnings:
Pregnancy and breast-feeding: St. John's wort is POSSIBLY UNSAFE when taken by mouth during pregnancy. There is some evidence that it can cause birth defects in unborn rats. No one yet knows whether it has the same effect in unborn humans. Nursing infants of mothers who take St. John's wort can experience colic, drowsiness, and listlessness. Until more is known, do not use St. John's wort if you are pregnant or breast-feeding.

Children: St. John's work is POSSIBLY SAFE when taken by mouth for up to 8 weeks in children 6-17 years-old.

Alzheimer's disease: There is concern that St. John's wort might contribute to dementia in people with Alzheimer's disease.

Anesthesia: Use of anesthesia in people who have used St. John's wort for 6 months may lead to serious heart complications during surgery. Stop using St. John's wort at least 2 weeks before a scheduled surgery.

Attention deficit-hyperactivity disorder (ADHD): There is some concern that St. John's wort might worsen symptoms of ADHD, especially in people taking the medication methylphenidate for ADHD. Until more is known, don't use St. John's wort if you are taking methylphenidate.

Bipolar disorder: People with bipolar disorder cycle between depression and mania, a state marked by excessive physical activity and impulsive behavior. St. John's wort can bring on mania in these individuals and can also speed up the cycling between depression and mania.

Depression: In people with major depression, St. John's wort might bring on mania, a state marked by excessive physical activity and impulsive behavior.

Infertility: There are some concerns that St. John's wort might interfere with conceiving a child. If you are trying to conceive, don't use St. John's wort, especially if you have known fertility problems.

Schizophrenia: St. John's wort might bring on psychosis in some people with schizophrenia.

Surgery: St. John's wort might affect serotonin levels in the brain and as a result interfere with surgical procedures. Stop using St. John's wort at least two weeks before a scheduled surgery.
Camphor
https://www.ncbi.nlm...les/PMC3612440/
Several animal and human investigations suggest anxiolytic, mood stabilizer, sedative, analgesic, and anticonvulsive and neuroprotective properties for lavender.
The main constituents of lavender are linalool, linalyl acetate, 1,8-cineole B-ocimene, terpinen-4-ol, and camphor. However, the relative level of each of these constituents varies in different species
file:///C:/Users/Neil/AppData/Local/Microsoft/Windows/INetCache/IE/LONUKTYN/1%20jmscr.pdf
Presenting series of 78 patients, who have been using camphor –based substances (CBS) from more than 5 years in topical and oral forms. All of these patients were dependent on these substances for reliving symptoms of headache, insomnia and even seizures. Patients have symptomatic symptoms on their withdrawal. 6 month withdrawal was 67% with 16% relapse of usage of CBS. Question arises, Does camphor makes the patient dependent? Does camphor results in permanent neural tissue damage

Eucalyptus oil
https://www.ncbi.nlm...pubmed/25028591
The present findings suggest that inhalation of 1,8-cineole may be used to relieve anxiety before, during, and after various operations.
No other research articles found.
Menthol
No research articles found to show that Menthol helps treat anxiety or depression.

Ashwagandha
(Withania somnifera )
https://www.ncbi.nlm...pubmed/25405876
All five studies concluded that WS intervention resulted in greater score improvements (significantly in most cases) than placebo in outcomes on anxiety or stress scales.
https://www.ncbi.nlm...pubmed/26068424
Our results provide evidence indicating that key constituents in WS may have an important role in the development of pharmacological treatments for neurological disorders associated with GABAergic signaling dysfunction such as general anxiety disorders, sleep disturbances, muscle spasms, and seizures.
https://www.ncbi.nlm...pubmed/19718255
300 mg twice a day.
Final BAI scores (anxiety test) decreased by 56.5% in the Ashwagandha group. Significant differences between groups were also observed in mental health, concentration, fatigue, social functioning, vitality, and overall quality of life with the Ashwagandha group exhibiting greater clinical benefit. No serious adverse reactions were observed in either group.

http://www.ncbi.nlm....pubmed/24497737
250 mg 2x/day

http://www.ncbi.nlm....pubmed/24330893
500 mg/day for bipolar, effective.

http://www.ncbi.nlm....pubmed/23439798
Each capsule contained 300 mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant. Each person took 2 capsules a day. The treatment group that was given the high-concentration full-spectrum Ashwagandha root extract exhibited a significant reduction in scores on all the stress-assessment scales on Day 60, relative to the placebo group. The serum cortisol levels were substantially reduced in the Ashwagandha group, relative to the placebo group. No serious adverse events were reported.

http://www.ncbi.nlm....pubmed/22546655
W. somnifera extract is effective in treating obsessive compulsive disorder
https://www.ncbi.nlm...pubmed/18697607
The results suggest the protective effect of WS in the management of ethanol (alcohol)withdrawal reactions.

https://www.ncbi.nlm...pubmed/17585686
Preliminary results suggest that Withania root extract can be used in the management sleep loss and associated oxidative stress.

http://www.ncbi.nlm....pubmed/19363747
Effective for anxiety

http://www.ncbi.nlm....pubmed/11194174
WSG also exhibited an antidepressant effect, comparable with that induced by imipramine in the 'behavioural despair' and 'learned helplessness' tests. The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression

http://www.ncbi.nlm....les/PMC3252722/
It has a Cognition Promoting Effect and was useful in children with memory deficit and in old age people loss of memory. It was also found useful in neurodegenerative diseases such as Parkinson's, Huntington's and Alzeimer's diseases. It has GABA mimetic effect and was shown to promote formation of dendrites. It has anxiolytic effect and improves energy levels and mitochondrial health. It is an anti-inflammatory and anti-arthritic agent and was found useful in clinical cases of Rheumatoid and Osteoarthritis.

http://www.ncbi.nlm....les/PMC3487234/
1,250 mg/day × 10 days
All volunteers tolerated WS without any adverse event.
Safety and side effects

http://www.ncbi.nlm....les/PMC2958355/
This product is comparative to lorazepam in its ability to control anxiety. That is impressive.
https://www.ncbi.nlm...les/PMC2958355/
250 mg twice a day.
At 6 weeks, significantly more patients met a priori response criteria in the drug group (88.2%) as compared with the placebo group (50%). The drug was well-tolerated and did not occasion more adverse effects than did placebo. It is concluded that this ethanolic extract of Withania somnifera has useful anxiolytic potential and merits further investigation.

https://www.ncbi.nlm...pubmed/28004351
This study provides scientific validation to the anxiolytic, anti-inflammatory and anti-apoptotic properties of ASH-WEX, which may serve as an effective dietary supplement for management of SD induced stress and associated functional impairments.

Members Comments
One member reported taking it during withdrawal and said it was very beneficial.
Brz - ashwagandha update:
had to stop - bummer.
definitely allergic. just like sk8ermama. i couldn't figure out why my allergies hadn't gone away even after the pollen count dropped way down. stopped the ashwagandha and my congestion and headaches subsided. not to mention i had a very tight chest feeling. very uncomfortable. my side effects are not uncommon from what i've learned. i may try again way down the road but now that i'm battling reflux, i don't want to complicate things. i've heard rhodiola is a similar adaptogen, but don't want to introduce anything new into my system right now.
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#10 fishinghat

fishinghat

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Posted 09 July 2018 - 03:43 PM

Multivitamins

Caution -Vitamin Toxicity. More than 60,000 instances of vitamin toxicity are reported annually to US poison control centers.
USP – Signifies a drug that meets quality standards if there are established quality standards for that type of product.
Vitamins should always be consumed with at least a small amount of foods which contain the same vitamin. This way any natural covitamins, enzymes or poteins needed to process the vitamin shoukld be available.
A (β-carotene) is a group of unsaturated nutritional organic compounds, that includes retinol, retinal, retinic acid and several provitamin A carotenoids, among which beta-catotene is the most important. Vitamin A has multiple functions: it is important for growth and development, for the maintenance of the immune system and good vision. Vitamin A is needed by the retina of the eye in the form of retinal. Vitamin A also functions as retinoic acid which is an important hormone-like growth factor for epithelial and other cells. Recommended Daily Allowance is from 600 to 900 micrograms/day (Maximum is 1700 to 3000 micrograms/day). Vitamin A toxicity is very serious and as it is fat soluble it may be stored in the human body. Consult with physician before taking Vitamin A supplements. Anxiety is a side effect of Vitamin A deficiency and as such Vitamin A will bring the anxiety under control but it is recommended that this be done by dietary changes rather than by supplements due to the risk of toxicity. Vitamin A allergy is rare.
https://www.ncbi.nlm...pubmed/21521362
Not anxiolytic.

https://www.ncbi.nlm...pubmed/24777547
A not anxiolytic.

https://www.ncbi.nlm...pubmed/17727954
Causes anxiety

Hypervitaminosis A (elevated Vitamin A levels)
Toxicity results from ingesting too much preformed vitamin A from foods (such as fish or animal liver), supplements, or prescription medications and can be prevented by ingesting no more than the recommended daily amount.
Diagnosis can be difficult but there are effective tests available. Hypervitaminosis A is usually treated by stopping intake of the offending food(s), supplement(s), or medication. Most people make a full recovery.
Wiki

"Per tablespoon (13.6 g), cod liver oil contains 136% of the established daily Tolerable Upper Intake Level (UL) for Preformed Vitamin A (Retinol). Vitamin A accumulates in the liver, and can reach harmful levels sufficient to cause hypervitaminosis A. Pregnant women may want to consider consulting a doctor when taking cod liver oil because of the high amount of natural forms of vitamin A such as retinol.

"The risks of fatty acid oxidation, hypervitaminosis, and exposure to environmental toxins are reduced when purification processes are applied to produce refined fish oil products."

The environmental toxins are important, especially mercury, other heavy metals and pesticides.
http://ajcn.nutritio...t/83/2/191.full
In developed nations, the increasing availability of and interest in fortified foods and supplements resulted in a large percentage of the population with preformed vitamin A intakes higher than recommended. Indeed, observational studies suggest that more than 75% of people may be routinely ingesting more than the recommended dietary allowance (RDA) for vitamin A, much of it as preformed vitamin A.

https://www.ncbi.nlm...t00572-0157.pdf
Chronic hypervitaminosis A may exist for many years among members of the general
public without recognition, resulting eventually in hepatocellular (liver) damage and hepatic fibrosis. Pre-existing liver disease may also affect the capacity of the organ to transport the vitamin into the circulation, thus potentiating its hepatotoxicity..

Symptoms may include:
Abnormal softening of the skull bone (in infants and children)
Blurred vision
Bone Pain or swelling Bulging of the soft spot in an infant's skull
Changes in alertness or consciousness
Decreased Appitite
Dizziness
Double vision (in young children)
Drowsiness
Hair changes, such as hair loss and oily hair
Headache
Irritability
Liver damage
Nausea
Poor weight gain (in infants and children)
Skin changes, such as cracking at corners of the mouth, higher sensitivity to sunlight, oily skin, peeling, itching, and yellow color to the skin
Vision changes
Vomiting

Dosages -
Liver is high in vitamin A. The liver of certain animals are particularly toxic.
Supplements - usually when taken above recommended dosages - can be toxic. Cod Liver Oilis particularly high in vitamin A.
http://nutritiondata...-and-oils/628/2
One tablespoon of Cod Liver oil contains 13,500 IU (4,500 μg/day) which exceeds the tolerable upper limit for an adult human by 50% for daily intake.
Most Vitamin A supplements deliver 5,000 to 25,000 IU (which is 1,667 to 8,333 μg/day)
Amazon

https://www.ncbi.nlm...ooks/NBK222318/
The half-life o0f Vitamin A is 128 days and allows for rapid build up of toxic levels.

Daily Tolerable Upper Level
Life stage group category Upper Level (μg/day)
Infants
0–6 months
7–12 months
600
600
Children
1–3 years
4–8 years
600
900
Males
9–13 years
14–18 years
19 – >70 years
1700
2800
3000
Females
9–13 years
14–18 years
19 – >70 years
1700
2800
3000
Pregnancy
<19 years
19 – >50 years
2800
3000
Lactation
<19 years
19 – >50 years
2800
3000
Source for above information is wiki

B complex is a class of water-soluble vitamins that play important roles in cell metabolism. Though these vitamins share similar names, research shows that they are chemically distinct vitamins that often coexist in the same foods. In general, supplements containing all eight are referred to as a vitamin B complex. General side effects, (usually transient) may include restlessness, nausea and insomnia. Vitamin B allergies are rare and are usually associated with Vitamin B 3, 6 and 12. Some allergic reactions can be severe. See individual B vitamin. The raw form of B vitamins are difficult to absorb. The methylated or phosphated forms (sometimes refered to as coenzyme form)is more readily absorbed. Since the B vitamins are so essential in our handling of stress many psychiatrists begin new patients off with a vitamin B blood assessment. There is little evidence that B viamins are effective against anxiety but only helps protect against the effect of further stress.
FH - One caution to add. If this is your first time taking B vitamins start with a low dose and work up from there. I was put on B complex when I was first diagnosed with anxiety and had a severe allergic reaction to it.. Allergy to B vitamins is uncommon but does happen. I can't even take the little kiddy pills without nausea and vomiting.
FN - Also, take them in the morning.....I learned that if I take a b complex any later than noon, it seems to interfere with my sleep....they seem to give me an energy boost, which isn't what I need at nighttime.....I've read that this is the case for quite a few people....
http://www.ncbi.nlm....pubmed/23738221
Used Max Stress B, effective, 30 days to start
Caution – Max Stress B contains many more active ingredients than just B Vitamins.

https://www.ncbi.nlm...pubmed/21905094
B complex not effective

B1 (thiamine) is the most active form is thiamine pyrophosphate (TPP), a coenzyme in the breakdown of sugars and amino acids. Synthetically thiamin is usually marketed as thiamin hydrochloride or thiamin mononitrate and is a made from Grewe diamine (a coal tar derivative) processed with ammonia and other chemicals.
Thiamine is used in the biosynthesis of the neurotransmitters acetocholine and gamma-aminobutyric Acid (GABA). Humans must obtain it from their diet. Thiamine deficiency has a potentially fatal outcome if it remains untreated. The RDA is set at about 1.0 mg. There are no reports available of adverse effects from consumption of excess thiamine by ingestion of food and supplements. Vitamin B1 toxicity is very rare but high doses can lower other B vitamins and homocysteine
https://www.livestro...rdose-symptoms/
No research found to indicate Thiamine is anxiolytic.
B2 (riboflavin) has reactions including activation of other vitamins. There is no evidence for riboflavin toxicity produced by excessive intakes, as its low solubility keeps it from being absorbed in dangerous amounts within the digestive tract. Allergic reactions are rare.
No research found to indicate riboflavin is anxiolytic.
B3 (niacin) is changed to NAD and NADP which are used in catabolism of fat, carbohydrate, protein, and alcohol, as well as cell signaling and DNA repair, and NADP mostly in anabolism reactions such as fatty acid and cholesterol synthesis. Niacin is involved in both DNA repair and the production of steroid hormones in the adrenal gland. Due to high energy use in the brain it is the most susceptible organ for niacin deficiency. RDA is 14 to 16 mg/day. Intake should not exceed 35 mg/day. Extended release tablets increase the risk of liver toxicity. The FDA does not recommend the taking of niacin supplements. Niacinamide does not seem to cause gastrointestinal upset or hepatotoxicity that the synthetic time-released niacin can cause.
It comes in 3 forms (nicotinic acid, niacinamide and nicotinamide). Taking niacin also might worsen allergies, gallbladder disease and symptoms of certain thyroid disorders. If you have diabetes, niacin can interfere with blood glucose control. Use niacin with caution if you have the complex form of arthritis gout. Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout. (Mayo Clinic)
No research found to indicate niacin is anxiolytic.
FH - CAUTION....Niacin can build up in the system and cause flushing, liver toxicity and really agitate your stomach. I would start with low doses around 0.25 to 0.5 mg per day and see how you handle it.
B5 (pantothenic acid) is a water soluble vitamin that is essential to synthesize and metabolize proteins, carbohydrates, and fats. The RDA is 5mg/day. There is no upper limit for consumption. Extremely high doses have been found to produce panic attacks. Synthetic pantothenic acid is processed with formaldehyde (a strong cancer causing agent. It exists in 2 other forms; pantotheno and calcium pantothenate.
No research found to indicate pantothenic acid is anxiolytic.
B6 (pyridoxine) is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gebe expression. It is a factor in the biosynthesis of five important neurotransmitters: serotoniin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid (GABA). The RDA is 1 – 3 mg/day. Doses of pyridoxine in excess of the RDA over long periods of time result in painful and ultimately irreversible neurological problems. There are 7 forms; Pyridoxine (most common), Pyridoxine 5'-phosphate, Pyridoxal, Pyridoxa 5'-phosphate, the metabolically active form (sold as 'P-5-P' vitamin supplement) Pyridoxamine (PM), Pyridoxamine 5'-phosphate (PMP) and 4-Pyridoxic acid (PA). Due to its half life of up to 25 days it is easy to buildup toxic amounts in the blood stream. Vitamin B6 toxicity is on the rise in the USA.
Vitamin B6 Toxicity
https://www.ncbi.nlm...pubmed/26417231
Fenugreek seed extract treats peripheral neuropathy in pyridoxine induced neuropathic mice. Our data showed that fenugreek has anti neuropathic effect and restores the function of nerve fibers
The German Commission E monograph recommends 6 grams per day, which can be taken all at once or divided between three meals. Since most fenugreek capsules are available in either 580 or 610 milligrams, a common dosing scheme would be 2-3 capsules three times a day.

https://www.ncbi.nlm.../pubmed/6308447
We describe seven adults who had ataxia and severe sensory-nervous-system dysfunction after daily high-level pyridoxine (vitamin B6) consumption. Four were severely disabled; all improved after withdrawal. Weakness was not a feature of this condition, and the central nervous system was clinically spared. Although consumption of large doses of pyridoxine has gained wide public acceptance, this report indicates that it can cause sensory neuropathy or neuronopathy syndromes and that safe guidelines should be established for the use of this widely abused vitamin.

https://www.ncbi.nlm...ooks/NBK114313/
Half-Life is 15 to 24 days.
https://www.ncbi.nlm.../pubmed/3630649
A newly recognised neurotoxic syndrome due to pyridoxine (B6) overdose is described. It is the largest series of B6 intoxication hitherto reported. A raised serum B6 level was present in 172 women of whom 60% had neurological symptoms, which disappeared when B6 was withdrawn and reappeared in 4 cases when B6 was restarted. The mean dose of B6 in the 103 women with neurological symptoms was 117 +/- 92 mgs, compared with 116.2 +/- 66 mgs in the control group. There was a significant difference (P less than 0.01) in the average duration of ingestion of B6 in the neurotoxic group of 2.9 +/- 1.9 years compared with 1.6 +/- 2.1 years in controls. The symptoms were paraesthesia, hyperaesthesia, bone pains, muscle weakness, numbness and fasciculation, most marked on the extremities and predominantly bilateral unless there was a history of previous trauma to the limb. These women were taking a lower dose of B6 than previously described (1,2), which may account for the complete recovery within 6 months of stopping B6.
https://www.ncbi.nlm...pubmed/10746516
50 mg B6 with Mg

https://www.ncbi.nlm...pubmed/15554143
Magne-B6 (a magnesium lactate/pyridoxine combination), effective. 14 days to start.
A total of four articles were found linking vitamin B6 to the treatment of anxiety and/or depression.

https://www.ncbi.nlm...pubmed/25137514
Supplementation with pyridoxine at doses greater than 50 mg/d for extended duration may be harmful and should be discouraged.
https://www.ncbi.nlm...pubmed/25056196

B7 (Biotin) no reported side effects or toxicity.
No research found to indicate biotin is anxiolytic.

B9 (Folic acid, folate) is essential for numerous bodily functions. Humans cannot synthesize folic acid, therefore, folic acid has to be supplied through the diet to meet their daily requirements. Folic acid is not found naturally but folate is. Some recent research has indicated that synthetic folic acid may interfer with the bodies ability to process folate. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions. It is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy. Children and adults both require folate to produce healthy red blood cells and prevent anemia. Low risk of toxicity. RDA is 400 micrograms/day and not to exceed 1000.
http://www.ncbi.nlm....pubmed/22528830

B12 (methylcobalaminVitamin B12 is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.
http://www.ncbi.nlm....pubmed/12796225
Not anxiolytic.

Vitamin C (ascorbic acid ) is a cofactor in at least eight enzyme reactions reactions, including several collogen synthesis reactions that, when dysfunctional, cause the most severe symptoms of scurvey. In animals, these reactions are especially important in wound-healing and in preventing bleeding from capillaries. Vitamin C may also act as an antioxidant against oxidative stress. The functions of Vitamin C include the synthesis of collogen, carnitine, and neurotransmitters (norepinephrine from dopamine) the synthesis and catabolism of tyrosine; and the metabolism of microsome. RDA is 75 to 90 mg/day with no more than 2000 mg/day maximum. The signs and symptoms of overdose is nausea, vomiting, diarrhea, flushing of the face, headache, fatigue and disturbed sleep. Vitamin C's anxiolytic properties is beleived to primarily be from its ability to repair oxidative effects from stress.
http://www.ncbi.nlm....pubmed/24511708
Effective at 1000 mg/day
http://www.ncbi.nlm....les/PMC2885294/
Effective
https://www.ncbi.nlm...pubmed/24979594
Effective
https://www.ncbi.nlm...pubmed/21036190
Effective and lowers cortisol levels.
https://www.ncbi.nlm...les/PMC2649700/
Ascorbate is proposed as a neuromodulator of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors.
https://www.ncbi.nlm...les/PMC3964749/
A paper explaining the relationship between oxidative stress and anxiety.

Vitamin D - Cholecalciferol and ergocalciferol
No Research shows Vitamin D, in any form, anxiolytic.
FH - You are definitely correct about taking the D3 with the calcium but would caution about watching out for immediate changes in behavior, clarity of thought, constipation, nausea and vomiting as these are symptoms of an allergic reaction that require immediate medical attention. If taking vit D3 you should have your calcium and D3 levels checked every 6 months. Long term use can cause hypercalcemia (too high calcium levels).

Vitamin E refers to a group of compounds that include both tocopherols and tocotrienols. Regular consumption of more than 1,000 mg (1,500 IU) of tocopherols per day may be expected to cause hypervitaminosis E with an associated risk of Vitamin K deficiency deficiency and consequently of bleeding problems. Vitamin E has many biological functions, the antioxidants function being the most important and best known. Other functions include enzymatic activities, gene expression, and neurological function(s). RDA is 15 mg/day.
Hypervitaminosis E is a state of vitamin E toxicity. Since vitamin E can act as an anticoagulant and may increase the risk of bleeding problems, many agencies have set a tolerable upper intake levels (UL) for vitamin E at 1,000 mg (1,500 IU) per day. This UL was established due to an increased incidence of hemorrhaging with higher doses of supplemental vitamin E. Doses of vitamin E above the UL can also magnify the antiplatelet effects of certain drugs such as anti-coagulant medications and aspirin, which can cause life-threatening symptoms in ill patients. Hypervitaminosis E may also counteract vitamin K, leading to a vitamin K deficiency.
http://jn.nutrition....138925.full.pdf
Half life is 2 - 3 days.
http://www.ncbi.nlm....pubmed/24511708
Not effective
https://www.ncbi.nlm...pubmed/21036190
Effective

Members comments on vitamins
Many used vitamins without any real comment on their perceived effectiveness.
One member did recommend Vitamin B complex.
And two stated that Vit B complex may have caused increased anxiety.
Another stated....."B Vitamins - "
"Some of the recommendations I've heard are: stay away from Vitamin B as it ramps up the nervous system and can actually increase anxiety."
Resources
Major sources of information includes NCBI, webmd, emedicine and drugs.com.
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Multivitamins
Centrum Forte

Lady nancy - A really good vitamin & mineral supplement (I used Centrum Forte) has helped me.

Calms Forte

Arcelus - Right now I'm also taking 300mg of chelated magnesium and I might take calms forte for sleep as well.
Uriel - Different things work for different people I have found a homepathic called Calms Forte for me they work great for the anxiety and down moods while i went thru withdrawl.

Active Ingredients | Purposes:
Avena Sativa 4X HPUS: stress, nervousness
Calcarea Phosphorica 3X HPUS: restlessness
Chamomilla 4X HPUS: nervous irritability
Ferrum Phosphoricum 3X HPUS: nervousness
Humulus Lupulus 4X HPUS: occasional sleeplessness
Kali Phosphoricum 3X HPUS: irritability
Magnesia Phosphorica 3X HPUS: mental anxiousness
Natrum Phosphoricum 3X HPUS: anxiousness
Passiflora 4X HPUS: restless sleep from exhaustion

Caution - Carefully investigate the possibility of interactions with your medications.

Nutricalm made by natures sunshine
https://www.naturess...-100-tabs/1617/
Provides vitamin C, thiamin (B1), riboflavin (B2), niacin, B6, folic acid, B12, biotin and pantothenic acid, plus schizandra fruit, choline, inositol, bee pollen, PABA, lemon bioflavonoids, valerian root extract, passionflower flowers extract and hops flowers extract.

Natural Calm
350 mg magnesium citrate
Sage - I also take the "Natural Calm" magnesium supplement 3 times a day... it has REALLY helped relax my muscles (had very tense neck and back since starting Cymbalta).

Dolovent


https://www.ncbi.nlm...les/PMC4393401/
Study shows that use of Dolovent helps releive migraine headaches.
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#11 Carleeta

Carleeta

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    Read so many painful stories on here and offering others support while trying to heal myself from cymbalta and other antidepressents.

Posted 09 July 2018 - 07:35 PM

Now that's a piece of work. I've read through 50% Fishinghat and you have my attention. Fabulous work!

#12 fishinghat

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Posted 10 July 2018 - 08:30 AM

Thanks Carleeta. That is about 1/4 of what the finished thread will be like.

#13 fishinghat

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Posted 12 July 2018 - 10:40 AM

Increasing Your GABA Production and Efficiency by Proper Diet and Supplements.

Summary - Eating foods high in GABA or taking GABA supplements have little success in treating anxiety or depression because while they enter the blood system they do NOT cross the Blood/Brain Barrier. However many flavinoids have been shown to facilitate GABA activity in the brain and help with anxiety and depression.
GABA is a neurotransmitter that blocks impulses between nerve cells. Low levels of GABA may be linked to anxiety or mood disorders like depression, epilepsy and chronic pain. Researchers suspect that GABA may boost mood or have a calming, relaxing effect on the nervous system.

http://www.livestron...e-highest-gaba/
GABA is not an essential nutrient but has been used therapeutically for anxiety, insomnia, stress and hypertension. Some prescription depressant drugs and sleeping medications act on GABA by facilitating its ability to bind to receptor sites in the brain. This produces a calming effect and can induce sleep. Taking a commercial GABA supplement is ineffective for this purpose because it is unable to penetrate the barrier surrounding the brain. This is why more powerful prescription medications are used to stimulate existing GABA in the body.

Importance -
https://www.ncbi.nlm...les/PMC3412149/
Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. Many references
Low levels of GABA have been associated with insomnia, depression and anxiety; however, to date there are very few human studies demonstrating the anti-anxiety benefits of GABA supplementation.
Flavonoid-Rich Foods and GABA Receptors
Flavonoids are phytonutrients found in plant-based foods, tea and wine and are known to enhance GABA function.
Foods high in GABA - Cheese, kefir, miso, sauerkraut, tempeh, yogurt, soy sauce and Thai Fermented Shrimp (Kung-Som) have NOT been shown to fight anxiety or depression.
Many probiotics react to ferment foods and produce GABA but there is little evidence that these foods cross the blood brain barrier or has an effect on depression or anxiety.

https://www.ars.usda...77Flavonoid.pdf
Detailed list of flavinoid containing foods.
General list of the Best Sources of Flavonoids
flavonols flavan-3-ols* flavones flavonones anthocyanidins
onions apples parsley oranges blueberries
apples bananas bell peppers grapefruit bananas
romaine lettuce blueberries celery lemons strawberries
tomatoes peaches apples tomatoes cherries
garbanzo beans pears oranges pears
almonds strawberries watermelon cabbage
turnip greens chili peppers cranberries
sweet potatoes cantaloupe plums
quinoa lettuce raspberries
garbanzo beans

Medical Research
https://www.ncbi.nlm...pubmed/25109791
citrus flavonoids ....including antidepressant (activity)

https://www.ncbi.nlm...pubmed/25656001
...the flavonoid fraction (F1C) with anxiolytic activity which is dose dependent, and has the ability to interact with the serotonergic system.

https://www.ncbi.nlm...pubmed/23596160
Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats.

https://www.ncbi.nlm...pubmed/24121702
Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder.

https://www.ncbi.nlm...pubmed/24679021
Purple grape juice as a protector against acute x-irradiation induced alterations on mobility, anxiety, and feeding behaviour in mice. This beneficial effect on short-term anxiety and mobility related activities could probably be included in the list of flavonoid bio-effects.

https://www.ncbi.nlm...pubmed/23603526
The experiments with different receptor blockers suggest an involvement of GABAergic system in the anxiolytic action of this bioflavonoid. However, this action is not seems to be mediated through serotonergic system.
https://www.ncbi.nlm...pubmed/26190180
https://www.ncbi.nlm...pubmed/25600371
https://www.ncbi.nlm...pubmed/21244373
https://www.ncbi.nlm...pubmed/25449359
https://www.ncbi.nlm...pubmed/21924247

And many many more research articles show the anxiety fighting charicteristics of various flavonoids.
https://www.ncbi.nlm...les/PMC4997290/
Higher flavonoid intakes may be associated with lower depression risk, particularly among older women.
https://www.ncbi.nlm...pubmed/23460966
https://www.ncbi.nlm...pubmed/24717328
https://www.ncbi.nlm...pubmed/24947870
And dozens more.

Members and foods they have consumed on the high flavinoid list.
garbanzo beans -1
raspberries - 3
lettuce - 1
quinoa - 3
Xiaojie - Red Peruvian quinoa. I thank God every day for his creating it. It is a protein-packed, vitamin and mineral-packed seed that you throw in your rice cooker and cook the same way you would cook rice (but I add a couple of tablespoons of coconut oil to it). Keeps you feeling energetic, and keeps your digestive system doing what it's meant to do, only more efficiently - so helps purge the body of crap - literally, lol. I HIGHLY recommend it eating a bowl of it every day. Sometimes I eat a bowl of it twice a day. I can tell by how good I feel after eating it that my body loves it. And it has weight loss benefits, as well. Eating lots of fresh vegetables, fish, nuts, coconut oil, and quinoa (very high in protein) daily.

sweet potatoes - 3
cantaloupe - 1
plums, cranberries, chili peppers, cabbage. peaches. romaine lettuce -1
turnip greens (Greens in general) - 13
watermelon - 2
strawberries - 4
almonds - 11
oranges - (Icluding the mention of citrus) - 9
tomatoes - 4
apples - 8
cherries - 4
lemons - 2
celery - 3
blueberries - 6
bananas- 12
bell peppers - 1
grapefruit - (also see 'citrus' above) - 3
FH - Buspirone (Buspar) is a seratonin 5-HT1A receptor partial agonist and a dopamine antagonist at the D2 receptor, D3 receptor and D4 receptors. It functions as a weak anti-anxiety medication similar to diazepam in strength (a weak benzo). DO NOT take with grapefruit or grapefruit juice.
Member warnings
Just read that one should not drink grapefruit juice while taking Zoloft...bad interaction See ...https://www.ncbi.nlm...pubmed/10890261for details.
Autimom - Did you know that GRAPEFRUIT products can cause an interaction with the following medications: Buspirone (BuSpar), Antiarrhythmia - Amiodarone (Cordarone), Antidepressant - Sertraline (Zoloft),
Antihistamine - Fexofenadine (Allegra),. Anti-seizure - Carbamazepine (Carbatrol, Tegretol), Calcium channel blocker (BP medication) - Nifedipine (Procardia), nimodipine (Nimotop), nisoldipine (Sular), Statin - Simvastatin (Zocor), lovastatin (Mevacor), atorvastatin .
rebecca - Avoid Grapefruit Juice. Grapefruit juice is an inhibitor of the cytochrome P-450 enzymes. These enzymes are known to metabolise (break down) (SSRI) antidepressants in the liver. Drinking grapefruit juice whilst you are taking an (SSRI) antidepressant can create a serious toxic reaction, because the (SSRI) antidepressant will build to toxic levels in the bloodstream! (only certain antidepressants)
Note - Because both CYP1A2 and CYP2D6 are responsible for duloxetine metabolism, potential exists for clinically important drug interactions when duloxetine is concurrently administered with CYP1A2 inhibitors, CYP2D6 inhibitors, and CYP2D6 substrates. (See Interactions.)( Drugs.com) while cytochrome P – 450 3A4 substrates, has also been implicated to be inhibited by grapefruit juice. There is NO medical research to show that grapefruit juice interacts with Cymbalta. This is confirmed by the FDA ...
See https://www.fda.gov/...g/ucm093664.htm
https://www.ncbi.nlm...pubmed/10851844
Several actual examples on interactions with selective serotonin re-uptake inhibitors, HMG-CoA reductase inhibitors, mibefradil, sildenafil, protease inhibitors and with grapefruit juice are discussed.

parsley - 2
onions (red) - 3
tea - A great many and will be addressed by types of tea tried.
chamomile flowers (tea) - 17
FN - chamomile tea helps some folks with the gastro issues (I wasn't one of them) but...helped me (with sleep) chamomile and valerian tea
FH - "There is a new sleep aide out called Somnapure. It is flying off the shelfs and being hailed as a wonder cure for insomnia. BUT.....As you can see the ingredients are listed below;

Supplement Facts
Serving Size: 2 Tablets
Servings Per Container: 30
Valerian (Valeriana Officinalis) Root Extract 500 mg*
Lemon Balm Extract Leaf 300 mg*
L Theonine 200 mg*
Hops Extract Strobile 120 mg*
Chamomile Flower Extract 50 mg*
Passion Flower Extract Aerial 50 mg*
Melatonin 3 mg*
* Daily Value not established.

"Most of these ingredients have strong drug interactions and/or side effects except for melatonin. There has been a rash of people landing in the hospital for reactions to this med, especially if they are on antidepressants. Use with caution."
Lemon Balm Tea
Definitely worth a try for most. Lemon balm is another good suggestion but it does contain a low concentration of beta-blockers. Beta blockers like atenolol are often used to help with anxiety and heart palpitations. One of their side effects is to lower blood pressure (this is part of their calming effect). The effect is so small that it isn't an issue for most unless they are already on BP medicine.
LNancy -What I did find helpful was Lemon Balm Tea which I can drink at any time of the day and it helps. When I have it at night with the meds that relax me I am sure to sleep though so if you are going to try it then do so in the evening in case it makes you sleepy.
Feverfew - 1
Tria - The herb Feverfew was given to me by a doctor but I was allergic to it.
Wiki - Long-term use of feverfew followed by abrupt discontinuation may induce a withdrawal syndrome featuring rebound headaches and muscle and joint pains. Feverfew can cause allergic reactions, including contact dermatitis. Other side effects have included gastrointestinal upset such as nausea, vomiting, abdominal pain, diarrhea, and flatulence. When the herb is chewed or taken orally it can cause mouth ulcer and swelling and numbness of the mouth. Feverfew should not be taken by pregnant women. It may interact with blood thinners and increase the risk of bleeding, and may also interact with a variety of medications metabolized by the liver.
Linden flowers - 3
passionflower - 6
LadyNancy - If you don't take any OTC sleeping aids you can also try some lemon balm or passionflower tea made quite strong at night. It helps relax the muscles which eases the pressure in the head. So far I have found that Lemon Balm, Passionflower and omega3 are very good. For nervousness, try Passionflower 2ml up to 3 times a day.
cocoa (unsweetened dark cocoa only) - 5
BRZ - my new anti anxiety drug is Lindt's 90% cocoa chocolate
wine - 22 - Alcohol is dangerous when taking Cymbalta but small amounts may help GABA production after coming off Cymbalta.
FH - when they (cramps) get real bad she can take about 6 or 7 tablespoons of wine and in 15 minutes they are gone.
Wagtail - I can feel the effects today & my balance is very bad so I have learned a lesson , NO wine whilst suffering w/d . I find that when I drink wine the side effects are worse
Zappalta - I am 80% better -I do find if I get overtired or have a glass of wine I have some symptoms return-so no wine when i dine out for now.
Zazzed - slight buzzing had a glass of wine it went away.... go figure
CV - There is nothing you can do (I found that a couple of glasses of red wine in the evening made a big and positive impact.
Shaun - -a glass of wine every couple nights has helped me a lot
HZN - I only drink a small glass of wine occasionally. On March 19 I became so sick with nausea that I thougt 4 ounces might help. WRONG! It made me feel so much WORSE!
Drugfree - Alcohol is a definite no-no. I had a glass of wine a few days ago and had a horrible sleep followed by a full day of feeling hung over. One glass of wine should not make me hung over.
Jen - Someone on this board recommended red wine in the evening ... and absolute Godsend. The red wine took away the symptoms completely and helped me get to sleep.
Flavinoid supplements
...a typical person should consume 20 to 100 grams of flavonoids each day.Other sources say 250 to 750 milligrams per day (0.25 to 0.75 grams per day). It is recommended to start dosage low and build slowly until you are comfortable. As of this date NO medical research has been done to determine the daily requirement for flavonoid intake. There are over 4000 flavonoids that have been identified and each act at slightly different doses. Bioflavonooids (from citrus sources) help to facilitate Vitamin C usage but some are sensative to them (1 member) and heartpounding, skip beats and other cardiac arythmias may occur.
Gaba Supplements
The only way to deliver GABA effectively is to circumvent the blood-brain barrier. Indeed, there are a small, limited number of over-the-counter supplements that are derivatives of GABA, such as phenibut and picamilon combines niacin and GABA and crosses the blood–brain barrier as a prodrug that later hydrolyzes into GABA and niacin.
Phenibut
There are numerous reports of withdrawal symptoms on Internet forums and blogs including "nervousness and shakiness, psychomotor agitation, feeling easily annoyed and irritated, fatigue, poor appetite, heart pounding and racing, nausea, insomnia, and feeling tense and keyed up", consistent with its GABAB agonist properties. There has been no systematic study of this problem. Very limited data to show it can be both anti-anxiety and antidepressant in nature.
http://www.ncbi.nlm....pubmed/23391959
http://www.ncbi.nlm....pubmed/21476277
http://www.ncbi.nlm....pubmed/20841974
http://www.ncbi.nlm....pubmed/19899708
http://www.ncbi.nlm....pubmed/19334514
http://www.ncbi.nlm....pubmed/18607733

Picamilon
Picamilon is able to cross the blood-brain barrier and then is hydrolyzed into GABA and niacin. The released GABA in theory would activate GABA receptors potentially producing an anxiolytic response. The second released component, niacin acts as a strong vasodilator, which might be useful for the treatment of migraine headaches. Very limited data to show it can be both anti-anxiety and antidepressant in nature.
Reported side effects include, but are not limited to, lightheadedness and decrease in blood pressure.
Phemibut has been researched more completely than picamilon. Neither are to be taken with benzos as they interfer with the performance of the benzo.
http://www.ncbi.nlm....pubmed/14558352
http://www.ncbi.nlm..../pubmed/2736292

Member comments on taking Gaba supplements... 12
AKA -By the way, I'm taking 400mg of SAM-e in the morning and 500 of GABA once in the morning and once at night. I've been feeling pretty good mood wise for the last two weeks on this combination. My persistent issue is sleep disturbances.
FH - both SAM-e and GABA can cause sleep disturbances including constant dreaming, erratic sleep and disturbing dreams.
FN - Caution -Aspartame causes "The ATP stores [adenosine triphosphate] in the cells are depleted, indicating that low concentrations of glucose are present in the cells, and this in turn will indirectly decrease the synthesis of acetylcholine, glutamate and GABA (gamma-aminobutyric acid)."
Note - Indicates one should decrease the use of aspartame during withdrawal.
Flossy - Apparently xanax depletes your natural gaba.The gaba is actually helping a lot! I am so angry and agitated at the moment due to cymbalta withdrawal and gaba is calming me a lot.
Note as mentioned above, benzos compete with gaba for the same receptors it does not deplete the gaba in your brain.
tt2k - They specialize in 5 htp, GABA, and other amino acids that totally help your body regulate and produce the chemicals your body needs to fight anxiety and depression. TOTALLY WAS A BLESSING!!!
phtech - How it works: Gaba is an inhibitory neurotransmitter that slows activity in the brain and makes it easier to fall asleep. How to use:Take 500mg to 1000 mg one hour before bedtime if you have trouble getting to sleep. IF your problem is that you wake in the middle of the night and cant go back to sleep, then take it then. Do not exceed recommended doses on the package. Do this for two weeks. If it doesn't help, talk to your doctor. Caution: combining GABA with prescription or over-the counter sleep aids can cause excessive sedation."
Cam - GABA - 250 mg when I'm feeling restless (helps your neurotransmitters kick in to relax)
GABA calm - 1 member
Contains magnesium, GABA, glycine, n-acetyl l-tyrosine and taurine also sorbitol, mannitol, stearic acid, modified cellulose gum, natural orange flavor, and magnesium stearate.

Gaba Plus - 1 member
maccacat - He started taking a supplement called Gaba Plus and told me he feels a difference.
Ingredients: GABA, glutamine, passionflower aerial parts, taurine and spirulina.

http://www.cymbaltaw...-advice-please/
Includes a detailed discussion on Gaba

Medicines that react with the Gaba receptors....
See ... https://en.wikipedia...eceptor_agonistAgonists which stimulate the gaba receptors.
and https://en.wikipedia...ptor_antagonistAntagonists which inhibit the gaba receptors.
FN - Trazadone works on the GABA receptors....
Note - to some extent but it also reacts with over 20 other receptors.

See - https://www.ncbi.nlm...pubmed/15610924
Both klonopin and baclofen work on the GABA receptors Wiki

Drug Interactions
https://link.springe...?no-access=true

Not involved with Serotonin Syndrome

Vitamin C
https://www.ncbi.nlm...les/PMC2649700/
Ascorbate is proposed as a neuromodulator (effects the performance of other neurons) of glutamatergic, dopaminergic, cholinergic and GABAergic transmission and related behaviors.

Antihistamines
The H2 antihistamine receptor is found throughout the hypothalamus, thalamus and central nervous system including neurons (nerve cells). It stimulates formation of cAMP (a compound used to transport energy), protein formation, muscle contraction, blood pressure and much more. The receptor is found in neurons and when stimulated it acts to inhibit other neurotransmitter formation including dopamine, GABA, acetylcholine, noradrenaline, histamine and serotonin. WIKI
 


#14 fishinghat

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Posted 12 July 2018 - 10:46 AM

Gaba (Cont.)
Antidepressants -
http://www.ncbi.nlm....pubmed/15451391
In comparison with saline, citalopram (Celexa) produced a mean increase of 35% in relative brain GABA concentration in the occipital cortex.

https://www.ncbi.nlm...pubmed/25082715
Zolpidem (Ambien) increases GABA in depressed volunteers maintained on SSRIs.

https://www.ncbi.nlm...pubmed/11925309
A significant increase in occipital cortex GABA concentrations was seen after SSRI treatment.

Articles On How Anti-Depressants Effect Gaba
http://www.cymbaltaw...nts-effect-gaba

Other Supplements that efffect Gaba
Details on these supplements will be given in another section.
Thiamine (Vitamin B1) is used in the biosynthesis of the neurotransmitters acetylcholine and gamma aminobutyric acid (GABA). Humans must obtain it from their diet. Thiamine deficiency has a potentially fatal outcome if it remains untreated. There are no reports available of adverse effects from consumption of excess thiamine by ingestion of food and supplements. Thiamine increases the flow of glutamate into the cells for use in neurotransmitter formation. Wiki
Note - Use of thiamine supplements may increase gaba concentrations in the brain but it may also increase acetylcholine. This may account for the variety of responses by members.

No research found to indicate Thiamine is anxiolytic.
B6 (pyridoxine) is involved in many aspects of macronutrient metabolism, neurotransmitter synthesis, histamine synthesis, hemoglobin synthesis and function, and gene expression. It is a factor in the biosynthesis of five important neurotransmitters: serotonin, dopamine, epinephrine, norepinephrine, and gamma-aminobutyric acid (GABA).
https://www.ncbi.nlm...pubmed/10746516
50 mg B6 with Mg
https://www.ncbi.nlm...pubmed/15554143
Magne-B6 (a magnesium lactate/pyridoxine combination), effective. 14 days to start.
Benzodiazepines
https://www.ncbi.nlm...les/PMC2943829/
Based on collective findings in this benzodiazepine withdrawal-anxiety model, we propose a functional model illustrating the changes in glutamate receptor populations at excitatory synapses during benzodiazepine withdrawal.
(Physically alters GABA receptor shape and function during withdrawal.)
http://www.ncbi.nlm....les/PMC3494928/
Chronic BZ treatment results in allosteric uncoupling of the GABA and BZ binding sites, suggesting changes in receptor subunit composition and/or receptor function (reviewed in ref. 7
(Multiple references to changes in the receptors)
Benzodiazepines enhance the effect of the GABA at the GABAAa receptor. Wiki
Anything for a quiet life? by C Heather Ashton DM, FRCP
People become tolerant to benzodiazepines probably because their nerve cells respond by producing fewer receptors for GABA/benzodiazepines. This phenomenon, known as "down regulation", means that the number of "high affinity" GABA receptors decreases in response to the enhancement of GABA caused by the drug. Benzodiazepines do not decrease GABA concentrations; instead they alter GABA-receptor affinity.
https://ajp.psychiat...ajp.161.12.2186
Panic disorder patients had a deficient GABA neuronal response (blunted reduction of occipital cortex GABA level) to acute benzodiazepine administration, compared to the healthy subjects, who exhibited a significant decrease in occipital cortex GABA levels after this intervention. The patients also appeared to have persistently low occipital cortex GABA after chronic benzodiazepine treatment.
I have found numerous articles like these that show that high dose and/or long-term use of Benzos causes improved activity of GABA synapses which leads the body to reduce the number of gaba synapses resulting in high blood concentrations of benzos and low concentration of gaba.
Caution - During withdrawal, fluoroquinolone-based antibiotics are best avoided if possible; they displace benzodiazepines from their binding site and reduce GABA function and, thus, may aggravate withdrawal symptoms.
L-theanine
L-theanine is an amino acid precursor to glutamate (involved in the synthesis of GABA) and glutamine. It can cross the blood brain barrier. It is only produced by plants and fungi and a component in some teas. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements. It is synthesized from glutamate using the enzyme glutamate decarboxylase and pyridoxal phosphate (which is the active form of vitamin B6) as a cofactor. This process converts glutamate, the principal excitatory neurotransmitter, into the principal inhibitory neurotransmitter (GABA).
http://en.wikipedia.org/wiki/Theanine

https://www.ncbi.nlm...pubmed/21208586
Effective, 400 mg/day
https://www.ncbi.nlm...pubmed/15378679
Not effective on anxiety, 200 mg/day
https://www.ncbi.nlm...les/PMC4137547/
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.
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#15 fishinghat

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Posted 12 July 2018 - 01:36 PM

Increasing Production of Endorphins
When you are low in endorphins, you are more likely to feel anxious, depressed, stressed out, and unable to enjoy life or experience joy.
https://en.wikipedia...wiki/Endorphins
Endorphins are endogenous opioid neuropeptides and peptide hormones in humans and other animals. They are produced by the central nervous system and the pituitary gland. The principal function of endorphins is to inhibit the transmission of pain signals; they may also produce a feeling of euphoria (pleasure,happiness) very similar to that produced by other opioids.

How to increase endorphin levels
1. Sniff some vanilla or lavender - Vanilla causes an increase in production of endorphins. This is wht it can help so many with anxiety. The endorphins released when inhaling lavender creates a calming effect that may even enhance sleep and relieve depression.
https://www.ncbi.nlm...les/PMC4325408/
http://www.sciencedi...221169115001033
Ward, A., & Ward, K. (2006). U.S. Patent Application 11/609,330.

Vanilla Oil - Comments from Members
Plzhelp - i just recently learned that 'vanilla' is now something i am currently allergic to (i get headaches).
Lavender Oil - Members 12 positive and 1 negative comment.
SCL - I also have a sleep blend of Serenity, lavender, sandalwood, and bergamot. The calming blend even helped me with a headache without meds!
Gail - What helps me is bubble bath with lavender essential oil.
CurlyKate - The tips on bathing aren't working, my skin feels so tingly and creepy crawly that even my hair and clothing are painful...lavender and any other smells are triggering migraines...lost all appetite...can't sleep...this really sucks!
Gene - I agree 100% with the lavender scent, amazing how calming it is
Warning - Many essential oils are toxic to the liver and may collect there. Especially if taken orally or applied on the skin in large quantities or freqjently.
The oils listed underneath are banned (FDA) and can cause toxicity if taken internally as well as dermally (eg. in a massage blend).
⦁ Almond butter
⦁ Boldo leaf
⦁ Calamus
⦁ Camphor
⦁ Horseradish
⦁ Jaborandi leaf
⦁ Mugwort
⦁ Mustard
⦁ Nightshade
⦁ Pennyoyal (both European and North American)
⦁ Rue
⦁ Sassafras
⦁ Savin
⦁ Southernwood
⦁ Stinging nettles
⦁ Tansy
⦁ Thuja
⦁ Wintergreen
⦁ Wormseed
⦁ Wormwood
http://essentialoils.../toxic-oils.htmgives details on each of these oils.

Medical research on DERMAL toxicity of essential oils.
https://www.ncbi.nlm...les/PMC3546250/
https://www.ncbi.nlm...pubmed/23663182
https://www.ncbi.nlm...pubmed/15771186
https://www.ncbi.nlm...pubmed/16324777
https://www.ncbi.nlm...pubmed/25272759
About lemon, ginger and clove toxicity.

https://www.ncbi.nlm...pubmed/15895251
Recent growth in aromatherapy sales has been accompanied by an unfortunate increase in accidental poisoning from these products. Clove oil warrants special attention.

2. take ginseng (red ginseng preferably)
https://www.ncbi.nlm...pubmed/16450289
http://muskrat.middl...ch/ginseng.html
Members - 6
Butterflygt - Combining that with breathing techniques, drinking lots of water and even green tea with ginseng and lemon it made everything bearable.

3. Exercise
https://www.ncbi.nlm...pubmed/18604371
Overtraining (OT) is a complex and multifactorial sport phenomenon, and there is no independent marker that can diagnose OT. The main stimulus for beta-end(1-31) secretion is to exercise because its secretion is volume/intensity dependent for both aerobic and anaerobic exercise. Excess training, however, may reduce beta-end(1-31) concentrations, thus altering its beneficial effects. Therefore, beta-end(1-31) could be used as an additional OT marker, mainly because its effects are strongly related to OT symptoms.
https://www.ncbi.nlm.../pubmed/1553453
https://www.ncbi.nlm.../pubmed/6091217
https://www.ncbi.nlm.../pubmed/9257407
and many more
As indicated by the first research article, the degree of exercise determines the quantities of endorphins. As many of our members related that light to moderate activities often made them feel better but heavy exercise often brought on an increase in withdrawal symptoms. Stretching also releases endorphins.
4. laughter
5. sex
6. chocolate (unsweetened cocoa) - One of the more unique neurotransmitters released by chocolate is phenylethylamine. This so called "chocolate amphetamine" causes endorphin levels to rise significantly.
https://www.ncbi.nlm.../pubmed/1805284
http://www.sciencedi...16503270600084X
https://www.elsevier...about-chocolate
and more.
Members on Cocoa - 4. all positive.
BRZ - my new anti anxiety drug is Lindt's 90% cocoa chocolate
Members on Chocolate - 18 comments, 6 mention dark unsweetened chocolate, and 4 negative comments about a sugar rush followed by a crash.
FN - for example, Lindt makes choco bars in different % ... the darkest is 90% chocolate ... bitter, but I've gotten to love it ... big boost.
Boot2 - i found if i combined chocolate (i am using unsweetened health food store kind now) and valerian- it feels like i am almost normal again...thought i;d pass that along.

7. music
8. Eat something spicy
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is a naturally occurring alkaloid derived from plants of the genus Capsicum, better known as chili pepper fruit. It is a member of the vanilloid family of compounds (e.g., vanillin from vanilla, eugenol from bay leaves, cloves, and zingerone from ginger) (Hayman and Kam, 2008).
https://www.research...ions_in_the_rat
http://www.phytochem...s/capsaicin.php
https://www.ncbi.nlm.../pubmed/2944026
http://www.rspublica.../april13/54.pdf
and many more articles.
 


#16 fishinghat

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Posted 12 July 2018 - 01:38 PM

Increasing Production of Endorphins (cont)

9. Eat your very favorite food.
10. Meditation - 49 members tried it, 48 positive reviews and 1 negative review.
Meditation has been shown to in crease the production of endorphins.
https://www.ncbi.nlm.../pubmed/7669835
https://www.ncbi.nlm.../pubmed/9748098
Harte JL, Eifert GH, Smith R. The effects of running and meditation on beta-endorphin, corticotropin-releasing hormone and cortisol in plasma, and on mood. Biol Psychol. 1995;40:251–65. [PubMed]
Yadav RK, Magan D, Mehta N, Sharma R, Mahapatra SC. Efficacy of a short-term yoga-based lifestyle intervention in reducing stress and inflammation: preliminary results. J Altern Complement Med. 2012;18:662–7. [PubMed]
And more.
Member tips and comments
CCod - Meditate daily for 20 minutes/day minimum. I use the Insight Timer app on my iPad or the Calm app. Use the Calm app if you have never tried meditation. Calm is really great if you have never meditated because she starts out with beginner instructions and short meditations that last 10minutes. It WORKS every single time. For headaches, anxiety, extreme anxiety, and yesterday, nausea got better. It is not religious or dogmatic; it's. Breathing.
Uriel - It may sound bizarre but I have been doing meditation for 15 min a day to a meditation cd and its pretty amazing how the breathing calms your whole system.
Butterfly - The name of the app is "Relieve Depression Hypnosis-Guided meditation and Mental Health". There is a few different ones on the app store you can try and they are free, I really liked this one.
TM - I spent a few months listening to guided Mindfulness Meditation sessions at bedtime, and found it useful for winding down and falling asleep. You can find them on YouTube, on CD's, and elsewhere on the net.
considering - I think meditation has helped me deal with bouts of low grade depression that I've experienced in the last seven years since I've been on Cymbalta. So I would highly recommend it to anyone. But I recommend that you have a teacher, even if it's meditation CDs of teachings from Sharon Saltzberg or Pema Chodron.

Tinajuli - Somehow I have an anti-reaction when I think of relaxing methods like meditation and yoga. I tried them so much when I had that real depression and they didn't help, and I was despaired because they didn't help.
Karen - The guided meditation takes my anxiety down a lot. It might not be for you, but it really helped me
Check out this site: http://www.30minutem...meditation.html
Shanna - Go to http://www.self-compassion.org(my psychologist recommended this resource). Download the 'Loving Kindness / Self-Compassion' meditation and the 'Soften, Soothe, Allow' meditation - they are free and they are a great way to start cutting yourself a bit of slack and help you feel a bit more on top of yourself.

TBS - I'd also recommend a cd set by Buddhist teacher Jack Kornfield (Not to be confused with Jack Canfield!!!) called The Inner Art of Meditation. It's a workshop he ran with talks and short meditations and probably my favorite of all time.
Zombie - I replaced the Cymbalta with Autogenics and Guided Meditations (not exotic meditation). My Pain Clinic has a psychologist who started me on Autogenics. I now do them daily. For guided meditations, I like this one: Susie Mantrell's Your Present: A Half-Hour of Peace. If you have access to a large library system, you will find many audio CDs on all of this so you can preview "programs" before buying CDs. Also, there are samples or mini-examples on youtube.
11. Increased exposure to sunlight.
https://www.ncbi.nlm...pubmed/24949966
https://www.ncbi.nlm...pubmed/26774381
https://www.ncbi.nlm...pubmed/16635689
https://www.ncbi.nlm...les/PMC2290997/
and more
There are numerous comments from members concerning getting enough sunlight each day. About half of the posts are in reference to the Vit D3 deficiency that member is suffering from and the rest are just general comments that sunlight is good for you especially if you have depression.
12. Certain touchs (hugs, massages...etc)
6 members mentioned messages in relation to their withdrawal. 5 positive. Many others got routine massages for their fibro and frequently mentioned how relaxed they were afterward.
TFL - Today was massage and am feeling better.
Paul - I ended up going to a spa and massage resort yesterday with the wife - didnt really find it relaxing at all!

13. Acupuncture
https://www.ncbi.nlm...pubmed/22073885
https://www.ncbi.nlm...pubmed/22073888
https://www.ncbi.nlm...pubmed/24215920
https://www.ncbi.nlm...pubmed/26896946
https://www.ncbi.nlm...pubmed/25595195
https://www.ncbi.nlm.../pubmed/7455665
and more
Member comments and tips - 15 reviews 14 positive.
FH - Many of my friends and family members have had acupuncture over the years. I think it is a great tool BUT there are a lot more idiots doing acupuncture than experts. In fact my family has only found one so far in the states that new what he was doing (I am sure there are others though).
Traceyish - I've been trying acupuncture, and a host of natural remedies but nothing is working.
GMI - I found a lot of relief from acupuncture in the early stages of withdrawal. I’ve mentioned in prior posts that I was never one to believe in acupuncture even though so many people have told me what wonders it's done for them. These types of acupuncture facilities are all over the country and one near you can be found on this link if you’re is interested in giving it a try: https://www.pocacoop...earch-by-state/
Zeus - However, my general practitioner thought different. She uses a combination of eastern and western medicine and suggested acupuncture. Wow what an improvement. I had one treatment this morning and no nausea since. Even the fatigue is better and I feel like eating again.
considering - Check out the U.S. network of Community Acupuncture Clinics. They are a great way to get low cost acupuncture treatment.
BCH - I used acupuncture, which helped amazingly well. Over a period of about 4 months I suffered very few side effect.
ECU - the auriculotherapy (like acupuncture, only done on the ear alone) was based on a 5 point protocol designed to treat heroin addicts in withdrawal, and got rid of all the physical symptoms (temporarily) and enabled me to function while my body adjusted.
cmonk - I had been going for acupuncture treatments and yes they are wonderful
Sarahj - Oh yeah, I realized how much acupuncture was helping me after the third treatment, I went once a week. So, I hope that it provides some benefit to you. One thing that I tried during the worst of the withdrawal is acupuncture. It really made a difference in my overall outlook on everything, not in a magic bullet kind of way, but my sense of being aware and wanting to take better care of myself seem to be heightened by the experience.
Rogerwilco -Acupuncture is definitely the best way I've found to treat withdrawal discomfort from pharma drugs. The thing about acupuncture is that it has side effects too... but they're all GOOD! I mean, like, WOW :!:
Ramona - acupuncture regularly now. It doesn't take away all the withdrawal symptoms, but it balances the systems in your body to help you feel better while you're going through this. Really calms down the anxiety, quiets your mind.
14. Deep breathing, sighs, yawns....
These activities cause an increase in the release of dopamine, endorphons and serotonin. This fact has been used by psychologists for decades to help control anxiety, depression and sleep. By causing yourself to yawn several time over a 10 or 15 minute period it will release enough of these neurotransmitters to help relax and induce sleep. Sighs work much in the same fashion bugt to a lesser degree, Breathing exercises are the most effective. A good psychologist should be used to teach the most effective techniques.
https://www.ncbi.nlm.../pubmed/9551709
Member comments and tips -
deep breathes, breath(ing) - 22 comments all positive
Raven - Breathe it deep calming breaths and hold them for about 5 seconds before slowly letting them out.
Gail - you need to breathe, yes breathe in and out slowly.
FH - Deep breathing. Close your eyes—and try taking deep, slow breaths— making each breath even deeper than the last. If you have a psychologist who could teach you relaxation techniques, controlled breathing and heart rate, etc. These techniques really do work.
Raven - Just do you best to stay calm and use breathing techniques. My husband and FH have given me great tips on breathing when anxiety strikes. FH because he is a veteran and my husband because he has asthma.
Keys to breathing:
** Take slow deep breaths (breath in deeply and slowly)
** Hold for at least 15 secs if you can
** Exhale slowly
***repeat as needed*

FN - What helped me the most with this was yoga ...the breathing exercises ... once learned, they can be done anywhere, anytime .... the release of the built up anxiety in my body was tremendous ...
Janson - . i've learned a few breathing exercises via yoga and that helps immensely to calm down those nerves that are about to snap. even without knowledge of specific breathing exercises, just take deep full breaths with hands on your stomach and see your tummy rise on the breath in and then fully breath out. so simple, so effective.
Note - There must have been well over 100 members that had posts similar to the one below. Shortness of breath, heart pounding, skip beats, tightness in the chest or chest pain. hese are classic anxiety symptoms and are the result of elevated adrenalin e levels. Adrenaline is a vasoconstrictor and bronchiole constrictor. These shallow rapid breaths allow CO2 to build in the lungs and worsens the symotoms. Alpha-agonists (eg. clonidine) and beta blockers (atenolol) work well t o block the effets of this excess adrenaline. Breathing exercises also help considerably in breaking this Cycle. As you can see below ZA got it really right.
Snap87 - Just scared with the shortness of breath and heart palpitations more than anything.
ZA - the 'out of breath' symptom is actually shallow breathing and I had that for about 2days it is very exhausting as it causes your ozygen saturation to drop. what worked for me 'was awareness -slow deep breathing -then a little aerobics. it helped to up my b/p and neuteralize by blood gases.
15. Conditioned Response -
One of the methods that can have a dramatic effect on anxiety is the development of a phrase in association with breathing exercises and relaxation techniques. This usually takes time to develop but is very effective. The process is begun by selecting a phrase...say the word "easy" for example. When you notice that you begin to get too anxious then lay down, close your eyes and begin your deep breathing exercises while also doing relaxation like 'progressive relaxatiion' all the time repeating the word 'easy' in your mind. With practice this becomes very effective and the need to lay down to acheive success is not necessary. You simply stop in place, close your eyes and say the word 'easy" to yourself while relaxing and breathing deeply. You then prodeed on with your activities. This can be further used by your spouse to help you control your anxiety. If your spouse notices you becoming anxious they can simply develop a certain place she/he touches you gently as a signal that you need to stop, breath and relax. With practise this becomes automatic and can easily be done in public without drawing attention to your state of mind. The is a conditioned response so it MUST be practised until it is a reflex action to be most helpful.
Three members report using this technique with excellant results.
Other Medical Research
https://www.ncbi.nlm...pubmed/15639542
it is suggested that melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by binding to its own receptors and increasing the release of beta-endorphin.
As well as ...
https://www.ncbi.nlm...pubmed/12579851
https://www.ncbi.nlm.../pubmed/3361078
https://www.ncbi.nlm.../pubmed/1668619
https://www.ncbi.nlm...les/PMC5038497/
and more.

Also....
https://www.ncbi.nlm...pubmed/12043836
Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina). Antidopaminergic activities of melatonin have been demonstrated in the striatum.

https://www.ncbi.nlm.../pubmed/6291701
The data of this study provide evidence for a further mechanism by which beta-endorphin may alter dopaminergic neurotransmission, namely by increasing dopamine reuptake into dopaminergic nerve endings.

https://www.ncbi.nlm.../pubmed/6263592
The data are consistent with the hypothesis that endorphins act at a presently unknown brain site(s) to increase the central sympathetic outflow to adrenal medulla and peripheral sympathetic nerve endings, thus stimulating peripheral catecholamine release and increasing plasma concentrations of epinephrine, norepinephrine, and dopamine.

https://www.ncbi.nlm...cles/PMC432218/
In cerebral cortex, brainstem, caudate nucleus, and thalamus, most responsive cells were inhibited by the peptides (endorphins) and by normorphine, while in hippocampus all responsive cells were excited. These results are consistent with the hypothesis that the endorphins and enkephalins may represent a new class of central neurotransmitters; among other functions, these peptides may play a role in the regulation of behavior and the expression of psychopharmacological agents such as the opiate alkaloids.
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#17 fishinghat

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Posted 12 July 2018 - 01:40 PM

Increasing Dopamine Levels
Summary;
⦁ The cycle is: tyrosine converts to L-Dopa to dopamine to norepinephrine and then epinephrine. Therefore caution should be used when trying to raise dopamine to treat depressison. Begin with small doses until releif is obtained. Do not take larger doses as any extra unused dopamine will be changed to noradrenaline and adrenaline and the result could be anxiety.
⦁ An overabundance of bad bacteria in the GI system leaves toxic byproducts called lipopolysaccharides which destroy the brain cells that make dopamine. Therefore a good probiotic should be used.
⦁ And don’t reach for artificial sweeteners. Aspartame decreases brain levels of both dopamine and serotonin, another important mood-boosting neurotransmitter.
⦁ L-tyrosine is the first dopamine supplement to consider. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease.
⦁ One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions.

Dopamine
Dopamine is also synthesized in plants and most animals. In the brain, dopamine functions as a neurotransmitter - a chemical released by nerve cells to send signals to other nerve cells. The brain includes several distinct dopamine pathways, one of which plays a major role in reward-motivated behavior. Most types of rewards increase the level of dopamine in the brain, and many addictive drugs increase dopamine neuronal activity. Other brain dopamine pathways are involved in motor control and in controlling the release of various hormones. It does not cross the blood brain barrier.
Dopamine deficiency can also manifest as certain psychiatric disorders including depression, addiction, attention deficit disorder (ADD), bipolar disorder, and Parkinson’s disease.
Major depressive disorder (MDD), The cause is believed to be a combination of genetic, environmental, and psychological factors. Risk factors include a family history of the condition, major life changes, certain medications, chronic health problems, and substance abuse. About 40% of the risk appears to be related to genetics. There is no laboratory test for major depression. Testing, however, may be done to rule out physical conditions that can cause similar symptoms. Much scientific evidence links lack of dopamine to depression and sometimes anxiety.
Nicotine increases dopamine by 200%, cocaine 400%, and amphetamines a jaw-dropping 1,000%.
Few people realize that they are “self-medicating” to get a dopamine boost when they engage in potentially addictive and self-destructive behaviors. The use and abuse of caffeine, alcohol, sugar, drugs, shopping, sex, video games, online porn, power, and gambling are all effective, but temporary, dopamine boosters.

Here’s a list of foods, drinks, and spices known to increase tyrosine or dopamine directly:
⦁ all animal products
⦁ almonds
⦁ apples
⦁ avocados
⦁ bananas
⦁ beets
⦁ chocolate
⦁ coffee
⦁ fava beans
⦁ green leafy vegetables
⦁ green tea
⦁ lima beans
⦁ oatmeal
⦁ olive oil
⦁ oregano
⦁ peanuts
⦁ rosemary
⦁ sea vegetables
⦁ sesame and pumpkin seeds
⦁ soy products
⦁ turmeric
⦁ watermelon
⦁ wheat germ
I’m going specifically mention bananas because they are a particularly good source of dietary dopamine.
Dopamine-Depleting Foods to Avoid
Eating a lot of saturated fat also decreases dopamine receptor sensitivity.
Sugar has been found to boost dopamine, but this is a temporary, unhealthy boost that is more drug-like than food-like and ultimately contributes to deficiency.

L-tyrosine is the first dopamine supplement to consider.
This amino acid is the precursor to dopamine.
If you don’t get enough l-tyrosine in your diet, or your body doesn’t properly convert it, you won’t be able to synthesize adequate dopamine. When looking for a supplement, consider n-acetyl-l-tyrosine. This is a highly absorbable form of l-tyrosine that readily enters the brain.
L-tyrosine can make headaches/migraines and existing thyroid issues worse. The body uses tyrosine to make thyroxine, a thyroid hormone. Tyrosine seems to be safe when used in doses up to 150 mg/kg per day for up to 3 months. Some people experience side effects such as nausea, headache, fatigue, heartburn, and joint pain. (Webmd)
Mucuna pruriens is a tropical legume that contains l-dopa, a dopamine precursor. Mucuna pruriens supplements are sold to enhance mood, memory, overall brain health, anti-aging, and libido. This herb was found to work even better than levodopa medications for Parkinson’s, a disease characterized by low dopamine. The plant contains relatively high (3–7% dry weight) levels of L-Dopa; some people are sensitive to L-DOPA and may experience nausea, vomiting, cramping, arrhythmias, and hypotension. The seeds of the plant contain about 3.1–6.1% L-Dopa, with trace amounts of serotonin, nicotine, and bufotenine (a tryptamine related to serotonin.)
Side effects include, if too high of a dosage is taken, users may experience vomiting, headaches, and sleeplessness. Other serious side effects, like high blood pressure, hair loss, and hallucinations are also possible. No more than 500 mg a day is generally necessary to experience all of Mucuna’s effects. If you take Mucuna too frequently, you may start to develop tolerances over time which cause you to increase dosage too quickly. https://nootriment.c...s-side-effects/
https://www.ncbi.nlm...pubmed/26058043
An average of 52.11% degradation of L-dopa was found in seeds of M. pruriens varieties. Since M. pruriens seeds and/or L-dopa are used for treatment of Parkinson's disease and as an aphrodisiac both in modern and/or traditional systems of medicine, the finding of high level of L-dopa degradation (in pure form and in M. pruriens extracts) into damaging quinones and ROS is very significant.

https://www.ncbi.nlm...les/PMC3942911/
Great review of this plant and its properties.

https://www.ncbi.nlm...les/PMC4213977/
Overview of its use in treating depression.

This product has a large number of drug interactions, especially with psychiatric meds so please check drug compatibilities carefully.

Curcumin is the main active ingredient in the spice turmeric. It readily crosses the blood-brain barrier where it boosts levels of dopamine. Curcumin has been found to be as effective for treating depression as the popular antidepressant Prozac. When buying a curcumin supplement look for one that contains piperine, a compound found in black pepper that increases curcumin absorption by a remarkable 2,000%.
https://www.ncbi.nlm...pubmed/28074653
According to a 2017 review of over 120 studies, curcumin has not been successful in any clinical trial, leading the authors to conclude that "curcumin is an unstable, reactive, non-bioavailable compound and, therefore, a highly improbable lead".

https://www.ncbi.nlm...pubmed/26024538
In Phase I clinical trials, curcumin had poor bioavailability, was rapidly metabolized, retained low levels in plasma and tissues, and was extensively and rapidly excreted, factors that make its in vivo bioactivity unlikely and difficult to accurately assess.
https://www.ncbi.nlm...pubmed/26972530
Also, curcumin normalizes the levels of dopamine, noradrenaline, and 5-hydroxyindoleacetic acid in the frontal cortex of rats. Taking all these results together, it may suggest that curcumin is potent compound acting against the depression in the male albino rats.
https://www.ncbi.nlm...pubmed/21928724
Curcumin increased both the swimming and climbing behavior in FST, thus its antidepressant like activity could be due to an increase in serotonin, norepinephrine and dopamine levels in the brain. Curcumin can be a useful antidepressant especially in cases which respond to drugs having mixed effects on serotonin and catecholamines levels in the brain.
https://www.ncbi.nlm...pubmed/20230279
Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway.
Our study suggests that the neuroprotective effect of curcumin is not related simply to its antiinflammatory and antioxidant properties, but involves other mechanisms, particularly by targeting the JNK pathway

https://www.ncbi.nlm...pubmed/18766332
Antidepressant activity of curcumin: involvement of serotonin and dopamine system.
The study provides evidences for mechanism-based antidepressant actions of curcumin. The coadministration of curcumin along with piperine may prove to be a useful and potent natural antidepressant approach in the management of depression.
And many other articles.
Side effects - Turmeric isn't approved by the U.S. Food and Drug Administration to treat any diseases, and taking turmeric supplements can cause unpleasant or dangerous side effects. The most common gastrointestinal side effects are stomachache, gas, nausea and indigestion and taking turmeric for long periods can cause ulcers in some people due to increasing stomach acid.
The curcumin in turmeric encourages the gallbladder to produce more bile, which may improve digestion. Because of the extra bile production, people who have gallstones or other conditions that block bile passages shouldn't take turmeric before consulting with their doctors. Turmeric may also contribute to the formation of kidney stones, particularly in people who have conditions that increase the risk of kidney stones.
Pregnant women shouldn't take turmeric as a supplement. According to MedlinePlus, the curcumin can stimulate the uterus or encourage the uterine lining to shed, which could increase the risk of miscarriage.
Because turmeric can increase stomach acid, it can interfere with the efficacy of drugs that reduce acid, such as acid reflux medications. The spice can also increase the effectiveness of some drugs, including blood thinners and diabetes medications. Taking turmeric with blood thinners can increase the risk of bleeding. This includes taking it with other herbs that act as blood thinners, including ginger, garlic, clove, ginseng and willow. Diabetics who take medication to help lower their blood sugar levels shouldn't take turmeric because it can drop blood sugar to potentially dangerous levels.

#18 fishinghat

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Posted 12 July 2018 - 01:43 PM

Increasing Dopamine Levels (cont)

Ginkgo biloba is traditionally used for a variety of brain-related problems such as poor concentration, memory problems, headaches, fatigue, mental confusion, depression, and anxiety. One of the ways ginkgo works is by raising dopamine.
Ginkgo LEAF EXTRACT is LIKELY SAFE for most people when taken by mouth in appropriate doses. It can cause some minor side effects such as stomach upset, headache, dizziness, constipation, forceful heartbeat, and allergic skin reactions.

There is some concern that ginkgo leaf extract might increase the risk of liver and thyroid cancers. However, this has only occurred in animals given extremely high doses of ginkgo. There is not enough information to know if it could happen in humans.

Ginkgo fruit and pulp can cause severe allergic skin reactions and irritation of mucous membranes. Ginkgo might cause an allergic reaction in people who are allergic to poison ivy, poison oak, poison sumac, mango rind, or cashew shell oil.

There is some concern that ginkgo leaf extract might increase the risk of bruising and bleeding. Ginkgo thins the blood and decreases its ability to form clots. A few people taking ginkgo have had bleeding into the eye and into the brain, and excessive bleeding following surgery. Ginkgo leaf extract can cause allergic skin reactions in some people.

The ROASTED SEED or CRUDE GINKGO PLANT is POSSIBLY UNSAFE when taken by mouth. Eating more than 10 roasted seeds per day can cause difficulty breathing, weak pulse, seizures, loss of consciousness, and shock. The FRESH SEED is even more dangerous. Fresh seeds are poisonous and are LIKELY UNSAFE. Eating fresh ginkgo seeds could cause seizures and death.

There isn't enough reliable information available to know if ginkgo is safe when applied to the skin.

Special Precautions & Warnings:
Pregnancy and breast-feeding: Ginkgo is POSSIBLY UNSAFE when taken by mouth during pregnancy. It might cause early labor or extra bleeding during delivery if used near that time. Not enough is known about the safety of using ginkgo during breast-feeding. Do not use ginkgo if you are pregnant or breast-feeding.

Infants and children: Ginkgo leaf extract is POSSIBLY SAFE when taken by mouth for a short time. Some research suggests that a specific combination of ginkgo leaf extract plus American ginseng might be safe in children when used short-term. Do not let children eat the ginkgo seed. It is LIKELY UNSAFE.

Bleeding disorders: Ginkgo might make bleeding disorders worse. If you have a bleeding disorder, don't use ginkgo.

Diabetes: Ginkgo might interfere with the management of diabetes. If you have diabetes, monitor your blood sugar closely.

Seizures: There is a concern that ginkgo might cause seizures. If you have ever had a seizure, don't use ginkgo.

Deficiency of the enzyme glucose-6-phosphate dehydrogenase (G6PD): Ginkgo might cause severe anemia in people have G6PD enzyme deficiency. Until more is known, use cautiously or avoid using ginkgo if you have G6PD deficiency.

Infertility: Ginkgo use might interfere with getting pregnant. Discuss your use of ginkgo with your healthcare provider if you are trying to get pregnant.

Surgery: Ginkgo might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using ginkgo at least 2 weeks before a scheduled surgery.
Drug Interactions
https://www.drugs.co...2&generic_only=
Ginkgo Biloba can react with over 500 different medications to primarily increase the risk of bleeding and seizures. Please review the list of meds at the above site to be sure you are not at risk of these interactions.
Talk to your doctor before using ginkgo together with Cymbalta. Some preparations of ginkgo biloba have caused seizures, and combining them with other medications that can also cause seizures such as Cymbalta may increase that risk.
Medical Research
https://www.ncbi.nlm...pubmed/25346240
Our results suggest that EGb 761 may be useful for reducing anhedonic depressive-like behavior.
https://www.ncbi.nlm...pubmed/21672588
It is suggested that EGb761 produces an antidepressant-like effect, and that an antioxidant effect against oxidative stress may be partly responsible for its observed neuroprotective effects.
https://www.ncbi.nlm...pubmed/20105177
The Ginkgo biloba extract EGb 761® and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.
The present results demonstrate that chronic but not acute treatment with EGb 761 increased dopaminergic transmission in the PFC. This finding may be one of the mechanisms underlying the reported effects of G. biloba in improving cognitive function.
https://www.ncbi.nlm...pubmed/22784425
https://www.ncbi.nlm...pubmed/20411379

L-theanine is a unique compound found in green, black, and white teas.
It increases levels of dopamine as well as serotonin and the relaxing neurotransmitter GABA (gamma-aminobutyric acid). L-Theanine improves recall, learning, and positive mood. You can get a dopamine boost by either taking an l-theanine supplement or by drinking tea.
See the section on "raising serotonin levels" for details on this supplement.

Phosphatidylserine acts as your brain’s “gatekeeper,” regulating nutrients and waste in and out of your brain. It can increase dopamine levels and improve memory, concentration, learning, and symptoms of ADHD.
Boost Dopamine with Exercise
But you don’t need to exercise strenuously to enhance your brain. Taking walks, or doing gentle, no-impact exercises like yoga, tai chi, or qi gong all provide powerful mind-body benefits.
And if you can get your exercise outdoors, that’s even better. Sunlight can increase the number of dopamine receptors and create vitamin D which activates the genes that release dopamine.
Increase Dopamine with Meditation
The benefits of meditation have been proven in over 1,000 studies. Regular meditators experience an enhanced ability to learn, increased creativity, and deep relaxation. It’s been shown that meditation increases dopamine, improving focus and concentration. Creative hobbies of all kinds, including knitting, quilting, sewing, drawing, photography, woodworking, and home repair, bring the brain into a meditative state. These activities increase dopamine, ward off depression, and protect against brain aging.
Music Gets Dopamine Flowing
Listening to music can cause release of dopamine. Brain scans show that the brain’s pleasure center lights up when listening to music similarly to when we eat, make love, or take drugs.
Boost Dopamine with Touch
All kinds of pleasurable touch increase dopamine. A therapeutic massage increases dopamine and serotonin and reduces the stress hormone cortisol. Stroking your dog can give both you and your pet a boost of dopamine and a slew of other feel-good brain chemicals. There’s evidence that having sex increases dopamine in lab rats. This has yet to be proven in humans.
The Role of Dopamine and Sleep
Research has found that dopamine plays a bigger role in sleep regulation than previously believed. It controls the production of the sleep hormone melatonin. Research suggests that lack of sleep may reduce the number of dopamine receptors.

https://www.ncbi.nlm...pubmed/18057326
https://www.ncbi.nlm...pubmed/12043836
https://www.ncbi.nlm.../pubmed/7534345
and others

Inhibition of dopamine release by melatonin has been demonstrated in specific areas of the mammalian central nervous system (hypothalamus, hippocampus, medulla-pons, and retina).
Note - This would indicate that patients with depression may want to limit thier use of melatonin due to possible lowering of dopamine and increased depression.
The Dopamine-Weight Loss Connection
There’s a strong link between obesity and dopamine dysfunction. Interestingly, people who are obese have fewer dopamine receptors than average. In fact, their brains behave much like that of a drug addict. Thus, since dopamine is in charge of the brain’s pleasure center, obese people will receive less pleasure and satisfaction from eating, making them want to eat more. If you struggle with your weight, you may be caught in a vicious cycle.

Blast Dopamine with a Cold Shower
If you’re game, take a cold shower or at least end your shower with a cold blast.
Taking a shower with 14C°/57F° water can increase dopamine substantially — up to 250%! Proponents of cold showers swear it boosts their mood and productivity all day, even more than drinking coffee

Acheiving Results
Dopamine is released when you achieve a goal, large or small.
If your big goal is to get organized, break it down into many small goals. Each goal can be as simple as organizing your emails, cleaning a closet, or emptying your junk drawer. Every time you cross one item off your to-do list, it gives you a nice spurt of dopamine.
Ideally, your goal should be hard — like quitting a bad habit or sticking with a budget to pay down your debt. The harder your goal, the more accomplishment you’ll feel, and that translates into more dopamine. Get a calendar, virtual or paper, and cross off each day that you’ve actively worked toward your goal. This “don’t break the chain” concept is a proven way to rewire your brain. Acknowledge and savor your victories every day for a daily dopamine boost.

A link to all references can be found at https://bebrainfit.c...rease-dopamine/
The remaining information came from either Wiki or NCBI medical abstracts.

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#19 fishinghat

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Posted 12 July 2018 - 01:51 PM

Reading Material and Treatment Programs

Informational Reading
A Mind Of Your Own
blanam - A great book is Kelly Brogan's "A Mind Of Your Own".
FH - Kelly Brogan, MD is absolutely correct. I remember my crying spell. It lasted about 3 or 4 weeks. I remember going for long walks in the park and crying every step, for no apparent reason. Everyone was asking me if I was OK. I waited for those spells to end before I went walking again.
blanam - Kelly Brogan, MD suggests that it can take from 6 month to 2 years for the brain/body to recalibrate.
kr15sy - I have been focusing on going Paleo to get healthy and lose weight, and after reading Dr. Kelly Brogan's A Mind of Your Own, and Dr. Perlmutter's Grain Brain, found out about the connection between your gut and your brain.

The Gifts of Imperfection
FN - If you're a reader, I highly recommend Brene Brown's The Gifts of Imperfection.

AngryinHouston - If you're a reader, I highly recommend Brene Brown's The Gifts of Imperfection.

The Antidepressant Solution
Jekaufman - BUY THE BOOK- "THE ANTIDEPRESSANT SOLUTION" By. Joseph Glenmullen. He writes a step-by-step guide to overcoming Antidepressant Withdrawl, Dependence and Addiction!
Unitedwecan - This book, The Antidepressant Solution, was written in 2005. It is by Joseph Glenmullen, M.D.. He also wrote Prozac Backlash. He teaches at Harvard Medical School. This book tells of the way money and power have corrupted the pharmecutical companies, the FDA and everyone involved. It also has a 5 step program that basically says to GO SLOW when weaning off these drugs.
pheonixjazzmine - I would like to suggest a book called "The Antidepressant Solution" by Joseph Glenmullen, M.D. Dr. According to Glenmullen, many doctors these days do not taper patients off of SSRI's slowly enough. His book guides people off of these drugs through verrrry gradual tapering schedules.
agrace - I have a book called "The Antidepressant Solution" by a Dr. Glenmullen which devotes a whole chapter on determining whether a symptom is that of an actual illness or just withdrawal. It's very good, although I don't think he goes nearly far enough in discussing the long term implications of these symptoms, although he briefly mentions that they have been documented to continue past a year,and he has a chart of over fifty side effects that cover everything from physical to mental/emotional to neurological.
Norther - In Joseph Glenmullen's book, 'The Antidepressant Solution' (devoted to withdrawal), he states the situation very clearly, on p.97:
"Q. Can antidepressants be taken every other day as part of tapering off them?
A. None of the short acting antidepressants should be taken every other day as a method of tapering them. Because of their short half-lives, the every other day schedule can result in roller coaster levels of the drugs and roller coaster levels of withdrawal symptoms."
However, patients seem to be told, time after time, to withdraw by alternating doses or missing out days - a surefire recipe for destabilising drug levels, and putting the patient through needless physiological chaos and withdrawal nightmares
rogerwilco - I found Dr Glenmullen's book very revealing of the situation I find myself in, and you can find it at addall.com.
Full Catastrophe Living
Gail - Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain and Illness (Delta, 1991);
This book treats all ailments the same way. Depression, anxiety, cancer, fibromalgia, anything, you name it.
Same (remedy) applies to all, mindfulness.
A really interesting book. Step by step. Easy to understand,

xanaxul - I forgot, I agree with you "Full catastrophe living..." Other of the John Kabat-Zinn books offers many cues for trauma survivors to cope and begin to rebuilt from the emotional wreckage that trauma lefts behind.
Limbo - A book that has always helped me is Dr. Jon Kabatt-Zinn's books. He has a mindfullness-based stress reduction program that is extremely helpful for chronic pain and depression. He runs these programs in hospitals but you can buy the books and audio CDs.
http://www.amazon.co...nn/e/B000AQ12GA
http://www.umassmed....t.aspx?id=41252

Walking with God through Pain and Suffering
IBS - I'm not sure what you like to read but I am reading a great book on suffering by Timothy Keller..called 'Walking with God through Pain and Suffering' It's completely biblical, based on the foundation you mentioned and I highly recommend it.

The Ragamuffin Gospel
SL - Praying like never before & have deriving the most comfort from (other than the Psalms) a book called 'The Ragamuffin Gospel' by Brennan Manning (awesome, you might wanna check it out) 'written for the bedraggled, beat up & burnt out.'

Anatomy of an Epidemic
TM - I introduced the topic because the no-proof-for-serotonin-deficiency is high on the list of SSRI critics; Robert Whitaker's book, Anatomy of an Epidemic is representative of this, and I recommend it.
BHF - One of the things I would like to share is the books that I have learned from. One of my favorites is Anatomy of an Epidemic by Robert Whittaker. I felt that the references to research let me use my own judgement to reach conclusions. He studied a wide range of psychotropic drugs. I bought copies of his book to lend and/or give away. I am particularly worried about some of my son's teenaged friends who are ripe for the industry to chew up. I also appreciated Unhinged and The Emperors New Drugs.
Papin - For anyone interested in learning more about recent research on long-term anti-depressant use, check out the book Anatomy of an Epidemic, by Robert Whitaker. He goes into a lot of detail about the history of psychotropic drugs and the efforts the APA goes to in order to cover up evidence that these drugs are, in fact, doing more harm than good.
Imdone - I encourage everyone to read Whitaker's "Anatomy of an Epidemic" and Breggin's "Your Drug May Be Your Problem."
Jesselee - Also, educate yourself and uplift yourself. I found the book, "Anatomy of an Epidemic" by Robert Whitaker to be helpful,
The Mood Cure
K65 - You may find the book "The Mood Cure" helpful. It addresses the underlying diet and medical causes (for me, hypothyroidism) of pain (both mental and physical). I have found it to be very useful in understanding and learning about natural and dietary means of treating that pain. The book also references 5HTP, as well as other supplements, as being helpful for people weaning off of antidepressants.
At Last A Life
Jennifer - I have read Claire Weekes and got a lot of helpful info there but the book that is truly helping me is At Last A Life by Paul David. It's up to date and hit the nail on the head on everything I am going through. He suffered for 10 years with severe anxiety and has gotten his life back.

The Healing Power of Vitamins, Minerals, and Herbs
Tria - It has info on most of the more common vitamins and supplements - The Healing Power of Vitamins, Minerals, and Herbs by Reader's Digest. I don't think it's in print anymore, but you may be able to find used copies online.

Essential Help for the nerves
Gail - If you have a chance to get her book, it will soothe you, at least for a while. Title ESSENTIAL HELP FOR YOUR NERVES.

Other Various Suggested reading by members
http://www.cymbaltaw...book#entry41552
Suggested readings

TM
Anatomy of an Epidemic, Robert Whitaker (2010)
Let Them Eat Prozac, David Healey (2006)
Pharmageddon, David Healey (2013)

Boundaries
IBS -I'm reading the book "Boundaries" by Cloud and Townshend...it's a great read...should have read a decade ago, but that's okay...

Surviving Panic Disorder: What You Need to Know
TM - Here's a link to a book you might wish to look into.
http://www.amazon.co...disordershipko

The Power of Anxious Thinking
BRZ - i highly recommend his latest podcast, The Power of Anxious Thinking: http://www.anxietygu...xious-thinking/its about an hour, the first 6 min or so is just chit chat, but then he gets into the meat of his topic. there is an article and then at the bottom a link for the podcast on that topic. the actual podcast section is the archives - also good stuff in there.
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Programs
http://www.theroadba...withdrawal.aspx
The Road Back is put out by the Church of Scientology

http://www.cymbaltaw...tion#entry45468
http://www.cymbaltaw..."the road back"
Discussions and information on the Road Back program.

http://www.cymbaltaw...book#entry44953
A discussion and information on TheRoadBackProgram.

Tinajuli - something that might be a joke, I don't know: Have you heard about The Road Back Programme? It might be just using the desperation of people who feel very silly afterwards but I thought screw it and ordered the stuff. They advise to take a supplement that kind of calms the reactions that take place in your body as soon as you take an anti-depressant, and when you go into withdrawal. It has to do with the JNK gene. (If you know whether that company is a joke, let me know!) What are ALA supplements? I really need something to help me with that fatigue, because work gets really hard when you're constantly extremely tired.

LadyNancy - I know someone who used The Road Back program to try to get off of Cymbalta and the last time I had any contact with her she was doing everything the book said to do and taking all the supplements and still not off it so unless you just like to pray a lot then in my opinion you should just go out and buy some Omega 3, a good Vitamin B complex and drink lots of water.
I haven't found anyone who had severe symptoms that found the program very helpful in actually getting through withdrawal symptoms.
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Psychological Therapies
General
FH - Psychiatrists only regulate meds but a good psychologist can help you control the anxiety without meds. They can teach you relaxation techniques, control your heart rate and breathing and much more. I would highly recommend one. These techniques can help you greatly reduce your need for meds. Pick a psychologist who has experience with Cognitive Behavioral Therapy or Mindfulness. These seem to be the best techniques for anxiety.
Way too many members recommended a good psychologist to list all quotes here.
REBT
brzghoff - my therapist who specializes in REBT, rational emotive behavioral therapy,
FN - You're young, and there are lots of other good alternatives for managing depression, anxiety and any other issues that landed you on the meds in the first place ... CBT and REBT are two ...
http://rebtnetwork.o...rary/ideas.html
REBT Website

FN - What is Rational Emotional Behavior Therapy (REBT)?
Understanding the Approach by Considering the Four Elements of its Name
Wyndy Dryden, Goldsmith's University of London
http://windydryden.c...nts_article.pdf

Excellent overview and introduction to REBT.

Brz -
1) go to http://rebtnetwork.org/library.html
2) look on the right hand side
3) scroll down in the box "news"
4) look for "New ebook released" How to Conquer Your Frustrations by Dr. William J. Knaus. the link is right there and says in blue hypertext "download the free ebook.

EQ - i would like to share a downloadable booklet i found last night that is free. great stuff. check it out if you like. its called "How To Conquer Your Frustrations" http://www.rebtnetwo...strations.pdf
it can be found on a web site i haven't been to in a long time: www.rebtnetowork.org .
https://www.ncbi.nlm.../pubmed/9479090
The results suggest that the treatment approach was successful in modifying irrational beliefs and anxiety.

https://www.ncbi.nlm...les/PMC5036761/
The findings revealed significant effects of a REHCT intervention program on problematic assumptions, death anxiety, and psychological distress reduction among the cancer patients and their family caregivers at the end of the intervention.
https://www.ncbi.nlm...les/PMC5428629/
REBC is a time-efficient and solution-focused therapeutic modality for assisting occupationally stressed employees
Scientific research into the efficacy of this method is limited.

Cognative Behavioral Therapy
FH - Therapy is a must. I was blessed with a dr who was adept at cognitive behavioral therapy (mindfulness therapy is also good). She taught me how to do breathing exercises, reduce heart rate, refocus my thinking from obsessive thoughts, and many more coping mechanism. It has proved very beneficial.
Brz - i also highly recommend seeing a therapist who specializes in cognitive behavioral therapy - and visit on as regular basis as much as you can possibly afford - like once a week. that combined with a conservative tapering schedule can be the difference between self destruction and preserving the relationships with those you love. i won't say there will be no struggle - because there will - but the idea is to minimize suffering and avoid permanent or long term damage.
Brz - i got good sleep and deployed some good cognitive strateges and things started to improve a little.

https://www.ncbi.nlm...pubmed/24314926
Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach
Manual based psychotherapies remain a treatment option, with the most compelling evidence for cognitive behavioral therapy.

https://www.ncbi.nlm...pubmed/25433401
Systematic review of management for treatment-resistant depression in adolescents.
The combination of antidepressant medication and psychotherapy should be recommended for adolescents who present with treatment-resistant depression.

https://www.ncbi.nlm...pubmed/24458008
The integrative management of treatment-resistant depression: a comprehensive review and perspectives.
Evidence suggests that cognitive therapy (CT) is an effective strategy for TRD.

https://www.ncbi.nlm...pubmed/26635099
Treatment-resistant panic disorder: a systematic review.
Augmentation of the pharmacological treatment with cognitive-behavioral therapy demonstrated some short-term efficacy in treatment-resistant PD.

https://www.ncbi.nlm...pubmed/16847460
Treatment-resistant anxiety disorders.
Anxiety disorders are treatable conditions and respond to the front-line interventions such as serotonin reuptake inhibitors and cognitive behavioral therapy.
Acceptance and Commitment Therapy for Generalized Anxiety Disorder in Older Adults: A Preliminary Report (full text)
Behavioral Therapy, March 2011

http://www.ncbi.nlm....les/PMC3496779/

Abstract excerpt: Some evidence suggests that acceptance-based approaches such as Acceptance and Commitment Therapy (ACT) may be well-suited to geriatric generalized anxiety disorder (GAD). The primary goal of this project was to determine whether ACT was feasible for this population. Seven older primary-care patients with GAD received 12 individual sessions of ACT; another 9 were treated with cognitive-behavioral therapy. No patients dropped out of ACT, and worry and depression improved. Findings suggest that ACT may warrant a large-scale investigation with anxious older adults.
Cathill - I just finished up with 4 months of cognitive behavioral therapy to help with my life long battle of depression. I have been on and off antidepressants for most of my adult life (usually very low levels). I have been on Cymbalta for over two years now, 40mg once a day, and now that I am armed with my new tools that I learned in therapy, fianlly ready to say good bye to this drug. I have tried getting off in the past, so I am well aware of the hell you go through getting off.
gsmommy - I did have anxiety and panic attacks nearly 10 years ago and took a med for it, paxil. I went through very aggressive cognitive behavioral therapy and weaned from the med and have not had panic attack since.
There are dozens and dozens of medical research articles showing the benefit of CBT on anxiety treatment primarily but also more limitedly on depression as well.
Mindfulness
Xana - JON KABAT-ZINN, PH.D., is founding Executive Director of the Center for Mindfulness in Medicine, Health Care, and Society at the University of Massachusetts Medical School. He is also the founding director of its renowned Stress Reduction Clinic and Professor of Medicine emeritus at the University of Massachusetts Medical School. He teaches mindfulness and Mindfulness-Based Stress Reduction (MBSR) in various venues around the world. He received his Ph.D. in molecular biology from MIT in 1971 in the laboratory of Nobel Laureate, Salvador Luria.

He is the author of numerous scientific papers on the clinical applications of mindfulness in medicine and health care, and of a number of books for the lay public: Full Catastrophe Living: Using the Wisdom of Your Body and Mind to Face Stress, Pain and Illness (Delta, 1991); Wherever You Go, There You Are: Mindfulness Meditation in Everyday Life (Hyperion, 1994); Coming to Our Senses: Healing Ourselves and the World Through Mindfulness (Hyperion, 2005); and Arriving at Your Own Door: 108 Lessons in Mindfulness (Hyperion, 2007). He is also co-author, with his wife Myla, of Everyday Blessings: The Inner Work of Mindful Parenting (Hyperion, 1997); and with Williams, Teasdale, and Segal, of The Mindful Way Through Depression: Freeing Yourself from Chronic Unhappiness (Guilford, 2007). Overall, his books have been translated into over 30 languages.

I did the training (half of it as I told you) with a former Z Segal PhD student. The book I've is the one by Williams, Teasdale, Segal and Kabat-Zinn, that comes with a CD with all the exercises guided by Kabat-Zinn. The book is about mindfulness applied to prevent depression relapse, but since it was written Minfulness that was developed as a technique to cope with stress by J Kabat-Zinn, has proven to be equally efective in treating the whole spectrum of anxiety disorders.
Pepe - The following technique (which I picked up from a book) has worked for me to slow down this constant train of thoughts and anxiety several times, and it still does.
1) Make yourself as comfortable as you can (sit or or lie down and close your eyes)
2) Try to get your respiration under control (inhale deep through your nose for 4 seconds, keep the air in for 3 seconds exhale for 7 seconds)
3) When your respiration has stabilized,try to observe yourself as a silent 'spectator'
4) You are NOT your thoughts or feelings, your thoughts and feelings should not kidnap you as a person. Try to observe your thoughts/feelings without any judgement. Just try to observe them. Don't ask yourself any questions regarding these thoughts/feelings.
5) Realize you are "observing" your thoughts/feelings. You, as a full person, are observing 'some thoughts/feelings' which are....just there.
6) Realize that these thoughts/feelings are just a (small) part of you, they are NOT you.
7) If you are able to objectively observe your thoughts/feelings they will gradually decrease in strength and speed.

TM - I spent a few months listening to guided Mindfulness Meditation sessions at bedtime, and found it useful for winding down and falling asleep. You can find them on YouTube, on CD's, and elsewhere on the net.
considering - I think meditation has helped me deal with bouts of low grade depression that I've experienced in the last seven years since I've been on Cymbalta. So I would highly recommend it to anyone. But I recommend that you have a teacher, even if it's meditation CDs of teachings from Sharon Saltzberg or Pema Chodron.
turbolag - I work with a therapist, that works with me on mindfulness and meditation, I also use Gert's anxiety CD course.
IBS - One therapy I've benefited from is DBT...it incorporates mindfulness and was designed by Dr. Marsha Linehan for people with Borderline personality disorder...so i better get going on it.
TM - 1. The Mindfulness & Acceptance Workbook for Depression by Kirk D. Strosahl and Patricia J. Robinson.
2. The Mindfulness & Acceptance Workbook for Anxiety by George H. Elfert and John P. Forsyth.
These books come with CD, guided imagery, and Mindfulness exercises. As a strategy for broadening your Mindfulness understanding and practice, look into Mindfulness classes in your area. You might inquire through your therapist, medical community, community college, night classes, or university. Search on YouTube for Vipassana Mindfulness Meditation
TM - Start with something to keep the anxiety down-- that's the wild card! I could not imagine using Mindfulness to intervene in a skyrocketing episode of anxiety or rage. Impossible!
I agree that the physical symptoms occupy too much band-width to enable Mindfulness or other therapy to be up-loaded early on in discontinuation-- there's just too much activity in your head at this time.
brz - i wish i could find the web site i found with a good description, but a great technique i use is sensory mindfulness. focus on one of your five senses, like sound. just listen to all the sounds around you, , don't judge them, just let them come and go and be aware of them. do that for 5-10 minutes, then switch to a different sense, sight - notice all the imgaes before you, again, don't judge them, just notice them and be aware - you can do the same with touch , taste - chew something flavorful like chocolate, savor it, note the subtleties. the idea is to take your focus away from the intrusive thoughts. same with focusing on your breath, in out, full but normal breathing. don't hyperventilate. just feel your breath go in and out, no judgement. it takes practice. i work on it ALL the time, so when the anxiety isn't as strong, it is easier and it can become a habit.
anothermind - are you referring to Prof Mark Williams - he has researched mindfulness and happiness? ... https://www.youtube....h?v=WY08aXxor20( here's a great talk from him at Alain de Botton's School of Life in London)
Andrew Solomon is another amazing speaker on anxiety and depression: http://www.ted.com/t...secret_we_share
and dozens of others with positive things to say about mindfulness therapy.
There are large amount of research showing the benefits of mindfulness for both anxiety and depression.
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#20 fishinghat

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Posted 12 July 2018 - 01:54 PM

Home Care
Sleep
Many members recommend sleeping as much as possible during withdrawal.
http://www.cymbaltaw...elps#entry72205
The document "How to sleep better"

How to Sleep Better
Tips for Getting a Good Night’s Sleep
Tip 1: Keep a regular sleep schedule
Getting back in sync with your body’s natural sleep–wake cycle—your circadian rhythm (daily rhythm)—is one of the most important strategies for achieving good sleep. If you keep a regular sleep schedule, going to bed and getting up at the same time each day, you will feel much more refreshed and energized than if you sleep the same number of hours at different times. This holds true even if you alter your sleep schedule by only an hour or two. Consistency is important.
⦁ Set a regular bedtime. Go to bed at the same time every night. Try not to break this routine on weekends when it may be tempting to stay up late. No more than 15 minutes earlier or later each day.
⦁ Wake up at the same time every day. If you’re getting enough sleep, you should wake up naturally without an alarm. If you need an alarm clock to wake up on time, you may need to set an earlier bedtime. As with your bedtime, try to maintain your regular wake–time even on weekends.
⦁ Nap to make up for lost sleep. If you need to make up for a few lost hours, use a daytime nap rather than sleeping late. DO NOT NAP MORE THAN 1 HOUR PER DAY as it may affect your evenings sleep. DO NOT NAP AFTER 5 PM. The best time to nap is early afternoon.

Fight after–dinner drowsiness. If you find yourself getting sleepy way before your bedtime, get off the couch and do something mildly stimulating to avoid falling asleep, such as washing the dishes, calling a friend, or getting clothes ready for the next day. If you give in to the drowsiness, you may will usually wake up later in the night and have trouble getting back to sleep.

⦁ Tip 2: Naturally regulate your sleep-wake cycle
Melatonin is your naturally produced hormone that regulates your sleep. Melatonin production is controlled by light exposure. Your brain will secrete more in the evening, as it becomes darker, Conversely, during the day your brain detects increasing light levels and begins producing serotonin, which causes one to wake and be alert.
Spending long days in an office away from natural light, for example, can impact your daytime wakefulness and make your brain sleepy. Then bright lights at night—especially from hours spent in front of the TV or computer screen—can suppress your body’s production of melatonin and make it harder to sleep. However, there are ways for you to naturally regulate your sleep-wake cycle, boost your body’s production of melatonin, and keep your brain on a healthy schedule.
Increase light exposure during the day
Remove your sunglasses in the morning and let light onto your face.
Spend more time outside during daylight. Try to take your work breaks outside in sunlight, exercise outside, or walk your dog during the day instead of at night.
Let as much light into your home/workspace as possible. Keep curtains and blinds open during the day.
Boost melatonin production at night
Turn off your television and computer. Many people use the television to fall asleep or relax at the end of the day. Not only does the light suppress melatonin production, but television can actually stimulate the mind, rather than relaxing it. Try listening to music or audio books instead, or practicing relaxation. If your favorite TV show is on late at night, record it for viewing earlier in the day.
Don’t read from a backlit device at night (such as an iPad). If you use a portable electronic device to read, use an eReader that is not backlit, i.e. one that requires an additional light source such as a bedside lamp.
Change your light bulbs. Avoid bright lights before bed, after 7 PM do not use a light greater than 25 watts. Reduce light exposure by significantly reducing the brightness on your TV or electronic device.
When it’s time to sleep, make sure the room is dark. The darker it is, the better you’ll sleep. Cover electrical displays, use heavy curtains or shades to block light from windows, or try an eye mask to cover your eyes. Most patients with chronic problems blacken their bedrooms entirely. Do not use nightlights if it can be done safely. Block all windows in the bedroom so light can not enter.
See... https://www.ncbi.nlm...n00057-0027.pdffor details
Tip 3: Create a relaxing bedtime routine
If you make a consistent effort to relax and unwind before bed, you will sleep easier and more deeply. A peaceful bedtime routine sends a powerful signal to your brain that it’s time to wind down and let go of the day’s stresses.
Keep noise down. If you can’t avoid or eliminate noise from barking dogs, loud neighbors, city traffic, or other people in your household, try masking it with a fan, recordings of soothing sounds, or white noise. You can buy a special sound machine or generate your own white noise by setting your radio between stations. Earplugs may also help. Sound machines can be purchased at local department stores.

Keep your room cool. The temperature of your bedroom also affects sleep. Most people sleep best in a slightly cool room. A bedroom that is too hot or too cold can interfere with quality sleep.

Make sure your bed is comfortable. You should have enough room to stretch and turn comfortably. If you often wake up with a sore back or an aching neck, you may need to invest in a new mattress or a try a different pillow. Experiment with different levels of mattress firmness, foam or egg crate toppers, and pillows that provide more support.
Relaxing bedtime rituals to try
⦁ Read a book or magazine by a soft light
⦁ Take a warm bath
⦁ Listen to soft music
⦁ Do some easy stretches
⦁ Wind down with a favorite hobby
⦁ Listen to books on tape
⦁ Make simple preparations for the next day
DO NOT exercise or do any significant physical activity after 6 PM. Anything considered work (laundry, dishes, etc) must be avoided after 6 PM.
Tip 4: Eat right and get regular exercise
Your daytime eating and exercise habits play a role in how well you sleep. It’s particularly important to watch what you put in your body in the hours leading up to your bedtime.
⦁ Stay away from big meals at night. Try to make dinnertime earlier in the evening, and avoid heavy, rich foods within two hours of bed. Fatty foods take a lot of work for your stomach to digest and may keep you up. Also be cautious when it comes to spicy or acidic foods in the evening, as they can cause stomach trouble and heartburn.
⦁ Avoid alcohol before bed. Many people think that a nightcap before bed will help them sleep. While it may make you fall asleep faster, alcohol reduces your sleep quality, waking you up later in the night. To avoid this effect, so stay away from alcohol in the hours before bed.
⦁ Eliminate caffeine. You might be surprised to know that caffeine can cause sleep problems up to ten to twelve hours after drinking it! No chocolate, most teas, coffee.
⦁ Avoid drinking too many liquids in the evening. Drinking lots of water, juice, tea, or other fluids may result in frequent bathroom trips throughout the night. Caffeinated drinks, which act as diuretics, only make things worse.
⦁ Quit smoking. Smoking causes sleep troubles in numerous ways. Nicotine is a stimulant, which disrupts sleep. Additionally, smokers actually experience nicotine withdrawal as the night progresses, making it hard to sleep.
⦁ Eliminate stimulants. No sugars, salty food or MSG. Sugar is a stimulant which can increase blood pressure and pulse. It can take significant time to process this material and slow down your metabolism. Salts like table salt and MSG provide sodium which is used by the body to help carry electrical system in our bodies. This can also increase heart rates and metabolism for several hours.
If you’re hungry at bedtime
For some people, a light snack before bed can help promote sleep. When you pair tryptophan–containing foods with carbohydrates, it may help calm the brain and allow you to sleep better. For others, eating before bed can lead to indigestion and make sleeping more difficult. Experiment with your food habits to determine your optimum evening meals and snacks. If you need a bedtime snack, try:
⦁ A small bowl of whole–grain, low–sugar cereal
⦁ Granola with low–fat milk or yogurt
⦁ A banana (not sugary fruits)
You’ll also sleep more deeply if you exercise regularly. As little as twenty to thirty minutes of daily activity helps. And you don’t need to do all thirty minutes in one session. You can break it up into five minutes here, ten minutes there, and still get the benefits. Try a brisk walk, a bicycle ride, or even gardening or housework. Serious exercise, even small amounts, must be done before 6 PM.
Some people prefer to schedule exercise in the morning or early afternoon as exercising too late in the day can stimulate the body, raising its temperature.
Tip 5: Get anxiety and stress in check
Do you find yourself unable to sleep or waking up night after night? Residual stress, worry, and anger from your day can make it very difficult to sleep well. When you wake up or can’t get to sleep, take note of what seems to be the recurring theme. That will help you figure out what you need to do to get your stress and anger under control during the day:
If you can’t stop yourself from worrying, especially about things outside your control, you need to learn how to manage your thoughts. When trying to go to sleep it is essential not to think about work, money, your family’s problems or other stressful subjects. These are very detrimental to sleep. Do not think about exciting subjects (a vacation, your favorite hobbies, etc.). Instead pick something mundane (boring). Pick a subject like weeding you garden, cleaning your car, etc. It will be difficult to stay focused on these boring subjects at first but it will become easier with time and practice.
If the stress of managing work, family, or school is keeping you awake, you need help with stress management. By learning how to manage your time effectively, handle stress in a productive way, and maintain a calm, positive outlook, you’ll be able to sleep better at night.
Relaxation techniques for better sleep
⦁ Deep breathing. Close your eyes—and try taking deep, slow breaths—making each breath even deeper than the last.
⦁ Progressive muscle relaxation. Starting at your toes, tense all the muscles as tightly as you can, then completely relax. Work your way up from your feet to the top of your head.
⦁ Visualizing a peaceful, restful place. Close your eyes and imagine a place or activity that is calming and peaceful for you. Concentrate on how relaxed this place or activity makes you feel.
Tip 6: Ways to get back to sleep
It’s normal to wake briefly during the night. In fact, a good sleeper won’t even remember it. But if you’re waking up during the night and having trouble falling back asleep, the following tips may help.
⦁ Stay out of your head. Hard as it may be, try not to stress over the fact that you’re awake or your inability to fall asleep again, because that very stress and anxiety encourages your body to stay awake.
⦁ Make relaxation your goal, not sleep. If you are finding it hard to fall back asleep, try a relaxation technique such as visualization (focus your eyes on something in the room), deep breathing, or meditation, which can be done without even getting out of bed. Remind yourself that although they’re not a replacement for sleep, rest and relaxation still help rejuvenate your body.
⦁ Stretching. If you wake during the night do NOT fight it or panic. If you can not go to sleep in 10 to 15 minutes, get up, wake 20 or 30 feet, stretch (touch your toes or stretch your arms), walk back to bed and lay back down again. Each time you stretch and lay down your body will produce a small amount of endorphins which help the body relax.
⦁ Postpone worrying and brainstorming. If you wake during the night feeling anxious about something, make a brief note of it on paper and postpone worrying about it until the next day when you are fresh and it will be easier to resolve. Similarly, if a brainstorm or great idea is keeping you awake, make a note of it on paper and fall back to sleep knowing you’ll be much more productive and creative after a good night’s rest.

FN - Sound machine/radio - I pick out which of the sounds (often I have high and low pitch, hissing, humming, and whirring all at the same time) I find most pleasing ... and somehow that helps me drift off to sleep ... It helps cover up outside noises.
Raven - I also sometimes find that putting headphones on and listening to your favorite music as loud as you can stand it helps drown out anything that might make you panic, it might even help you fall asleep.

https://www.ncbi.nlm...pubmed/26047492
This meta-analysis indicates that short and long sleep duration was significantly associated with increased risk of depression in adults.

https://www.ncbi.nlm...pubmed/26179204
Geriatric Depression Scale and Geriatric Anxiety Inventory scores are both significantly correlated with sleep disturbance. Geriatric Depression Scale scores are uniquely associated with daytime dysfunction, and Geriatric Anxiety Inventory scores are uniquely associated with perceived sleep quality, sleep latency, and global Pittsburgh Sleep Quality Index scores.
https://www.ncbi.nlm...les/PMC3900629/
Contributions to depressive symptoms increase at both short and long sleep durations.
Many articles exist that show this relationship of sleeping to much or to little contributes to anxiety and depression symptoms.
There are many studies that reflect the fact that withdrawal decreases sleep and increases withdrawal symptoms. Many studies also reflect that by increasing sleep by use of natural or prescription drugs help with withdrawal sympotoms.

Diet
Please refer to previous sections on diet to improve serotonin, endorphin and dopamine levels.
Increase protein intake to help body to heal. Protein is very big in helping to overcome any illness. Can be added as a powder to a smoothie or other liquid.
FN - the amino acids ... just be very cautious, and research every single thing he/she tells you on your own ... they're powerful, and if not used with great care and caution, can be harmful.

Blood pressure monitoring
FH - Just wanted to pass along a growing trend in a new way drs can get accurate feedback on your anxiety levels and how to adjust your medicine.

As we have discussed many times on this site most antidepressants and especially antianxiety drugs will lower you blood pressure to some degree. Ever wonder why a dr will start you out on a low dose of a medicine first and then slowly increase it as needed? Well part of the reason is to be sure you do not take any more meds then necessary. The other part is to make sure your body has a chance to adjust to any changes in blood pressure. Any dr who puts you on a full dose to begin with is doing you no favors unless you are just desperate for help. By ramping up slowly you can see if you will develop any significant side effects before they overwhelm you; you can see if you have a reaction to a medicine before you get carried away with a full dose and to give your body a chance to adjust to any changes in BP.

What drs are doing now (and we can do this as well) is to monitor the systolic part of our blood pressure. The systolic is the top large number of our blood pressure. So if your bp is 120/80 then the 120 is the systolic number. The general guidelines are that if the systolic is over 120 then the anxiety levels are to high and an increase in meds may be necessary. If the systolic drops to near 90 (say 90/50) then this indicates that there is more medicine in your system than you need and the dr may cut back on a dose.
Now drs are using this method along with the information on how you feel to determine if any changes are needed. Of course you don't always carry a dr around in your back pocket so it is important to realize that you can use this method as well.
As many of you know I take clonidine and hydroxyzine to control my anxiety. Both of course can affect bp but have no withdrawal. So by monitoring my bp I can tell when I need to get more medicine in my body (systolic over 120) or to drop a little in medicine dose (systolic near 90). By the way if you get dizzy when you stand up too fast this is an indication your bp is getting low and you need to check it. This is also a way to determine if you are stable enough to start weaning again. As your bp drops it indicates your stress levels are decreasing and it may be time to start weaning again. If your bp starts to go over 120 on the systolic then it may be time to slow down or pause a little bit BEFORE it gets too bad.
PLEASE READ; Important.
Blood pressure must be taken the same way each time. You must be sitting or lying still for 2 minutes or more. This is called a resting blood pressure. If you choose to set then it must always be taken in a setting position each time. DO NOT base any of your decisions on one single bp. Bp fluctuates due to many factors. Activity around you, your health, when and what you eat, etc. So when I need to check things out I take 2 or 3 blood pressures during the day. You are looking for a pattern. I have found that at least in my case it is easy to quickly determine that my bp is rising or falling after a few bp readings. Do not take a bp within 5 minutes of another blood pressure. It takes the vessels in the arm or wrist time to adjust back to normal. It is best to wait 10 minutes if you need to try and get another bp.
I know for me this has helped as a early warning system on when my withdrawal is ramping up and gives me better control. I hope it helps you all as well.

Taking Meds
FH - At this point, like with most medicines I would recommend the teaspoon tea cup rule. For those new to the site this is the safety approach to taking a new medicine to avoid allergic reactions, severe side effects or incompatible reactions. If the medicine calls for, example, 100 mg every 8 hours start with 10 mg (part of a tablet), then 20 then 50 then 75, etc. Some sort of step mechanism to be sure your body can handle the medicine appropriately before going to a full dose. This helps avoid a lot of needless suffering.

GI Disturbances
FH - Remember if your stomach is an issue you shouldn't drink anything hot or cold as this caused the muscles to tighten even more. Slightly warm water is the best and sometimes a hot pad on the stomach help calms it as well.
FH - It is like the old question, which came first the chicken or the egg. Anxiety causes an increase in adrenaline and serotonin activity. Adrenaline affects the heart and serotonin in the stomach and intestines. What most people do not realize is that the heart and stomach are controlled by the vagus nerve. So if anxiety increases then the stomach problems increase and vice versa, if stomach problems increase then anxiety increases. Anxiety increases due to feed back from the stomach and the vagus nerve. Old drs use to call this the head/gut connection. Stomach issues are also another stressor for the body and any time you can reduce a source of stress your anxiety will improve. Consider when you have had a bad case of the flu. You are tired and sick but also irritable, agitated, etc. The flu makes you stressed. As the flu subsides your psychological symptoms reduce as well. Chronic long-term stress usually causes IBS (irritable bowel syndrome) because of constant increase in serotonin activity in the GI tract.
Jim - He put me on 150 mg of Zantac twice a day in order to reduce production of stomach acid. Within 2 hours of taking the first dose I was shocked to feel my anxiety reduce by probably 75%. I was astonished at how my stomach was exacerbating my anxious feelings. Sometimes even when I didn't feel particularly anxious about anything, my stomach would well up and I would suddenly feel like I was about to go into the most important job interview on my life.
FH - Stomach issues, IBS, acid refux, etc have long been correlated to the severity of anxiety. During my own withdrawal I found that relief of heartburn by zantac and antacids would not only relieve my heartburn but also reduce my anxiety levels some. You need to realize that stomach ailments are a source of more stress on the body and would add to your anxiety symptoms. It is also believed that by returning the acid levels in the stomach to normal allows your medicine to be absorbed more efficiently and therefore it does a better job.
FN - I remembered this discussion, and I had some Zantac on hand. So, I figured I'd try an experiment to see how it works on anxiety .... I'm having no acid reflux/GERD symptoms of the sort that tell me I need to take it ... and I haven't associated my weird stomach sensation with acid reflux ...
Anyway, I took 75 mg...about 7 a.m.... and amazingly, shortly thereafter, the anxiety stuff dropped down several notches ... so, at about 9 a.m. I took another 75 mg tab (can't take more than two in a 24 hr period) ...
Well, the anxiety/weird stomach stuff that I call "anxiety" totally cleared up ... I mean totally ....
https://draxe.com/gu...ain-connection/
A fairly good overview of the brain/gut connection.

FH - Basically with stress proper digestion and acid production changes. Bad bacteria in the stomach are able to better compete with good bacteria. With poor digestion improper nutrition increases to the body and has an inflamatory effect on many organs including the brain. Stress reduction, probiotics and a good diet are essential in bringing things back into balance. See the section on probiotics for details on what conditions can be caused by this inproper digestion. See the earlier section in this thread on Probiotics.

Peppermint
Fishinghat -You can have her suck on a peppermint lozenge. This relaxes the esophagus/stomach but does not affect the lower intestines and does not aggravate constipation or diarrhea. Be sure it has real peppermint not peppermint flavoring. I have occasional esophageal spasms (a weaker form of dry heaves) and they work well for me. I buy mine at a health food store for about $3 for 10 lozenges. Peppermint contains menthol, which has an antispasmodic effect that relaxes the muscles of the digestive tract.
notsobad - I've had issues with motion sickness (that I didn't have when I was a kid)...and I wonder if it's all connected somehow. I went through phases with ginger and chewing peppermint gum, which made the situation survivable but still unpleasant.
MC - here are a couple of remedies that has helped my nausea in the past . Mint tea, peppermint tea, green apples and life saver 'wint-o-green' flavor.
Many members mention the GI benefits they recieve from using peppermint. Peppermint contains high amounts of menthol which is an antispasmotic and smooth muscle relaxant.

Keeping a Journal
Many members promote the keeping of a journal. You will find that this type of record is much more accurate trhan our memories plus it is a good reference when talking to the dr or going back to look for similar experiences. My journal has helped me immensely over the years.

Cravings
Chart: what do food cravings mean (nutrient shortage indicated by cravings)... scroll down the page, chart is at bottom)
http://betterraw.com...-you-chart.html

Members frequently mention cravings during withdrawal. Ten mention craving sugar, 7 mention craving carbs, 3 salt, 2 coffee, and they also mention ice, ice cream, oranges and orange juice, pineapple.
It is interesting that these items has a unique dietary profile.
Coffee raises tyrosine and dopoamine
Salt and ice cream are high in sodium, calcium and magnesium (electrolytes)
Oranges, orange juice and pineapple are high in bioflavanoids and vitamin C as well as sugar.

The sugar craving may be because of low blood sugar during withdrawal which has been mentioned by many members.

16 members mention developing low blood sugar during withdrawal, uually associated with headaches or dizziness. 2 members mentioned that their blood sugar readings were like a rollercoaster during withdrawal and 4 mentioned it stayed normal. I could not find any research articles linking Cymbalta withdrawal to hypoglycemia.

Stimulants (Make anxiety worse)
Caffeine
Over-the-counter cold preparations contain phenylpropylamine and pseudoephedrine*
Sleep deprivation
m*********
Magnesium*
MSG
Alcohol
Stress
amphetamines
ecstasy
nicotine
Ginseng
L-Tyrosine
B Vitamins*
aspartame
Coconut Oil
Taurine
DHEA
Ginkgo
Iodine
Arginine
Sugar
Kava
* - Only some people have this reaction.

Things containing caffeine..
Coffee, Espresso, Cappuccino, some Teas, Low calorie, non-cola soda containing aspartame, Low calorie colas containing aspartame or saccharine, Energy drinks, Some types of alcoholic drinks.
Chocolate ....Baking, Dark, Sweet and semisweet, Pudding, Cereals, Fudge , Milk chocolate, Syrup, Mousse, Soymilk, Fat free cookies, Cookies, Cake, Frozen Yogurt, Ice cream, Frosting, and Shakes .
Java Pops, Chai Mints, Green Tea, Warp Mints, Penguin mints, and cinnamons. Caffeinated Energy Strips, Caffeinated Fruity Lollipops, HyDrive Energy Chews, Caffeinated Nixie Tubes, Foosh Energy Mints, Atomic Energy Bites, Buzz Bites, KickBricks, Energy Chews, Reload Energy Strips, Movit Gummies, Caffeinated jellybeans, Morning Spark, Oatmeal, Sumseeds (caffeinated sunflower seeds), Lightning Rods (beef sticks), Engobi "Energy Go Bites" (crispy snacks), Jolt Gum, Blitz Energy Gum, Think Gum Stay Alert, Vibe Black, Black Go Fast!, Dozens and dozens of herbal supplements.
https://www.caffeine...ffeine-database
List of energy drinks with caffiene. (over 100)

FCB - Air, I'd think coffee is better than the diet coke! Those artificial sweeteners can really mess with your body and mind (anxiety-creating, among other effects) plus the other junk that is in pop. Coffee on the other hand, has been found to have health benefits. Dark roast coffee has less caffeine. Sweeten it with honey or maple syrup - they have a medium glycemic index and have other health benefits, and sweeter than sugar so you use less (or try stevia, I heard the body does not process stevia as a sugar).

http://www.cymbaltaw...ety/?hl=improve
What makes anxiety worse.

Depressants (Make depression worse)
Oxalic acid is found in members of the spinach family and cabbage, broccoli, brussels sprouts, chives and lamb's quarters are high in oxalates, as are sorrel and parsley. Rhubarb leaves contain about 0.5% oxalic acid.
Can cause depression, lack of minerals, kidney stones, and more. Cooking does not affect oxalic acid. People with kidney disease, a history of kidney stones or suffer from depression should avoid these foods.
Aspartame
Gluten
High Fat Dairy
Sugar
alcohol
Trans fats
Sodium
Caffiene
Pesticide residue on foods
GHB
Organic solvents (paint, varnish, stains, cleaning solvents, paint thinner, etc).
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#21 fishinghat

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Posted 12 July 2018 - 03:42 PM

Mammalian Diving Reflex
The diving reflex, also known as the diving response and mammalian diving reflex is a response to immersion that overrides the basic homeostatic reflexes, which is found in all air-breathing vertebrates. It optimizes respiration by preferentially distributing oxygen stores to the heart and brain which allows staying underwater for extended periods of time. It is exhibited strongly in humans, in particular babies up to 6 months old. The greatest bradycardia effect is induced when the subject is holding breath with face submerged.
Method description - The Dive Reflex, originally noted in cold water diving, is a first rate vagus nerve stimulation method capable of rapidly chilling down anxiety, panic, stress and body-wide inflammation as well as elevating moods. At first the dive reflex was done by dipping the face from the lips to the scalp line into very cold water for 30 seconds to 1 minute. This would quickly melt away anxiety and stress. Later it was found that a large zip-lock plastic bag filled with ice or ice cubes applied to the face from the scalp line to the lips would perform as well without leaving the user appearing like they just emerged from a river. The Dive Reflex, because of its ability to stimulate the vagus nerve, has proved helpful for:
Swift reduction of all forms of anxiety.
Rapidly dampening down a panic attack.
Performance anxiety, test anxiety, and phobia work.
Reducing body-wide inflammation.
Use in lowering intense fight/flight in PTSD work.
Reducing stress.
Lowering anger.
Thwarting worry and rumination.
Elevating moods.

https://www.ncbi.nlm...les/PMC3768097/
Harnessing the suprabulbar circuits of origin that control diving physiology may promote feedback therapies designed to remedy high HR and hypertension associated with anxiety.
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Reiki
Reiki is a form of alternative medicine developed in 1922. Since originating in Japan, Reiki has been adapted into varying cultural traditions across the world. Reiki practitioners use a technique called palm healing or hands-on healing through which a "universal energy" is allegedly transferred through the palms of the practitioner to the patient in order to encourage emotional or physical healing.
Reiki is pseudoscience. It is based on qi ("chi"), which practitioners say is a universal life force, although there is no empirical evidence that such a life force exists. Clinical research has not shown Reiki to be effective as a medical treatment for any medical condition. The American Cancer Society, Cancer Research UK, and the National Center for Complementary and Integrative Health state that Reiki should not be a replacement for conventional treatment.
Wiki

sk8 - also started reiki... I noticed since reiki i have been able to wean way easier (not sure if it is a coincidence or not but anything helps)...
ExCymbaltaUser - i am a reiki student, and received an attunement august 19, which sent me into a massive detox (like the worst flu ever) after which all my withdrawal symptoms completely evaporated over the next week or so, while I continued giving myself reiki healing every day.
Christene - I have some wonderful Reiki music to plug into and used visualization with this process. I know this has keep me centered and help in the cleansing and healing process.
and others

https://www.ncbi.nlm...pubmed/24582620
Although the number of studies is limited, based on the size Cohen's d statistics calculated in this review, there is evidence to suggest that Reiki therapy may be effective for pain and anxiety.

https://www.ncbi.nlm...pubmed/25835541
As this included only 25 people with anxiety and 17 with depression and 20 more with either anxiety or depression, but which was not specified, the results could only be reported narratively. They show no evidence that Reiki is either beneficial or harmful in this population.

https://www.ncbi.nlm...pubmed/26163604
The results of this study indicate that Reiki may decreasepain, anxiety and fatigue in oncology patients.

https://www.ncbi.nlm...pubmed/20635803
Significant differences were observed between the experimental and treatment groups on measures of pain, depression, and anxiety; no changes in heart rate and blood pressure were noted. Content analysis of treatment notes and interviews revealed five broad categories of responses: Relaxation; Improved Physical Symptoms, Mood, and Well-Being; Curiosity and a Desire to Learn More; Enhanced Self-Care; and Sensory and Cognitive Responses to Reiki.

and many many more.
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#22 fishinghat

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Posted 12 July 2018 - 03:47 PM

Major Natural Human Supplements

SAMe - S-Adenosyl methionine is a common substrate involved in methylmethyl group transfers, transsulfuration, and aminopropylation. Although these reactions occur throughout the body, most SAM-e is produced and consumed in the liver. More than 40 methyl transfers from SAM-e are known, to various substrates such as nucleic acids, proteins, lipids etc. The half-life is about 100 minutes. Wiki
Safety and side effects
Side effects from SAMe are rare and, if they occur, usually mild.
SAMe can cause:
⦁ Upset stomach
⦁ Nausea
⦁ Mild insomnia
⦁ Dizziness
⦁ Irritability
⦁ Anxiety
⦁ Sweating
⦁ Constipation
⦁ Diarrhea Mayo

Possible interactions include:
⦁ Antidepressants and other drugs and supplements that increase levels of serotonin. Don't take SAMe with antidepressants. The combination could cause effects similar to a condition caused by high levels of the chemical serotonin to accumulate in your body (serotonin syndrome).
⦁ Antipsychotics. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Amphetamines. Be cautious when taking these drugs with SAMe. The combination could increase the risk of serotonin syndrome.
⦁ Dextromethorphan. Taking SAMe with this cough suppressant could increase the risk of serotonin syndrome.
⦁ Narcotics. Taking SAMe with meperidine (Demerol) or tramadol (Ultam, ConZip) could increase the risk of serotonin syndrome.
⦁ St. John's wort. Be cautious when taking this supplement with SAMe. The combination could cause serotonin syndrome.
Mayo

https://nccih.nih.go...upplements/SAMe
S-Adenosyl methionine (SAM-e); In Depth
At least 40 studies in people have evaluated SAMe for depression, and many of them showed evidence of beneficial effects. However, most of these trials lasted only a few weeks, included a small number of participants, and were not of the highest scientific quality. Also, some studies used injected SAMe rather than an oral form (taken by mouth).
https://examine.com/...syl-methionine/
Detailed summary of scientific studies including safety, dose, interactions, etc.
Great info.

https://www.ncbi.nlm...pubmed/27727432
Not useful in treating depression.


5HTP
http://www.umm.edu/h...tryptophan-5htp
Overview
5-hydroxytryptophan (5-HTP) is a chemical that the body makes from tryptophan (an essential amino acid that you get from food). After tryptophan is converted into 5-HTP, the chemical is changed into another chemical called serotonin (a neurotransmitter that relays signals between brain cells). 5-HTP dietary supplements help raise serotonin levels in the brain.
A 2002 review concluded that although the data evaluated suggests that 5-HTP is more effective than placebo in the treatment of depression, the evidence was insufficient to be conclusive due to a severe lack of high quality research. More and larger studies are needed to determine if 5-HTP is truly effective in treating depression. Wiki
Safety
5-HTP is POSSIBLY SAFE when taking by mouth appropriately. 5-HTP has been used safely in doses up to 400 mg daily for up to one year. However, some people who have taken it have developed a condition called eosinophilia-myalgia syndrome (EMS), a serious condition involving extreme muscle tenderness (myalgia) and blood abnormalities (eosinophilia). Some people think EMS might be caused by an accidental ingredient or contaminant in some 5-HTP products. However, there is not enough scientific evidence to know if EMS is caused by 5-HTP, a contaminant, or some other factor. Until more is known, 5-HTP should be used cautiously.

Other potential side effects of 5-HTP include heartburn, stomach pain, nausea, vomiting, diarrhea, drowsiness, sexual problems, and muscle problems.

5-HTP is POSSIBLY UNSAFE when taken by mouth in large doses. Doses from 6-10 grams daily have been linked to severe stomach problems and muscle spasms.
Special precautions & warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking 5-HTP if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Surgery: 5-HTP can affect a brain chemical called serotonin. Some drugs administered during surgery can also affect serotonin. Taking 5-HTP before surgery might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Tell patients to stop taking 5-HTP at least 2 weeks before surgery.

Are there interactions with medications?
Major - Do not take this following combination.
Medications for depression (Antidepressant drugs)
5-HTP increases a brain chemical called serotonin. Some medications for depression also increase serotonin. Taking 5-HTP along with these medications for depression might increase serotonin too much and cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking medications for depression.

Some of these medications for depression include fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), amitriptyline (Elavil), clomipramine (Anafranil), imipramine (Tofranil), and others.
Medications for depression (MAOIs)
5-HTP increases a chemical in the brain. This chemical is called serotonin. Some medications used for depression also increase serotonin. Taking 5-HTP with these medications used for depression might cause there to be too much serotonin. This could cause serious side effects including heart problems, shivering, and anxiety.

Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Moderate - Be cautious with this combination.
Carbidopa (Lodosyn)
5-HTP can affect the brain. Carbidopa (Lodosyn) can also affect the brain. Taking 5-HTP along with carbidopa can increase the risk of serious side effects including rapid speech, anxiety, aggressiveness, and others.
Dextromethorphan (Robitussin DM, and others)
5-HTP can affect a brain chemical called serotonin. Dextromethorphan (Robitussin DM, others) can also affect serotonin. Taking 5-HTP along with dextromethorphan (Robitussin DM, others) might cause too much serotonin in the brain and can result in serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking dextromethorphan (Robitussin DM, and others).
Meperidine (Demerol)
5-HTP increases a chemical in the brain called serotonin. Meperidine (Demerol) can also increase serotonin in the brain. Taking 5-HTP along with meperidine (Demerol) might cause too much serotonin in the brain and serious side effects including heart problems, shivering, and anxiety.
Pentazocine (Talwin)
5-HTP increases a brain chemical called serotonin. Pentazocine (Talwin) also increases serotonin. Taking 5-HTP along with pentazocine (Talwin) might increase serotonin too much. This might cause serious side effects including heart problems, shivering, and anxiety. Do not take 5-HTP if you are taking pentazocine (Talwin).
Sedative medications (CNS depressants)
5-HTP might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking 5-HTP along with sedative medications might cause too much sleepiness.

Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.
Tramadol (Ultram)
5-HTP increases a brain chemical called serotonin. Tramadol (Ultram) can also increase serotonin. Taking 5-HTP along with tramadol (Ultram) might cause too much serotonin in the brain and might result in side effects including confusion, shivering, stiff muscles, and others.
Herbs and supplements with sedative properties
5-HTP can cause sleepiness or drowsiness. Using it along with other herbs and supplements that have the same effect might cause too much sleepiness. Some of these herbs and supplements include calamus, California poppy, catnip, hops, Jamaican dogwood, kava, St. John's wort, skullcap, valerian, yerba mansa, and others.
Herbs and supplements with serotonergic properties
5-HTP increases a brain chemical called serotonin. Taking 5-HTP along with other herbs and supplements that increase serotonin might lead to too much serotonin and cause side effects including heart problems, shivering and anxiety. Other herbs and supplements that increase serotonin levels include Hawaiian baby woodrose, L-tryptophan, S-adenosylmethionine (SAMe), and St. John's wort.
A total of 74 drugs (242 brand and generic names) are known to interact with 5-hydroxytryptophan.
55 major drug interactions
19 moderate drug interactions
For the complete list and to see what the interaction is go to:
http://www.drugs.com...3&generic_only=

#23 fishinghat

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Posted 12 July 2018 - 03:49 PM

Major Natural Human Supplements (cont)

Member comments
No brain zaps in 5 days
I decided to stop taking it completely b/c I really didn't think it was doing much of anything for me/I wasn't withdrawling and started taking 25 to 50 mg 5-HTP about a week ago. The 5-HTP doesn't really seem to be helping me. I am feeling more depressed...
The brain zaps are horrid, but 5-HTP really does ease them dramatically. I'm taking 100mg in the morning, and 50mg before bed. It really does help you sleep, and lifts your mood.
Tria - My head seems clearer and I just seem to feel more normal (knock on wood - don't want to jinx myself!) I can't say this is all due to the 5-HTP as she started me on a few other supplements as well but I only start one new supplement at a time, give it a couple weeks then start another, and my mood did improve after starting the 5-HTP.
AKAnole - I took 150mg of 5HTP every day for a few months. I stopped in December thinking I no longer needed it then over the holidays the depression came back suddenly.
brz - i am still not sure how best to take 5htp, it seems to work on a delayed "as needed" basis. does that make sense? it takes about a day to kick in but as soon as i get my anxiety under control it doesn't seem to be a problem to just stop. - which is not what i was expecting when i started last october. since many people take it on a regular basis, that is what i do. i take one 100mg time release pill every morning. just wanted to pass along my experience. however, while i have had good results from the 5htp for anxiety, i can't speak to its effectiveness as a sleep aid.

Penguin1982 - There was a post I read that even though the half life is only 12 hrs, it can stay in your liver and fat stores for months. Didn't realize that when I started supplementing with 200mg 5htp and 750mg GABA at night only to find myself peeing every ten min and shivering beyond control. After seeing that post I realized I was getting waaaay too much serotonin and creating serotonin syndrome for myself . I've since stopped both and seem to be coming back around .
AKAnole - 5 HTP to supplement the lack of serotonin that I was experiencing. It helped but didn't curb the anxiety I would experience at times. L-Tryptophan which I think works better for me mood wise but I can't take it at night or else it disrupts my sleep
FN - 5HTP worked/works great for me as well ... I did stop using it daily, and have been using it just once in a while, and was doing just fine ... however, I'm now actually considering going back on it daily, as I've been working a really stressful temp job, and I'm starting to feel a bit "unsteady" ...
There is a rebound effect from 5-htp if it is stopped cold turkey. Next time try phasing it out over a 2 week period and you will do a lot better
http://www.cymbaltaw...5-htp/?hl=helps
5thp information and discussion.

https://examine.com/supplements/5-htp/
Detailed summary of scientific studies on 5HTP including anxiety and depression.

https://www.ncbi.nlm...les/PMC3415362/
Lack of effectiveness and dangers of its use.

5-HTP is not found in the foods we eat, although tryptophan is. Eating foods with tryptophan does not increase 5-HTP levels very much, however. As a supplement, 5-HTP is made from the seeds of an African plant called Griffonia simplicifolia.
Source: http://www.umm.edu/a...m#ixzz2Q0VyOr4w

1. 5-HTP is changed into serotonin
2. Our body uses tryptophan to make 5-HTP
3. Vitamin B6, vitamin C, folic acid and magnesium are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption.
4. Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
5. Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
6. The following foods contain tryptophan: red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.

5-HTP can be a wonder drug for anxiety and depression but MUST be used correctly.
1st – Start out slow. Build slow
50 mg once per day for 3 days
50 mg twice a day for 3 days
50 mg three times per day for 3 days then
50-50-75 for 3 days
50-75-75 for 3 days
75-75-75 dor 3 dats and then
100-75-75
100-100-75
100- 3 times a day (maximum dose).
As you ramp up watch for stomach upset (stop at that point)
If at anytime your symptoms are minimal do not go up any more.
2nd – Absolutely do not take with a ssri/snri as it may cause seratonin syndrome (easily recognized by a fever over 102F).
3rd – Check list of incompatable drugs. Drugs.com
4th – After you have been emotionally stable for a couple weeks you need to slowly, slowly decrease the 5-HTP as your system may not need as much now that it has had a chance to catch up. Many people start out using 150 mg/day and feel fine and then taper down to 75 mg for the long haul. This is important as with long term usage 5-HTP can deplete some necessary nutrients in the body.
5th – 5-HTP can be gotten for our body by consuning foods rich in tryptophan along with a small supplement of Vitamin B6, vitamin C, folic acid and magnesium. Foods high in tryptophan include red meat, dairy products, nuts, seeds, legumes, soybeans and soy products, tuna, shellfish, chicken and turkey.
6th - Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan.
7th - Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes.
L-theanine:
Member's comments
(puritan's pride) 200 mg capsules 2- 3/ day. I have been taking this prior to cymbalta detox. It helped me reduce my dosage of clonazepam. Within 20-30 mins I feel more calm. I do believe it is helping keep the anxiety in check.
Tinabee - For now I have started taking fish oil and a supplement called Theanine Serene that is supposed to help with anxiety. I know it sounds silly since I've only taken the anxiety supplement for a couple days but I really feel like it has helped.
200mg L-Theanine in the morning with a full glass of water on an empty stomach, you can take again in late afternoon 100 to 200 mg if needed (make sure it is suntheanine - it helps with headaches and pain as any painkiller I had just did not cut it)
Member's comments were generally favorable.

http://www.cymbaltaw...page-2?hl=helps
Page 1 and 2, detailed information on L theanine and its usage.
Research
The research shows that all green tea leaves contain both L-theanine and D- theanine BUT only the special processing used by the manufacturer produces pure L-Theanine and is the choice of many of the research biologists.

https://www.ncbi.nlm...pubmed/22214254
https://www.ncbi.nlm...pubmed/16759779
https://www.ncbi.nlm...pubmed/14755608

Rapid Commun Mass Spectrom. 2004;18(3):251-6.
Analysis of derivatized and underivatized theanine enantiomers by high-performance liquid chromatography/atmospheric pressure ionization-mass spectrometry.
Five of the six products contained significant amounts of D-theanine. Only one product, SunTheanine, appeared to contain only the L-theanine enantiomer.

https://www.ncbi.nlm...les/PMC3049752/
Note - Suntheanine is the pure ingredient and that is what you want. That is the pure L-theanine. D-theanine is not absorbed by our bodies.
L-theanine is an amino acid precursor to glutamate and glutamine.

Key Points
It can cross the blood brain barrier. It is only produced by plants and fungi. It inhibits glutamine transporters and glutamate transporters, and thus blocks the reuptake of glutamine and glutamate. Theanine increases serotonin, dopamine, GABA, and glycine levels in various areas of the brain. Caution – Most plants that contain L-theanine also contain caffeine and it can be a significant contaminant in L-theanine supplements.Theanine has been studied for its potential ability to reduce mental and physical stress, improve cognition, and boost mood and cognitive performance in combination with caffeine. In combination with caffeine it may increase anxiety.
Scientific Information
A National Standard monograph that reviews current research on theanine reports that it is likely safe in doses of 200–250 mg up to a maximum daily dose of 1,200 mg. Theanine is used to help with anxiety, blood pressure control, mood, and cognition. Natural Standard rates the evidence to support the usage for anxiety, blood pressure control, and mood as “unclear or conflicting scientific evidence” and the evidence for cognition as “fair negative scientific evidence.” Many of the studies of theanine were done in combination with caffeine as found in tea. While the studies found that the combination had some effect on mood, the studies found that theanine alone had little effect. More sufficiently designed studies in humans are warranted to further our understanding of the effects of theanine.

https://www.ncbi.nlm...pubmed/21208586
Effective, 400 mg/day
https://www.ncbi.nlm...pubmed/15378679
Not effective on anxiety, 200 mg/day
https://www.ncbi.nlm...les/PMC4137547/
Used to treat PTSD. It was successful in treating 8 gene problems associated with PSTD in the hippocampus and amygdala.

#24 fishinghat

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Posted 12 July 2018 - 03:52 PM

Major Natural Human Supplements (cont)

L-Tryptophan
Recommendations

"The basic metabolic process is ...
Tryptophan to 5HTP to seratonin to melatonin."

First of all determine if you may need additional dietary input.

"Depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain or unexplained weight loss, slow growth in children, overeating and/or carbohydrate cravings, poor dream recall, and insomnia can all be signs that a person may need more tryptophan." The most common of these seam to be the anxiety traits (eg. irritability) and the craving of carbohydrates.

Second determine what is needed for this process.

This includes Vitamin B6, vitamin C, folic acid and magnesium which are necessary for the metabolization of tryptophan. In addition, tyrosine and phenylalanine compete with tryptophan for absorption. A review of your diet can shed some light on how much of each is currently available to your body. Adding unneeded amounts of some of these can actually be detrimental. Blood test can be done for the B vitamins (a standard test for new psychiatric patients with may pdocs). A blood test is also available for blood magnesium levels.
One complication is the interference of tyrosine and phenylalanine to the uptake of L-tryptophan. A recommended daily intake for phenylalanine and tyrosine is 25 mg per kilogram of body weight, or 11 mg per pound. For a 70 kg person this is 1750 mg (phenylalanine + tyrosine).
Unluckily these compounds are found in nearly the same food as L-Tryptophan. Tyrosine, which can also be synthesized in the body from phenylalanine, is found in many high- protein food products such as chicken, turkey, fish, milk, yogurt, cheese, peanuts, almonds, pumpkin seeds, soy products, sesame seeds, lima beans, avocados and bananas. For example, the white of an egg has about 250 mg per egg, while lean beef/lamb/pork/salmon/chicken/turkey contains about 1000 mg per 3 ounces (85 g) portion. So increasing you ingestion of these foods may not provide more L-tryptophan to your body and therefore a supplement might be considered.

Third, what else interfers with the conversion of tryptophan to serotonin.

Several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes. So..no smoking, keep blood sugar levels in normal range, no drinking (alcoholic) and moderate protein ingestion. Again the excessive protein ingestion may cause interference by tyrosine and phenylalanine to the uptake of L-tryptophan.

How else to control serotonin levels.
The conversion of seratonin to melatonin at night hekps our body deplete excessive seratonin and gives the brain a chance to rest/relax and repair. Once light dims below 25 watts the pineal gland in the brain begins to convert seratonin to melatonin which is used to cause sleepiness in the evenings. Many block ut the windows in there bedroom and regulate light levels carefully after 5 PM.

How to try to get L-tryptophan levels increased in the body.
Can not be synthsized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.
http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm (200 mg) per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs of white poultry meat per day with an upper limit of 4 lbs per day (not practical). I would suggest around 0.5 lbs of white poultry meat per day. Increasing the L-Tryptophan levels will give your body a chance to absorb additional amounnts if the interferences are minimal.

FH - Do I follow this diet? Yes I do. I can't say it has cured my anxiety but I do find it slightly improved and definitely more stable.

What if it is not effective.

If this regime is not effective then the substitution of L-Tryptophan supplements might be in order as described above. This would eliminate the risk of tyrosine and phenylalanine interference. Work with your dr and the schedule above to build up slowly and cut back once stabilized.

An earlier section lists foods that can elevate serotonin.

Key Points
Can not be synthsized by our bodies and must be part of our diets. DO NOT EXCEED FDA LIMIT ON DOSES. The normal recommendation is for dietary intake is chicken or turkey. White poultry meat contains about 40% more L tryptophan then dark meat.
http://nutritiondata.self.com/The RDA for tryptophan is 0.2 gm per day, while the average daily intake is 1-1.5gm per day. The therapeutic range is up to 4gm per day, and medical supervision of treatment can be helpful. The 0.2 mg equates out to around 0.2 lbs od white poultry meat per day.

This supplement must be taken together with vitamin C, magnesium and B-complex vitamins to support the transformation of tryptophan into serotonin.

L tryptophan reacts with most antidepressants (seratonin syndrome), MAOIs, benzos and sedatives. There is an extensive number of drug interactions. Please research before use.

Scientific Information
Tryptophan (Trp) Content of Various Foods
Food Tryptophan
[g/100 g of food] Protein
[g/100 g of food] Tryptophan/Protein [%]
egg white, dried 1.00 81.10 1.23
spirulina, dried 0.93 57.47 1.62
cod, atlantic, dried 0.70 62.82 1.11
soybeans, raw 0.59 36.49 1.62
cheese, Parmesan 0.56 37.90 1.47
sesame seed 0.37 17.00 2.17
cheese, cheddar 0.32 24.90 1.29
sunflower seed 0.30 17.20 1.74
pork, chop 0.25 19.27 1.27
turkey 0.24 21.89 1.11
chicken 0.24 20.85 1.14
beef 0.23 20.13 1.12
oats 0.23 16.89 1.39
salmon 0.22 19.84 1.12
lamb, chop 0.21 18.33 1.17
perch, Atlantic 0.21 18.62 1.12
chickpeas, raw 0.19 19.30 0.96
egg 0.17 12.58 1.33
wheat flour, white 0.13 10.33 1.23
baking chocolate, unsweetened 0.13 12.9 1.23
milk 0.08 3.22 2.34
rice, white, medium-grain, cooked 0.028 2.38 1.18
quinoa, uncooked 0.167 14.12 1.2
quinoa, cooked 0.052 4.40 1.1
potatoes, russet 0.02 2.14 0.84
tamarind 0.018 2.80 0.64
banana 0.01 1.03 0.87
No matter what type of poultry you like to eat, you’ll get 250 to 310 milligrams of tryptophan in a 3-ounce serving. Turkey has a little less than chicken, and dark meat contains less than light meat. Dark-meat turkey has 250 milligrams compared to dark-meat chicken with 270 milligrams of tryptophan. Turkey’s light meat has 270 milligrams, while light meat from chicken has 310 milligrams.

L-tryptophan is possibly unsafe when taken by mouth. It has been linked to over 1500 reports of eosinophilia-myalgia syndrome (EMS) and 37 deaths. EMS is a neurological condition with symptoms that include fatigue; intense muscle pain; nerve pain; skin changes; baldness; rash; and pain and swelling affecting the joints, connective tissue, lungs, heart, and liver. Symptoms tend to improve over time, but some people may still experience symptoms up to 2 years after they develop EMS. Some people report that their symptoms have never gone away completely. Since the FDA has limited the doses available the occurrence of EMS has markedly dropped.

L-tryptophan can cause some side effects such as heartburn, stomach pain, belching and gas, nausea, vomiting, diarrhea, and loss of appetite. It can also cause headache, lightheadedness, drowsiness, dry mouth, visual blurring, muscle weakness, and sexual problems. This supplement must be taken together with vitamin C and B-complex vitamins to support the transformation of tryptophan into serotonin. Dosages range from 5 to 1000 mg/day.

http://www.ncbi.nlm....les/PMC3195213/
http://www.ncbi.nlm....les/PMC2908021/

brz - how well does the st john's wort work for anxiety? it makes it worse for me, same with L tryptophan. i checked into l tryptophan. after doing a lot of research i picked some up and took one 500 mg capsule tuesday night. within 20-30 min it kicked in. real mellow, i wasn't able to go to sleep right away, but was very comfortable for an hour before dozing off. slept all night the next day i felt great! wednesday night i took one 500 mg capsule. within 20-30 min i felt hyper, my heart rate went up and boom! anxiety! it was terrible. i was up for several hours
TM - The experiment with L-Tryptophan didn't work. That's okay-- forget about it. I'm old school: I'm suspicious of supplements and won't take any. I think they are another crap-shoot.

General Comments
http://www.cymbaltaw...rove#entry72249
Information on SAM-e, L-tryptophan and 5htp.
Special Note
Metabolic limitations - All of these items mentioned above are 'natural' in our diets and/or body. However, each has to have certain enzymes, vitamins (such as B6, B12, Vit C, etc.), minerals or other components to be processed into dopamine, serotonin, adrenaline or other neurotransmitters. They may also have items which compete with them in the body such as tyrosine or phenylalanine. The reactions may or may not produce more or less of a neurotransmitter but will that even get to the brain? Many of these products just don't cross the blood brain barrier (a membrane around the brain) so even though they are produced they do no good for mood. Some require special enzymes, insulin, certain proteins, etc to cross the barrier and all these items have their own requirements and limitations. This becomes clearly evident in looking at all the individual comments on these supplements. The effects are all over the place. Each persons body is different and has its own nutritional shortages or overages and therefore it may be impossible to tell in advance what reaction may occur to one of these supplements.
L- Tyrosine
An amino acid. Tyrosine is a hydrophilic amino acid and is significantly less soluble in water than its precursor, phenylalinine.
L-phenylalinine is converted by the body to L-tyrosine which is changed to L-DOPA then to dopamine followed by norepiniphrine and finally epinephrine (adrenaline).
Tyrosine is a precursor to neurotransmitters and increases plasma neurotransmitter levels (particularly dopamine and norepinephrine),but has little if any effect on mood in normal subjects. The effect on mood is noted in humans subjected to stressful conditions.
A number of studies have found tyrosine to be useful during conditions of stress, cold, fatigue, prolonged work and sleep deprivation, with reductions in stress hormone levels, reductions in stress-induced weight loss seen in animal trials, and improvements in cognitive and physical performance seen in human trials. Wiki
If you don’t get enough l-tyrosine in your diet, or your body doesn’t properly convert it, you won’t be able to synthesize adequate dopamine. When looking for a supplement, consider n-acetyl-l-tyrosine. This is a highly absorbable form of l-tyrosine that readily enters the brain. L-tyrosine and phenylalanine compete with tryptophan for absorption. Tryptophan is converted to serotonin by the body so if too much L-tyrisine is present n the blood stream then serotonin levels may decrease. One of the functions of Vitamin C include the synthesis norepinephrine from dopamine and the synthesis and catabolism (breakdown) of tyrosine. So vitamin C may increase tyrosine or decrease tyrosine in the body depending on conditions. Webmd.com

Member Comments
a neurostransmitter to help mental alertness and helps support glands especially the thyroid. I take 750 mg capsule 2x's/day
doriono - I was having anxiaty attacks all the time. I trid all sorts of supplements and finnally tried L-Tyrosine. It work like a miracle! I used NOW L-Tyrosine for 3 month and never got an attack again. It's been 6 months now.
Tomitsu - L-Tyrosine also helped me
https://examine.com/...nts/l-tyrosine/
Details the results of over 50 research articles on L-tyrosine.

No significant link found for L-tyrosine in fighting anxiety or depression.

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#25 fishinghat

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Posted 12 July 2018 - 04:03 PM

Nutritional Causes of Anxiety and Depression
Unless otherwise noted all information is either from http://www.rightdiagnosis.com/or
https://www.ncbi.nlm.nih.gov/pmc/

Amino Acids

Testing
https://www.mayomedi...terpretive/9265
The Mayo clinic does a complete detailed analysis of all amino acids in the body.

Amino Acid Imbalance
http://journals.lww....chronic.12.aspx
As early as in the 1960s of the last century Harper has investigated the potential effects exerted by amino acid imbalances. Adverse effects have been observed in experimental animals consuming diets containing disproportionate amounts of amino acids. Such effects may also appear in humans when homeostatic mechanisms regulating amino acid concentrations in body fluids are deficient or defective because of liver or kidney damage, malnutrition or a genetic defect of amino acid metabolism. Moreover, also an overload associated with parenteral or enteral supplied amino acids/proteins can lead to amino acid imbalances.
Note - Many amino acids compete directly with each other in the body, when that is combined with taking supplements, imbalanced diet, genetic limitations and digestive issues it can easily lead to an amino acid imbalance.
Tryptophan
https://www.ncbi.nlm...pubmed/22683764
Tryptophan deficiency linked to depression.
https://www.ncbi.nlm...pubmed/23904410
https://www.ncbi.nlm...pubmed/21377656
https://www.ncbi.nlm...les/PMC2908021/
The modern Western diet often is very high in fats and carbohydrates, and sometimes complete proteins (containing all the essential amino acids) are lacking. Additionally, some seemingly healthy vegetarian and vegan diets may be lacking in sources of Tryptophan. https://nootriment.c...han-deficiency/

Threonine
http://aminoacidstud...nine_deficiency
Deficiency (extremely rare) linked to emotional agitation. Mostly occurs in vegetarians,
Isoleucine
http://aminoacidstud...cine_deficiency
Deficiency rare but can include irritability.

Methionine
http://aminoacidstud...g/l-methionine/
"deficiency of L-methionone can cause or exacerbate depression and allergies and lead to an excess of toxins"
https://www.ncbi.nlm...les/PMC5501805/
Our findings suggest that imbalances in specific metabolite levels (which included methionine) may be involved in the pathogenesis of MDD (Major Depressive Disorder).

http://ajcn.nutritio...76/5/1151S.full
Decades of research on the biochemical and molecular roles of SAMe in cellular metabolism have provided an extensive foundation for its use in clinical studies, including those on depression, dementia, vacuolar myelopathy, liver disease, and osteoarthritis.
S-Adenosyl-l-methionine (SAMe), first discovered in 1952 , is formed from the essential amino acid methionine and adenosine triphosphate.

http://www.tandurust...deficiency.html
There are several uses of methionine in our body, it is necessary in synthesis of RNA and DNA, it helps to absorb selenium. In order to make a proper utilization of methionine, it requires cofactors such as vitamin B6, B12, choline, folic acid and magnesium.
Methionine deficiency is contributory factor in causing diseases such as childhood rheumatic fever, muscle paralysis, hair loss, depression, folic acid deficiency.
Methionine deficiency is usually associated with an overall protein deficiency. http://www.ndhealthf...wiki/Methionine

Phenylalanine
http://aminoacidstud...-phenylalanine/
People deficient in phenylalanine may experience symptoms such as lethargy, confusion, cognitive impairment, poor appetite, and depression.
http://www.umm.edu/h...t/phenylalanine
Same
http://www.nature.co...lication_detail
The genetic disorder phenylketonuria (PKU) is the inability to metabolize phenylalanine because of a lack of the enzyme phenylalanine hydroxylase. Phenylketonuria affects about one in 12,000 babies. Individuals treated late or never treated may develop severe behavioral or psychiatric problems (depression, anxiety, and phobias) in the third or fourth decade. In a few case reports, untreated individuals with PKU (Excess phenylalanine) with normal intelligence were diagnosed in adulthood only as a result of a sudden and severe psychiatric deterioration.

Uncommon - From eating a low protein diet or from genetic mutations.
http://www.tandurust...ncy-causes.html

Tyrosine
http://aminoacidstud...d_mental_health
Due to the important role tyrosine has in producing neurotransmitters there has been several studies looking at the relationship between this amino acid and depression. It has been established that women taking oral contraceptives tend to have lower tyrosine concentrations and this may trigger depression
It’s possible that the metabolism of tyrosine is abnormal in people suffering from depression. There is some research to suggest that tyrosine supplementation may help elevate people out of a depressed state.
The best results have been achieved when taken together with 5-HTP supplements. 5-HTP is a phytochemical similar to that amino acid tryptophan. It helps to elevate serotonin levels in the brain to improve mood.
Rose D and Cramp D. 1970. Reduction of plasma tyrosine by oral contraceptives and oestrogens: a possible consequence of tyrosine aminotransferase induction. Clinica Chimica Acta Volume 29, Issue 1, (pp. 49-53).”
Moller S. (1981). Effect of oral contraceptives on tryptophan and tyrosine availability: evidence for a possible contribution to mental depression. Neuropsychobiology. Volume 7, Issue 4, (pp. 192-200).”
Kishimoto H, and Hama Y. (1976). The level and diurnal rhythm of plasma tryptophan and tyrosine in manic-depressive patients. Yokohama Medical Bulletin, Volume 27, (pp. 89-97).” \l "
Gelenberg A and Gibson C (1984). Tyrosine for the treatment of depression. Nutrition and Health. Volume 3, Issue 3, (pp. 163-73).”
Low energy levels and an erratic mood may be linked to a deficiency in l-tyrosine. Often the symptoms of low tyrosine are similar to that of hypothyroidism. People may experience flu-like symptoms, unexplained weight gain, poor temperature regulation, low blood pressure, sluggish metabolism, depression, dry skin, constipation and brittle hair or fingernails.
Uncommon - Due to low protein diet or genetic mutations.
----------------------------------------------------------------------------------------------------------
Vitamins, Deficiency and Toxicity

Vitamin C
Vitamin C deficiency
https://www.ncbi.nlm...pubmed/25835231
https://www.ncbi.nlm...pubmed/17372835
https://www.ncbi.nlm.../pubmed/8451160
https://www.ncbi.nlm...les/PMC3540126/
All the above link it to depression.
Rare

Vitamin D - The two major forms are vitamin D2 or ergocalciferol, and vitamin D3 or cholecalciferol.
Vitamin D deficiency (depression)
https://www.ncbi.nlm...pubmed/23377209
http://ajcn.nutritio...87/4/1080S.full
Vitamin D deficiency is now recognized as a pandemic. The major cause of vitamin D deficiency is the lack of appreciation that sun exposure in moderation is the major source of vitamin D for most humans.
https://www.scienced...41202111148.htm
And many more.

Vitamin D Deficiency (anxiety)
https://link.springe...0067-006-0348-5
https://www.ncbi.nlm...iciency anxiety
https://www.ncbi.nlm...pubmed/26203431
and many more.
Fairly Common due to improper diet, not enough sun, dark pigmented skin, kidney disease, digestive absorbtion disorder, genetics, and obesity.
https://www.webmd.co...-d-deficiency#2

Vitamin D toxicity is on the uncrease due to over use/overdose of Vitamin D. Currently Vitamin D supplementation is very popular and routine levels of your vitamin D should be performed if you are taking the supplements.

Vitamin E
Includes....
Alpha Tocopherol
Beta Tocopherol
Gamma Tocopherol and
Delta Tocopherol

Deficiency
https://www.ncbi.nlm...pubmed/21979061
https://www.ncbi.nlm...pubmed/19472364
Linked to anxiety.
https://www.ncbi.nlm...pubmed/15508016
Linked to depression
Rare - Caused by genetics or Fat malabsorption - Some dietary fat is needed for the absorption of vitamin E from the gastrointestinal tract. Anyone diagnosed with cystic fibrosis, individuals who have had part or all of their stomach removed or who have had a gastric bypass, and individuals with malabsorptive problems such as Chrohn's Disease, liver disease or exocrine pancreatic insufficiency may not absorb fat (people who cannot absorb fat often pass greasy stools or have chronic diarrhea and bloating). Abetalipoproteinemia is a rare inherited disorder of fat metabolism that results in poor absorption of dietary fat and vitamin E. - Wiki
B Vitamins
General
http://ajcn.nutritio...t/92/2/269.full
http://file.scirp.or...02_49431046.pdf
Details on the relationships of various B vitamins to depression.

https://www.ncbi.nlm...pubmed/25173634
Genetic mutations commonly effect B vitamin production and use resulting in various psychological disorders.

FH - Where I am a blood work up including levels of b vitamins is sort of standard. If your levels of B vitamins is normal then they do not recommend taking a B vitamin supplement because two high a dose can cause side effects.
Thiamine (B1)
Deficiency
http://www.bmj.com/r...sychosis-which-
https://www.research..._clinical_trial
Linked to depression.
http://journals.sage...533210110392941
Fairly common - Thiamine deficiency fairly common in alcoholics. Beriberi (Thiamine deficiency) may also be caused by shortcomings other than inadequate intake: diseases or operations on the digestive tract, alcoholism, dialysis, geneetic morphs, etc. All these causes mainly affect the central nervous system, and provoke the development of what is known as Wernicke's disease or Wernicke's Encephalopathy.
Wernicke's disease is one of the most prevalent neurological or neuropsychiatric diseases. In autopsy series, features of Wernicke lesions are observed in approximately 2% of general cases. https://en.wikipedia...eficiency#Cause
Niacin (B3)
Deficiency
https://www.ncbi.nlm...les/PMC4198903/
https://www.research...w_of_literature
http://www.bmj.com/r...sychosis-which-
And others link low Niacin to causing depression.
Moderately common - Niacin deficiency is more likely to be caused by problems that affect absorption of niacin or tryptophan. The most common cause is alcoholism. Other possible causes include disorders of the digestive tract and prolonged treatment with the tuberculosis drug isoniazid.
https://www.webmd.co...-treatments#1-3
Vitamin B6 (pyridoxine)
Deficiency
https://www.ncbi.nlm...pubmed/15479988
https://www.ncbi.nlm...pubmed/25401165
https://www.ncbi.nlm...pubmed/18838531
and other articles link low vitamin B6 to depression.

https://www.ncbi.nlm.../pubmed/4547177https://www.ncbi.nlm.../pubmed/6889807
and other articles link oral contraceptives to low B6 and depression.

A deficiency of vitamin B6 alone is relatively uncommon and often occurs in association with other vitamins of the B complex. The elderly and alcoholics have an increased risk of vitamin B6 deficiency, as well as other micronutrient deficiencies. Evidence exists for decreased levels of vitamin B6 in women with type 1 diabetes and in patients with systemic inflammation, liver disease, rheumatoid arthritis, and those infected with HIV. Use of oral contraceptives and treatment with certain anticonvulsants, isoniazid, cycloserine, penicillamine, and hydrocortisone negatively impact vitamin B6 status. Hemodialysis reduces vitamin B6 plasma levels.
https://en.wikipedia...n_B6#Deficiency

Caution
https://www.ncbi.nlm.../pubmed/3630649
Because of suppliments and certain medical therapies including some chemotherapies, vitamin B6 toxicity is becoming much more common.

Note - A search of vitamin B6 supplements on Amazon shows that many supplements currently on the market are well above the recommended dietary allowances. The long half life (see below) allows for toxic levels to build rapidly.
Cin - a good mult-vitamin, but don't overdo it on the B vitamins (even though they are water soluble, I actually got vit. B6 toxicity and that caused some nerve issues that I'm not sure will ever completely reverese),
Three membvers have reported Vitamin B6 toxicity.
https://www.ncbi.nlm...ooks/NBK114313/
Half-Life is 15 to 24 days.

Folate (Folic Acid, Vitamin B9)
Deficiency
https://examine.com/...nts/folic-acid/
Bjelland I, et al. Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatry. (2003)
Kelly CB et al.. The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. J Psychopharmacol. (2004)
Almeida OP, et al. Contribution of the MTHFR gene to the causal pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging. (2005)
And others link deficiency to depression.
Moderately common -
Folate is a water-soluble vitamin. It dissolves in water and isn’t stored in your fat cells. This means that you need to keep taking folate as your body cannot develop a reserve.
A diet low in fresh fruits, vegetables, and fortified cereals is the main cause of folate deficiency. In addition, overcooking your food can sometimes destroy the vitamins. Folate levels in your body can become low in just a few weeks if you don’t eat enough folate-rich foods.
Diseases that affect absorption in the gastrointestinal tract can cause folate deficiencies. Such diseases include:
⦁ Chrohn's Disease
⦁ Celiac Disease
⦁ certain types of cancers
⦁ severe kidney problems that require dialysis
Some people have a genetic mutation that hinders their body from properly and efficiently converting dietary or supplemental folate to its usable form, methylfolate.
Certain medications can cause folate deficiency. These include:
⦁ phenytoin (Dilantin)
⦁ trimethoprim-sulfamethoxalole
⦁ methotrexate
⦁ sulfasalazine
Alcohol interferes with folate absorption. It also increases folate excretion through the urine.
https://www.healthli...ficiency#causes
Toxicity
https://www.livestro...d-in-your-body/
Depression
http://www.healthy-v...n-toxicity.html
Taking Pancreatic enzymes, methotrexate, genetics can cause vitamin B9 toxicity.

Vitamin B12 (cobalamin)
Deficiency
https://examine.com/...ts/vitamin-b12/
Carney MW, Sheffield BF. Serum folic acid and B12 in 272 psychiatric in-patients. Psychol Med. (1978)
Penninx BW, et al. Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry. (2000)
Lerner V, et al. Vitamin B12 and folate serum levels in newly admitted psychiatric patients. Clin Nutr. (2006) Morris MS, et al. Depression and folate status in the US Population. Psychother Psychosom. (2003)
and many other articles link low levels of vitamin B12 to depression.
https://www.health.h...ul-201301105780
Moderately common - More common in the elderly, vegetarians, those taking proton pump inhibitors (24 hour heart burn medicine) or have Celiac Disease or serious digestive issues.
Toxicity
https://www.mayoclin...12/art-20363663
"your body is capable of storing several years' worth of vitamin B-12," May cause anxiety. The majority of B12 toxicity is from taking too much supplements or megadoses of Vitamin C.

Half-life is 6 days.
https://www.nature.c...ticles/198200a0

Pantothenic Acid (Vitamin B5)
Deficiency
http://www.sciencedi...antothenic-acid
http://www.umm.edu/h...antothenic-acid
Links to depression.

Uncommon - Groups at risk of deficiency are alcoholics, women on oral contraceptives, the elderly, and people with impaired absorption due to certain digestive disorders.
https://www.justvita...5/#.WnyZJORy65c

Choline
Deficiency
http://ajcn.nutritio.../90/4/1056.full
https://www.psycholo...he-case-choline
http://folk.uib.no/m...1_jimd_34_3.pdf
Low levels linked to anxiety
Deficiency caused by fatty liver disease, alcoholics, the obese, elderly and diabetics.

Toxicity
https://www.scienced...925492717301464
https://www.hindawi....rt/2011/650450/
http://www.psy-journ...(80)90065-7/pdf
High levels linked to depression

http://lpi.oregonsta...holine#toxicity
Toxicity normally caused by diet, Methotrexate and/or taking supplements.
-----------------------------------------------------------------------------------------------------------
Minerals/Metals, Deficiency and Toxicity

Calcium
hypocalcemia
http://www.sciencedi...y/hypocalcaemia
http://psycnet.apa.o.../1989-19007-001
https://www.drugs.co...pocalcemia.html
and others link low calcium to anxiety

hypercalcemia
http://www.cleveland.../hypercalcemia/
http://www.amjmedsci...2436-8/fulltext
http://www.jpsmjourn...(08)00145-0/pdf
and others link high calcium to anxiety and depression.
Fairly common

FH - When I think of a natural product I think of something like calcium carbonate (the active ingredient in Tums). I do not use Tums because of the other ingredients. I purchase 100% calcium carbonate (food grade) and put the right amount in an empty vegetable gelatin capsule and use that for my antacid. Cheap, safe (as long as I routinely my blood calcium levels) and effective.

http://www.cymbaltaw...nic/?hl=caution
All about calcium and zinc supplements for anxiety.

Iron
Deficiency
http://www.jogc.com/...bstract?rss=yes
http://jn.nutrition..../135/2/267.full
http://journals.tbzm...JARCM-3-219.pdf
and others link deficiency to depression.
https://www.livestro...5-iron-anxiety/
Limited evidence of iron deficiency causing anxiety.

Toxicity
https://www.ncbi.nlm...pubmed/23333676
https://www.ncbi.nlm...les/PMC5581806/
Limited evidence of iron toxicity causing depression.

https://rd.springer....?no-access=true
Limited evidence that excessive iron can cause anxiety
Moderately common

Magnesium
Deficiency Toxicity
https://www.ncbi.nlm...pubmed/25690713
https://www.ncbi.nlm...pubmed/23289218
https://www.ncbi.nlm...pubmed/23950577
Blood levels of magnesium do not necessarily relate to depression or anxiety. Many patients respond to magnesium therapy even though their blood levels may already be high or normal. No concrete determination has been made as to when to take magnesium for depression or anxiety.
Both deficiency and excessive levels are fairly common.
FH - Be sure and have your serum magnesium levels checked at least once per year as the supplement can elevate magnesium levels with time which can cause calcium to drop and create additional muscle/joint issues.
FH - I did have my routine blood magnesium drawn a couple weeks ago and it was high. This would explain my low calcium. I have been dropping my magnesium intake a little at a time and repeating the blood test. As I drop it my calcium increases. I am now off the magnesium and hopefully at my next test on the 30th my calcium and magnesium will both be back to normal. This is why I always recommend people who are taking magnesium to have a blood magnesium test run every 6 months.
Potassium/Sodium
Deficiency of sodium and or potassium are linked to depression and anxiety during dehydration and low Vitamin D levels.
Toxicity
https://www.ncbi.nlm...oxicity anxiety
https://www.ncbi.nlm...pubmed/23523745
https://www.ncbi.nlm...pubmed/23653461
https://www.ncbi.nlm...pubmed/24704193
https://www.ncbi.nlm...les/PMC5536667/
High sodium levels highly correspond to anxiety and some indiation it can cause depression.
https://www.ncbi.nlm.../pubmed/2919849
Limited evidence that high potassium causes anxiety
List of causes are extensive.
FH - Sodium can be a real issue for those suffering from anxiety. Anyone under stress (physical or mental) produces lactic acid. That is why many of us get body aches during times of high stress. Salt consumption, as everyone knows, puts high amount of sodium into the blood stream. It reacts with the lactic acid in our bodies to produce sodium lactate, a very strong neurostimulant. I am particularly sensitive to it. A simple salty hotdog will double my anxiety for 2 or 3 hours. Obviously I can reduce that by forcing fluids, say 2 or 3 glasses in an hour or two. This has lead me to eating at home where I can have a salt free diet. No processed foods from the grocery stores either. Anyone else sensitive to salt intake? Kind of curious.
Salt might be nature's antidepressant
http://www.scienceda...90310152329.htm
(Because it is a neural stimulant and in high enough quantities may cause anxiety)

Zinc
Deficiency
https://www.ncbi.nlm...pubmed/23806573
https://www.ncbi.nlm...pubmed/21946308
https://www.ncbi.nlm...pubmed/24367556
https://www.ncbi.nlm...pubmed/21093288
and many more articles link low blood zinc levels to depression.
https://www.ncbi.nlm...pubmed/17166602
https://www.ncbi.nlm...ubmed/23493534/
https://www.ncbi.nlm...ubmed/18975044/
and many more articles link low blood zinc levels to anxiety.

Excess zinc...
⦁ Zinc absorption from dandruff shampoos and denture creams.
⦁ Supplements
Increasing in occurrance.

Zinc Deficiency
Uncommon -

http://www.cymbaltaw...nic/?hl=caution
All about calcium and zinc supplements for anxiety.
Manganese
Toxicity
https://www.ncbi.nlm...pubmed/25064383
Elevated manganese linked to anxiety
https://www.ncbi.nlm...pubmed/16343629
https://www.ncbi.nlm...pubmed/16962176
https://www.ncbi.nlm...pubmed/17018581
Elevated manganese linked to anxiety and depression.
Uncommon

Selenium
Deficiency
https://www.ncbi.nlm...pubmed/18449137
https://www.ncbi.nlm.../pubmed/1873372
https://www.ncbi.nlm...les/PMC3566946/
and others link low selenium levels to both anxiety and depression.
Very uncommon

Toxicity
https://pubchem.ncbi...ection=Symptoms
Limited indication that high selenium can cause depression.
Getting to be fairly common.
Selenium in Chinese grains like Chinese rice have been a source of selenium poisoning. Many areas of China have soils rich in selenium and natives who eat vegetables and meats in those areas are subject to bouts of selenium poisoning. Some of the vegetables exported from China come from those regions. Periodic outbreaks of selenosis have occurred in regions of China where high concentrations of selenium are found in the soil.
The richest food sources of selenium are seafood, followed by muscle meats. Drinking water is not considered to be a significant source of selenium in North America except in areas, where high levels of selenium in soil contribute to the selenium content of the water, higher levels of selenium may be found in wells used for drinking water. This frequently occurs in areas of the upper midwest and far west in the USA. Some plants, including garlic, Brazil nuts, and multiple mustard species, garlic, onion, and broccoli, wheat, and soy are rich in selenomethionine, a form of selenium. (‘selenium accumulators’). Brazil nuts grown in areas of Brazil with selenium-rich soil may provide more than 100 μg of selenium in one nut, while those grown in selenium-poor soil provide 10 times less.
Astragalus is a medicinal herb frequently grown in China and is a significant source of selenium poisoning. The researchers investigated an outbreak of acute selenium poisoning after reports of cases of toxicity started to surface in March 2008. They defined a case as the onset of symptoms of selenium toxicity within 2 weeks of ingesting a dietary supplement. There were 227 affected persons from 9 states, including Florida, Georgia, Kentucky, Michigan, North Carolina, Pennsylvania, Tennessee, Texas, and Virginia.
Selenium toxicity is actually more common in livestock than people. All animal species are susceptible to selenium toxicosis. However, poisoning is more common in forage-eating animals such as cattle, sheep, horses, and other herbivores that may graze selenium-containing plants. This is particularly true in the western part of the United States where the soil is rich in selenium. One thing that the states of Montana, South Dakota and Wyoming have in common is high selenium in the soil, water and plants. High selenium content in soil is absorbed by plants and passed on to livestock which has been linked to human cases of selenium poisoning. In 142 adults living on farms in seleniferous regions of South Dakota, the range of serum selenium was 123–363 μg/L (mean 197, SD ± 55, median 184)
Selenium toxicity is most frequently the cause of allergic reactions to multivitamins. Most multivitamins provide 40 to 60 mcg/day (which does not include selenium from the diet) while the dietary intake is recommended at 55 mcg.
https://www.ncbi.nlm...les/PMC3153292/

Fluoride
Toxicity
https://www.ncbi.nlm...pubmed/24184405
https://www.ncbi.nlm...pubmed/23222693
https://www.ncbi.nlm...les/PMC5594553/
and others link fluoride exposure to anxiety and depression.

Causes of Fluorine toxicity...
⦁ Twenty percent of modern pharmaceuticals contain fluorine.
⦁ Children may experience gastrointestinal distress upon ingesting excessive amounts of floride toothpaste. Between 1990 and 1994, over 628 people, mostly children, were treated after ingesting too much fluoride-containing toothpaste.
⦁ Around one-third of the world’s population drinks water from groundwater resources. Of this, about 10 percent, approximately 300 million people, obtains water from groundwater resources that are heavily contaminated with arsenic or fluoride
⦁ accidental or intentional consumption of insecticides and rodenticides.

Cholesterol /Triglyceride

Deficiency
www.ncbi.nlm.nih.gov/pubmed/10367605
https://www.ncbi.nlm...pubmed/16250690
https://www.ncbi.nlm...pubmed/23197842
Decreased HDL and/or LDL linked to anxiety and/or depression.

Toxicity
https://www.ncbi.nlm...pubmed/16250690
https://www.ncbi.nlm...pubmed/12211884
https://www.ncbi.nlm...pubmed/11778348
https://www.ncbi.nlm.../pubmed/8884036
https://www.ncbi.nlm.../pubmed/1536278
https://www.ncbi.nlm...pubmed/10900559
Elevated LDL and Triglyceride linked to anxiety.
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#26 fishinghat

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Posted 12 July 2018 - 04:09 PM

Surgical Causes of Anxiety

Special Note -

Glossary -
Cholecystectomy - The surgical removal of the gall bladder

https://www.ncbi.nlm...pubmed/19337637
J Gastrointestin Liver Dis. 2009 Mar;18(1):67-71.
Postcholecystectomy syndrome - an algorithmic approach.
BACKGROUND AND AIM:
The postcholecystectomy syndrome includes a heterogeneous group of diseases, usually presenting as abdominal symptoms following gallbladder removal. The clinical management of these patients is frequently without an evidence-based approach.
METHOD:
We evaluated 80 patients with postcholecystectomy problems consecutively admitted during a period of 36 months. The liver function tests (LFTs) assessment and transabdominal ultrasound (TUS) were followed by endoscopic ultrasound (EUS). Endoscopic retrograde cholangio-pancreatography (ERCP) was then performed depeding on the results. With knowledge of the final diagnosis, the probable evaluation and outcomes were reassessed assuming that ERCP would have been performed as the initial procedure. Final diagnosis was confirmed by a combination of imaging findings, as well as clinical follow-up of 6 months.
RESULTS:
In 53 patients biliary or pancreatic diseases were diagnosed: common bile duct stones, chronic pancreatitis, pancreatic cancer, papillary tumors, cholangiocarcinoma, insufficient cholecystectomy or sphincter of Oddi dysfunction. The other 27 patients had non-biliary symptoms (dyspepsia, IBS, etc.) and were consequently managed according to the symptoms. The sensitivity and specificity of EUS were high in the subgroup of patients with biliary or pancreatic symptoms (96.2% and 88.9%) and helped to indicate subsequent ERCP.
CONCLUSION:
An algorithmic approach which used EUS for the initial evaluation of the patients with postcholecystectomy problems decreased the number of ERCPs by 51%, having as a consequence a decreased morbidity and mortality in this group of patients.

https://www.ncbi.nlm.../pubmed/7729279
Dig Dis Sci. 1995 May;40(5):1149-56.
Abnormal sphincter of Oddi response to cholecystokinin in postcholecystectomy syndrome patients with irritable bowel syndrome. The irritable sphincter.
Abstract
Standard biliary manometry, including cholecystokinin (CCK) provocation, was performed on 42 consecutive patients (36 F, 6 M, median age 45 years) with postcholecystectomy syndrome (PCS) who had no evidence of organic disease but who had objective clinical features suggesting sphincter of Oddi dysfunction (SOD) (classes I and II). Patients were subdivided into those with (N = 14) and without (N = 28) irritable bowel syndrome (IBS) using a validated symptom questionnaire based on the modified Rome criteria. Resting sphincter of Oddi (SO) motor parameters (basal pressure, contractile amplitude and frequency, and proportion of retrograde contractions), the presence of abnormal manometry, and the presence of an abnormal response to CCK were compared in the two groups. No significant differences in resting parameters of SO motor activity between patients with and without IBS were observed, and abnormal biliary manometry as a whole was not more prevalent in either group (8/13 and 18/27, respectively). An abnormal response to CCK (failure of complete inhibition of phasic contractions), however, was demonstrated in five of 12 patients with IBS compared with only one of 23 patients without IBS (P = 0.01). In patients with postcholecystectomy SOD, an abnormal response of the SO to CCK thus appears to be an important feature of the subset of patients with concomitant IBS.
Note - That is 33% who had IBS.

https://www.ncbi.nlm...les/PMC3335764/
Aliment Pharmacol Ther.
Biliary events and an increased risk of new onset irritable bowel syndrome: A population-based cohort study
Background
Prospective data are lacking to determine if IBS a risk factor for cholecystectomy, or if biliary disease and cholecystectomy predisposes to the development of IBS.
Methods
Validated symptom surveys sent to cohorts of Olmsted County, MN, (1988–1994) with follow-up in 2003. Medical histories were reviewed to determine any “biliary events” (defined by gallstones or cholecystectomy). Analyses examined: 1) time to a biliary event post initial survey and separately, 2) risk of IBS (Rome II) in those with vs. without a prior biliary event.
Results
1908 eligible subjects mailed a follow-up survey. For aim 1) of the 726 without IBS at initial survey, 44 (6.1%) had biliary events during follow up, in contrast to 5 of 93 (5.4%) with IBS at initial survey (HR 0.8, 95% CI 0.3-2.1). For aim 2) of the 59 subjects with a biliary event at initial survey, 10 (17%) reported new IBS on the follow-up survey, while in 682 without a biliary event up to 1.5 years prior to the second survey, 58 (8.5%) reported IBS on follow-up (OR=2.2, 95% CI 1.1-4.6, p=0.03).
Conclusion
There is an increased risk of new IBS in community subjects who have been diagnosed as having a biliary event.
Note - apparently fairly common after cholecystectomy (removal of Gall Bladder). I think you are on to somethin g here.

https://www.ncbi.nlm...pubmed/25761193
Having the gall bladder removed in patients with gall bladder issues reduced the presence of depression.

https://www.ncbi.nlm...pubmed/26053886
PLoS One. 2015 Jun 8;10(6):e0129962. doi: 10.1371/journal.pone.0129962. eCollection 2015.
Increased Risk of Depressive Disorder following Cholecystectomy for Gallstones.
Abstract
BACKGROUND:
Prior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database.
METHODS:
Using ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy.
RESULTS:
Of 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not.
CONCLUSIONS:
There is an association between cholecystectomy and subsequent risk of DD among females, but not in males.

https://www.ncbi.nlm...pubmed/27601483
BMJ Open. 2016 Sep 6;6(9):e007969. doi: 10.1136/bmjopen-2015-007969.
Does preoperative depression and/or serotonin transporter gene polymorphism predict outcome after laparoscopic cholecystectomy?
Abstract
OBJECTIVE:
To determine whether preoperative psychological depression and/or serotonin transporter gene polymorphism are associated with poor outcomes after the common procedure of laparoscopic cholecystectomy.
DESIGN:
Patients undergoing laparoscopic cholecystectomy were genotyped for the serotonin transporter gene 5-HTTLPR polymorphism and assessed for psychological morbidity before and 6 weeks after surgery. The main outcome was postoperative depression; secondary outcomes included fatigue, perceived pain, quality of life and subjective perception about return to usual.
RESULTS:
Full genetic and psychological data were obtained from 273 out of 330 patients consented to the study (82% female). Significantly fewer people with preoperative depression (Beck Depression Inventory (BDI) score >5) had returned to employment (57% vs 86%, p<0.001) or made a full recovery (11% vs 44%, p<0.001) 6 weeks after surgery. Independent predictors for subjective return to usual after surgery included preoperative depression, body mass index and postoperative pain scores. Independent predictors of postoperative depression included preoperative antidepressant use and preoperative depression. SS genotype was associated with use of antidepressants preoperatively and higher anxiety levels after surgery. However, it was not associated with other salient postoperative psychosocial outcomes.
CONCLUSIONS:
Depressive psychological morbidity preoperatively, pain and body mass index appear to be important factors in predicting recovery after this common surgical procedure. There may be a place to include preoperative brief psychological screening to enable targeted support. Our results suggest that the serotonin transporter gene is unlikely to be a useful clinical predictor of outcome in this group.
TRIAL REGISTRATION NUMBER:
ISRCTN40219584.
Note - If the serotonin transporter gene is not involved with this type of depression than ssri/snri would probably be worthless and might explain your treatment resistant depression.

https://www.ncbi.nlm...les/PMC5508800/
"In this large population-based cohort study, cholecystectomy was associated with postoperative diarrhoea and stomach pain. Cholecystectomy for gallstone colic was associated with nausea in men. There were no associations between quality of life, symptoms of anxiety and depression, constipation, heartburn, or acid regurgitation."

Note - From Wiki
Postcholecystectomy syndrome describes the presence of abdominal symptoms after surgical removal of the gallbladder (cholecystectomy), 2 years after the surgery.
Symptoms of postcholecystectomy syndrome may include:
· Dyspepsia, nausea, and vomiting.
· Flatulence, bloating, and diarrhea.
· Persistent pain in the upper right abdomen.
Symptoms occur in about 5 to 40 percent of patients who undergo cholecystectomy,and can be transient, persistent or lifelong. The chronic condition is diagnosed in approximately 10% of postcholecystectomy cases.
Chronic diarrhea in postcholecystectomy syndrome is a type of bile acid diarrhea (type 3). This can be treated with a bile acid sequestrant like cholestyramine, colestipol or colesevelam, which may be better tolerated.
Treatment
Some individuals may benefit from diet modification, such as a reduced fat diet, following cholecystectomy. The liver produces bile and the gallbladder acts as reservoir. From the gallbladder, bile enters the intestine in individual portions. In the absence of gallbladder, bile enters the intestine constantly, but in small quantities. Thus, it may be insufficient for digestion of fatty foods. Postcholecystectomy syndrome treatment depends on the identified violations that led to it. Typically, the patient is recommended dietary restriction table with fatty foods, enzyme preparations, antispasmodics, sometimes cholagogue.
If the pain is caused by biliary microlithiasis, oral ursodeoxycholic acid can alleviate the condition.
A trial of bile acid sequestrant therapy is recommended for bile acid diarrhoea.

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#27 fishinghat

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Posted 12 July 2018 - 04:14 PM

Minerals/Metals, Deficiency and Toxicity

Calcium
hypocalcemia
http://www.sciencedi...y/hypocalcaemia
http://psycnet.apa.o.../1989-19007-001
https://www.drugs.co...pocalcemia.html
and others link low calcium to anxiety

hypercalcemia
http://www.cleveland.../hypercalcemia/
http://www.amjmedsci...2436-8/fulltext
http://www.jpsmjourn...(08)00145-0/pdf
and others link high calcium to anxiety and depression.
Fairly common

FH - When I think of a natural product I think of something like calcium carbonate (the active ingredient in Tums). I do not use Tums because of the other ingredients. I purchase 100% calcium carbonate (food grade) and put the right amount in an empty vegetable gelatin capsule and use that for my antacid. Cheap, safe (as long as I routinely my blood calcium levels) and effective.

http://www.cymbaltaw...nic/?hl=caution
All about calcium and zinc supplements for anxiety.

Iron
Deficiency
http://www.jogc.com/...bstract?rss=yes
http://jn.nutrition..../135/2/267.full
http://journals.tbzm...JARCM-3-219.pdf
and others link deficiency to depression.
https://www.livestro...5-iron-anxiety/
Limited evidence of iron deficiency causing anxiety.

Toxicity
https://www.ncbi.nlm...pubmed/23333676
https://www.ncbi.nlm...les/PMC5581806/
Limited evidence of iron toxicity causing depression.

https://rd.springer....?no-access=true
Limited evidence that excessive iron can cause anxiety
Moderately common

Magnesium
Deficiency Toxicity
https://www.ncbi.nlm...pubmed/25690713
https://www.ncbi.nlm...pubmed/23289218
https://www.ncbi.nlm...pubmed/23950577
Blood levels of magnesium do not necessarily relate to depression or anxiety. Many patients respond to magnesium therapy even though their blood levels may already be high or normal. No concrete determination has been made as to when to take magnesium for depression or anxiety.
Both deficiency and excessive levels are fairly common.
FH - Be sure and have your serum magnesium levels checked at least once per year as the supplement can elevate magnesium levels with time which can cause calcium to drop and create additional muscle/joint issues.
FH - I did have my routine blood magnesium drawn a couple weeks ago and it was high. This would explain my low calcium. I have been dropping my magnesium intake a little at a time and repeating the blood test. As I drop it my calcium increases. I am now off the magnesium and hopefully at my next test on the 30th my calcium and magnesium will both be back to normal. This is why I always recommend people who are taking magnesium to have a blood magnesium test run every 6 months.
Potassium/Sodium
Deficiency of sodium and or potassium are linked to depression and anxiety during dehydration and low Vitamin D levels.
Toxicity
https://www.ncbi.nlm...oxicity anxiety
https://www.ncbi.nlm...pubmed/23523745
https://www.ncbi.nlm...pubmed/23653461
https://www.ncbi.nlm...pubmed/24704193
https://www.ncbi.nlm...les/PMC5536667/
High sodium levels highly correspond to anxiety and some indiation it can cause depression.
https://www.ncbi.nlm.../pubmed/2919849
Limited evidence that high potassium causes anxiety
List of causes are extensive.
FH - Sodium can be a real issue for those suffering from anxiety. Anyone under stress (physical or mental) produces lactic acid. That is why many of us get body aches during times of high stress. Salt consumption, as everyone knows, puts high amount of sodium into the blood stream. It reacts with the lactic acid in our bodies to produce sodium lactate, a very strong neurostimulant. I am particularly sensitive to it. A simple salty hotdog will double my anxiety for 2 or 3 hours. Obviously I can reduce that by forcing fluids, say 2 or 3 glasses in an hour or two. This has lead me to eating at home where I can have a salt free diet. No processed foods from the grocery stores either. Anyone else sensitive to salt intake? Kind of curious.
Salt might be nature's antidepressant
http://www.scienceda...90310152329.htm
(Because it is a neural stimulant and in high enough quantities may cause anxiety)

Zinc
Deficiency
https://www.ncbi.nlm...pubmed/23806573
https://www.ncbi.nlm...pubmed/21946308
https://www.ncbi.nlm...pubmed/24367556
https://www.ncbi.nlm...pubmed/21093288
and many more articles link low blood zinc levels to depression.
https://www.ncbi.nlm...pubmed/17166602
https://www.ncbi.nlm...ubmed/23493534/
https://www.ncbi.nlm...ubmed/18975044/
and many more articles link low blood zinc levels to anxiety.

Excess zinc...
⦁ Zinc absorption from dandruff shampoos and denture creams.
⦁ Supplements
Increasing in occurrance.

Zinc Deficiency
Uncommon -

http://www.cymbaltaw...nic/?hl=caution
All about calcium and zinc supplements for anxiety.
Manganese
Toxicity
https://www.ncbi.nlm...pubmed/25064383
Elevated manganese linked to anxiety
https://www.ncbi.nlm...pubmed/16343629
https://www.ncbi.nlm...pubmed/16962176
https://www.ncbi.nlm...pubmed/17018581
Elevated manganese linked to anxiety and depression.
Uncommon

Selenium
Deficiency
https://www.ncbi.nlm...pubmed/18449137
https://www.ncbi.nlm.../pubmed/1873372
https://www.ncbi.nlm...les/PMC3566946/
and others link low selenium levels to both anxiety and depression.
Very uncommon

Toxicity
https://pubchem.ncbi...ection=Symptoms
Limited indication that high selenium can cause depression.
Getting to be fairly common.
Selenium in Chinese grains like Chinese rice have been a source of selenium poisoning. Many areas of China have soils rich in selenium and natives who eat vegetables and meats in those areas are subject to bouts of selenium poisoning. Some of the vegetables exported from China come from those regions. Periodic outbreaks of selenosis have occurred in regions of China where high concentrations of selenium are found in the soil.
The richest food sources of selenium are seafood, followed by muscle meats. Drinking water is not considered to be a significant source of selenium in North America except in areas, where high levels of selenium in soil contribute to the selenium content of the water, higher levels of selenium may be found in wells used for drinking water. This frequently occurs in areas of the upper midwest and far west in the USA. Some plants, including garlic, Brazil nuts, and multiple mustard species, garlic, onion, and broccoli, wheat, and soy are rich in selenomethionine, a form of selenium. (‘selenium accumulators’). Brazil nuts grown in areas of Brazil with selenium-rich soil may provide more than 100 μg of selenium in one nut, while those grown in selenium-poor soil provide 10 times less.
Astragalus is a medicinal herb frequently grown in China and is a significant source of selenium poisoning. The researchers investigated an outbreak of acute selenium poisoning after reports of cases of toxicity started to surface in March 2008. They defined a case as the onset of symptoms of selenium toxicity within 2 weeks of ingesting a dietary supplement. There were 227 affected persons from 9 states, including Florida, Georgia, Kentucky, Michigan, North Carolina, Pennsylvania, Tennessee, Texas, and Virginia.
Selenium toxicity is actually more common in livestock than people. All animal species are susceptible to selenium toxicosis. However, poisoning is more common in forage-eating animals such as cattle, sheep, horses, and other herbivores that may graze selenium-containing plants. This is particularly true in the western part of the United States where the soil is rich in selenium. One thing that the states of Montana, South Dakota and Wyoming have in common is high selenium in the soil, water and plants. High selenium content in soil is absorbed by plants and passed on to livestock which has been linked to human cases of selenium poisoning. In 142 adults living on farms in seleniferous regions of South Dakota, the range of serum selenium was 123–363 μg/L (mean 197, SD ± 55, median 184)
Selenium toxicity is most frequently the cause of allergic reactions to multivitamins. Most multivitamins provide 40 to 60 mcg/day (which does not include selenium from the diet) while the dietary intake is recommended at 55 mcg.
https://www.ncbi.nlm...les/PMC3153292/

Fluoride
Toxicity
https://www.ncbi.nlm...pubmed/24184405
https://www.ncbi.nlm...pubmed/23222693
https://www.ncbi.nlm...les/PMC5594553/
and others link fluoride exposure to anxiety and depression.

Causes of Fluorine toxicity...
⦁ Twenty percent of modern pharmaceuticals contain fluorine.
⦁ Children may experience gastrointestinal distress upon ingesting excessive amounts of floride toothpaste. Between 1990 and 1994, over 628 people, mostly children, were treated after ingesting too much fluoride-containing toothpaste.
⦁ Around one-third of the world’s population drinks water from groundwater resources. Of this, about 10 percent, approximately 300 million people, obtains water from groundwater resources that are heavily contaminated with arsenic or fluoride
⦁ accidental or intentional consumption of insecticides and rodenticides.

Cholesterol /Triglyceride

Deficiency
www.ncbi.nlm.nih.gov/pubmed/10367605
https://www.ncbi.nlm...pubmed/16250690
https://www.ncbi.nlm...pubmed/23197842
Decreased HDL and/or LDL linked to anxiety and/or depression.

Toxicity
https://www.ncbi.nlm...pubmed/16250690
https://www.ncbi.nlm...pubmed/12211884
https://www.ncbi.nlm...pubmed/11778348
https://www.ncbi.nlm.../pubmed/8884036
https://www.ncbi.nlm.../pubmed/1536278
https://www.ncbi.nlm...pubmed/10900559
Elevated LDL and Triglyceride linked to anxiety.
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#28 fishinghat

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Posted 12 July 2018 - 04:19 PM

Nutritional Blood Tests for Causes for Anxiety and/or Depression.
Items proceeded by an asterisk are analysis that are routinely performed by many Psychiatrists.
Omega 3 and 6
Amino Acids
to include...
Tryptophan
Threonine
Isoleucine
Methionine
Phenylalanine
Tyrosine

Vitamins
to include...
C
*D
E
*B vitamins


Minerals
Calcium
Iron
Magnesium
Potassium
Sodium
Zinc
Manganese
Selenium

Lipid Profile
Cholesterol
Triglycerides

Misc.
Choline
Flouride

Psychiatrists also often perform the following tests
Testosterone
Estrogen
*Thyroid Function
Liver Function - (FH - The AD manufacturers usually recommend an annual Liver Function Test (LFT) to keep an eye on that issue.
Parathyroid Function
Pituitary Function

An increasing number of psychiatrists are also opting to do a genetic screening for genetic mutations.
https://genesight.co...CFdC3wAodswYJSw
https://genomind.com...idepressants-2/
https://www.psycholo...ssion-treatment
http://mayoresearch....ene-testing.asp
https://www.pathway....th-dna-insight/

Wagtail - Just over a year ago I put myself in the care of a highly recommended integrative GP ,who has helped me a great deal .
A few weeks ago he ordered special blood tests to be done on me . These blood tests aren’t done regularly because Medicare refuse to pay for them or even pay any rebate .
I had to pay for them myself & was quite pleased to do so $300 & worth every cent !.
The results came back yesterday & not surprisingly to me , it appears that I have the autoimmune disease ‘ Hashimoto thyroiditis ‘ & possibility is , that I have had it for most of my life like my daughter .

Bearfan - She also ordered some blood tests. I had an abnormality here. On my Vitamin D levels, I was extremely low. The normal range is >50, and mine were only 5. So she had to prescribe me a high dose of Vitamin D that I have to take once a week, then after a month I take a slightly lower dose once a day. And continue to do that for 3 months until get my levels checked again.
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Competition of Minerals and Vitamins in the Body.

Doses of magnesium can also be relatively large and should, ideally, be taken apart from other minerals. Magnesium competes with calcium for absorption.
If you take high doses of zinc long-term (50 mg or more per day for 10 weeks or longer ), be aware that it can cause copper deficiency, so you may need to supplement with copper as well.
Hypervitaminosis E may also counteract vitamin K, leading to a vitamin K deficiency.
Tyrosine and phenylalanine compete with tryptophan for absorption.
Niacin can cause an excess of uric acid in the blood (hyperuricemia), putting you at risk of gout. (Mayo Clinic)
Long term use of vitamin D can cause hypercalcemia (too high calcium levels).
Iron, copper and zinc are competitive for absorption.
The use of prescription drugs also helps in the deficiency of minerals. Antibiotics, Tylenol, Advil, Motrin, and aspirin all inhibit the absorption of minerals especially zinc, chromium and calcium.
Research has shown the best bioavailable minerals are amino acid chelated minerals.
Fiber which contains phytates, tea which contains tannins and rhubarb and spinach which contains oxalates are known as bad chelates. This is because phytates, tannins and oxalates bind the minerals in the body to themselves in the same way that amino acids do, this results in the minerals not being absorbed by the body but excreted instead.

Methionine effects the concentration of vitamin B6, B12, choline, folic acid and magnesium.
Vitamin C can enhance iron absorption from supplements and plant foods.
The fat-soluble vitamins (A, D, E and K) are likely to be better absorbed if taken with a meal that contains fats. In fact, one study found that taking vitamin D with dinner rather than breakfast increased blood levels of vitamin D by about 50%.
Moderate to large doses of fat-soluble vitamins reduce absorption of other fat-soluble vitamins - by about 10 to 50% - due to competition.
Vitamin B1 in high doses can lower other B vitamins and homocysteine.
Absorption of vitamin K appears to be particularly reduced by taking other fat-soluble vitamins.
Vitamin A absorption is least affected and may actually be better absorbed when taken with vitamin E.
Taking vitamins D, E, or K several hours before or after other fat-soluble vitamins would seem to maximize their absorption.
Vitamin C can inhibit copper absorption, and too much copper can lead to vitamin C deficiency.
Zinc inhibits both copper and iron; magnesium. Also copper, iron and calcium all compete for absorption, so too much of one can lead to low blood levels of the others.
Taking antibiotics for a long time can also deplete the body's levels of several B vitamins. On the other hand, taking vitamin B-12 with the antibiotic tetracycline may interfere with the medication's absorption and effectiveness.
Weight loss medication that prevents your body from absorbing fat also prevents your body from absorbing fat-soluble vitamins.
Taking Magnesium with food can reduce the occurrence of diarrhea.
Taking iron with food can reduce the chance of stomach upset.
l-leucine was inhibited by l-valine, l-isoleucine and l-methionine
l-lysine was inhibited by l-arginine, l-phenylalanine and l-histidine.
Little or no competition was observed for the glycine uptake site.
Many other amino acids compete with each other for absorption.
https://www.consumer...-take-vitamins/
https://www.livestro...other-vitamins/
http://www.foodminer...human-body.html
https://www.scienced...300962977903528
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#29 fishinghat

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Posted 12 July 2018 - 04:29 PM

List of medical/medicinal causes of Anxiety not including stress
There are over 400 medical conditions that can cause anxiety. Too many to list here.
http://www.rightdiag...iety/causes.htm
Medications or substances that may cause Anxiety
There are 100s of drugs, medications, substances or toxins that can cause anxiety. Too many to list here.
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List of Causes of Depressive Symptoms
Again, this list would contain over 600 medical conditions that may cause depression.
http://www.rightdiag...toms/causes.htm
Medications or substances causing Depressive symptoms
There are 100s of drugs, medications, substances or toxins that can cause depression.

Post Menapausal Depression
https://www.ncbi.nlm...pubmed/25622021
Hormone-related factors and post-menopausal onset depression: results from KNHANES (2010-2012).
"Greater numbers of pregnancies and exogenous hormone use were also associated with increased risk of depression."

https://www.ncbi.nlm...pubmed/26384055
Effect of previous diagnoses of depression, menopause status, vasomotor symptoms, and neuroticism on depressive symptoms among climacteric women: A 30-month follow-up.
"The research suggested that neuroticism plays an important role in the persistence of depression among climacteric women after 30 months."
Definition - Neuroticism is a long-term tendency to be in a negative emotional state. People with neuroticism tend to have more depressed moods - they suffer from feelings of guilt, envy, anger, and anxiety more frequently and more severely than other individuals. Neuroticism is the state of being neurotic.
Those who score highly on neuroticism tend to be particularly sensitive to environmental stress and respond poorly to it. They may perceive every day, run-of-the-mill situations as menacing and major; trivial frustrations are problematic and may lead to despair.

https://www.ncbi.nlm...pubmed/25585035
Ovarian hormone fluctuation, neurosteroids, and HPA axis dysregulation in perimenopausal depression: a novel heuristic model.
mood disorders was synthesized to describe a heuristic model of perimenopausal depression development.
RESULTS:
The rate of major depressive disorder and clinically meaningful elevations in depressive symptoms increases two- to threefold during the menopause transition. While the mechanisms by which ovarian hormone fluctuation might impact mood are poorly understood, growing evidence from basic and clinical research suggests that fluctuations in ovarian hormones and derived neurosteroids result in alterations in regulation of the HPA axis by γ-aminobutyric acid (GABA). The authors' heuristic model suggests that for some women, failure of the GABAA receptor to regulate overall GABA-ergic tone in the face of shifting levels of these neurosteroids may induce HPA axis dysfunction, thereby increasing sensitivity to stress and generating greater vulnerability to depression.
CONCLUSIONS:
The proposed model provides a basis for understanding the mechanisms by which the changing hormonal environment of the menopause transition may interact with the psychosocial environment of midlife to contribute to perimenopausal depression risk. Future research investigating this model may inform the development of novel pharmacological treatments for perimenopausal depression and related disorders, such as postpartum depression and premenstrual dysphoric disorder.
Definition - The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three endocrine glands: the hypothalanus, the pituatary gland (a pea-shaped structure located below the thalamus), and the adrenal glands (small, conical organs on top of the kidneys).
Neil's Note -The involvement of the HPA axis and GABA are widely accepted as the key in developing menopausal depression.
https://www.ncbi.nlm...pubmed/26552926
[Depression during the perimenopause].
The chances of developing depression seem to be higher during the perimenopause than during the premenopause. The difficulty in measuring the fluctuations of female hormones during the perimenopausal stage may be the reason why no correlation between depression and the fluctuations of hormones has yet been unambiguously established. Future studies and meta-analysis could provide a more accurate estimate of the risk of developing depression during the perimenopause and could give detailed information about the relationship between hormonal factors and perimenopausal depression.

https://www.ncbi.nlm...pubmed/23398127
Do menopausal status and use of hormone therapy affect antidepressant treatment response? Findings from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study
In this study, citalopram treatment outcome was not affected by menopausal status. Hormonal contraceptives and Hormonal Therapy also did not affect probability of good outcome.

https://www.ncbi.nlm...pubmed/25768800
Individualized homeopathic treatment and fluoxetine for moderate to severe depression in peri- and postmenopausal women (HOMDEP-MENOP study): a randomized, double-dummy, double-blind, placebo-controlled trial.
RESULTS:
After a 6-week treatment, homeopathic group was more effective than placebo by 5 points in Hamilton Scale. Response rate was 54.5% and remission rate, 15.9%. There was a significant difference among groups in response rate definition only, but not in remission rate. Fluoxetine-placebo difference was 3.2 points. No differences were observed among groups in the Beck Depression Inventory. Homeopathic group was superior to placebo in Greene Climacteric Scale (8.6 points). Fluoxetine was not different from placebo in Greene Climacteric Scale.
CONCLUSION:
Homeopathy and fluoxetine are effective and safe antidepressants for climacteric women. Homeopathy and fluoxetine were significantly different from placebo in response definition only. Homeopathy, but not fluoxetine, improves menopausal symptoms scored by Greene Climacteric Scale.

https://www.ncbi.nlm...pubmed/25257397
Menopausal status could modulate the association between 5-HTTLPR and antidepressant efficacy in depressed women: a pilot study.
Abstract
The aim of this study was to evaluate the association between the functional polymorphic region of the serotonin transporter gene (5-HTTLPR) and antidepressant efficacy in menopausal and non-menopausal women. Since serotonergic system has been shown to be linked to estrogens, menopausal status of women may explain previous contradictory results on antidepressant efficacy in major depressive episode related to 5-HTTLPR in women. Seventy-four women (43 non-menopausal and 31 menopausal) and 29 men with a major depressive episode were genotyped for the 5-HTTLPR and assessed prospectively for antidepressant efficacy after 4 weeks of treatment. Non-menopausal women with at least one copy of the long allele had better antidepressant efficacy than those who were homozygous for the short allele, whereas no difference was found in menopausal women. Furthermore, antidepressant response was correlated with an interaction between the 5-HTTLPR polymorphism and age in women, but not in men. This finding suggested that the differences in antidepressant response were not linked to age but, rather, to menopausal status of women. Further research on a bigger sample is needed with steroids measurements to determine how menopausal status and 5-HTTLPR polymorphism influence antidepressant response.

https://www.ncbi.nlm...pubmed/24434020
Urinary phytoestrogens and depression in perimenopausal US women: NHANES 2005-2008.
Lower lignans but not isoflavones concentrations were statistically significantly associated with an increased risk of depression in perimenopausal women. Because of medical risks associated with the use of hormone therapy, further investigation on the effect of lignans on the risk of depression in perimenopausal women is warranted.
Neil's Notes- If related to low lignans than ligand supplements might help!!??

https://www.ncbi.nlm...pubmed/27891399
Effect of Citalopram in Combination with Omega-3 on Depression in Post-menopausal Women: A Triple Blind Randomized Controlled Trial.
Using omega-3, in combination with Citalopram greatly reduce the severity of depression in post-menopausal women when compared to citalopram only.

https://www.ncbi.nlm...pubmed/26538987
Low vitamin D, and bone mineral density with depressive symptoms burden in menopausal and postmenopausal women.
The current study revealed that there was a strong association between vitamin D level and BMD (bone marrow density) in Arab women during the menopausal and post-menopausal period.
Neil's Notes - Have you had your Vitamin D levels and bone density checked?
https://www.ncbi.nlm...pubmed/26280374
Higher serum total testosterone levels correlate with increased risk of depressive symptoms in Caucasian women through the entire menopausal transition.
In our cohort, testosterone levels were low but progressively increased from premenopause through post menopause. In addition to age and history of depression, we identified race to have a significant interaction between the association of testosterone levels and depressive symptoms.
Neil'sNotes - Higher testosterone in white women increased the risk of pot-M depression.
Have you had your hormone levels checked including testosterone?

https://www.ncbi.nlm...pubmed/18502089
Effectiveness of antidepressant treatments in pre-menopausal versus post-menopausal women: a pilot study on differential effects of sex hormones on antidepressant effects.
"Our study suggests that menopausal status and old age are predictors of a poor response to antidepressant treatment. Furthermore, the FSH (Follicle Stimulating Hormone) may interfere with the mechanism of action of the antidepressant agents.
Definition - Follicle-stimulating hormone (FSH) is a gonadotropin, a hormone. FSH is synthesized and secreted by the pituatary gland and regulates the development, growth and reproductive processes of the body. FSH and luteinizing hormone (LH) work together in the reproductive system.
Neil's Notes - Have you had your FSH and LH checked? These are commonly altered after and during menopause.

https://www.ncbi.nlm...pubmed/17196795
Response to SSRIs and role of the hormonal therapy in post-menopausal depression.
In conclusion, HT appeared to improve the antidepressant response to SSRIs. Furthermore, in post-menopausal women, LH basal levels may be taken into account as possible predictor of response.

https://www.ncbi.nlm...v/pubmed/284768
Effects of Danazol on pituitary gonadotrophins in post-menopausal women.
Abstract
Multiple sampling was carried out in 4 postmenopausal women for measurement of LH and FSH before and at the end of a 1-week treatment period with Danazol (400 mg daily). A small but significant depression of FSH was found in 3 of 4 subjects, while a significant depression of LH was only seen in 1 subject. In view of the very modest gonadotrophin suppression demonstrated in these women it is possible that Danazol also exerts its profound and sometimes rapid effects through inhibition of positive oestrogen feedback and by direct actions on the ovaries and endometrium.
Neil's Notes - Can Danazol treat Post-D if due to high FSH and/or LH?
https://www.ncbi.nlm...pubmed/22476613
The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice.
The results showed that SECO (10 mg/kg) treatment could significantly reduce the duration of immobility of OVX mice in these two models compared with the control group (OVX mice + vehicle), which was similar to the positive control imipramine. In addition, SECO treatment could substantially increase brain monoamine (norepinephrine and dopamine) levels in OVX mice. The present studies showed that SECO can reverse depressive-like behavior and exhibit monoamine-enhancing effects.

Neil's Notes - The previous document had some studies showing low lignan levels in depressed post-M women. While there is not much scientific evidence that it helps depression there is considerable positive testimony in forums and blogs for the use of flaxseed (high in lignans) to help with depression. Dosage of 40 grams of crushed flaxseed or flaxseed in bread daily is the normal recommendation. This contains phytoestrogens as well so that may be part of the benefit.
Tryptophan for PMD
Neil's Notes - I found several articles that showed there was no relationship between serotonin levels and depression in menopausal and post-menopausal women. This may help explain why use of ssri and snri is limited in its effectiveness. Tryptophan showed no help in treating menopausal depression.

Thyroid
https://www.ncbi.nlm...pubmed/26042394
Our study supports the importance of thyroid functionality in cognitive functioning in a group of women after menopause. The values of TSH, TT3, TT4, TPO-AB, and AB-TSHR were higher and FT4 was lower in examined women.

https://www.ncbi.nlm.../pubmed/6415363
A study of thyroid function in the pre- and post-menopause.
Abstract
Serum levels of thyroid-stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), free triidotthyronine (FT3), free thyroxine (FT4) and thyroxine-binding globulin (TBG) were measured in 382 healthy women who were attending a menopause clinic. Of these women, 140 were in the pre-menopausal phase, 162 had been post-menopausal for less than 3 yr and 60 had been post-menopausal for greater than 3 yr. Analysis of the results as a function of climacteric situation, revealed that the only significant difference was a lower serum concentration of FT3 in the women who had been post-menopausal for over 3 yr than in the women who were in the pre-menopausal phase. Statistical analysis of the results as a function of both climacteric situation and age showed that the serum level of TBG increases with age, while serum levels of circulating thyroid hormones decrease, and that although the menopause does not bring about marked changes in thyroid function, it nevertheless tends to reduce that function, especially when menopause occurs at the expected time. Finally, by correlating values with T4 values on an individual basis, it was possible to ascertain that when physiological changes in thyroid function do occur in the climacteric, they are not caused by primary changes in TSH secretion.

https://www.ncbi.nlm...pubmed/17701801
Can thyroid dysfunction explicate severe menopausal symptoms?
Abstract
Many of the menopausal manifestations look like those accredited to thyroid hyperfunction or hypofunction. Can thyroid dysfunction explicate severe menopausal symptoms? The study comprised 350 women with different menopausal symptoms. All women had serum TSH, T3 and free T4 estimated. Women with thyroid dysfunction were appropriately treated and other women were treated with ERT. The study showed that 21 women (6%) had hypothyroidism and 18 (5.1%) had hyperthyroidism. Marked improvement in the menopausal-like symptoms occurred after treatment of the thyroid dysfunction. Elderly women with severe or resistant menopausal symptoms can be offered TSH, T3 and T4 assays to rule out the thyroid disturbances before attempting hormone replacement therapy.
Notes - Other articles exist as well linking thyroid blood levels to severity of menopausal and Post-menopausal symptoms including depression.
Miscellaneous
https://www.scienced...50805110335.htm
A diet high in refined carbohydrates may lead to an increased risk for new-onset depression in postmenopausal women, according to a study published in The American Journal of Clinical Nutrition.

https://www.research...pausal_Symptoms
Evaluation of the Efficacy and Tolerability of
Micronutrient Supplementation in Treatment of
Post Menopausal Symptoms
Micronutrient supplementation (Menopace ® Tablets) was provided by Meyer Organics Pvt Ltd Thane
Depression: On the 90 th day of treatment, 10 (66.7%) women in the active group compared to only 2 (22.2%) in placebo group showed significant improvement
Anxiety: At baseline, 18 and 13 women in the active and placebo group reported anxiety, respectively. Out of them, 15 in active group and 8 in the placebo group reported moderate to good improvement at the 60 th
day. Furthermore, at the 90 th day, all 18 (100%) women in active group compared to 10 (76%) in placebo group reported moderate to good improvement.

http://www.bumc.bu.e...371&PageID=7136
Testosterone insufficiency in women: fact or fiction?
By André Guay and Susan R. Davis
Excerpt from World Journal of Urology 2002. 20:106-110
It has become apparent that androgens play a significant role in women’s health. More than the expected level of androgens in a woman’s blood stream causes obvious symptoms of androgen excess; less readily apparent are the consequences of female androgen deficiency. The symptoms are subtle, affecting a woman’s sexual desire, satisfaction, and mood, and are commonly mistaken as signs of an underlying depression, prompting referral for counseling and psychotherapy, when hormone measurements would be more appropriate and more fruitful. Androgen deficiency in women is a topic that the medical community has been slow to address. This is partially attributed to the fact that the most common symptom is decreased libido, a very common nonspecific complaint that has long been associated with the psychological issues of stress and depression. One of the earliest reports showing an association between decreased sexual desire and decreased testosterone in women was published in 1959, but acceptance of this association has been slow. However, more evidence now shows that many women-pre-menopausal and post-menopausal-do suffer from androgen deficiency. Because the symptoms of such a deficiency resemble those of depression, misdiagnosis and lack of treatment are common. Improved awareness of the symptoms, diagnostic procedures, and appropriate available treatments are needed, to avoid misdiagnosis and unnecessary or inappropriate treatments.

Wild Yam is an excellent natural menopause treatment for regulating hormones, especially progesterone. This hormone plays a role in controlling moods, and is used to help with depression, moodiness, irritability and anger.
Notes - No scientific evidence to back this claim that it helps depression only the other menopausal symptoms.
Cimicifuga (Black Cohosh) relieves all symptoms of menopause including night sweats and hot flashes, vaginal dryness, bleeding and mood swings. It is especially suited to women experiencing arthritic pains in the joints of the hands, headaches on the right side of the head and neck, and despairing depression. Normal dose is 20-80 mg once or twice daily.
https://www.ncbi.nlm...pubmed/23769553
Effective on menopause symptoms

https://www.ncbi.nlm...fuga depression
Effective on depression.

https://www.ncbi.nlm...pubmed/12609559
Slight positive effect on menopausal depression.

https://www.ncbi.nlm...pubmed/15969244
Significantly reduced menopausal depression.

Many more articles.
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#30 fishinghat

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Posted 12 July 2018 - 04:35 PM

Precription Meds
Cautions and Warnings – Stress starts a series of actions that include the release of adrenaline and other neural stimulants. This causes an increase in respiration, pulse, and blood pressure as well as general metabolism. Any medicine which will help alleviate anxiety will have the effect of lowering the pulse, blood pressure and respiration. This decrease helps explain the frequent weight gains when taking anxiety medicine. The taking of more than one anxiety medicine at a time or too much of an anxiety medicine can pose a risk of low blood pressure and pulse. Not only is it essential that these medications be discussed with your physician but they should still be approached with care. When prescribed an anxiety medicine you should consider starting with a partial dose and gradually working your dose upward as you feel comfortable with any side effects. Nearly all medicines can have side effects. The risk of a serious side effect may be very low BUT you never know, you could be the one. By starting with a low dose it will give you a chance to determine what side effects or allergic reaction will occur before a larger dose is attempted.
Cimetidine – (Tagamet) Increases the absorption of a great many medicines. Please check your meds to see if they can be taken with Tagamet.
Liver and kidney damage is frequent with use of most of these medicines and patients should insist upon a liver function blood test (LFT) and to have their kidney functions checked at least annually. The liver is a detoxification organ for our body and processes most of the medicines we take.
http://www.cymbaltaw...xiety/?hl=helps
Contains list of prescription and OTC antidepressants and there effects and cautions.
Also contains lists of anxiety medications and research on treatment resistant anxiety and depression.

http://www.cymbaltaw...mend#entry68953
Alternate Treatments for Anxiety

Clonidine
Clonidine (Catapres, Kapvay, Nexiclon, Clophelin) is a classic blood pressure medicine BUT it is very effective on anxiety. It is an alpha adrenergic antagonist which means it stimulates the alpha adrenaline synapses located in the frontal lobes of the brain. When these synapses are stimulated by the clonidine the brain thinks that it is due to adrenaline and it tells the adrenal gland to produce less adrenaline. It is a little slow to kick in, about an hour and a half. It has a 12 hour half life. Most drs prescribe 0.1 mg twice a day. One to be taken about an hour before bedtime and the other in the morning. Because it decreases adrenaline it has a strong calming effect which helps a person get to sleep and stay a sleep. It is not unusual for people to have a little drowsiness from clonidine until they get use to it (1 or 2 weeks). It does NOT work faster sublingual (under the tongue) like benzos. These have no withdrawal but your blood pressure may spike for a couple weeks if you cold turkey. Due to the lowering of blood pressure and sleepiness it is common for the patient to start with ½ tablet at bedtime. Once the patient adjusts to the medicine they begin a ½ tablet in the morning. As sleepiness and blood pressure stabilize they are slowly worked up to the 2 tablets (0.1 mg each) a day. They also make a slow release patch for clonidine which avoids the peaks up and down in blood pressure and sleepiness associated with taking clonidine every 12 hours.
Begins working 60 to 90 minutes
Peak levels – 3 to 5 hrs
Half Life – 12 - 16 hrs
There are too many research articles on clonidine's anxiolytic properties to list here.
FH - I started clonidine but it was a relief to me NOT to be able to feel my heart pound through my chest. As long as your bp is OK you shouldn't have a problem.
That is why the slow start up. This gives your heart a chance to adapt to the new med. I did the same slow start up and my bp stayed within normal range. Just keep monitoring your bp and you should be OK.
FN - clonidine worked wonders for me
http://www.cymbaltaw...elps#entry71818
Cymbalta, clonidine and hydroxyzine and alcoholism information

Hydroxyzine, (Vistaril, Atarax) - is an H(1)R antagonist, is very effective against anxiety in most people but some get no help from it at all. It is not addictive nor does it have withdrawal but it also can lower blood pressure some but that usually goes away with time. This medicine should be started slowly to give your body a chance to adjust to the blood pressure effect. Normal dose is 25 mg four times a day but can go as high as 400mg/day.
Begins working in 30 minutes or less
Peak levels - 2 hrs
Half Life – 15 to 20 hrs
https://www.ncbi.nlm...pubmed/21154375
https://www.ncbi.nlm...pubmed/12444816
https://www.ncbi.nlm.../pubmed/7875114
Anxiolytic, Sleepiness begins to subside after 1st week and no withdrawal.
https://www.ncbi.nlm.../pubmed/9809861
https://www.ncbi.nlm.../pubmed/2430410
Do not take with cimetidine as it increases hydroxyzine levels in the blood.
https://www.ncbi.nlm...les/PMC1512309/
Effective, sleepiness slowly decreases.
http://www.cymbaltaw...elps#entry71818
Cymbalta, clonidine and hydroxyzine and alcoholism information
https://dailymed.nlm...4b-8e1fae02af2e
(Manufacturer)
For symptomatic relief of anxiety and tension associated with psychoneurosis and as an adjunct in organic disease states in which anxiety is manifested: in adults, 50–100 mg q.i.d.; children under 6 years, 50 mg daily in divided doses and over 6 years, 50–100 mg daily in divided doses.

https://www.drugs.co...ose_for_Anxiety
Usual Adult Dose for Anxiety
-Oral: 50 to 100 mg 4 times a day
-IM: 50 to 100 mg immediately, then every 4 to 6 hours as needed

http://www.pdr.net/d...ine-pamoate-744
(Physicians Desk Reference)
Oral dosage
Adults
50 to 100 mg PO 4 times daily as needed, adjusted to patient response.


https://www.mayoclin...se/drg-20311434
(Mayo Clinic)
For oral dosage forms (capsules or suspension):
⦁ To help control anxiety and tension:
⦁ Adults—50 to 100 milligrams (mg) 4 times a day.

Atenolol is a beta 1 adrenergic receptor antagonist, also known as a beta blocker. It does not pass through the blood brain barrier which limits its side effects compared to other beta blockers. It has been linked to a higher risk of type 2 diabetes. It may cause drowsiness and lower blood pressure. Typical dosage around 25 mg four times/day. Dosage should be slowly increased.
Begins working in 30 minutes to an hour
Peak levels – 2 – 4 hrs
Half Life – 6 - 8 hrs
https://www.ncbi.nlm.../pubmed/3549876
Effective but blood pressure drops.
https://www.ncbi.nlm.../pubmed/4054193
Side Effects
https://www.ncbi.nlm.../pubmed/1777372
https://www.ncbi.nlm.../pubmed/4047384
Not effective
https://www.ncbi.nlm.../pubmed/2196620
30% found it effective.
SF - So now I am on one. It is called Atilonol (Atenolol?) and calms down your heart rate too.
Buspirone (Buspar) is a seratonin 5-HT1A receptor partial agonist and a dopamine antagonist at the receptors. It functions as a weak anti-anxiety medication similar to diazepam in strength (a weak benzo). No withdrawal or tolerance issues. Dosage should be kept low if taking a ssri and/or snri or St. John's Wort as it may cause seratonin syndrome. DO NOT take with grapefruit or grapefruit juice. May lower blood pressure. Typical dosage is 10 to 20 mg three times per day.
Buspar in conjunction with sesamol exhibited decreased anxiety in test animals. (See sesamol below)
Begins working 3 to 7 days after begin dosing
Peak levels - 1 hrs
Half Life – 2 - 4 hrs
https://www.ncbi.nlm...les/PMC3608295/
With Sesamol
https://www.ncbi.nlm...pubmed/22998742
Buspar (15mg) and Melatonin (3 mg) yielded the best anti-depressant effect of any combination concentration tested. (See Melatonin below)
https://www.ncbi.nlm...pubmed/25156283
Buspar and melatonin in combination is anxiolytic.

Benzodiazipines and Z-Drugs
Usage data

https://www.ncbi.nlm...pubmed/25517224
In 2008, approximately 5.2% of US adults aged 18 to 80 years used benzodiazepines. The percentage who used benzodiazepines increased with age from 2.6% (18-35 years) to 5.4% (36-50 years) to 7.4% (51-64 years) to 8.7% (65-80 years). Benzodiazepine use was nearly twice as prevalent in women as men. The proportion of benzodiazepine use that was long term (> 120 days) increased with age from 14.7% (18-35 years) to 31.4% (65-80 years), while the proportion that received a benzodiazepine prescription from a psychiatrist decreased with age from 15.0% (18-35 years) to 5.7% (65-80 years). In all age groups, roughly one-quarter of individuals receiving benzodiazepine involved long-acting benzodiazepine use.

https://www.ncbi.nlm...pubmed/25613443
Estimates of the number of benzodiazepine-dependent persons in Germany range from 128 000 to 1.6 million.

Use benzodiazepines for only 4 weeks or less to minimize risk of addiction.

https://www.ncbi.nlm...les/PMC4318457/
Dependency problems with benzodiazepines have been a familiar phenomenon for
about 40 years for this reason, pharmaceutical companies and the German Federal Institute for Drugs and Medical Devices (BfArM) have restricted the standard period of use to 2–4 weeks since the 1980s. According to the current law on prescriptions of medical drugs, hypnotics and tranquillizers can be prescribed for period can be extended if sound reasons exist.

http://www.smw.ch/co...smw-2011-13277/
Within weeks of chronic use, tolerance to the pharmacological effects can develop and withdrawal becomes apparent once the drug is no longer available, which are both conditions indicative of benzodiazepine dependence.
Withdrawal symptoms are observed following discontinuation or abrupt reduction of BDZs dosage, even after a relatively short treatment period (three to four weeks). Such physiological symptoms are the main signs of physical dependence. The most frequent are insomnia, gastric problems, tremors, agitation, fearfulness and muscle spasms. Less frequently observed are irritability, sweating, depersonalisation, hypersensitivity to stimuli, depression, suicidal behaviour, psychosis, seizures and delirium tremens. Over-rapid withdrawal from BDZs also increases the severity of the symptoms. Slow and gradual reduction of dosage customised to the individual accompanied by psychological support are the most effective way of managing withdrawal. Complete withdrawal can require four weeks to several years.

National Health Committee. Guidelines for assessing and treating anxiety disorders. Wellington (New Zealand): National Health Committee; 1998.
Recommend restricting their use to no more than 3–4 weeks

https://www.ncbi.nlm...pubmed/17535048
Recommend restricting their use to no more than 3–4 weeks

https://www.ncbi.nlm...t1-ndt-11-1885/
Review of research listing proper use of benzos.
In general, compounds with higher potency and a shorter half-life are associated with a greater likelihood of developing withdrawal syndromes and dependence.
A significant risk of dependence is recognized in some patients receiving treatment for longer than one month, and health professionals should be aware of this when considering the relative treatment benefits and risks.

https://www.ncbi.nlm...pubmed/16639148
Benzodiazepine dependence could be prevented by adherence to recommendations for short-term prescribing (2-4 weeks only when possible).

Clinical Guideline 22 (amended). Anxiety: management of anxiety (panic disorder, with or without agoraphobia, and generalised anxiety disorder) in adults in primary, secondary and community care" (PDF). National Institute for Health and Clinical Excellence. 2007. pp. 23–25. Retrieved 2009-08-08.
According to National Institute for Health and Clinical Excellence (NICE), benzodiazepines can be used in the immediate management of GAD, if necessary. However, they should not usually be given for longer than 2–4 weeks. The only medications NICE recommends for the longer term management of GAD are antidepressants.

McIntosh A, Cohen A, Turnbull N, et al. (2004). "Clinical guidelines and evidence review for panic disorder and generalised anxiety disorder" (PDF). National Collaborating Centre for Primary Care. Retrieved 2009-06-16.

Barbui C, Cipriani A (2009). "Proposal for the inclusion in the WHO Model List of Essential Medicines of a selective serotonin-reuptake inhibitor for Generalised Anxiety Disorder" (PDF). WHO Collaborating Centre for Research and Training in Mental Health. Retrieved 2009-06-23.

Based on the findings of placebo-controlled studies, they do not recommend use of benzodiazepines beyond two to four weeks, as tolerance and physical dependence develop rapidly, with withdrawal symptoms including rebound anxiety occurring after six weeks or more of use.

https://www.ncbi.nlm...pubmed/25613443
Benzodiazepines are generally highly effective when first given, but they should generally be given only for strict indications and for a limited time. If these drugs still need to be given beyond the short term, timely referral to a specialist is indicated, and possibly also contact with the addiction aid system.

http://www.rcpsych.a...diazepines.aspx
Royal College of Psychiatrists
How long should I take a benzodiazepine for?
Up to 4 weeks - no longer. This should really be just to give other (often psychological) treatments a chance to work.



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