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Digital Scale Instead Of Bead Counting


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#31 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 27 November 2019 - 06:41 PM

I am going to read the responses and elaborate more in a moment here just want to say i have not changed the actual dose, only the type of gel cap used. Was using enteric until 7-10 days ago. Then used non enteric and gained some improvement.

This morning after taking the enteric capsule again, after the 7-10 days of being on the non enteric gelcap, symptoms multiplied greatly.

#32 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 27 November 2019 - 06:54 PM

Frog, I wish i cld say i was on 7 beads only. I'll get there. If I was in your shoes, I would take 4 beads a.m and 3 p.m. therefore getting your daily allotted 7 beads, but at more regular intervals.
I was taking 40 beads once a day and having crashes in mood and symptoms increasing after the 12 hour mark or so.
So I decided to split the dose to 20 beads 2x per day. It helped stabilize things quite a bit.
There was some confusion so I want to emphasize I have had no dose changes in number of beads in the past 2 weeks, only in delivery package;) enteric vs. Non enteric. In fact, I have been on the split dose for about 6 weeks or so. Been on a total of 40 beads per day in whichever dose system, once a day/twice a day since September.

#33 frog

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Posted 27 November 2019 - 08:44 PM

Hrk I hope you and I are feeling better soon. 

 

Fishinghat and IUN I definitely feel like I'm not getting a steady amount of the drug then as I definitely feel relief later in the day and then by the time I get home I start to feel crappy again. I think it would make sense to even things out.

 

I took 7 beads this am so I'm thinking I'll take 4 beads again in a little bit and then 4 again in the morning? Doing 4 and 3 seems like it'll get very confusing and because of the half life 4 and 4 should still keep me at around the same amount I think? Although whenever I start to taper off this remainder would I be removing just one total bead or one from each dose? 


#34 Lovey

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    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 27 November 2019 - 09:36 PM

You can start with 4 and 4 until you can get more stabilized. That is probably a very good idea. When reducing, I would probably recommend only going down one dose, to 4 and 3. I would take 4 in the a.m. and 3 in the p.m. personally because it causes a little excitability in me (read:restlessness) sometimes. Taking a lower dose closer to bed ups my chances of better sleep. I still have mot taken my p.m. dose tonight. I am waiting a little longer to try and shake off my body's overreaction.... I took a xanax and it has calmed things down. Feeling a little better, ready for bed soon.

#35 fishinghat

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Posted 28 November 2019 - 09:40 AM

I am going to read the responses and elaborate more in a moment here just want to say i have not changed the actual dose, only the type of gel cap used. Was using enteric until 7-10 days ago. Then used non enteric and gained some improvement.

This morning after taking the enteric capsule again, after the 7-10 days of being on the non enteric gelcap, symptoms multiplied greatly.


Sure sounds like it is an issue with the enteric coated capsules. Can you post the brand name? I would like to do a little research.

#36 fishinghat

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Posted 28 November 2019 - 09:43 AM

Hrk I hope you and I are feeling better soon. 
 
Fishinghat and IUN I definitely feel like I'm not getting a steady amount of the drug then as I definitely feel relief later in the day and then by the time I get home I start to feel crappy again. I think it would make sense to even things out.
 
I took 7 beads this am so I'm thinking I'll take 4 beads again in a little bit and then 4 again in the morning? Doing 4 and 3 seems like it'll get very confusing and because of the half life 4 and 4 should still keep me at around the same amount I think? Although whenever I start to taper off this remainder would I be removing just one total bead or one from each dose?


I agree, it shouldn't hurt things at all to try.

#37 fishinghat

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Posted 28 November 2019 - 10:04 AM

I am working on your naphthol question right now hrk. Should be back soon. Having trouble posting though, I just hope the website isn't about to crash.

#38 fishinghat

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Posted 28 November 2019 - 10:44 AM

https://www.ncbi.nlm...les/PMC2695226/
"Compared with most antidepressants, duloxetine exhibits some unusual absorption properties. Duloxetine is rapidly hydrolyzed in acidic media to naphthol, which has no antidepressant activity.10 To overcome this issue, the pellets inside the duloxetine capsule are enteric coated, but the capsule is not. This enteric coating of the pellets resists dissolution until pellets reach a segment of the gastrointestinal tract where the pH is favorable. This explains why the maximal plasma concentration (Cmax) of duloxetine usually does not occur until 6 hours post dose."

https://www.fiercebi...ter-on-cymbalta
Eli Lilley
"As duloxetine is rapidly hydrolyzed in acidic media to naphthol, caution is advised in using Cymbalta in patients with conditions that may slow gastric emptying (e.g., some diabetics)."

https://pubchem.ncbi...xicity-Excerpts
No available toxicity data on 1 naphthol but a closely related compound, 2-naphthol has the following notation...
"Produces crampy abdominal pain, nausea, vomiting, and sometimes convulsions. Intestinal or percutaneous absorption may lead to severe nephritis, liver injury, and acute hemolytic anemia. Lens opacities and retinal changes have been described. Alpha isomer (1-naphthol) is said to be even more toxic. "


 


#39 invalidusername

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Posted 28 November 2019 - 12:14 PM

You can start with 4 and 4 until you can get more stabilized. That is probably a very good idea. When reducing, I would probably recommend only going down one dose, to 4 and 3. I would take 4 in the a.m. and 3 in the p.m. 

 

I agree with H on this one. The larger dose in the morning, smaller in the afternoon. The slight difference in peak level of duloxetine is minimal, but a good trade-off for stability overall.


#40 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 28 November 2019 - 04:23 PM

Thanks for the input fh, iun, frog. Fh the capsule it comes in is blue on one side and white on the other. There is an X on the blue and number 12 on the white. I do not know the manufacturer. I will call the pharmacy and see if i can get any more info. I am using the non enteric coated capsules and feeling a little improved today.

#41 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 28 November 2019 - 04:25 PM

I don't know what gastric emptying means to be honest.
Also, I tend to have low blood sugar even pre-Cymbalta. if this means anything...I am definitely not diabetic though which is good:) How are you all doing today?

#42 invalidusername

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Posted 28 November 2019 - 04:51 PM

Gastric emptying is simply the process of transferring the contents of the stomach to the intestines. Various factors can influence the time that is taken from available enzymes to types of food stuffs...

 

So so day this end. Getting stressed with my headaches. Getting headaches cos I'm stressed... :P


#43 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 28 November 2019 - 05:06 PM

Thx iun. I have a headache today too. Stress related I'm sure. I am hoing to try CBD oil today I think...maybe.... i have it here, just not sure.... its very gray and gloomy here. Its a national holiday of" Thanksgiving" here in the United States today.

#44 invalidusername

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Posted 28 November 2019 - 05:26 PM

It's normally always stress!! CBD is worth a go for sure. I did a write up on it for the site somewhere if you are not too familiar with it.

 

Not much "thanksgiving" over here either,,, but us Brits never have much to be thankful for - least of all our national health system!!


#45 fishinghat

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Posted 28 November 2019 - 06:27 PM

Some people suffer from slow gastric emptying which means the food stays in the stomach significantly longer than 1 hour and thus the enteric coating on the beads may begin to breakdown. Also the stomach is more acidic if there is heartburn and this can cause the enteric coating to breakdown faster as well.

#46 invalidusername

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Posted 28 November 2019 - 07:05 PM

I seem to recall that FDA document that I found the other day mentioned a delay of 2 hours being significant with regards to the coating... but would need to check.


#47 Lovey

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Posted 28 November 2019 - 09:29 PM

This is all very good information, thank you both. I seem to metabolize food quickly, and need to eat small portions every 2 hours. Easier on the system this way as well. Yes healthcare is a real money maker. This I know for sure. Preventative care is where its at for me as much as possible. Healthy food intake is number one in my opinion. Accompanied by a decent amount of activity/movement/light exercise, a good 8-10 hours of sleep is what I need. We have got a widespread recall on all romaine lettuce right now so no salad for a couple weeks. Makes me leary of other lettuce you know? Why only romaine? Better safe than sorry. I'll be doing broccoli and carrots for a bit instead. My spike of terrible symptoms is calming down more today. Though stress of holiday brings its own challenges. Nonetheless, I am proud of the day I put in. Good balance of rest, work, leisure and self care. Even had a family visit with no fatalities. Ha!

#48 fishinghat

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Posted 29 November 2019 - 08:46 AM

All vegetables have proteins and/or complex carbohydrates on their surface as part of cell membranes and outer membranes. These compounds make the vegetables easier to wash as well as providing some antibacterial action. The lettuce family does not have that layer of protection. It should also be notes that solutions made for vegetable washing are very helpful in removing these and other contaminants.

#49 Lovey

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    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 29 November 2019 - 01:34 PM

Fishing hat fascinating! You are a treasure trove of useful information!!! Thank you:)

#50 fishinghat

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Posted 29 November 2019 - 02:33 PM

Anytime hrk. CNN had a news section on that lettuce subject about an hour before your post. Good timing.

#51 invalidusername

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Posted 29 November 2019 - 06:38 PM

LOL... Hrk are you a rabbit?! :D :D

 

...and yes, Hat usually knows something about everything. He is a massive talking walking encyclopedia.. :)


#52 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 29 November 2019 - 10:10 PM

My spirit animal is a butterfly, but I eat a lot like a rabbit!! Had sushi tonight which was a rare treat. I stay away from all grains as much as possible. I have celiac disease and its a lifestyle choice. I hope the sun is showing tomorrow. 4 days of gloomy overcast skies. I may need to go to the tanning salon for some UV rays. My symptom flare has calmed down a lot. I feel more mellow less anger and unexplained rage. I have been having some kind of dissociation yesterday and today. I forget the other word you used for it, but like I am outside of myself watching. It is SO BIZARRE. A stress reaction. Trying my best to hold it together and not give into the runaway imagination and fears that come up. How's frog doing?

#53 frog

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Posted 30 November 2019 - 12:37 AM

I believe it's called depersonalization. I don't think I've experienced it myself but it sounds very bizarre! If anything I feel like I'm too much in my head doing battle between the normal part of my brain and the part that's still recovering. 

 

Gloomy days can be so tough even when you're feeling well. I was definitely very affected by the season change before moving to California. The sun is so healing! I also find that being around nature makes me happy. I'm lucky to live in San Francisco where there's no real winter although the rainy season has finally come and it's going to be overcast and raining for the next week. I don't know where you live, but maybe you have an indoor conservatory in your city that you can visit. The warmth and humidity and greenery always helped take the winter blues away when I lived in Chicago. 

 

Also have you heard of SAD light boxes or lamps? They are designed for people who have seasonal affective disorder. There are different kinds: ones that you turn on and position near you for about half an hour each day or others that come with an alarm clock and help you wake up gently and more naturally. They are meant to mimic the sun's effect to the eyes and brain and help with your natural internal clock during winter when it's always dark and gray. Might be a healthier alternative than UV light :)

 

I'm having a better evening today. I feel very 'normal' with almost no anxiety/thoughts. I had this kind of evening once a few weeks ago. I didn't think I'd have one again with how the past few weeks have gone. It seems like every time I get through a particularly stressful event, it's followed by some better days. This time I made it through Thanksgiving and 3 weeks ago I started a new job. The good moments seem so fleeting and the bad days feel endless. My husband says I've improved a lot over the last month and I'm trying to believe him!


#54 Lovey

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    Trying to get off of this poisonous drug. Need support and help!Down from 120mg to 7mg.
    Am currently taking 18 beads 2x per day. A split dose method. 4 am and 4 pm. Pausing to stabilize.

Posted 30 November 2019 - 05:57 AM

Frog, your words are so well received and encouraging! I will write more later. I am so happy you have some peace today. May much more follow!

#55 fishinghat

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Posted 30 November 2019 - 09:35 AM

LOL... Hrk are you a rabbit?! :D :D
 
...and yes, Hat usually knows something about everything. He is a massive talking walking encyclopedia.. :)


Emphasis on the word "massive". lol

#56 invalidusername

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Posted 30 November 2019 - 02:25 PM

Nice reply there Frog, I was thinking along the similar lines when H mentioned the UV. I've never really experimented with the SAD light therapy, and of all people I should (and LDN) as we bother have delayed sleep phase disorder - meaning we go to bed in the early hours and sleep all through the morning. This time of year, I get about 3 hours daylight. Not good. 

 

On the other note, there is both depersonalisation and derealisation and people often refer to them as one and the same thing, but there is a difference.

 

Derealisation is when the environment, people and things seem strange, unreal etc whereas depersonalisation is when you, yourself seem not of this earth. The latter can often include the former, in which case it is often referred to as simply "disassociation" as an umbrella terms covering all above symptoms.


#57 Lovey

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Posted 30 November 2019 - 08:42 PM

Hey friends thinking of y'all. I got in an awesome paint session tonight in my studio. I need to make time for it more often.

I have dissociation symptoms as iun described above. All the weirdness of environmental strangeness as well as feeling like a "visitor"...but so we all are in the truest respect. This life is temporary and heaven is our true home. Still, it creates such a feeling of lonliness, wanting to be united with God and being away from his immediate presence. He is here in Spirit and within us as well. Sometimes the faith is weak and I struggle with it. Trying to fellowship more with other believers, as it is critical in being part of God's family.

#58 Lovey

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Posted 30 November 2019 - 08:47 PM

As for the SAD lights, I am not sure. I may be in the minority on this, but I think some UV is neccessary. It aids in vitamin D production. It seems silly just sitting in front of a bright light bulb. I sure appreciate the intention and idea to help... idk if it would though...I wld love to try it before purchasing.

#59 frog

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Posted 30 November 2019 - 10:43 PM

True. The 'sun lamps' don't do anything to aid in Vitamin D production. It's more so to help elevate mood a bit and even more importantly to keep your internal clock working right through the dark months since it does trick your brain to think the sun is out and it's time to get up. That's also why you're really only supposed to use them in the morning. I don't know if you can try before you buy, but Amazon has a VERY generous return policy most of the time so I bet you could buy one, give it a try and return it if you didn't care for it. If you get the ones that come with an alarm clock you don't even really need to take any time to sit in front of a light. These ones are meant to imitate a sunrise and they start to slowly get brighter maybe 15 minutes before your alarm is about to go off so you wake up more naturally from the light rather than that horrifying alarm noise. Apparently your eyes absorb the light even through your eyelids so you're getting the 'sun' passively without having to do anything. It's been sunny here for months so I haven't bothered but we're now about to get rain for at least a week straight so I might dig mine out. 





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