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Never Felt This Way In My Entire Life


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#1 DepressedGramma

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Posted 04 January 2019 - 09:30 PM

After taking Cymbalta 120 daily for over 4 years along with Buproprion XL,weaned to 60 daily Cym only. After a year at that dosage, currently weaning to get off it completely since it doesn't work. OMG I am in a living hell. No bead counting needed cuz I have 20mg and 30mg capsules. My Escitalopram started on 12/21/18 taken with 50Cymbalta. Each week Cym decreased by 10mg. Today I am at 30mg.For the past 2 weeks I have been miserable:
Uncontrollable crying,suicidal thoughts, paranoia, irritability off the charts!
Had to join outpatient psychiatric program..avoiding hospitalization.
New MD has given me Valium today cuz Clonazepam makes me worse. I am so scared.

#2 Ozgun

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Posted 05 January 2019 - 08:28 AM

Welcome, welcome!

Before FishingHat gets on, I wanted to express my opinions. I think your symptoms are a result of weaning too fast with too much. I don't know if you read any of the threads, but most people here try to wean %1-3 a week.

Don't be scared, you have us to help you. And my advice would be to reinstate a dosage where you feel stable enough, and go from there. And "Summary of Cymbalta Withdrawal.." topic has got you covered.

I hope I did you justice, FishingHat.

#3 gail

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    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 05 January 2019 - 10:03 AM

Hello DG,

Before Fishinghat comes along, what is the dosage of the escitalopram?

Ozgun is right about going to fast, I would also advise you to get back on the dosage that you felt comfortable with. Like 50 mg. Stay there till you're better. And then you bead count.

Fishinghat will come by later, we don't want seretonin syndrome, so we need your escitalopram dosage. You will be all right with all of us standing by you. Promise!

#4 invalidusername

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Posted 05 January 2019 - 02:00 PM

Hi DG and a welcome from me.
 
So 4 years of 120mg, 1 year at 60mg and now 2 weeks at 50mg with escitalopram, and 30mg as of today.
 
The girls have already covered you with the main point. Whilst the 10mg drop may have seemed like a small move, it wasn't. The further drop today to 30mg is a no-brainer. 
 
All your symptoms you have listed are textbook for withdrawal, so for now try your best to tell yourself that it is the medication doing this to you. I know that doesn't help in the moment, but thinking long-term, where it is the effect of the pills, it has to pass... and it will.
 
But for now, as the girls have said, get back to your last stable dose - this is after all what it says in the patient information leaflet. Then we can start getting you cross-tapering on an easier schedule.
 
As Ozgun has rightly pointed out to another member, you are going from an SNRI to a SSRI. The chemical compound, and therefore the levels being controlled in your brain, are going to be all off. The "N" is no longer being regulated. This "N" is norepinephrine which balances out your adrenaline response. With this out of whack, you will be going backwards and forwards between depression and anxiety - and everything in-between. 
 
You've done exactly the right thing by coming here. We'll look after you :)

#5 fishinghat

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Posted 05 January 2019 - 05:34 PM

Welcome DG. It sounds like these guys pretty well covered everything. The ssri usually take 4 to 8 weeks to kick in and in the mean time just hold on. I don't know if the dr told you but the clonazepam and valium are benzos and they can have a wicked withdrawal as well. Did you stop the clonazepam and if so when?


#6 DepressedGramma

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Posted 06 January 2019 - 04:45 PM

Thank you ALL for ur replies. So is my psychiatrist wrong with the weaning?
Dropping 10mg weekly is too drastic?
Escitalopram is 10mg daily. I was crying too much a year ago while on BOTH Buproprion XL 300 and Cymbalta at 120.
I'm convinced that my longterm usage of psychotropic meds has messed up my brain..long term

#7 DepressedGramma

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Posted 06 January 2019 - 04:48 PM

The Clonazepam doesn't help. Valium is lowest dose at 2mg. I had a bad episode of anxiety so new MD at outpatient center made this change.

#8 fishinghat

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Posted 07 January 2019 - 08:16 AM

I have no problem with your dr dropping you 10 mg every week on your Cymbalta IF he/she is making similar increases in your Escitalopram. You started on the Escitalopram Dec 21st so it may not really kick in until the end of January. This is a fairly routine cross over but you will definitely suffer until the Escitalopram kicks in.

As far as the clonazepam/valium is concerned, benzos work well for anxiety for most but I personally prefer to try hydroxyzine and or clonidine first as they are not addictive and no withdrawal. If they don't work then you can always go to the benzo. Benzos are very addictive and so are to be used only for 4 weeks or less. Their withdrawal is pretty tough as well. I have heard that long-term use has been linked to dementia but haven't had a chance to confirm that yet.

It has been well documented that these psych meds do effect the nerve cells in the brain and once the patient comes off these meds it takes around 2 years for them to recover. If you are planning on coming off them then you better plan on a slow long term weaning.

#9 DepressedGramma

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Posted 07 January 2019 - 06:53 PM

I have had no increase in Lexapro dosage. I really need to discuss the meds situation with new psychiatrist at outpatient program. We ae awaiting results on genetic testing done and hoping for useful information. Thanks for your support..oh I am in the States..so time difference is reason for my delay in reply.

#10 fishinghat

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Posted 07 January 2019 - 07:01 PM

No problem. I am sure the dr will kick you up to 20 mg on the Lexapro when you have come off more of the Cymbalta.


#11 DepressedGramma

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Posted 19 January 2019 - 01:12 PM

Genesight test results show that I am a poor metabolizer of a long list of antidepressants. In addition, I possess a genetic variant that is associated with poor response to SSRI's ...interesting, complex, my younger self responded fabulously to Prozac. Alas..my brain has aged and been bombarded with too high doses of Cymbalta for these past 5 years. Fishinghat..doc suggested increasing Lexapro just like you said, but I don't want to do that fearing both poor responsive and Serotonin Syndrome.
My current plan:
I drop to 20mg Cymbalta today along with the 10mg Lexapro, 2mg Valium and WAIT FOR IT..going to begin a mood stabilizer, 25mg Lamotrogine(Lamictal)today. Doc does not support the practice of opening capsules and bead counting. My goal is to be done with Cymbalta. Thank you dear friends.

#12 fishinghat

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Posted 19 January 2019 - 02:08 PM

Sounds like a plan. You know, just my opinion but I have not been too impressed with the genetic testing results so far. Hopefully with time they will be able to say this one will work for you but that one won't. Something a little more specific without going through this trial and error.

Please keep us informed on how you are doing as that is the way we can all learn and be better educated for the future.

#13 gail

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    5 months on cymbalta, scary side effects, never felt good.
    Needed understanding and support, and a place where I was not alone. To read others stories and realizing that I was not the only one going through all that crap.
    In hope that one day, I can return the favors in some kind of way.

Posted 19 January 2019 - 02:28 PM

DG,

I do think that's a good plan, lowering one at the same time your are upping the other.

So, 20 mg Cymbalta with 10 mg lexapro. At that rate, I don't see a serotonin syndrome.

Don't worry about Lamictal, it's a smooth mood stabilizer, and at 25, I see no problems.
I remember starting it slowly, can't remember the reasons, but they were serious.

Fishinghat, am I rigt when I say thAt seretonin syndrome is improbable in this case?

#14 fishinghat

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Posted 19 January 2019 - 02:46 PM

I agree Gail. Just watch for feeling bad with a spike in temperature (> 102F) but you should be OK.

#15 invalidusername

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Posted 19 January 2019 - 03:54 PM

...or hyperactivity - feeling wired. That is a sure sign. But fever usually accompanies most as Hat said.

 

20mg Cymbalta is no more than 5mg Lexapro equivalent, so no issues for sure, unless shown previously to smaller doses, which is extrememely rare.

 

From what I have read about genetic testing, there is a looooong way to go. Looks promising, but unfortunately results are far from accurate at the present time. I wouldn't put any stock in it myself. Prevention rather than cure should be for all, not only those who are prone to mental health. There are schemes trying to take off over here in the UK for government funding to teach about mental health in schools. This is what we need in the short term. And given that it is costing the NHS stupid amount of money, I fail to see why they aren't backing it yet. Silly sods.


#16 DepressedGramma

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Posted Today, 12:19 AM

Thanks for your support!



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