Digital Scale Instead Of Bead Counting
#31
Posted 27 November 2019 - 06:41 PM
This morning after taking the enteric capsule again, after the 7-10 days of being on the non enteric gelcap, symptoms multiplied greatly.
#32
Posted 27 November 2019 - 06:54 PM
I was taking 40 beads once a day and having crashes in mood and symptoms increasing after the 12 hour mark or so.
So I decided to split the dose to 20 beads 2x per day. It helped stabilize things quite a bit.
There was some confusion so I want to emphasize I have had no dose changes in number of beads in the past 2 weeks, only in delivery package;) enteric vs. Non enteric. In fact, I have been on the split dose for about 6 weeks or so. Been on a total of 40 beads per day in whichever dose system, once a day/twice a day since September.
#33
Posted 27 November 2019 - 08:44 PM
Hrk I hope you and I are feeling better soon.
Fishinghat and IUN I definitely feel like I'm not getting a steady amount of the drug then as I definitely feel relief later in the day and then by the time I get home I start to feel crappy again. I think it would make sense to even things out.
I took 7 beads this am so I'm thinking I'll take 4 beads again in a little bit and then 4 again in the morning? Doing 4 and 3 seems like it'll get very confusing and because of the half life 4 and 4 should still keep me at around the same amount I think? Although whenever I start to taper off this remainder would I be removing just one total bead or one from each dose?
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#34
Posted 27 November 2019 - 09:36 PM
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#35
Posted 28 November 2019 - 09:40 AM
I am going to read the responses and elaborate more in a moment here just want to say i have not changed the actual dose, only the type of gel cap used. Was using enteric until 7-10 days ago. Then used non enteric and gained some improvement.
This morning after taking the enteric capsule again, after the 7-10 days of being on the non enteric gelcap, symptoms multiplied greatly.
Sure sounds like it is an issue with the enteric coated capsules. Can you post the brand name? I would like to do a little research.
#36
Posted 28 November 2019 - 09:43 AM
Hrk I hope you and I are feeling better soon.
Fishinghat and IUN I definitely feel like I'm not getting a steady amount of the drug then as I definitely feel relief later in the day and then by the time I get home I start to feel crappy again. I think it would make sense to even things out.
I took 7 beads this am so I'm thinking I'll take 4 beads again in a little bit and then 4 again in the morning? Doing 4 and 3 seems like it'll get very confusing and because of the half life 4 and 4 should still keep me at around the same amount I think? Although whenever I start to taper off this remainder would I be removing just one total bead or one from each dose?
I agree, it shouldn't hurt things at all to try.
#38
Posted 28 November 2019 - 10:44 AM
https://www.ncbi.nlm...les/PMC2695226/
"Compared with most antidepressants, duloxetine exhibits some unusual absorption properties. Duloxetine is rapidly hydrolyzed in acidic media to naphthol, which has no antidepressant activity.10 To overcome this issue, the pellets inside the duloxetine capsule are enteric coated, but the capsule is not. This enteric coating of the pellets resists dissolution until pellets reach a segment of the gastrointestinal tract where the pH is favorable. This explains why the maximal plasma concentration (Cmax) of duloxetine usually does not occur until 6 hours post dose."
https://www.fiercebi...ter-on-cymbalta
Eli Lilley
"As duloxetine is rapidly hydrolyzed in acidic media to naphthol, caution is advised in using Cymbalta in patients with conditions that may slow gastric emptying (e.g., some diabetics)."
https://pubchem.ncbi...xicity-Excerpts
No available toxicity data on 1 naphthol but a closely related compound, 2-naphthol has the following notation...
"Produces crampy abdominal pain, nausea, vomiting, and sometimes convulsions. Intestinal or percutaneous absorption may lead to severe nephritis, liver injury, and acute hemolytic anemia. Lens opacities and retinal changes have been described. Alpha isomer (1-naphthol) is said to be even more toxic. "
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#39
Posted 28 November 2019 - 12:14 PM
You can start with 4 and 4 until you can get more stabilized. That is probably a very good idea. When reducing, I would probably recommend only going down one dose, to 4 and 3. I would take 4 in the a.m. and 3 in the p.m.
I agree with H on this one. The larger dose in the morning, smaller in the afternoon. The slight difference in peak level of duloxetine is minimal, but a good trade-off for stability overall.
#40
Posted 28 November 2019 - 04:23 PM
#42
Posted 28 November 2019 - 04:51 PM
Gastric emptying is simply the process of transferring the contents of the stomach to the intestines. Various factors can influence the time that is taken from available enzymes to types of food stuffs...
So so day this end. Getting stressed with my headaches. Getting headaches cos I'm stressed...
#44
Posted 28 November 2019 - 05:26 PM
It's normally always stress!! CBD is worth a go for sure. I did a write up on it for the site somewhere if you are not too familiar with it.
Not much "thanksgiving" over here either,,, but us Brits never have much to be thankful for - least of all our national health system!!
#45
Posted 28 November 2019 - 06:27 PM
#46
Posted 28 November 2019 - 07:05 PM
I seem to recall that FDA document that I found the other day mentioned a delay of 2 hours being significant with regards to the coating... but would need to check.
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#47
Posted 28 November 2019 - 09:29 PM
#48
Posted 29 November 2019 - 08:46 AM
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#52
Posted 29 November 2019 - 10:10 PM
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#53
Posted 30 November 2019 - 12:37 AM
I believe it's called depersonalization. I don't think I've experienced it myself but it sounds very bizarre! If anything I feel like I'm too much in my head doing battle between the normal part of my brain and the part that's still recovering.
Gloomy days can be so tough even when you're feeling well. I was definitely very affected by the season change before moving to California. The sun is so healing! I also find that being around nature makes me happy. I'm lucky to live in San Francisco where there's no real winter although the rainy season has finally come and it's going to be overcast and raining for the next week. I don't know where you live, but maybe you have an indoor conservatory in your city that you can visit. The warmth and humidity and greenery always helped take the winter blues away when I lived in Chicago.
Also have you heard of SAD light boxes or lamps? They are designed for people who have seasonal affective disorder. There are different kinds: ones that you turn on and position near you for about half an hour each day or others that come with an alarm clock and help you wake up gently and more naturally. They are meant to mimic the sun's effect to the eyes and brain and help with your natural internal clock during winter when it's always dark and gray. Might be a healthier alternative than UV light
I'm having a better evening today. I feel very 'normal' with almost no anxiety/thoughts. I had this kind of evening once a few weeks ago. I didn't think I'd have one again with how the past few weeks have gone. It seems like every time I get through a particularly stressful event, it's followed by some better days. This time I made it through Thanksgiving and 3 weeks ago I started a new job. The good moments seem so fleeting and the bad days feel endless. My husband says I've improved a lot over the last month and I'm trying to believe him!
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#55
Posted 30 November 2019 - 09:35 AM
LOL... Hrk are you a rabbit?!
...and yes, Hat usually knows something about everything. He is a massive talking walking encyclopedia..
Emphasis on the word "massive". lol
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#56
Posted 30 November 2019 - 02:25 PM
Nice reply there Frog, I was thinking along the similar lines when H mentioned the UV. I've never really experimented with the SAD light therapy, and of all people I should (and LDN) as we bother have delayed sleep phase disorder - meaning we go to bed in the early hours and sleep all through the morning. This time of year, I get about 3 hours daylight. Not good.
On the other note, there is both depersonalisation and derealisation and people often refer to them as one and the same thing, but there is a difference.
Derealisation is when the environment, people and things seem strange, unreal etc whereas depersonalisation is when you, yourself seem not of this earth. The latter can often include the former, in which case it is often referred to as simply "disassociation" as an umbrella terms covering all above symptoms.
#57
Posted 30 November 2019 - 08:42 PM
I have dissociation symptoms as iun described above. All the weirdness of environmental strangeness as well as feeling like a "visitor"...but so we all are in the truest respect. This life is temporary and heaven is our true home. Still, it creates such a feeling of lonliness, wanting to be united with God and being away from his immediate presence. He is here in Spirit and within us as well. Sometimes the faith is weak and I struggle with it. Trying to fellowship more with other believers, as it is critical in being part of God's family.
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#58
Posted 30 November 2019 - 08:47 PM
#59
Posted 30 November 2019 - 10:43 PM
True. The 'sun lamps' don't do anything to aid in Vitamin D production. It's more so to help elevate mood a bit and even more importantly to keep your internal clock working right through the dark months since it does trick your brain to think the sun is out and it's time to get up. That's also why you're really only supposed to use them in the morning. I don't know if you can try before you buy, but Amazon has a VERY generous return policy most of the time so I bet you could buy one, give it a try and return it if you didn't care for it. If you get the ones that come with an alarm clock you don't even really need to take any time to sit in front of a light. These ones are meant to imitate a sunrise and they start to slowly get brighter maybe 15 minutes before your alarm is about to go off so you wake up more naturally from the light rather than that horrifying alarm noise. Apparently your eyes absorb the light even through your eyelids so you're getting the 'sun' passively without having to do anything. It's been sunny here for months so I haven't bothered but we're now about to get rain for at least a week straight so I might dig mine out.
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