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Cymbalta Increases Chromogranin A


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#1 fishinghat

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Posted 21 September 2014 - 03:22 PM

Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory proteins, i.e., it is located in secretory vesicles of neurons and endocrine cells such as islet beta cell secretory granules in pancreas.

Examples of cells producing chromogranin A (ChgA) are chromaffin cells of the adrenal medulla, paraganglia, enterochromaffin-like cells and beta cells of the pancreas. It is present in islet beta cell secretory granules.

 

Chromogranin A is the precursor to several functional peptides including vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin. These peptides negatively modulate the neuroendocrine function of the releasing cell (autocrine) or nearby cells (paracrine). They also help control blood pressure.

Chromogranin A induces and promote the generation of secretory granules such as those containing insulin in pancreatic islet beta cells.

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https://www.ncbi.nlm...pubmed/25100382


#2 FiveNotions

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Posted 21 September 2014 - 03:36 PM

er, FH, would you translate that for us mere mortals? ;) 

 

In terms of being on, or withdrawing from, Cymbalta ... what does this mean for us?


#3 fishinghat

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Posted 21 September 2014 - 04:29 PM

Being on Cymbalta - This protein (Chromogranin A) can be elevated by Cymbalta. Higher levels of Chromogranin A then higher levels of vasostatin-1, vasostatin-2, pancreastatin, catestatin and parastatin will be produced. These compounds block aldosterone and  angiotensin production which causes a lowering of BP.

 

Vasostatin I and II) inhibit vasoconstriction, promote fibroblast adhesion (Connective tissue strength), inhibit parathyroid hormone secretion (which controls levels of calcium and phosphorus in the blood) , trigger microglial-cell-mediated neuronal apoptosis (triggers nerve cell death), and have bacteriolytic and antifungal effects. 

 

Once off Cymbalta the Chromogranin A levels return to normal as does aldosterone and  angiotensin production as does the bp.


#4 FiveNotions

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Posted 21 September 2014 - 05:07 PM

Now that is really interesting ... esp. about the blocking of aldosterone and angiotensin thus causing low bp.

How does that factor into my experience, and a number of others here, of having high bp (and I also had tachycardia) while on Cymbalta?

#5 fishinghat

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Posted 21 September 2014 - 05:25 PM

I knew someone smart would ask that question!!  That is a good question and I wish I had a good answer. I have read a dozen articles about how Cymbalta raises bp.  I am not sure but I think there may have been alcohol involved.  lol  Nothing on this research made sense. Stress causes aldosterone to increase as does angiotensin. Again, alcohol.


#6 FiveNotions

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Posted 21 September 2014 - 05:39 PM

There's just no end to the physiological and psychological "fun and games" associated with this stuff, is there? / sarc





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