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#1 Usedtobejoyful

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Posted 25 June 2020 - 10:20 AM

I am trying to withdraw from this awful medicine. I am transitioning to Wellbutrin (at 300 mg now), from Duluxotine, I was up to 120 mg (60 twice a day). I am down to 20 mg once a day, she went from 60 twice a day to 30 once a day, then she stopped it. OMG I had almost every symptom and it was terrifying, as I am normally a easy-going person, working 3 jobs to a non functioning adult...I called and she put me back on 20 mg a day for 2 weeks then wanted me to do every other day. I am waiting for a call back, because I think I need to go much longer, and maybe even go back up to 30? Then start the whole bead removal process?  I have been on it for several years, just increasing from 90 to 120 in January. I am on it for depression (2 suicide attempts, been 9 years since hospitalization for that) I need some help transitioning. advice? I am experiencing most of the symptoms and am having trouble with working, concentrating, functioning, etc. 

 

I've been reading through the threads and I am thinking I definitely need to go way longer for withdrawal. Please help...

 

Joy 


#2 fishinghat

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Posted 25 June 2020 - 11:38 AM

Welcome Joy

 

How long you been on the Wellbutrin now and at what dose?


#3 Usedtobejoyful

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Posted 25 June 2020 - 01:39 PM

I have been on the Wellbutrin since April 30, starting at 150 mg, Three weeks ago bumped to 300.


#4 invalidusername

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Posted 25 June 2020 - 02:13 PM

Joy,

 

Welcome to the forum...

 

The issue here is that you are cutting out the serotonin element completely here. Wellbutrin is a mix of ad classes in so much that it has the norepinphrine of the cymbalta, but adds dopamine - but it does nothing for serotonin. On the plus side there is no risk of serotonin syndrome, but combination of the two can increase the effects of the Cym, so upping the dose too much whilst at 300mg Wellbutrin is not recommended.

 

Also making such a big jump can be just as much a problem of dropping too much. 

 

Can you also tell us whether you are on immediate release or extended release Wellbutrin as this will effect dosage?

 

IUN


#5 fishinghat

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Posted 25 June 2020 - 02:20 PM

Here is the situation Joy.  It takes Wellbutrin 6 to 8 weeks to kick in so it may still be a little over a monthg before you feel the full effects of the 300 mg Wellbutrin. Also, Wellbutrin controls norepinephrine (similar to adrenaline) and dopamine while Cymbalta controlls norepinephrine and serotonin. The reason I mention this is that once the Wellbutrin fully kicks in you may still have some issues with serotonin balance until your body adjusts. This would include some emotional swings and maybe some GI issues. Hopefully the Wellbutrin will be able to compensate for that but you should be prepared in case.
 
You can come off the Cymbalta slower than the dr recommended but you would be at risk for seizures. In addition, you should not consider the use of alcohol while on Wellbutrin. Using Wellbutrin with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. On the other hand, sudden withdrawal from alcohol following regular or chronic use can also increase your risk of seizures during treatment with Wellbutrin.

 

There are some medications your dr can prescribe for any anxiety type symptoms but I hesitate to mention them as they may make the depression worse. 


#6 Usedtobejoyful

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Posted 25 June 2020 - 03:28 PM

Thank you, for the quick responses. I am on the XL Wellbutrin. The doctor said today it is fine for me to continue the 20mg, and do the tapering at my own pace. I am open for any of your suggestions, my doctor (psychiatrist) will work with me on this.

#7 Usedtobejoyful

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Posted 25 June 2020 - 03:32 PM

Oh and I rarely drink anything, not planning on having anything anytime soon I did research all the side effects of Wellbutrin, so I am aware of that. I also kind of had heard about the side effects of going off Cymbalta, but wow. Just wow.

#8 fishinghat

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Posted 25 June 2020 - 03:49 PM

Yea, the withdrawal symptoms can be horrible for sure. They can even last for months after the last dose although that shouldn't be the situation considering you are on the Wellbutrin. If she does not see any problem with staying on the Cymbalta (20 mg) while on Wellbutrin that is good. In such a case I would stay on the 20 mg until you have been on the 300 mg Wellbutrin for 8 weeks and then, depending on how you are doing, start a slow bead count on the Cymbalta. 


#9 Usedtobejoyful

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Posted 25 June 2020 - 04:33 PM

Thank you so much!!! I feel better just knowing I have someone to help me through this "Tish" lol. Just watched the video that was shared on another thread. Gave me quite the chuckle!

#10 fishinghat

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Posted 25 June 2020 - 05:29 PM

We will give you all the help we can Joy. We will make it through this together.


#11 invalidusername

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Posted 25 June 2020 - 06:03 PM

I think you saw Andy Bailey's Pregabalin video! I posted that for another new member earlier today. It is fantastic... really got me thru some of my darkest days that did.

 

Not having recalled anyone mixing the WB and Cym, it needed a bit of looking into, but as I said before, you won't have Serotonin issues, so aside from the possible seizures that Hat mentioned, it would be wise to go relatively slow - perhaps so you are getting towards the 10mg for 6 weeks on the WB and then cross-taper for another couple of months for that last 10mg whilst the WB properly kicks in. You should also be out of the start-up effects from the WB, so anything you will be getting you can blame on the Cym.

 

What you don't want to do is drop the Cym quickly during the start-up of the WB as you will not know which symptom is caused by which, so I would keep the Cym steady as Hat says so you at least know how your system is going to take to the WB.

 

Hope that all makes sense. Been a long day for me in the UK, so might be rabbiting a bit!!


#12 Usedtobejoyful

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Posted 25 June 2020 - 06:29 PM

I think you say Andy Bailey's Pregabalin video! I posted that for another new member earlier today. It is fantastic... really got me thru some of my darkest days that did.
 
Not having recalled anyone mixing the WB and Cym, it needed a bit of looking into, but as I said before, you won't have Serotonin issues, so aside from the possible seizures that Hat mentioned, it would be wise to go relatively slow - perhaps so you are getting towards the 10mg for 6 weeks on the WB and then cross-taper for another couple of months for that last 10mg whilst the WB properly kicks in. You should also be out of the start-up effects from the WB, so anything you will be getting you can blame on the Cym.
 
What you don't want to do is drop the Cym quickly during the start-up of the WB as you will not know which symptom is caused by which, so I would keep the Cym steady as Hat says so you at least know how your system is going to take to the WB.
 
Hope that all makes sense. Been a long day for me in the UK, so might be rabbiting a bit!!


#13 Usedtobejoyful

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Posted 25 June 2020 - 06:32 PM

Thank you!!!! No you are not rambling, makes perfect sense....though my brain is messed up right now, lol

#14 Usedtobejoyful

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Posted 25 June 2020 - 06:36 PM

Haha....I certainly am blonde...was trying to use the quote thing and completely messed that up. And I saw rabbiting as rambling. Oh well.. potato/patahtoe....

#15 invalidusername

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Posted 25 June 2020 - 07:21 PM

LOL!! Blame the Cymbalta - we always do!! 

 

Hat is a great one for that. I am always pulling him up on this typos - not that I don't make any myself - but I just get a kick out of it :)


#16 Usedtobejoyful

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Posted 06 November 2020 - 10:51 PM

Just an update, I stayed on the 20 mg till into August, then start ed micro-dosing. I have had some rough times, got overconfident once and thought I was good, lol... won't do that again. I am down to about 10 beads a day. (Seriously could they make them a bit smaller??? Sheesh it's not easy to do it) but I open the capsule and dump out what I won't use into an empty script bottle, and put the capsule back together. I did order empty capsules on Amazon, but they must have been for elephants, so they will probably be donated to the zoo or some essential oils people, lol. I am feeling ok. Not terrible, though I feel off sometimes, actually had a doctor not even get close to me and said, we need to do a COVID test. What a freaking circus that was....oh, of course I was negative, and I took the opportunity to go see my aunt in the nursing home (my state requires a negative COVID test within the last 7 days to be eligible to visit in a room at two ends of a 10 ft table with masks and a chaperone, super fun when you can't hear so well from the ringing in your ears, lol)
So I am going slow as I can. Still awful dreams but not as terrifying.occasional gastric issues, headache...anyway thanks for letting me ramble. Hope you are all well

#17 fishinghat

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Posted 07 November 2020 - 07:44 AM

Well you have come a long ways USTBJ. The experience is can certainly a traumatic one. Just keep hanging in there and you will be OK. Thank you for the update.


#18 invalidusername

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Posted 07 November 2020 - 09:40 AM

Good to hear from you - and sounds like a standard way forward that you are on. Glad you could visit your family. Regardless of not being able to hear, your presence there will undoubtedly be of much benefit and gratitude to her. A lovely thing to do.

 

It is also very easy to get complacent with these things, but glad that you have learned from it! Remember to stay steady for as long as you need to  - there is no race. The better you deal with the reduction of beads, the easier it will be when you come to day zero. Unfortunately, it doesn't stop when you have got there. There is still a little further to go, but it sounds like you are well aware of what needs to be done.

 

Keep in touch and take care.

 

IUN





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