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#1 fishinghat

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Posted 20 December 2019 - 09:51 AM

When the new warning is issued I will post it.

 

https://www.yahoo.co...-204415509.html

The Food and Drug Administration said Thursday it would add new warnings to packaging for Neurontin, Lyrica and generic versions, which are used to treat seizures, nerve pain, restless leg syndrome and other conditions.
The new labels will warn doctors against prescribing the drugs with other medications that can slow breathing, including opioid painkillers. The breathing risks also apply to elderly patients and those with existing lung problems.
The medications, known generically as gabapentin and pregabalin, are among the most prescribed in the U.S. Both physician prescribing and misuse have increased as doctors, hospitals and other health care providers have scaled back their use of opioids amid a national epidemic.
Poison control centers have reported increased calls involving the nerve drugs, which are often abused in combination with opioids, cocaine and marijuana. Neurontin and related generics have long been considered nonaddictive and are not tracked as closely by regulators.


#2 fishinghat

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Posted 20 December 2019 - 10:40 AM

Addiction. 2017 Sep;112(9):1580-1589. doi: 10.1111/add.13843. Epub 2017 May 15.

Risk to heroin users of polydrug use of pregabalin or gabapentin.


Abstract

AIM:

To examine the risk to heroin users of also using gabapentin or pregabalin (gabapentoids).

DESIGN:

Multi-disciplinary study: we (a) examined trends in drug-related deaths and gabapentoid prescription data in England and Wales to test for evidence that any increase in deaths mentioning gabapentin or pregabalin is associated with trends in gabapentoid prescribing and is concomitant with opioid use; ( interviewed people with a history of heroin use about their polydrug use involving gabapentin and pregabalin; and © studied the respiratory depressant effects of pregabalin in the absence and presence of morphine in mice to determine whether concomitant exposure increased the degree of respiratory depression observed.

SETTING:

England and Wales.

PARTICIPANTS:

Interviews were conducted with 30 participants (19 males, 11 female).

MEASUREMENTS:

(a) Office of National Statistics drug-related deaths from 1 January 2004 to 31 December 2015 that mention both an opioid and pregabalin or gabapentin; ( subjective views on the availability, use, interactions and effects of polydrug use involving pregabalin and gabapentin; and © rate and depth of respiration.

RESULTS:

Pregabalin and gabapentin prescriptions increased approximately 24% per year from 1 million in 2004 to 10.5 million in 2015. The number of deaths involving gabapentoids increased from fewer than one per year prior to 2009 to 137 in 2015; 79% of these deaths also involved opioids. The increase in deaths was correlated highly with the increase in prescribing (correlation coefficient 0.94; 5% increase in deaths per 100‚ÄČ000 increase in prescriptions). Heroin users described pregabalin as easy to obtain. They suggested that the combination of heroin and pregabalin reinforced the effects of heroin but were concerned it induced 'blackouts' and increased the risk of overdose. In mice, a low dose of S-pregabalin (20 mg/kg) that did not itself depress respiration reversed tolerance to morphine depression of respiration (resulting in 35% depression of respiration, P < 0.05), whereas a high dose of S-pregabalin (200 mg/kg) alone depressed respiration and this effect summated with that of morphine.

CONCLUSIONS:

For heroin users, the combination of opioids with gabapentin or pregabalin potentially increases the risk of acute overdose death through either reversal of tolerance or an additive effect of the drugs to depress respiration.


#3 invalidusername

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Posted 20 December 2019 - 07:25 PM

Bit delayed for a med that had falsified data from drug trials... but better late than never I guess...


#4 fishinghat

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Posted 11 February 2020 - 10:46 AM

Actual FDA warning.

https://www.fda.gov/...entin-neurontin



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