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Antidepressants And Movement Disorders


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#1 fishinghat

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Posted 27 June 2020 - 03:27 PM

https://pubmed.ncbi....h.gov/32546134/

 

Antidepressants and Movement Disorders: A Postmarketing Study in the World Pharmacovigilance Database

 

"...disproportionality of movement disorders' reporting was assessed among adverse drug reactions related to any antidepressant, from January 1967 to February 2017, through a case/non-case design. The association between nine subtypes of movement disorders (akathisia, bruxism, dystonia, myoclonus, parkinsonism, restless legs syndrome, tardive dyskinesia, tics, tremor) and antidepressants was estimated."

 

"We found a significant increased ROR for antidepressants in general for all subtypes of movement disorders, with the highest association with bruxism (ROR 10.37, 95% CI 9.62-11.17) and the lowest with tics (ROR 1.49, 95% CI 1.38-1.60). When comparing each of the classes of antidepressants with the others, a significant association was observed for all subtypes of movement disorders except restless legs syndrome with serotonin reuptake inhibitors (SRIs) only. Among antidepressants, mirtazapine, vortioxetine, amoxapine, phenelzine, tryptophan and fluvoxamine were associated with the highest level to movement disorders and citalopram, paroxetine, duloxetine and mirtazapine were the most frequently associated with movement disorders. An association was also found with eight other antidepressants. "
 


#2 invalidusername

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Posted 13 July 2020 - 05:57 PM

"A recent observational study found a harmful association between the incidence of parkinsonism or associated extrapyramidal symptoms and use of antidepressants duloxetine, mirtazapine, citalopram, escitalopram, paroxetine, sertraline, venlafaxine, bupropion, and fluoxetine"

 

Oooooh, yup.

 

"However, the association between SRIs and parkinsonism is well documented"

 

Bit of a misnomer. Written about subjectively, but very little data.

 

Another very good article here;

 

https://www.ncbi.nlm...rticle_2711.pdf

 

And these two, but cannot gain access to full text;

 

https://onlinelibrar....1002/mds.23828

https://journals.lww..._During.15.aspx


#3 fishinghat

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Posted 14 July 2020 - 08:48 AM

Thanks for the add-on. More good info.


#4 invalidusername

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Posted 14 July 2020 - 05:11 PM

I have requested full text from the authors on the Parkinson's paper as it isn't one I have and it looks like it might help researching my father's condition...

 

Sincerely hope they offer sympathy in supplying the text.





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