Feeling Suicidal. Not Sure If I Have Any Options Left.
Posted 24 July 2020 - 06:18 AM
Posted 24 July 2020 - 08:12 AM
As you probably know Zinc can cause severe anxiety. It can also build up in the body to heightened levels. Zinc is not only common in the supplements but also in denture creams, dandruff shampoo and others. A number of class action suits are being pursued against the latter two products for causing severe bouts of anxiety. Zinc has a half life of 47 hours so can build up to excessive levels with time. The RDA for Zinc is 8 mg/day for women. May I ask your dosage?
Zinc also competes with copper, iron, and magnesium.
Posted 24 July 2020 - 09:09 AM
If it was the zinc, I hope that it wouldnt have set me back for too long. This withdrawal thing is so strange. When you go to sleep at night, it's a coin toss how you're going to feel the next morning. When I'm in a window I wish I could just stay awake forever, that way I wouldnt have to worry about sleep sending me back into a wave!
Posted 26 July 2020 - 06:54 PM
Having a really rough day. Wondering if it might be the probiotics, even though they really help me with my reflux. I'm way more sensitive to everything since having my withdrawal meltdown. I hate how long it takes to recover from these things but its somewhat nice to know that I'm never doing anything that affects the absorption of cymbalta again.
Posted 27 July 2020 - 05:38 AM
If we stay on cymbalta and yet have it so nothing sets us back or affects absorption, does this nervous system syndrome ever go away? I've always taken ppi's or something that sets me back so I never fully recover. I'm wondering if I just leave it for a year and be extra safe that maybe I can resume my taper and take another few years to get off this poison. By then I'll probably be dead from throat cancer but oh well!
Posted 27 July 2020 - 08:11 AM
No indication that Cymbalta causes histamine intolerance and considering it does not react with histamines or the receptors it is doubtful. Of course sibo is a common source of histamine intolerance.
While there is no published link between Cymbalta and Mast Cell Activation Disorders the complexity of allergies and compounds that each person has in there system as well as genetics it can't be ruled out.
Posted 27 July 2020 - 09:28 AM
Sorry - aside from the above, just a quick update to say that the wife is now on her PPI every other day and work just as well as every day.
She has also now decided to start her Zoloft - her decision as her depression has got a lot worse. She agreed to let me get the PPI dose down before starting, so I am hoping that will help given that the dose is now the equivalent of 10mg/day.
Looked online and there were a couple of studies that showed levels to be more or less comparable taking every other day as it was every day.
Posted 27 July 2020 - 06:07 PM
The depression is explainable - no question, but the anxiety not so.
I really wanted to follow up with some of these tests, but the wife has just had enough and insisted on giving the Zoloft a go.
But that said, this doesn't sort the GI issues... but one thing at a time. We'll have to wait and see what the Zoloft does and then look into the stomach further.
Posted 28 July 2020 - 09:19 AM
I'm assuming it has something to do with cymbalta absorption in some way as no one else with sibo gets affected like this. Maybe the reduction in acid and inflammation?
Posted 28 July 2020 - 09:24 AM
There are over 100 bacteria that frequently occur in the digestive tract. Good ones and bad ones. Their characteristics depend on what compounds they release during digestion and what compounds they directly generate. It is hard to say the exact cause \but I may be able to help. On your bottle of probiotics it should give the specific bacteria that it contains. If you can give me that list I will try and find out which ones should be helping with the reflux and which ones may be causing the side effects. Maybe we can find a better on point product for you.
Posted 28 July 2020 - 09:36 AM
Just the s boulardii and l plantarum seem to be enough to stop my reflux. I'm wondering if its the s boulardii which is actually a yeast based probiotic. Maybe I experience die off from it? Who knows!
Posted 28 July 2020 - 09:43 AM
Posted 30 July 2020 - 07:55 AM
Well, I was surprised. Most probiotic research deals with its antibacterial action against pathogens, stabilizing bacterial populations in the gut and treating diarrhea. In addition, a lot research is on a mixture of probiotic strains not on one strain at a time. There is little information on how individual species affect pH in the GI tract. I did find a lot of interesting info though that may apply to your situation. As most of those probiotic strains encourage good bacteria and may kill bad bacteria you will possibly be exposed to endotoxins from the bad bacteria. Also, a great many of the species you listed have significant impact on digestive neurotransmitters.
Posted 30 July 2020 - 11:05 AM
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